JAK1 and INSR

  • Number of citations of the paper that reports this interaction (PMID 9492017)
  • 17
  • Data Source:
  • BioGRID (affinity chromatography technology)
  • HPRD (in vivo, in vitro)

JAK1

INSR

Gene Name Janus kinase 1 insulin receptor
Image
Gene Ontology Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions 69 interactors: ABL1 BRCA1 BTK CCR1 CCR5 CSF2RB CSF3R CXCR4 EIF2AK2 ELP2 ERBB2 FER FES GHR GNB2L1 GRB2 HIST3H3 IFNAR2 IFNGR1 IGF1R IL10RA IL21R IL2RB IL2RG IL3RA IL4R IL5RA IL6ST IL7R IL9R INPP5D INSR IRS1 IRS2 JAK3 JAKMIP1 MDK OSMR PDGFRA PDGFRB PIK3R1 PLA2G4A PLAUR PLCG2 PRKCZ PRMT5 PTK2B PTPN11 PTPN2 PTPN6 PTPRC RAF1 SH2B2 SHB SOCS1 SOCS3 STAM STAM2 STAT1 STAT2 STAT3 STAT5A STAT6 SYK TEC TNFRSF1A TOP1 TSHR TYK2 77 interactors: ACP1 ADRB2 AHSG ARF1 ARHGAP26 CALM1 CALM2 CALM3 CAV1 CAV3 CBL CEACAM1 CRK CRKL CSK DOK1 DOK4 DOK5 ENPP1 FABP4 FRS2 GAB1 GNB2L1 GRB10 GRB14 GRB7 HRAS IGF1R IGF2 INS INSRR IRF7 IRS1 IRS2 JAK1 JAK2 KHDRBS1 KRT27 KRT31 MAD2L1 MAPK3 PIK3R1 PIK3R3 PLCG1 PRKCA PRKCD PTK2 PTPN1 PTPN11 PTPN12 PTPN2 PTPN6 PTPRC PTPRF RAF1 RASA1 SH2B1 SH2B2 SHC1 SMAD2 SNX1 SNX2 SNX4 SNX6 SOCS1 SOCS2 SOCS3 SOCS6 SORBS1 SRC STAT5A STAT5B SYNCRIP TEAD1 VAV1 VAV3 YWHAB
Entrez ID 3716 3643
HPRD ID 00992 00975
Ensembl ID ENSG00000162434 ENSG00000171105
Uniprot IDs P23458 P06213
PDB IDs 3EYG 3EYH 4E4L 4E4N 4E5W 4EHZ 4EI4 4FK6 4GS0 4I5C 4IVB 4IVC 4IVD 4K6Z 4K77 4L00 4L01 1GAG 1I44 1IR3 1IRK 1P14 1RQQ 2AUH 2B4S 2DTG 2HR7 2Z8C 3BU3 3BU5 3BU6 3EKK 3EKN 3ETA 3LOH 3W11 3W12 3W13 3W14 4IBM
Enriched GO Terms of Interacting Partners?
Tagcloud ?
2c4  assign  b10  b3  b9  cd2  complementation  crossed  crosses  crossing  facs  gbp  guanylate  hlas  hybrids  ifn  oas  oligoadenylate  pairwise  permitted  responsiveness  restore  rounds  submitted  synthetase  u3  u4  unresponsive  unresponsiveness 
birthweight  cognate  curly  delays  determinant  dwarfing  edema  eliminated  embryogenesis  embryos  epidermis  generalized  hypoplasia  igf1r  igf2  igr1r  indistinguishable  manifested  mildly  muscles  nullizygotes  nullizygous  ossification  phenotypically  recognizes  retardation  solely  thin  xr 
Tagcloud (Difference) ?
2c4  assign  b10  b3  b9  cd2  complementation  crossed  crosses  crossing  facs  gbp  guanylate  hlas  hybrids  ifn  oas  oligoadenylate  pairwise  permitted  responsiveness  restore  rounds  submitted  synthetase  u3  u4  unresponsive  unresponsiveness 
birthweight  cognate  curly  delays  determinant  dwarfing  edema  eliminated  embryogenesis  embryos  epidermis  generalized  hypoplasia  igf1r  igf2  igr1r  indistinguishable  manifested  mildly  muscles  nullizygotes  nullizygous  ossification  phenotypically  recognizes  retardation  solely  thin  xr 
Tagcloud (Intersection) ?