KCNJ2 and KCNJ8

Number of citations of the paper that reports this interaction (PMID 10559219)
17

Data Source:
HPRD (in vivo, in vitro)

		KCNJ2	KCNJ8
Gene Name		potassium channel, inwardly rectifying subfamily J, member 2	potassium channel, inwardly rectifying subfamily J, member 8
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Smooth Endoplasmic Reticulum Rough Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Voltage-gated Potassium Channel Complex Intercalated Disc T-tubule Intrinsic Component Of Membrane Neuronal Cell Body Dendritic Spine	Mitochondrion Plasma Membrane Voltage-gated Potassium Channel Complex ATP-sensitive Potassium Channel Complex Myofibril Sarcolemma
	Molecular Function	Inward Rectifier Potassium Channel Activity Phosphatidylinositol-4,5-bisphosphate Binding Identical Protein Binding Voltage-gated Potassium Channel Activity Involved In Cardiac Muscle Cell Action Potential Repolarization	Inward Rectifier Potassium Channel Activity ATP Binding ATP-activated Inward Rectifier Potassium Channel Activity G-protein Activated Inward Rectifier Potassium Channel Activity Sulfonylurea Receptor Binding
	Biological Process	Potassium Ion Transport Synaptic Transmission Potassium Ion Import Regulation Of Skeletal Muscle Contraction Via Regulation Of Action Potential Magnesium Ion Transport Cellular Potassium Ion Homeostasis Protein Homotetramerization Relaxation Of Cardiac Muscle Regulation Of Resting Membrane Potential Regulation Of Membrane Repolarization Cellular Response To Mechanical Stimulus Potassium Ion Transmembrane Transport Cardiac Muscle Cell Action Potential Involved In Contraction Membrane Repolarization During Action Potential Membrane Depolarization During Cardiac Muscle Cell Action Potential Membrane Repolarization During Cardiac Muscle Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Relaxation Of Skeletal Muscle Positive Regulation Of Potassium Ion Transmembrane Transport	Kidney Development Potassium Ion Transport Synaptic Transmission Heart Development Response To PH Potassium Ion Import Response To Lipopolysaccharide Regulation Of Ion Transmembrane Transport Vasodilation Response To Exogenous DsRNA Defense Response To Virus
Pathways		GABA B receptor activation Inwardly rectifying K+ channels GABA receptor activation Activation of G protein gated Potassium channels Classical Kir channels Activation of GABAB receptors Potassium Channels Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell G protein gated Potassium channels Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits Transmission across Chemical Synapses	Inwardly rectifying K+ channels ATP sensitive Potassium channels Potassium Channels
Drugs
Diseases
GWAS		Cardiac repolarization ( 22342860) Formal thought disorder in schizophrenia ( 22648509) Obesity-related traits ( 23251661) Primary tooth development (number of teeth) ( 23704328 20195514) Primary tooth development (time to first tooth eruption) ( 23704328 20195514) Pulmonary function (interaction) ( 23284291) QT interval ( 19305409) Refractive error ( 23396134) Thyrotoxic hypokalemic periodic paralysis ( 22863731 22399142)
Protein-Protein Interactions		14 interactors: AKAP5 CASK DLG1 DLG2 DLG3 DLG4 FLNA IL16 INADL KCNJ11 KCNJ16 KCNJ4 KCNJ8 TRAK2	4 interactors: ABCC8 ABCC9 KCNJ11 KCNJ2
Entrez ID		3759	3764
HPRD ID		02815	02962
Ensembl ID		ENSG00000123700	ENSG00000121361
Uniprot IDs		P63252	Q15842
PDB IDs
Enriched GO Terms of Interacting Partners?		Receptor Localization To Synapse Synaptic Transmission Receptor Clustering Nucleotide Phosphorylation Protein Localization To Synapse Cell-cell Signaling Potassium Ion Import Regulation Of Ion Transmembrane Transport Regulation Of Ion Transport Establishment Or Maintenance Of Apical/basal Cell Polarity Protein Localization To Membrane Potassium Ion Transmembrane Transport Cellular Protein Localization Potassium Ion Transport Nucleotide Metabolic Process Signaling Nucleobase-containing Small Molecule Metabolic Process Cell Communication Protein Localization Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Regulation Of Cellular Process Metal Ion Transport Membrane Organization Cortical Actin Cytoskeleton Organization Cortical Cytoskeleton Organization Establishment Or Maintenance Of Cell Polarity Small Molecule Metabolic Process Cellular Localization Positive Regulation Of Ion Transport Cell Junction Assembly Organophosphate Metabolic Process Chemotaxis Tight Junction Assembly Cation Transport Monovalent Inorganic Cation Transport Regulation Of Membrane Potential Regulation Of Establishment Of Protein Localization Transport Negative Regulation Of Phosphatase Activity Cell Morphogenesis Involved In Differentiation Positive Regulation Of Transport Negative Regulation Of Dephosphorylation Apical Junction Assembly Regulation Of Protein Localization Positive Regulation Of Ion Transmembrane Transport Cell Projection Morphogenesis Cell Part Morphogenesis Protein Stabilization Axon Guidance Negative Regulation Of Transport	Potassium Ion Import Potassium Ion Transmembrane Transport Potassium Ion Transport Synaptic Transmission Monovalent Inorganic Cation Transport Metal Ion Transport Cell-cell Signaling Cation Transmembrane Transport Cation Transport Ion Transmembrane Transport Transmembrane Transport Ion Transport Positive Regulation Of Ion Transmembrane Transport Regulation Of Skeletal Muscle Contraction Via Regulation Of Action Potential Energy Reserve Metabolic Process Relaxation Of Skeletal Muscle Positive Regulation Of Ion Transport Regulation Of Insulin Secretion Regulation Of Peptide Hormone Secretion Regulation Of Hormone Secretion Regulation Of Membrane Potential Energy Derivation By Oxidation Of Organic Compounds Cellular Response To Nicotine Regulation Of Resting Membrane Potential Cellular Potassium Ion Homeostasis Regulation Of Skeletal Muscle Contraction Regulation Of Protein Secretion Membrane Repolarization During Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Generation Of Precursor Metabolites And Energy Regulation Of Ion Transmembrane Transport Transport Membrane Depolarization During Cardiac Muscle Cell Action Potential Membrane Repolarization Relaxation Of Cardiac Muscle Potassium Ion Homeostasis Positive Regulation Of Potassium Ion Transmembrane Transport Cellular Chemical Homeostasis Signaling Cell Communication Relaxation Of Muscle Regulation Of Membrane Repolarization Regulation Of Heart Rate By Cardiac Conduction Regulation Of Ion Transport Regulation Of Protein Transport Magnesium Ion Transport Regulation Of Secretion Response To ATP Regulation Of Establishment Of Protein Localization Cardiac Muscle Cell Action Potential Involved In Contraction
Tagcloud ?		alpha1 alpha1beta1gamma1 alphak45r ampk ampkalpha1 ampkbeta1 ampkgamma1 andersen arrhythmia beta1gamma1 coexpression crna currents dead gammar70q inward ischaemia k45r kir2 myocytes nedd4 paralysis participates periodic r70q rectifier s795a tawil xenopus	abundances agt ahr amongst aryl came car3 coherency constitutive contrasting creg1 ctsc e2f6 enpp1 gatm gstm4 halogenated hydrocarbon hydrocarbons inferences me1 overlap pdk1 physiologic profiled slc35a3 sqrdl transcriptomic xenobiotic
Tagcloud (Difference) ?		alpha1 alpha1beta1gamma1 alphak45r ampk ampkalpha1 ampkbeta1 ampkgamma1 andersen arrhythmia beta1gamma1 coexpression crna currents dead gammar70q inward ischaemia k45r kir2 myocytes nedd4 paralysis participates periodic r70q rectifier s795a tawil xenopus	abundances agt ahr amongst aryl came car3 coherency constitutive contrasting creg1 ctsc e2f6 enpp1 gatm gstm4 halogenated hydrocarbon hydrocarbons inferences me1 overlap pdk1 physiologic profiled slc35a3 sqrdl transcriptomic xenobiotic
Tagcloud (Intersection) ?