JAK1 and ELP2

Number of citations of the paper that reports this interaction (PMID 10954736)
18

Data Source:
HPRD (in vivo)

		JAK1	ELP2
Gene Name		Janus kinase 1	elongator acetyltransferase complex subunit 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoskeleton Focal Adhesion Endomembrane System Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane	Histone Acetyltransferase Complex Cytoplasm Transcription Elongation Factor Complex Elongator Holoenzyme Complex
	Molecular Function	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Growth Hormone Receptor Binding Protein Binding ATP Binding Protein Phosphatase Binding CCR5 Chemokine Receptor Binding	RNA Polymerase II Core Binding Protein Kinase Binding
	Biological Process	Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Migration Cytokine-mediated Signaling Pathway Cell Differentiation Intracellular Signal Transduction Peptidyl-tyrosine Autophosphorylation Interleukin-2-mediated Signaling Pathway Regulation Of Cell Proliferation Innate Immune Response Response To Antibiotic Interferon-gamma-mediated Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway	Chromatin Organization Regulation Of Transcription From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter Regulation Of JAK-STAT Cascade
Pathways		Signaling by FGFR in disease Signaling by EGFRvIII in Cancer Interferon gamma signaling Toll Like Receptor TLR1:TLR2 Cascade Toll Like Receptor 5 (TLR5) Cascade Interleukin receptor SHC signaling Gastrin-CREB signalling pathway via PKC and MAPK MyD88 dependent cascade initiated on endosome Interleukin-7 signaling SOS-mediated signalling SHC-mediated signalling TRIF-mediated TLR3/TLR4 signaling ERK1 activation ERK1 activation GPCR downstream signaling Signaling by VEGF Toll Like Receptor 3 (TLR3) Cascade Signalling to RAS Downstream signal transduction Interleukin-2 signaling Platelet activation, signaling and aggregation Frs2-mediated activation Axon guidance IRS-mediated signalling Interleukin-6 signaling VEGFA-VEGFR2 Pathway Activated TLR4 signalling VEGFR2 mediated cell proliferation GRB2 events in ERBB2 signaling MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation NCAM signaling for neurite out-growth RAF/MAP kinase cascade Signalling to p38 via RIT and RIN Innate Immune System Signaling by Insulin receptor Insulin receptor signalling cascade ISG15 antiviral mechanism Interferon Signaling Signaling by Ligand-Responsive EGFR Variants in Cancer IRS-related events SHC-related events Signaling by FGFR ARMS-mediated activation Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Interleukin receptor SHC signaling GPVI-mediated activation cascade Signaling by GPCR FCERI mediated MAPK activation SHC1 events in ERBB2 signaling Signaling by SCF-KIT DAP12 signaling Toll Like Receptor 9 (TLR9) Cascade Signaling by PDGF DAP12 interactions Regulation of IFNA signaling G-protein beta:gamma signalling GRB2 events in EGFR signaling SHC-related events triggered by IGF1R Signaling by ERBB4 Antiviral mechanism by IFN-stimulated genes Signaling by ERBB2 Toll Like Receptor 2 (TLR2) Cascade Signaling by EGFR Signaling by Interleukins SHC1 events in ERBB4 signaling Toll Like Receptor 4 (TLR4) Cascade Signaling by EGFR in Cancer Fc epsilon receptor (FCERI) signaling Interleukin-3, 5 and GM-CSF signaling Signaling by Leptin Signalling to ERKs Prolonged ERK activation events ERK activation Toll Like Receptor 7/8 (TLR7/8) Cascade IGF1R signaling cascade Toll Like Receptor TLR6:TLR2 Cascade IRS-related events triggered by IGF1R MyD88 cascade initiated on plasma membrane ERK activation G beta:gamma signalling through PI3Kgamma Downstream signaling of activated FGFR Interferon alpha/beta signaling Signalling by NGF SOS-mediated signalling MAP kinase activation in TLR cascade SHC-mediated signalling Cytokine Signaling in Immune system NGF signalling via TRKA from the plasma membrane MyD88-independent cascade Signaling by Overexpressed Wild-Type EGFR in Cancer ERK2 activation SHC1 events in EGFR signaling FRS2-mediated cascade IRS-mediated signalling ERK2 activation Regulation of IFNG signaling	Chromatin modifying enzymes Chromatin organization HATs acetylate histones
Drugs
Diseases
GWAS
Protein-Protein Interactions		69 interactors: ABL1 BRCA1 BTK CCR1 CCR5 CSF2RB CSF3R CXCR4 EIF2AK2 ELP2 ERBB2 FER FES GHR GNB2L1 GRB2 HIST3H3 IFNAR2 IFNGR1 IGF1R IL10RA IL21R IL2RB IL2RG IL3RA IL4R IL5RA IL6ST IL7R IL9R INPP5D INSR IRS1 IRS2 JAK3 JAKMIP1 MDK OSMR PDGFRA PDGFRB PIK3R1 PLA2G4A PLAUR PLCG2 PRKCZ PRMT5 PTK2B PTPN11 PTPN2 PTPN6 PTPRC RAF1 SH2B2 SHB SOCS1 SOCS3 STAM STAM2 STAT1 STAT2 STAT3 STAT5A STAT6 SYK TEC TNFRSF1A TOP1 TSHR TYK2	7 interactors: CTDP1 IKBKAP JAK1 JAK2 STAT1 STAT3 STAT5B
Entrez ID		3716	55250
HPRD ID		00992	15443
Ensembl ID		ENSG00000162434	ENSG00000134759
Uniprot IDs		P23458	Q6IA86
PDB IDs		3EYG 3EYH 4E4L 4E4N 4E5W 4EHZ 4EI4 4FK6 4GS0 4I5C 4IVB 4IVC 4IVD 4K6Z 4K77 4L00 4L01
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Cellular Response To Organic Substance Cellular Response To Cytokine Stimulus Response To Organic Substance Response To Cytokine Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Immune Response Defense Response Signaling Cell Communication Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Immune System Process Immune System Process Immune Response Cellular Response To Stimulus Innate Immune Response Response To Stimulus Intracellular Signal Transduction Cellular Response To Organonitrogen Compound JAK-STAT Cascade Growth Hormone Receptor Signaling Pathway Cellular Response To Peptide Hormone Stimulus Regulation Of Cell Proliferation Cellular Response To Growth Hormone Stimulus Response To Stress Cellular Response To Peptide Regulation Of Cell Activation Regulation Of Signal Transduction Response To Organonitrogen Compound Regulation Of Signaling Response To Hormone JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Peptidyl-tyrosine Autophosphorylation Response To Peptide Hormone Peptidyl-tyrosine Phosphorylation Response To Peptide Response To Growth Hormone Cellular Response To Hormone Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Cell Activation Positive Regulation Of Immune System Process Regulation Of Lymphocyte Activation Protein Autophosphorylation Epidermal Growth Factor Receptor Signaling Pathway Immune Response-regulating Signaling Pathway ERBB Signaling Pathway	JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Response To Growth Hormone JAK-STAT Cascade Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Response To Interferon-gamma Cytokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Innate Immune Response Response To Cytokine Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Transcription From RNA Polymerase II Promoter Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cytokine-mediated Signaling Pathway Response To Interleukin-2 Response To Peptide Hormone Interferon-gamma-mediated Signaling Pathway Cellular Response To Organonitrogen Compound Response To Peptide Cellular Response To Interferon-gamma Defense Response Cellular Response To Hormone Stimulus Response To Interferon-gamma Regulation Of Cell Proliferation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Cellular Component Movement Positive Regulation Of Cellular Biosynthetic Process Response To Organonitrogen Compound Tumor Necrosis Factor-mediated Signaling Pathway Response To Lipid Acute-phase Response Regulation Of Transcription From RNA Polymerase II Promoter Peptidyl-tyrosine Autophosphorylation Intracellular Signal Transduction Cellular Response To Organic Substance Regulation Of Immune Response Regulation Of Type I Interferon-mediated Signaling Pathway Response To Lipopolysaccharide Response To Hormone Response To Molecule Of Bacterial Origin Positive Regulation Of Cellular Component Movement Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Smooth Muscle Cell Proliferation Immune System Process Response To Antibiotic Transcription Elongation From RNA Polymerase II Promoter
Tagcloud ?		2c4 assign b10 b3 b9 cd2 complementation crossed crosses crossing facs gbp guanylate hlas hybrids ifn oas oligoadenylate pairwise permitted responsiveness restore rounds submitted synthetase u3 u4 unresponsive unresponsiveness	accomplished biocompatibility c5 conduit dodecyl elastin elongated elp1 elp3 elps endowed fabrication glutamic glutaraledhyde immunofluorostaining isoleucine itc penta pentapeptide redv s100 schwann vpavg vpgeg vpgig vpgkg vpgvg wst
Tagcloud (Difference) ?		2c4 assign b10 b3 b9 cd2 complementation crossed crosses crossing facs gbp guanylate hlas hybrids ifn oas oligoadenylate pairwise permitted responsiveness restore rounds submitted synthetase u3 u4 unresponsive unresponsiveness	accomplished biocompatibility c5 conduit dodecyl elastin elongated elp1 elp3 elps endowed fabrication glutamic glutaraledhyde immunofluorostaining isoleucine itc penta pentapeptide redv s100 schwann vpavg vpgeg vpgig vpgkg vpgvg wst
Tagcloud (Intersection) ?