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JAK1 and TEC
Number of citations of the paper that reports this interaction (PMID
9178903
)
16
Data Source:
HPRD
(in vivo)
JAK1
TEC
Gene Name
Janus kinase 1
tec protein tyrosine kinase
Image
Gene Ontology Annotations
Cellular Component
Nucleus
Cytoplasm
Cytosol
Cytoskeleton
Focal Adhesion
Endomembrane System
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Cytosol
Cytoskeleton
Cell-cell Junction
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Molecular Function
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Growth Hormone Receptor Binding
Protein Binding
ATP Binding
Protein Phosphatase Binding
CCR5 Chemokine Receptor Binding
Non-membrane Spanning Protein Tyrosine Kinase Activity
Receptor Binding
Protein Binding
ATP Binding
Lipid Binding
Metal Ion Binding
Biological Process
Protein Phosphorylation
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Cell Migration
Cytokine-mediated Signaling Pathway
Cell Differentiation
Intracellular Signal Transduction
Peptidyl-tyrosine Autophosphorylation
Interleukin-2-mediated Signaling Pathway
Regulation Of Cell Proliferation
Innate Immune Response
Response To Antibiotic
Interferon-gamma-mediated Signaling Pathway
Regulation Of Interferon-gamma-mediated Signaling Pathway
Type I Interferon Signaling Pathway
Regulation Of Type I Interferon-mediated Signaling Pathway
Adaptive Immune Response
Protein Phosphorylation
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Integrin-mediated Signaling Pathway
Regulation Of Platelet Activation
Cell Differentiation
Intracellular Signal Transduction
Peptidyl-tyrosine Autophosphorylation
Fc-epsilon Receptor Signaling Pathway
Regulation Of Cell Proliferation
Tissue Regeneration
Innate Immune Response
T Cell Receptor Signaling Pathway
B Cell Receptor Signaling Pathway
Pathways
Signaling by FGFR in disease
Signaling by EGFRvIII in Cancer
Interferon gamma signaling
Toll Like Receptor TLR1:TLR2 Cascade
Toll Like Receptor 5 (TLR5) Cascade
Interleukin receptor SHC signaling
Gastrin-CREB signalling pathway via PKC and MAPK
MyD88 dependent cascade initiated on endosome
Interleukin-7 signaling
SOS-mediated signalling
SHC-mediated signalling
TRIF-mediated TLR3/TLR4 signaling
ERK1 activation
ERK1 activation
GPCR downstream signaling
Signaling by VEGF
Toll Like Receptor 3 (TLR3) Cascade
Signalling to RAS
Downstream signal transduction
Interleukin-2 signaling
Platelet activation, signaling and aggregation
Frs2-mediated activation
Axon guidance
IRS-mediated signalling
Interleukin-6 signaling
VEGFA-VEGFR2 Pathway
Activated TLR4 signalling
VEGFR2 mediated cell proliferation
GRB2 events in ERBB2 signaling
MyD88:Mal cascade initiated on plasma membrane
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
NCAM signaling for neurite out-growth
RAF/MAP kinase cascade
Signalling to p38 via RIT and RIN
Innate Immune System
Signaling by Insulin receptor
Insulin receptor signalling cascade
ISG15 antiviral mechanism
Interferon Signaling
Signaling by Ligand-Responsive EGFR Variants in Cancer
IRS-related events
SHC-related events
Signaling by FGFR
ARMS-mediated activation
Toll-Like Receptors Cascades
Toll Like Receptor 10 (TLR10) Cascade
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
Interleukin receptor SHC signaling
GPVI-mediated activation cascade
Signaling by GPCR
FCERI mediated MAPK activation
SHC1 events in ERBB2 signaling
Signaling by SCF-KIT
DAP12 signaling
Toll Like Receptor 9 (TLR9) Cascade
Signaling by PDGF
DAP12 interactions
Regulation of IFNA signaling
G-protein beta:gamma signalling
GRB2 events in EGFR signaling
SHC-related events triggered by IGF1R
Signaling by ERBB4
Antiviral mechanism by IFN-stimulated genes
Signaling by ERBB2
Toll Like Receptor 2 (TLR2) Cascade
Signaling by EGFR
Signaling by Interleukins
SHC1 events in ERBB4 signaling
Toll Like Receptor 4 (TLR4) Cascade
Signaling by EGFR in Cancer
Fc epsilon receptor (FCERI) signaling
Interleukin-3, 5 and GM-CSF signaling
Signaling by Leptin
Signalling to ERKs
Prolonged ERK activation events
ERK activation
Toll Like Receptor 7/8 (TLR7/8) Cascade
IGF1R signaling cascade
Toll Like Receptor TLR6:TLR2 Cascade
IRS-related events triggered by IGF1R
MyD88 cascade initiated on plasma membrane
ERK activation
G beta:gamma signalling through PI3Kgamma
Downstream signaling of activated FGFR
Interferon alpha/beta signaling
Signalling by NGF
SOS-mediated signalling
MAP kinase activation in TLR cascade
SHC-mediated signalling
Cytokine Signaling in Immune system
NGF signalling via TRKA from the plasma membrane
MyD88-independent cascade
Signaling by Overexpressed Wild-Type EGFR in Cancer
ERK2 activation
SHC1 events in EGFR signaling
FRS2-mediated cascade
IRS-mediated signalling
ERK2 activation
Regulation of IFNG signaling
Signaling by SCF-KIT
Signaling by Interleukins
Fc epsilon receptor (FCERI) signaling
Cytokine Signaling in Immune system
FCERI mediated Ca+2 mobilization
Interleukin-3, 5 and GM-CSF signaling
Innate Immune System
Drugs
Diseases
GWAS
Crohn's disease (
23128233
)
Protein-Protein Interactions
69 interactors:
ABL1
BRCA1
BTK
CCR1
CCR5
CSF2RB
CSF3R
CXCR4
EIF2AK2
ELP2
ERBB2
FER
FES
GHR
GNB2L1
GRB2
HIST3H3
IFNAR2
IFNGR1
IGF1R
IL10RA
IL21R
IL2RB
IL2RG
IL3RA
IL4R
IL5RA
IL6ST
IL7R
IL9R
INPP5D
INSR
IRS1
IRS2
JAK3
JAKMIP1
MDK
OSMR
PDGFRA
PDGFRB
PIK3R1
PLA2G4A
PLAUR
PLCG2
PRKCZ
PRMT5
PTK2B
PTPN11
PTPN2
PTPN6
PTPRC
RAF1
SH2B2
SHB
SOCS1
SOCS3
STAM
STAM2
STAT1
STAT2
STAT3
STAT5A
STAT6
SYK
TEC
TNFRSF1A
TOP1
TSHR
TYK2
30 interactors:
ARHGEF12
BMX
BTK
DOK1
ERBB2
FASLG
GNA12
IKBKG
JAK1
JAK2
KIT
LYN
PIK3R1
PIK3R2
PIK3R3
PIP4K2A
PIP5K1A
PLCG1
PLCG2
PLK4
PRLR
PTPN18
PTPN21
RHOA
SHC1
SOCS1
STAP1
TP53
VAV1
WAS
Entrez ID
3716
7006
HPRD ID
00992
02786
Ensembl ID
ENSG00000162434
ENSG00000135605
Uniprot IDs
P23458
P42680
PDB IDs
3EYG
3EYH
4E4L
4E4N
4E5W
4EHZ
4EI4
4FK6
4GS0
4I5C
4IVB
4IVC
4IVD
4K6Z
4K77
4L00
4L01
2LUL
Enriched GO Terms of Interacting Partners
?
Cell Surface Receptor Signaling Pathway
Cytokine-mediated Signaling Pathway
Cellular Response To Organic Substance
Cellular Response To Cytokine Stimulus
Response To Organic Substance
Response To Cytokine
Signal Transduction
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Regulation Of Immune Response
Defense Response
Signaling
Cell Communication
Enzyme Linked Receptor Protein Signaling Pathway
Regulation Of Immune System Process
Immune System Process
Immune Response
Cellular Response To Stimulus
Innate Immune Response
Response To Stimulus
Intracellular Signal Transduction
Cellular Response To Organonitrogen Compound
JAK-STAT Cascade
Growth Hormone Receptor Signaling Pathway
Cellular Response To Peptide Hormone Stimulus
Regulation Of Cell Proliferation
Cellular Response To Growth Hormone Stimulus
Response To Stress
Cellular Response To Peptide
Regulation Of Cell Activation
Regulation Of Signal Transduction
Response To Organonitrogen Compound
Regulation Of Signaling
Response To Hormone
JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway
Peptidyl-tyrosine Autophosphorylation
Response To Peptide Hormone
Peptidyl-tyrosine Phosphorylation
Response To Peptide
Response To Growth Hormone
Cellular Response To Hormone Stimulus
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Signal Transduction
Regulation Of Phosphorylation
Cell Activation
Positive Regulation Of Immune System Process
Regulation Of Lymphocyte Activation
Protein Autophosphorylation
Epidermal Growth Factor Receptor Signaling Pathway
Immune Response-regulating Signaling Pathway
ERBB Signaling Pathway
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme Linked Receptor Protein Signaling Pathway
Cell Surface Receptor Signaling Pathway
Intracellular Signal Transduction
Innate Immune Response
Fc Receptor Signaling Pathway
Immune Response
Fc-epsilon Receptor Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Immune System Process
Regulation Of Immune Response
Blood Coagulation
Hemostasis
Regulation Of Body Fluid Levels
Signal Transduction
Wound Healing
Immune Response-regulating Signaling Pathway
Response To Organic Substance
Signaling
Defense Response
Response To Wounding
Cell Communication
Regulation Of Signal Transduction
Regulation Of Intracellular Signal Transduction
Phosphate-containing Compound Metabolic Process
Neurotrophin TRK Receptor Signaling Pathway
Antigen Receptor-mediated Signaling Pathway
Neurotrophin Signaling Pathway
Cellular Response To Organic Substance
Regulation Of Immune System Process
Cell Activation
Regulation Of Signaling
Regulation Of Catalytic Activity
Cellular Response To Stimulus
Peptidyl-tyrosine Phosphorylation
Immune Response-activating Cell Surface Receptor Signaling Pathway
Regulation Of Kinase Activity
Response To Growth Factor
Cell Differentiation
Cellular Response To Peptide Hormone Stimulus
Growth Hormone Receptor Signaling Pathway
Cellular Response To Peptide
Cellular Response To Growth Hormone Stimulus
Movement Of Cell Or Subcellular Component
Phagocytosis
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Fc Receptor Mediated Stimulatory Signaling Pathway
Fc-gamma Receptor Signaling Pathway
Epidermal Growth Factor Receptor Signaling Pathway
Phosphorylation
Tagcloud
?
2c4
assign
b10
b3
b9
cd2
complementation
crossed
crosses
crossing
facs
gbp
guanylate
hlas
hybrids
ifn
oas
oligoadenylate
pairwise
permitted
responsiveness
restore
rounds
submitted
synthetase
u3
u4
unresponsive
unresponsiveness
Tagcloud (Difference)
?
2c4
assign
b10
b3
b9
cd2
complementation
crossed
crosses
crossing
facs
gbp
guanylate
hlas
hybrids
ifn
oas
oligoadenylate
pairwise
permitted
responsiveness
restore
rounds
submitted
synthetase
u3
u4
unresponsive
unresponsiveness
Tagcloud (Intersection)
?