ALK and PTPRZ1

Number of citations of the paper that reports this interaction (PMID 17681947)
22

Data Source:
HPRD (in vivo, in vitro)

		ALK	PTPRZ1
Gene Name		anaplastic lymphoma receptor tyrosine kinase	protein tyrosine phosphatase, receptor-type, Z polypeptide 1
Image
Gene Ontology Annotations	Cellular Component	Integral Component Of Plasma Membrane Protein Complex Extracellular Vesicular Exosome	Proteinaceous Extracellular Matrix Integral Component Of Plasma Membrane Perineuronal Net
	Molecular Function	NF-kappaB-inducing Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding	Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding
	Biological Process	Activation Of MAPK Activity Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Proliferation Phosphorylation Peptidyl-tyrosine Phosphorylation NIK/NF-kappaB Signaling Regulation Of Apoptotic Process Protein Autophosphorylation Neuron Development Positive Regulation Of NF-kappaB Transcription Factor Activity	Hematopoietic Progenitor Cell Differentiation Protein Dephosphorylation Axonogenesis Central Nervous System Development Learning Or Memory Peptidyl-tyrosine Dephosphorylation Oligodendrocyte Differentiation Regulation Of Oligodendrocyte Progenitor Proliferation
Pathways
Drugs		Adenosine triphosphate
Diseases
GWAS
Protein-Protein Interactions		13 interactors: IKBKG IRS1 JAK3 MDK NPM1 PIK3R1 PLCG1 PTN PTPRZ1 SHC1 SHC3 TNFRSF8 ZC3HC1	10 interactors: ADD2 ALK ARHGAP35 CTNNB1 FYN GIT1 HMGB1 MDK PTN TNR
Entrez ID		238	5803
HPRD ID		00104	01481
Ensembl ID		ENSG00000171094	ENSG00000106278
Uniprot IDs		B6D4Y2 Q9UM73	B4DFE7 C9JFM0 P23471
PDB IDs		2KUP 2KUQ 2XB7 2XBA 2XP2 2YFX 2YHV 2YJR 2YJS 2YS5 2YT2 3AOX 3L9P 3LCS 3LCT 4ANL 4ANQ 4ANS 4DCE 4FNW 4FNX 4FNY 4FNZ 4FOB 4FOC 4FOD 4JOA	3JXF 3S97
Enriched GO Terms of Interacting Partners?		Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Fc Receptor Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Growth Hormone Receptor Signaling Pathway Signaling Cellular Response To Growth Hormone Stimulus Positive Regulation Of Cellular Biosynthetic Process Cell Communication Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cellular Metabolic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Insulin Receptor Signaling Pathway Response To Growth Hormone Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Kinase Activity Innate Immune Response Cellular Response To Stimulus Defense Response Cellular Response To Fibroblast Growth Factor Stimulus Response To Peptide Hormone Response To Fibroblast Growth Factor Immune Response-regulating Signaling Pathway Regulation Of Immune Response Cellular Response To Organonitrogen Compound Regulation Of Apoptotic Process Response To Peptide Negative Regulation Of Apoptotic Process Cellular Response To Insulin Stimulus Regulation Of Cell Proliferation Negative Regulation Of Programmed Cell Death Cell Surface Receptor Signaling Pathway Response To Hormone Regulation Of Cell Death Negative Regulation Of Cell Death Cellular Response To Growth Factor Stimulus Cellular Response To Hormone Stimulus Learning Or Memory Positive Regulation Of Metabolic Process Response To Growth Factor Response To Organic Substance Cognition Response To Insulin	Nervous System Development System Development Neuron Differentiation Multicellular Organismal Development Locomotion Anatomical Structure Development Movement Of Cell Or Subcellular Component Forebrain Development Developmental Process Generation Of Neurons Neuron Development Neurogenesis Cell Development Chemotaxis Learning Or Memory Cognition Cell Morphogenesis Involved In Differentiation Cell Differentiation Brain Development Head Development Neuron Projection Development Cell Migration Axon Guidance Cell Motility Learning Central Nervous System Development Single-organism Behavior Regulation Of Cell Morphogenesis Response To External Stimulus Cell Morphogenesis Regulation Of DNA-templated Transcription, Initiation Organ Development Regulation Of Cellular Component Organization Axonogenesis Cell Projection Organization Axon Development Negative Regulation Of Neuron Death Cell Morphogenesis Involved In Neuron Differentiation Behavior Neuron Projection Morphogenesis Regulation Of Neurogenesis Regulation Of Cell Division Regulation Of Apoptotic Process Regulation Of Neuron Death Telencephalon Development Regulation Of Cell Death Cell Projection Morphogenesis Regulation Of Cell Development Cell Part Morphogenesis Cellular Component Disassembly Involved In Execution Phase Of Apoptosis
Tagcloud ?		2d accelerate alkaline chi2 depressed dihydroxyvitamin disuse forces fractures hydroxyvitamin hyperparathyroidism immobilization inclined oh osteopenia osteoporotic parathyroid pg phosphorus po4 pth regionally resorption sci serum skeleton subgroup subjects twelve	alters annotation ca3 candidate cdh23 dataset disequilibrium ear fdr filtering gwas harbored hist3h3 hypotheses hypothetical icsnpathway il27ra innate modulates morphogenesis pneumoconiosis rs11592462 rs2230656 rs2292151 rs8120 snps stereocilia strongest ticam1
Tagcloud (Difference) ?		2d accelerate alkaline chi2 depressed dihydroxyvitamin disuse forces fractures hydroxyvitamin hyperparathyroidism immobilization inclined oh osteopenia osteoporotic parathyroid pg phosphorus po4 pth regionally resorption sci serum skeleton subgroup subjects twelve	alters annotation ca3 candidate cdh23 dataset disequilibrium ear fdr filtering gwas harbored hist3h3 hypotheses hypothetical icsnpathway il27ra innate modulates morphogenesis pneumoconiosis rs11592462 rs2230656 rs2292151 rs8120 snps stereocilia strongest ticam1
Tagcloud (Intersection) ?