JAK1 and CSF2RB

Number of citations of the paper that reports this interaction (PubMedID 11557047)
0

Data Source:
HPRD (in vivo)

		JAK1	CSF2RB
Description		Janus kinase 1	colony stimulating factor 2 receptor subunit beta
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Endosome Cytosol Plasma Membrane Focal Adhesion Cytoplasmic Side Of Plasma Membrane Endomembrane System Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Receptor Complex	Plasma Membrane External Side Of Plasma Membrane Membrane Granulocyte Macrophage Colony-stimulating Factor Receptor Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Growth Hormone Receptor Binding Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Phosphatase Binding Ubiquitin Protein Ligase Binding CCR5 Chemokine Receptor Binding Metal Ion Binding	Cytokine Receptor Activity Interleukin-3 Receptor Activity Interleukin-5 Receptor Activity Protein Binding Coreceptor Activity Signaling Receptor Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Cell Surface Receptor Signaling Pathway Via JAK-STAT Cytokine-mediated Signaling Pathway Regulation Of Cell-cell Adhesion Cell Differentiation Positive Regulation Of Homotypic Cell-cell Adhesion Intracellular Signal Transduction Interleukin-15-mediated Signaling Pathway Interleukin-4-mediated Signaling Pathway Interleukin-2-mediated Signaling Pathway Interleukin-7-mediated Signaling Pathway Interleukin-9-mediated Signaling Pathway Interleukin-11-mediated Signaling Pathway Type III Interferon-mediated Signaling Pathway Response To Antibiotic Regulation Of Multicellular Organismal Process Type II Interferon-mediated Signaling Pathway Type I Interferon-mediated Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT Interleukin-6-mediated Signaling Pathway T-helper 17 Cell Lineage Commitment Cellular Response To Virus Cellular Response To Interleukin-7 Interleukin-10-mediated Signaling Pathway Protein Localization To Cell-cell Junction Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Sprouting Angiogenesis	Signal Transduction Cell Surface Receptor Signaling Pathway Via JAK-STAT Respiratory Gaseous Exchange By Respiratory System Immunoglobulin Mediated Immune Response Cytokine-mediated Signaling Pathway Response To Lipopolysaccharide Cellular Response To Interleukin-3 Interleukin-5-mediated Signaling Pathway Interleukin-3-mediated Signaling Pathway Granulocyte-macrophage Colony-stimulating Factor Signaling Pathway Positive Regulation Of Leukocyte Proliferation
Pathways		Interleukin-6 signaling Interleukin-6 signaling MAPK3 (ERK1) activation MAPK1 (ERK2) activation ISG15 antiviral mechanism Interleukin-7 signaling Interleukin-7 signaling Other interleukin signaling RAF/MAP kinase cascade Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling IL-6-type cytokine receptor ligand interactions Interferon gamma signaling Regulation of IFNG signaling Regulation of IFNG signaling Interleukin-20 family signaling Interleukin-15 signaling Interleukin-15 signaling Interleukin-35 Signalling Interleukin-9 signaling Interleukin-2 signaling Interleukin-12 signaling Interleukin-12 signaling Interleukin-27 signaling Interleukin-27 signaling Interleukin-21 signaling Interferon alpha/beta signaling Interleukin receptor SHC signaling Regulation of IFNA/IFNB signaling Regulation of IFNA/IFNB signaling Signaling by CSF3 (G-CSF) Signaling by CSF3 (G-CSF) Potential therapeutics for SARS Inactivation of CSF3 (G-CSF) signaling Inactivation of CSF3 (G-CSF) signaling SARS-CoV-2 activates/modulates innate and adaptive immune responses IFNG signaling activates MAPKs Evasion by RSV of host interferon responses PD-L1(CD274) glycosylation and translocation to plasma membrane	Interleukin-3, Interleukin-5 and GM-CSF signaling Interleukin-3, Interleukin-5 and GM-CSF signaling RAF/MAP kinase cascade Surfactant metabolism Defective CSF2RB causes SMDP5 Defective CSF2RA causes SMDP4 Interleukin receptor SHC signaling
Drugs		Myricetin 2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-one Ruxolitinib Tofacitinib Baricitinib Fostamatinib Fedratinib Filgotinib Abrocitinib Upadacitinib Pralsetinib Ivarmacitinib	Sargramostim NPI 32101 Resatorvid
Diseases
GWAS		Appendicular lean mass ( 33097823) Autoimmune thyroid disease ( 32581359) Bevacizumab-induced proteinuria ( 34616010) Cognitive function in longevity ( 33607172) Core binding factor acute myeloid leukemia ( 27903959) Eosinophil count ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Liver enzyme levels (alkaline phosphatase) ( 33972514) Medication use (thyroid preparations) ( 31015401) Monocyte percentage of white cells ( 32888494) Multiple sclerosis ( 31604244) Neutrophil percentage of granulocytes ( 27863252) Plasma anti-thyroglobulin levels ( 29678681) Platelet count ( 32888494) Plateletcrit ( 32888494) Sum eosinophil basophil counts ( 27863252)	Blood protein levels ( 30072576) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Femur bone mineral density x serum urate levels interaction ( 34046847) Inflammatory bowel disease ( 27569725) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Mosquito bite size ( 28199695) Multiple sclerosis ( 24076602 31604244) Multiple sclerosis and LDL levels (pleiotropy) ( 26920376) Perceived unattractiveness to mosquitoes ( 28199695)
Interacting Genes		77 interacting genes: ABL1 AGTR1 BRCA1 BTK CCR1 CCR5 CISH CSF2RB CSF3R CXCR4 EIF2AK2 ELP2 ERBB2 FER FES GAB1 GHR GRB2 H3-4 IFNAR2 IFNGR1 IGF1R IL10RA IL21R IL2RB IL2RG IL3RA IL4R IL5RA IL6ST IL7R IL9R INPP5D INSR IRS1 IRS2 JAK2 JAK3 JAKMIP1 MDK OSMR PDGFRA PDGFRB PIK3R1 PLA2G4A PLAUR PLCG2 PRKCZ PRMT5 PTK2B PTPN11 PTPN2 PTPN6 PTPRC RACK1 RAF1 SH2B2 SHB SOCS1 SOCS2 SOCS3 STAM STAM2 STAT1 STAT2 STAT3 STAT5A STAT6 STUB1 SYK TEC TNFRSF1A TOP1 TSHR TTC3 TYK2 USP6	27 interacting genes: CISH CSF2 CSF2RA EPOR FES FYN HCK IKBKB IL3 IL3RA IL5RA JAK1 JAK2 KDR KIT LCK LYN MAD2L1 PRKCB PTPN11 PTPN6 RACK1 SHC1 STAT1 STAT3 SYK YWHAZ
Entrez ID		3716	1439
HPRD ID		00992	00739
Ensembl ID		ENSG00000162434	ENSG00000100368
Uniprot IDs		A0A8V8TPQ9 P23458 Q6P669	P32927 Q6NSJ8
PDB IDs		3EYG 3EYH 4E4L 4E4N 4E5W 4EHZ 4EI4 4FK6 4GS0 4I5C 4IVB 4IVC 4IVD 4K6Z 4K77 4L00 4L01 5E1E 5HX8 5IXD 5IXI 5KHW 5KHX 5L04 5WO4 6AAH 6BBU 6C7Y 6DBN 6ELR 6GGH 6HZU 6N77 6N78 6N79 6N7A 6N7B 6N7C 6N7D 6RSB 6RSC 6RSD 6RSE 6RSH 6SM8 6SMB 6TPE 6TPF 6W8L 8EXJ 8S85	1C8P 1EGJ 1GH7 2GYS 2NA8 2NA9 4NKQ 5DWU 8TLD
Enriched GO Terms of Interacting Partners?		Cytokine-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction Cell Surface Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Signaling Pathway Via STAT Regulation Of Multicellular Organismal Process Regulation Of Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cell Population Proliferation Cytokine Receptor Activity Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Population Proliferation Regulation Of Cell Activation Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Hemopoiesis Regulation Of Cell Differentiation Protein Tyrosine Kinase Activity Regulation Of Signal Transduction Regulation Of Developmental Process Regulation Of Immune System Process Peptidyl-tyrosine Phosphorylation Positive Regulation Of Lymphocyte Activation Regulation Of Cell Development Positive Regulation Of Cell Activation Regulation Of Lymphocyte Activation Positive Regulation Of Immune System Process Immune System Process Cell Activation Receptor Complex Positive Regulation Of Signal Transduction Plasma Membrane Non-membrane Spanning Protein Tyrosine Kinase Activity Positive Regulation Of Developmental Process Regulation Of Signaling Regulation Of Cell Communication External Side Of Plasma Membrane Regulation Of Lymphocyte Differentiation Regulation Of Multicellular Organismal Development Growth Hormone Receptor Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT Phosphorylation Leukocyte Activation Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Cell Communication Positive Regulation Of Signaling Intracellular Signal Transduction Regulation Of T Cell Activation Protein Phosphorylation Lymphocyte Activation Regulation Of Cell Adhesion	Cytokine-mediated Signaling Pathway Phosphorylation Cell Surface Receptor Signaling Pathway Protein Phosphorylation Peptidyl-tyrosine Phosphorylation Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Signal Transduction Positive Regulation Of Cell Population Proliferation Fc Receptor Signaling Pathway Regulation Of Developmental Process Enzyme-linked Receptor Protein Signaling Pathway Protein Kinase Activity Positive Regulation Of Signal Transduction Protein Modification Process Phosphate-containing Compound Metabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Population Proliferation Regulation Of Multicellular Organismal Development Cell Surface Receptor Signaling Pathway Via STAT SH2 Domain Binding Kinase Activity Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Phosphotyrosine Residue Binding Interleukin-3-mediated Signaling Pathway Regulation Of Signal Transduction Hemopoiesis Regulation Of Leukocyte Proliferation Positive Regulation Of Multicellular Organismal Process Growth Hormone Receptor Signaling Pathway Cytoplasmic Side Of Plasma Membrane Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Protein Autophosphorylation Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Multicellular Organismal Process Immune System Process Regulation Of Immune System Process Fc-gamma Receptor Signaling Pathway Positive Regulation Of Developmental Process Regulation Of Anatomical Structure Morphogenesis Regulation Of Signaling Regulation Of Cell Communication Antigen Receptor-mediated Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Leukocyte Proliferation Immune Response
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