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JAK1 and PRMT5
Number of citations of the paper that reports this interaction (PubMedID
10531356
)
0
Data Source:
HPRD
(in vitro)
JAK1
PRMT5
Description
Janus kinase 1
protein arginine methyltransferase 5
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Endosome
Cytosol
Plasma Membrane
Focal Adhesion
Cytoplasmic Side Of Plasma Membrane
Endomembrane System
Membrane
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Receptor Complex
Chromatin
Nucleus
Nucleoplasm
Chromosome
Cytoplasm
Golgi Apparatus
Cytosol
Protein-containing Complex
Methylosome
Histone Methyltransferase Complex
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Growth Hormone Receptor Binding
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Protein Phosphatase Binding
Ubiquitin Protein Ligase Binding
CCR5 Chemokine Receptor Binding
Metal Ion Binding
P53 Binding
Transcription Corepressor Activity
Protein Binding
Methyltransferase Activity
Methyl-CpG Binding
Histone Arginine N-methyltransferase Activity
Protein-arginine N-methyltransferase Activity
Transferase Activity
Protein-arginine Omega-N Symmetric Methyltransferase Activity
Histone Methyltransferase Activity
Identical Protein Binding
Ribonucleoprotein Complex Binding
Histone H4R3 Methyltransferase Activity
Protein-containing Complex Binding
Protein Heterodimerization Activity
E-box Binding
Histone H3 Methyltransferase Activity
Biological Process
Regulation Of Transcription By RNA Polymerase II
Protein Phosphorylation
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Cytokine-mediated Signaling Pathway
Regulation Of Cell-cell Adhesion
Cell Differentiation
Positive Regulation Of Homotypic Cell-cell Adhesion
Intracellular Signal Transduction
Interleukin-15-mediated Signaling Pathway
Interleukin-4-mediated Signaling Pathway
Interleukin-2-mediated Signaling Pathway
Interleukin-7-mediated Signaling Pathway
Interleukin-9-mediated Signaling Pathway
Interleukin-11-mediated Signaling Pathway
Type III Interferon-mediated Signaling Pathway
Response To Antibiotic
Regulation Of Multicellular Organismal Process
Type II Interferon-mediated Signaling Pathway
Type I Interferon-mediated Signaling Pathway
Growth Hormone Receptor Signaling Pathway Via JAK-STAT
Interleukin-6-mediated Signaling Pathway
T-helper 17 Cell Lineage Commitment
Cellular Response To Virus
Cellular Response To Interleukin-7
Interleukin-10-mediated Signaling Pathway
Protein Localization To Cell-cell Junction
Positive Regulation Of Protein Localization To Nucleus
Positive Regulation Of Sprouting Angiogenesis
Spliceosomal SnRNP Assembly
Chromatin Organization
Chromatin Remodeling
DNA-templated Transcription Termination
Regulation Of DNA-templated Transcription
Regulation Of Mitotic Nuclear Division
Regulation Of Gene Expression
Peptidyl-arginine Methylation
Methylation
Circadian Regulation Of Gene Expression
Peptidyl-arginine N-methylation
Endothelial Cell Activation
Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation
Negative Regulation Of Cell Differentiation
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of MRNA Splicing, Via Spliceosome
Rhythmic Process
Positive Regulation Of Oligodendrocyte Differentiation
Regulation Of ERK1 And ERK2 Cascade
Golgi Ribbon Formation
Liver Regeneration
Regulation Of Signal Transduction By P53 Class Mediator
Positive Regulation Of Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway
Pathways
Interleukin-6 signaling
Interleukin-6 signaling
MAPK3 (ERK1) activation
MAPK1 (ERK2) activation
ISG15 antiviral mechanism
Interleukin-7 signaling
Interleukin-7 signaling
Other interleukin signaling
RAF/MAP kinase cascade
Interleukin-10 signaling
Interleukin-4 and Interleukin-13 signaling
IL-6-type cytokine receptor ligand interactions
Interferon gamma signaling
Regulation of IFNG signaling
Regulation of IFNG signaling
Interleukin-20 family signaling
Interleukin-15 signaling
Interleukin-15 signaling
Interleukin-35 Signalling
Interleukin-9 signaling
Interleukin-2 signaling
Interleukin-12 signaling
Interleukin-12 signaling
Interleukin-27 signaling
Interleukin-27 signaling
Interleukin-21 signaling
Interferon alpha/beta signaling
Interleukin receptor SHC signaling
Regulation of IFNA/IFNB signaling
Regulation of IFNA/IFNB signaling
Signaling by CSF3 (G-CSF)
Signaling by CSF3 (G-CSF)
Potential therapeutics for SARS
Inactivation of CSF3 (G-CSF) signaling
Inactivation of CSF3 (G-CSF) signaling
SARS-CoV-2 activates/modulates innate and adaptive immune responses
IFNG signaling activates MAPKs
Evasion by RSV of host interferon responses
PD-L1(CD274) glycosylation and translocation to plasma membrane
snRNP Assembly
RMTs methylate histone arginines
Regulation of TP53 Activity through Methylation
Drugs
Myricetin
2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-one
Ruxolitinib
Tofacitinib
Baricitinib
Fostamatinib
Fedratinib
Filgotinib
Abrocitinib
Upadacitinib
Pralsetinib
Ivarmacitinib
Diseases
GWAS
Appendicular lean mass (
33097823
)
Autoimmune thyroid disease (
32581359
)
Bevacizumab-induced proteinuria (
34616010
)
Cognitive function in longevity (
33607172
)
Core binding factor acute myeloid leukemia (
27903959
)
Eosinophil count (
32888494
27863252
)
Eosinophil percentage of granulocytes (
27863252
)
Eosinophil percentage of white cells (
27863252
32888494
)
Liver enzyme levels (alkaline phosphatase) (
33972514
)
Medication use (thyroid preparations) (
31015401
)
Monocyte percentage of white cells (
32888494
)
Multiple sclerosis (
31604244
)
Neutrophil percentage of granulocytes (
27863252
)
Plasma anti-thyroglobulin levels (
29678681
)
Platelet count (
32888494
)
Plateletcrit (
32888494
)
Sum eosinophil basophil counts (
27863252
)
Cortical amyloid beta load (
29860282
)
Vertical cup-disc ratio (adjusted for vertical disc diameter) (
31959993
)
Interacting Genes
77 interacting genes:
ABL1
AGTR1
BRCA1
BTK
CCR1
CCR5
CISH
CSF2RB
CSF3R
CXCR4
EIF2AK2
ELP2
ERBB2
FER
FES
GAB1
GHR
GRB2
H3-4
IFNAR2
IFNGR1
IGF1R
IL10RA
IL21R
IL2RB
IL2RG
IL3RA
IL4R
IL5RA
IL6ST
IL7R
IL9R
INPP5D
INSR
IRS1
IRS2
JAK2
JAK3
JAKMIP1
MDK
OSMR
PDGFRA
PDGFRB
PIK3R1
PLA2G4A
PLAUR
PLCG2
PRKCZ
PRMT5
PTK2B
PTPN11
PTPN2
PTPN6
PTPRC
RACK1
RAF1
SH2B2
SHB
SOCS1
SOCS2
SOCS3
STAM
STAM2
STAT1
STAT2
STAT3
STAT5A
STAT6
STUB1
SYK
TEC
TNFRSF1A
TOP1
TSHR
TTC3
TYK2
USP6
93 interacting genes:
ACE2
AIRIM
ARGLU1
CACNB2
CALU
CAPN1
CDC37
CDK19
CDK8
CDYL2
CLK1
CLK3
CLNS1A
COPRS
CTDP1
DIO3
DNMT3A
DRC4
DUSP14
EIF4A1
EIF4A3
ELOA
EPHB6
EZH2
FAM47E
FAM76B
G3BP2
GLI1
GRHL3
GTPBP2
H2AC20
H2AC4
H3-4
H3-5
H4C1
H4C16
HOXC4
ILF3
ING5
JAK1
JAK2
JAK3
KANK2
LDHAL6B
LENG8
LNX1
LUC7L
MAGEB2
MBP
MCRS1
MEF2D
MXI1
MYOD1
MYOG
NCL
NELFCD
NTAQ1
OLA1
PDCD4
PDGFRA
PHYHIP
POLR2A
PRPF38A
RBFOX2
RBM23
RNF4
RSRP1
SIN3A
SLU7
SNRNP70
SNRPB
SNRPD1
SNRPD3
SPAG8
SREBF1
SSTR1
SUPT5H
TRIB3
TRIM54
TYK2
UBC
UBE3A
WDR5
WDR77
YWHAG
YWHAQ
YWHAZ
ZDHHC17
ZMYND19
ZNF2
ZNF224
ZNF436
ZUP1
Entrez ID
3716
10419
HPRD ID
00992
04955
Ensembl ID
ENSG00000162434
ENSG00000100462
Uniprot IDs
A0A8V8TPQ9
P23458
Q6P669
B4DV00
O14744
PDB IDs
3EYG
3EYH
4E4L
4E4N
4E5W
4EHZ
4EI4
4FK6
4GS0
4I5C
4IVB
4IVC
4IVD
4K6Z
4K77
4L00
4L01
5E1E
5HX8
5IXD
5IXI
5KHW
5KHX
5L04
5WO4
6AAH
6BBU
6C7Y
6DBN
6ELR
6GGH
6HZU
6N77
6N78
6N79
6N7A
6N7B
6N7C
6N7D
6RSB
6RSC
6RSD
6RSE
6RSH
6SM8
6SMB
6TPE
6TPF
6W8L
8EXJ
8S85
4GQB
4X60
4X61
4X63
5C9Z
5EMJ
5EMK
5EML
5EMM
5FA5
6CKC
6K1S
6RLL
6RLQ
6UGH
6UXX
6UXY
6V0N
6V0O
6V0P
7BO7
7BOC
7KIB
7KIC
7KID
7L1G
7M05
7MX7
7MXA
7MXC
7MXG
7MXN
7S0U
7S1P
7S1Q
7S1R
7S1S
7SER
7SES
7U30
7UOH
7UY1
7UYF
7ZUP
7ZUQ
7ZUU
7ZUY
7ZV2
7ZVL
7ZVU
8CSG
8CTB
8CYI
8G1U
8VEO
8VET
8VEU
8VEW
8VEX
8VEY
8X6L
9C10
9DOD
9E3A
9E3B
9E3C
9EYU
9EYV
9EYW
9EYX
9MGL
9MGM
9MGN
9MGP
9MGQ
9MGR
9N3N
9N3O
9N3P
9N3Q
9N3R
Enriched GO Terms of Interacting Partners
?
Cytokine-mediated Signaling Pathway
Cell Surface Receptor Signaling Pathway
Signal Transduction
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Cell Surface Receptor Signaling Pathway Via STAT
Regulation Of Multicellular Organismal Process
Regulation Of Receptor Signaling Pathway Via JAK-STAT
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Regulation Of Cell Population Proliferation
Cytokine Receptor Activity
Positive Regulation Of Multicellular Organismal Process
Positive Regulation Of Cell Population Proliferation
Regulation Of Cell Activation
Enzyme-linked Receptor Protein Signaling Pathway
Regulation Of Hemopoiesis
Regulation Of Cell Differentiation
Protein Tyrosine Kinase Activity
Regulation Of Signal Transduction
Regulation Of Developmental Process
Regulation Of Immune System Process
Peptidyl-tyrosine Phosphorylation
Positive Regulation Of Lymphocyte Activation
Regulation Of Cell Development
Positive Regulation Of Cell Activation
Regulation Of Lymphocyte Activation
Positive Regulation Of Immune System Process
Immune System Process
Cell Activation
Receptor Complex
Positive Regulation Of Signal Transduction
Plasma Membrane
Non-membrane Spanning Protein Tyrosine Kinase Activity
Positive Regulation Of Developmental Process
Regulation Of Signaling
Regulation Of Cell Communication
External Side Of Plasma Membrane
Regulation Of Lymphocyte Differentiation
Regulation Of Multicellular Organismal Development
Growth Hormone Receptor Signaling Pathway
Growth Hormone Receptor Signaling Pathway Via JAK-STAT
Phosphorylation
Leukocyte Activation
Regulation Of Leukocyte Cell-cell Adhesion
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Intracellular Signal Transduction
Regulation Of T Cell Activation
Protein Phosphorylation
Lymphocyte Activation
Regulation Of Cell Adhesion
Nucleus
Regulation Of Gene Expression
Regulation Of Macromolecule Biosynthetic Process
Regulation Of RNA Metabolic Process
Nucleoplasm
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of Primary Metabolic Process
Methylosome
RNA Binding
Regulation Of RNA Splicing
Regulation Of Metabolic Process
U1 SnRNP Binding
U1 SnRNP
Regulation Of MRNA Splicing, Via Spliceosome
Growth Hormone Receptor Binding
Regulation Of Transcription By RNA Polymerase II
Protein Binding
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
RNA Splicing
Spliceosomal Complex
Regulation Of MRNA Processing
MRNA Metabolic Process
Growth Hormone Receptor Signaling Pathway Via JAK-STAT
MRNA Splicing, Via Spliceosome
Small Nuclear Ribonucleoprotein Complex
Regulation Of MRNA Metabolic Process
RNA Splicing, Via Transesterification Reactions
PICln-Sm Protein Complex
Non-membrane Spanning Protein Tyrosine Kinase Activity
Positive Regulation Of RNA Splicing
Spliceosomal SnRNP Assembly
Chromosome
MRNA Processing
Protein Tyrosine Kinase Activity
Structural Constituent Of Chromatin
Growth Hormone Receptor Signaling Pathway
7-methylguanosine Cap Hypermethylation
Protein Localization To Chromatin
Protein-RNA Complex Assembly
Extrinsic Component Of Plasma Membrane
Protein Modification Process
RNA Metabolic Process
Positive Regulation Of MRNA Splicing, Via Spliceosome
Positive Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Macromolecule Metabolic Process
U4 SnRNP
Negative Regulation Of Macromolecule Biosynthetic Process
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Tagcloud (Intersection)
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