ALK and PTPRZ1

Number of citations of the paper that reports this interaction (PubMedID 17681947)
0

Data Source:
HPRD (in vitro, in vivo)

		ALK	PTPRZ1
Description		ALK receptor tyrosine kinase	protein tyrosine phosphatase receptor type Z1
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GO Annotations	Cellular Component	Plasma Membrane Membrane Protein-containing Complex Receptor Complex Extracellular Exosome	Extracellular Region Plasma Membrane Membrane Extracellular Matrix Synapse Perineuronal Net
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Heparin Binding Kinase Activity Transferase Activity Receptor Signaling Protein Tyrosine Kinase Activator Activity Identical Protein Binding	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Integrin Binding Protein Binding Hydrolase Activity
	Biological Process	Response To Stress Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Brain Development Phosphorylation Hippocampus Development Adult Behavior Swimming Behavior Peptidyl-tyrosine Autophosphorylation Regulation Of Cell Population Proliferation Regulation Of Apoptotic Process Regulation Of Neuron Differentiation Protein Autophosphorylation Neuron Development Negative Regulation Of Lipid Catabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Dopamine Receptor Signaling Pathway Regulation Of Primary Metabolic Process Response To Environmental Enrichment Energy Homeostasis Positive Regulation Of Dendrite Development	Hematopoietic Progenitor Cell Differentiation Protein Dephosphorylation Signal Transduction Axonogenesis Central Nervous System Development Learning Or Memory Neuron Projection Development Regulation Of Myelination Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Neuron Apoptotic Process Oligodendrocyte Differentiation Positive Regulation Of Oligodendrocyte Differentiation Regulation Of Oligodendrocyte Progenitor Proliferation
Pathways		Signaling by ALK Signaling by ALK ALK mutants bind TKIs ASP-3026-resistant ALK mutants NVP-TAE684-resistant ALK mutants alectinib-resistant ALK mutants brigatinib-resistant ALK mutants ceritinib-resistant ALK mutants crizotinib-resistant ALK mutants lorlatinib-resistant ALK mutants Signaling by ALK fusions and activated point mutants MDK and PTN in ALK signaling MDK and PTN in ALK signaling	Other interleukin signaling MDK and PTN in ALK signaling
Drugs		ATP Crizotinib Ceritinib Alectinib Fostamatinib Lorlatinib Gilteritinib Brigatinib
Diseases		Non-small cell lung cancer
GWAS		Adiponectin levels (BMI-adjusted) ( 26299439) Body mass index ( 25673413) Body size at age 10 ( 32376654) Carbamazepine-induced reaction with eosinophilia and systemic symptoms ( 31066027) Carbamazepine-induced serious cutaneous adverse reaction ( 31066027) Dentures ( 31235808) Gestational age at birth (child effect) ( 31194736) Glucose homeostasis traits ( 25524916) Low density lipoprotein cholesterol levels ( 33339817) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Pre-treatment viral load in HIV-1 infection ( 31219150) Simvastatin-induced myopathy ( 31220337) Spontaneous coronary artery dissection ( 32887874) Systolic blood pressure ( 26969751) Total cholesterol levels ( 33339817)	Hand grip strength ( 27325353) Heel bone mineral density ( 30598549) Lung adenocarcinoma ( 28604730)
Interacting Genes		19 interacting genes: APBB1 DUSP19 ERBB2 HES1 IKBKG IRS1 JAK3 MDK NPM1 PIK3R1 PLCG1 PPM1A PTN PTPN11 PTPRZ1 SHC1 SHC3 TNFRSF8 ZC3HC1	13 interacting genes: ADD2 ALK ARHGAP35 CTNNB1 FYN GIT1 HMGB1 IL34 MDK MGAT5B PTN PTPRF TNR
Entrez ID		238	5803
HPRD ID		00104	01481
Ensembl ID		ENSG00000171094	ENSG00000106278
Uniprot IDs		A0A0K2YUJ3 B6D4Y2 Q9UM73	B4DFE7 P23471
PDB IDs		2KUP 2KUQ 2XB7 2XBA 2XP2 2YFX 2YHV 2YJR 2YJS 2YS5 2YT2 3AOX 3L9P 3LCS 3LCT 4ANL 4ANQ 4ANS 4CCB 4CCU 4CD0 4CLI 4CLJ 4CMO 4CMT 4CMU 4CNH 4CTB 4CTC 4DCE 4FNW 4FNX 4FNY 4FNZ 4FOB 4FOC 4FOD 4JOA 4MKC 4TT7 4Z55 5A9U 5AA8 5AA9 5AAA 5AAB 5AAC 5FTO 5FTQ 5IMX 5IUG 5IUH 5IUI 5KZ0 5VZ5 6AT9 6CDT 6E0R 6EBW 6EDL 6MX8 7BTT 7JY4 7JYR 7JYS 7JYT 7LRZ 7LS0 7MZW 7MZY 7N00 7NWZ 7NX3 7NX4 7R7K 7R7R 8ARJ 9G5I 9GBE	3JXF 3S97 5AWX 5H08 8FN8 8FN9
Enriched GO Terms of Interacting Partners?		Regulation Of Apoptotic Process Phosphotyrosine Residue Binding Regulation Of Programmed Cell Death Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Insulin Receptor Binding Epidermal Growth Factor Receptor Signaling Pathway Neurotrophin TRKA Receptor Binding Negative Regulation Of Apoptotic Process ERBB Signaling Pathway Negative Regulation Of Programmed Cell Death Regulation Of Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Development Signal Transduction Positive Regulation Of Gene Expression Positive Regulation Of Glial Cell Differentiation Regulation Of Oligodendrocyte Differentiation Negative Regulation Of Cell Adhesion Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Hemopoiesis Negative Regulation Of T Cell Differentiation Insulin-like Growth Factor Receptor Binding Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Positive Regulation Of Biosynthetic Process Negative Regulation Of Lymphocyte Differentiation Negative Regulation Of T Cell Activation Receptor Tyrosine Kinase Binding Leukocyte Activation Positive Regulation Of Gliogenesis Intracellular Signal Transduction Positive Regulation Of Vascular Endothelial Cell Proliferation Regulation Of Glial Cell Differentiation Positive Regulation Of Oligodendrocyte Differentiation Positive Regulation Of Immune System Process Leukocyte Activation Involved In Immune Response Negative Regulation Of Leukocyte Cell-cell Adhesion Cell Activation Involved In Immune Response Cellular Response To Growth Factor Stimulus Regulation Of Immune System Process Negative Regulation Of Lymphocyte Activation Lymphocyte Activation Cell Activation Response To Growth Factor Negative Regulation Of Cell Differentiation Regulation Of Multicellular Organismal Development Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Leukocyte Activation Insulin-like Growth Factor Receptor Signaling Pathway	Regulation Of Response To Wounding Cell Migration Regulation Of Oligodendrocyte Differentiation Regulation Of Neuron Projection Development Cell Motility Positive Regulation Of Neuron Projection Development Regulation Of Glial Cell Differentiation Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Developmental Process Positive Regulation Of Oligodendrocyte Differentiation Regulation Of Cellular Component Organization Regulation Of Cell Projection Organization Leukocyte Migration Regulation Of Gliogenesis Schaffer Collateral - CA1 Synapse Positive Regulation Of Leukocyte Chemotaxis Regulation Of Axon Regeneration Regulation Of Neuron Projection Regeneration Neuron Projection Development Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Cell Development Learning Or Memory Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Glial Cell Differentiation Cell Development Nervous System Development Cognition Positive Regulation Of Chemotaxis Positive Regulation Of Leukocyte Migration Growth Factor Activity Heparin Binding Positive Regulation Of Blood Vessel Branching Learning Positive Regulation Of Cell Projection Organization Regulation Of Multicellular Organismal Development Regulation Of Neurogenesis Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway System Development Regulation Of Blood Vessel Branching Leukocyte Chemotaxis Involved In Inflammatory Response Positive Regulation Of Gliogenesis Positive Regulation Of Epithelial Cell Proliferation Response To Mechanical Stimulus Cell Projection Organization Positive Regulation Of Cellular Component Organization Regulation Of Cell Communication Signal Transduction Regulation Of Signaling Positive Regulation Of Cell Development
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