KCNJ2 and KCNJ4

Number of citations of the paper that reports this interaction (PMID 12032359)
34

Data Source:
HPRD (in vivo, in vitro)

		KCNJ2	KCNJ4
Gene Name		potassium channel, inwardly rectifying subfamily J, member 2	potassium channel, inwardly rectifying subfamily J, member 4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Smooth Endoplasmic Reticulum Rough Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Voltage-gated Potassium Channel Complex Intercalated Disc T-tubule Intrinsic Component Of Membrane Neuronal Cell Body Dendritic Spine	Plasma Membrane Voltage-gated Potassium Channel Complex Basolateral Plasma Membrane Cell Junction Cytoplasmic Vesicle Membrane Postsynaptic Membrane
	Molecular Function	Inward Rectifier Potassium Channel Activity Phosphatidylinositol-4,5-bisphosphate Binding Identical Protein Binding Voltage-gated Potassium Channel Activity Involved In Cardiac Muscle Cell Action Potential Repolarization	Inward Rectifier Potassium Channel Activity Protein Binding PDZ Domain Binding
	Biological Process	Potassium Ion Transport Synaptic Transmission Potassium Ion Import Regulation Of Skeletal Muscle Contraction Via Regulation Of Action Potential Magnesium Ion Transport Cellular Potassium Ion Homeostasis Protein Homotetramerization Relaxation Of Cardiac Muscle Regulation Of Resting Membrane Potential Regulation Of Membrane Repolarization Cellular Response To Mechanical Stimulus Potassium Ion Transmembrane Transport Cardiac Muscle Cell Action Potential Involved In Contraction Membrane Repolarization During Action Potential Membrane Depolarization During Cardiac Muscle Cell Action Potential Membrane Repolarization During Cardiac Muscle Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Relaxation Of Skeletal Muscle Positive Regulation Of Potassium Ion Transmembrane Transport	Potassium Ion Transport Synaptic Transmission Potassium Ion Import Regulation Of Ion Transmembrane Transport
Pathways		GABA B receptor activation Inwardly rectifying K+ channels GABA receptor activation Activation of G protein gated Potassium channels Classical Kir channels Activation of GABAB receptors Potassium Channels Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell G protein gated Potassium channels Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits Transmission across Chemical Synapses	GABA B receptor activation Inwardly rectifying K+ channels GABA receptor activation Activation of G protein gated Potassium channels Classical Kir channels Activation of GABAB receptors Potassium Channels Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell G protein gated Potassium channels Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits Transmission across Chemical Synapses
Drugs
Diseases
GWAS		Cardiac repolarization ( 22342860) Formal thought disorder in schizophrenia ( 22648509) Obesity-related traits ( 23251661) Primary tooth development (number of teeth) ( 23704328 20195514) Primary tooth development (time to first tooth eruption) ( 23704328 20195514) Pulmonary function (interaction) ( 23284291) QT interval ( 19305409) Refractive error ( 23396134) Thyrotoxic hypokalemic periodic paralysis ( 22863731 22399142)
Protein-Protein Interactions		14 interactors: AKAP5 CASK DLG1 DLG2 DLG3 DLG4 FLNA IL16 INADL KCNJ11 KCNJ16 KCNJ4 KCNJ8 TRAK2	10 interactors: CASK DLG1 DLG2 DLG4 GNGT2 IL16 KCNJ2 LIN7B PRKCD SNTA1
Entrez ID		3759	3761
HPRD ID		02815	02738
Ensembl ID		ENSG00000123700	ENSG00000168135
Uniprot IDs		P63252	P48050 Q58F07
PDB IDs			3GJ9
Enriched GO Terms of Interacting Partners?		Receptor Localization To Synapse Synaptic Transmission Receptor Clustering Nucleotide Phosphorylation Protein Localization To Synapse Cell-cell Signaling Potassium Ion Import Regulation Of Ion Transmembrane Transport Regulation Of Ion Transport Establishment Or Maintenance Of Apical/basal Cell Polarity Protein Localization To Membrane Potassium Ion Transmembrane Transport Cellular Protein Localization Potassium Ion Transport Nucleotide Metabolic Process Signaling Nucleobase-containing Small Molecule Metabolic Process Cell Communication Protein Localization Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Regulation Of Cellular Process Metal Ion Transport Membrane Organization Cortical Actin Cytoskeleton Organization Cortical Cytoskeleton Organization Establishment Or Maintenance Of Cell Polarity Small Molecule Metabolic Process Cellular Localization Positive Regulation Of Ion Transport Cell Junction Assembly Organophosphate Metabolic Process Chemotaxis Tight Junction Assembly Cation Transport Monovalent Inorganic Cation Transport Regulation Of Membrane Potential Regulation Of Establishment Of Protein Localization Transport Negative Regulation Of Phosphatase Activity Cell Morphogenesis Involved In Differentiation Positive Regulation Of Transport Negative Regulation Of Dephosphorylation Apical Junction Assembly Regulation Of Protein Localization Positive Regulation Of Ion Transmembrane Transport Cell Projection Morphogenesis Cell Part Morphogenesis Protein Stabilization Axon Guidance Negative Regulation Of Transport	Receptor Localization To Synapse Nucleotide Phosphorylation Protein Localization To Synapse Regulation Of Ion Transport Establishment Or Maintenance Of Apical/basal Cell Polarity Regulation Of Ion Transmembrane Transport Cell-cell Signaling Positive Regulation Of Ion Transport Receptor Clustering Synaptic Transmission Maintenance Of Apical/basal Cell Polarity Regulation Of Membrane Potential Maintenance Of Cell Polarity Protein Localization To Membrane Regulation Of Actin Filament-based Process Response To External Stimulus Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Regulation Of Membrane Repolarization Cortical Actin Cytoskeleton Organization Establishment Or Maintenance Of Cell Polarity Nucleotide Metabolic Process Cardiac Muscle Cell Action Potential Involved In Contraction Positive Regulation Of Potassium Ion Transport Cortical Cytoskeleton Organization Negative Regulation Of Cell Adhesion Nucleobase-containing Small Molecule Metabolic Process Regulation Of Sodium Ion Transmembrane Transport Cardiac Muscle Cell Action Potential Muscle System Process Regulation Of Cardiac Muscle Cell Contraction Positive Regulation Of Transport Membrane Organization Regulation Of Potassium Ion Transport Negative Regulation Of Wound Healing Regulation Of Sodium Ion Transport Positive Regulation Of Phospholipid Scramblase Activity Regulation Of Skeletal Muscle Contraction Via Regulation Of Action Potential Positive Regulation Of Glucosylceramide Catabolic Process Positive Regulation Of Sphingomyelin Catabolic Process Regulation Of Vasoconstriction By Circulating Norepinephrine Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction Positive Regulation Of Ion Transmembrane Transport Phosphorylation Organophosphate Metabolic Process Regulation Of Striated Muscle Contraction Action Potential Protein Stabilization Negative Regulation Of Homotypic Cell-cell Adhesion Relaxation Of Skeletal Muscle
Tagcloud ?		alpha1 alpha1beta1gamma1 alphak45r ampk ampkalpha1 ampkbeta1 ampkgamma1 andersen arrhythmia beta1gamma1 coexpression crna currents dead gammar70q inward ischaemia k45r kir2 myocytes nedd4 paralysis participates periodic r70q rectifier s795a tawil xenopus
Tagcloud (Difference) ?		alpha1 alpha1beta1gamma1 alphak45r ampk ampkalpha1 ampkbeta1 ampkgamma1 andersen arrhythmia beta1gamma1 coexpression crna currents dead gammar70q inward ischaemia k45r kir2 myocytes nedd4 paralysis participates periodic r70q rectifier s795a tawil xenopus
Tagcloud (Intersection) ?