ALK and MDK

Number of citations of the paper that reports this interaction (PMID 12122009)
42

Data Source:
HPRD (in vivo)

		ALK	MDK
Gene Name		anaplastic lymphoma receptor tyrosine kinase	midkine (neurite growth-promoting factor 2)
Image
Gene Ontology Annotations	Cellular Component	Integral Component Of Plasma Membrane Protein Complex Extracellular Vesicular Exosome	Extracellular Region Cytoplasm Cell Projection
	Molecular Function	NF-kappaB-inducing Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding	Growth Factor Activity Heparin Binding
	Biological Process	Activation Of MAPK Activity Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Proliferation Phosphorylation Peptidyl-tyrosine Phosphorylation NIK/NF-kappaB Signaling Regulation Of Apoptotic Process Protein Autophosphorylation Neuron Development Positive Regulation Of NF-kappaB Transcription Factor Activity	Behavioral Fear Response Signal Transduction Notch Signaling Pathway Nervous System Development Short-term Memory Response To Wounding Cell Migration Dentate Gyrus Development Cerebellar Granular Layer Development Cerebral Cortex Development Cell Differentiation Adrenal Gland Development Defecation Response To Drug Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Behavior Response To Glucocorticoid Positive Regulation Of Cell Division
Pathways			Signaling by NOTCH2 Signaling by NOTCH NOTCH2 Activation and Transmission of Signal to the Nucleus
Drugs		Adenosine triphosphate
Diseases
GWAS			Immunoglobulin A ( 20694011)
Protein-Protein Interactions		13 interactors: IKBKG IRS1 JAK3 MDK NPM1 PIK3R1 PLCG1 PTN PTPRZ1 SHC1 SHC3 TNFRSF8 ZC3HC1	17 interactors: ALK JAK1 JAK2 LRP1 LRP2 MAPK6 NCL PTPRZ1 RPL18A SDC1 SDC3 SDC4 SRPK2 STAT1 TGM1 TSPAN1 UBQLN4
Entrez ID		238	4192
HPRD ID		00104	01200
Ensembl ID		ENSG00000171094	ENSG00000110492
Uniprot IDs		B6D4Y2 Q9UM73	P21741
PDB IDs		2KUP 2KUQ 2XB7 2XBA 2XP2 2YFX 2YHV 2YJR 2YJS 2YS5 2YT2 3AOX 3L9P 3LCS 3LCT 4ANL 4ANQ 4ANS 4DCE 4FNW 4FNX 4FNY 4FNZ 4FOB 4FOC 4FOD 4JOA	1MKC 1MKN
Enriched GO Terms of Interacting Partners?		Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Fc Receptor Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Growth Hormone Receptor Signaling Pathway Signaling Cellular Response To Growth Hormone Stimulus Positive Regulation Of Cellular Biosynthetic Process Cell Communication Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cellular Metabolic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Insulin Receptor Signaling Pathway Response To Growth Hormone Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Kinase Activity Innate Immune Response Cellular Response To Stimulus Defense Response Cellular Response To Fibroblast Growth Factor Stimulus Response To Peptide Hormone Response To Fibroblast Growth Factor Immune Response-regulating Signaling Pathway Regulation Of Immune Response Cellular Response To Organonitrogen Compound Regulation Of Apoptotic Process Response To Peptide Negative Regulation Of Apoptotic Process Cellular Response To Insulin Stimulus Regulation Of Cell Proliferation Negative Regulation Of Programmed Cell Death Cell Surface Receptor Signaling Pathway Response To Hormone Regulation Of Cell Death Negative Regulation Of Cell Death Cellular Response To Growth Factor Stimulus Cellular Response To Hormone Stimulus Learning Or Memory Positive Regulation Of Metabolic Process Response To Growth Factor Response To Organic Substance Cognition Response To Insulin	Phototransduction, Visible Light Retinoid Metabolic Process Diterpenoid Metabolic Process Detection Of Visible Light Phototransduction Detection Of Light Stimulus Isoprenoid Metabolic Process Detection Of Abiotic Stimulus Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Response To Interferon-gamma Positive Regulation Of Extracellular Vesicular Exosome Assembly Response To Light Stimulus Protein Metabolic Process Regulation Of Extracellular Vesicular Exosome Assembly Glycosaminoglycan Catabolic Process Chondroitin Sulfate Metabolic Process Response To Radiation System Development Signal Transduction Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Detection Of Stimulus Developmental Process Regulation Of Cytokine-mediated Signaling Pathway Glycosaminoglycan Biosynthetic Process Proteoglycan Metabolic Process Signaling Cell Communication Response To Abiotic Stimulus Multicellular Organismal Development Interferon-gamma-mediated Signaling Pathway Anatomical Structure Development Cell Proliferation JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Positive Regulation Of Transport Response To External Stimulus Growth Hormone Receptor Signaling Pathway Positive Regulation Of Organelle Assembly Cellular Response To Interferon-gamma Cellular Response To Growth Hormone Stimulus Response To Interferon-gamma Glycoprotein Metabolic Process Glycosaminoglycan Metabolic Process Response To Toxic Substance Cellular Response To Stimulus Tumor Necrosis Factor-mediated Signaling Pathway Peptidyl-tyrosine Autophosphorylation Response To Growth Hormone Regulation Of Type I Interferon-mediated Signaling Pathway Pathogenesis
Tagcloud ?		2d accelerate alkaline chi2 depressed dihydroxyvitamin disuse forces fractures hydroxyvitamin hyperparathyroidism immobilization inclined oh osteopenia osteoporotic parathyroid pg phosphorus po4 pth regionally resorption sci serum skeleton subgroup subjects twelve	aacr angiogenic attractive cranialis electrotransfer henceforth heterodimerizing igr intratumor lethal mdkdelta81 midkine mitogenic muscles n91 neovascularization neuroblastoma neurotrophic nude plasmid player portion secretable sh sy5y ther tibialis tractable tumorigenic
Tagcloud (Difference) ?		2d accelerate alkaline chi2 depressed dihydroxyvitamin disuse forces fractures hydroxyvitamin hyperparathyroidism immobilization inclined oh osteopenia osteoporotic parathyroid pg phosphorus po4 pth regionally resorption sci serum skeleton subgroup subjects twelve	aacr angiogenic attractive cranialis electrotransfer henceforth heterodimerizing igr intratumor lethal mdkdelta81 midkine mitogenic muscles n91 neovascularization neuroblastoma neurotrophic nude plasmid player portion secretable sh sy5y ther tibialis tractable tumorigenic
Tagcloud (Intersection) ?