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ITGA5 and VTN
Data Source:
BioGRID
(pull down)
ITGA5
VTN
Description
integrin subunit alpha 5
vitronectin
Image
GO Annotations
Cellular Component
Ruffle
Endoplasmic Reticulum
Golgi Apparatus
Plasma Membrane
Cell-cell Junction
Focal Adhesion
Integrin Complex
External Side Of Plasma Membrane
Cell Surface
Membrane
Cell Junction
Cytoplasmic Vesicle
Ruffle Membrane
Integrin Alpha5-beta1 Complex
Synapse
Postsynaptic Membrane
Anchoring Junction
Alphav-beta3 Integrin-vitronectin Complex
Glutamatergic Synapse
Extracellular Region
Basement Membrane
Extracellular Space
Endoplasmic Reticulum
Golgi Lumen
Symbiont-containing Vacuole
Extracellular Matrix
Rough Endoplasmic Reticulum Lumen
Extracellular Exosome
Alphav-beta3 Integrin-vitronectin Complex
Blood Microparticle
Protein Complex Involved In Cell-matrix Adhesion
Peptidase Inhibitor Complex
Molecular Function
Virus Receptor Activity
Signaling Receptor Binding
Epidermal Growth Factor Receptor Binding
Platelet-derived Growth Factor Receptor Binding
Integrin Binding
Calcium Ion Binding
Protein Binding
Signaling Receptor Activity
Vascular Endothelial Growth Factor Receptor 2 Binding
Metal Ion Binding
Cell Adhesion Molecule Binding
Scavenger Receptor Activity
Integrin Binding
Extracellular Matrix Structural Constituent
Protein Binding
Collagen Binding
Heparin Binding
Polysaccharide Binding
Identical Protein Binding
Extracellular Matrix Binding
Biological Process
Angiogenesis
Formation Of Primary Germ Layer
Cell-substrate Junction Assembly
Cell Adhesion
Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules
Leukocyte Cell-cell Adhesion
Cell-matrix Adhesion
Integrin-mediated Signaling Pathway
Female Pregnancy
Memory
Tissue Development
Positive Regulation Of Cell-substrate Adhesion
Response To Muscle Activity
CD40 Signaling Pathway
Positive Regulation Of Cell Migration
Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway
Cell-substrate Adhesion
Cell Adhesion Mediated By Integrin
Cell-cell Adhesion Mediated By Integrin
Heterotypic Cell-cell Adhesion
Wound Healing, Spreading Of Epidermal Cells
Endodermal Cell Differentiation
Regulation Of Angiogenesis
Symbiont Entry Into Host Cell
Cell-cell Adhesion
Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway
Positive Regulation Of Sprouting Angiogenesis
Negative Regulation Of Anoikis
Immune Response
Cell Adhesion
Cell-matrix Adhesion
Integrin-mediated Signaling Pathway
Positive Regulation Of Cell-substrate Adhesion
Positive Regulation Of Smooth Muscle Cell Migration
Vesicle-mediated Transport
Cell Migration
Cell Differentiation
Regulation Of Cell Adhesion
Negative Regulation Of Blood Coagulation
Extracellular Matrix Organization
Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway
Cell Adhesion Mediated By Integrin
Endodermal Cell Differentiation
Negative Regulation Of Proteolysis
Positive Regulation Of Receptor-mediated Endocytosis
Oligodendrocyte Differentiation
Protein Polymerization
Negative Regulation Of Fibrinolysis
Smooth Muscle Cell-matrix Adhesion
Positive Regulation Of Wound Healing
Liver Regeneration
Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway
Positive Regulation Of Integrin-mediated Signaling Pathway
Pathways
Elastic fibre formation
Fibronectin matrix formation
Cell surface interactions at the vascular wall
Integrin cell surface interactions
Integrin cell surface interactions
Signal transduction by L1
RUNX2 regulates genes involved in cell migration
GPER1 signaling
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Molecules associated with elastic fibres
Integrin cell surface interactions
Syndecan interactions
ECM proteoglycans
ECM proteoglycans
Regulation of Complement cascade
Developmental Lineage of Pancreatic Ductal Cells
Drugs
Resveratrol
Tauroursodeoxycholic acid
Abciximab
Zinc
Copper
Zinc acetate
Zinc chloride
Zinc sulfate, unspecified form
Diseases
GWAS
Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) (
26426971
)
Advanced age-related macular degeneration (
26691988
)
Heel bone mineral density (
30598549
)
LDL cholesterol (
30275531
)
Low density lipoprotein cholesterol levels (
32154731
33339817
)
Osteoprotegerin levels (
25080503
)
Interacting Genes
32 interacting genes:
ACKR5
ANGPT1
ANGPT2
ANGPTL3
ARHGAP5
AUP1
CD9
CLK1
COL18A1
COL1A1
EGFR
ERBB2
FGFR2
FLT4
FN1
GIPC1
GRK6
ITGB1
ITGB3
ITGB5
L1CAM
LGALS3BP
NISCH
PECAM1
RABIF
SHARPIN
SPP1
STAMBP
TNC
UBAP1
VCL
VTN
50 interacting genes:
ADH5
ADTRP
AMPH
APP
CBX1
CD247
CKS2
COPS5
CRADD
CSNK2A1
DLG2
DLG3
EGF
ETV7
FGF2
FGG
GEM
GLUD1
GOPC
HGF
IGF2
IGFBP5
ITGA2B
ITGA5
ITGA8
ITGAV
ITGB3
ITGB6
ITGB8
KNG1
LACRT
LNX2
PLAUR
POMC
PRDX4
PRKACA
PRKCA
PRKCB
PRKCG
PVR
RHOXF1
RPL13A
SERPINE1
SIX1
SNTG1
TGFB1
TGFB2
TNFRSF11B
UBQLN2
VEGFA
Entrez ID
3678
7448
HPRD ID
00627
01902
Ensembl ID
ENSG00000161638
ENSG00000109072
Uniprot IDs
B2R627
P08648
D9ZGG2
P04004
PDB IDs
3VI3
3VI4
4WJK
4WK0
4WK2
4WK4
7NWL
7NXD
9B9J
9B9K
9CKV
1OC0
1S4G
1SSU
2JQ8
3BT1
3BT2
4K24
6O5E
7RJ9
Enriched GO Terms of Interacting Partners
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Cell Adhesion
Integrin Binding
Cell-substrate Adhesion
Cell-matrix Adhesion
Regulation Of Cell Migration
Regulation Of Cell Motility
Regulation Of Locomotion
Angiogenesis
Anatomical Structure Formation Involved In Morphogenesis
Positive Regulation Of Cell Migration
Extracellular Matrix
Positive Regulation Of Cell Motility
Positive Regulation Of Locomotion
Cell Surface Receptor Signaling Pathway
Integrin-mediated Signaling Pathway
Cell Migration
Receptor Complex
Response To Growth Factor
Signal Transduction
Cell Adhesion Mediated By Integrin
Enzyme-linked Receptor Protein Signaling Pathway
Cell Motility
Extracellular Exosome
Regulation Of Vascular Endothelial Growth Factor Signaling Pathway
Cellular Response To Growth Factor Stimulus
Regulation Of Response To Wounding
Regulation Of ERK1 And ERK2 Cascade
Focal Adhesion
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Regulation Of Cell Adhesion
Extracellular Space
Negative Regulation Of Blood Coagulation
Cell Junction Organization
Negative Regulation Of Hemostasis
Negative Regulation Of Coagulation
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Transmembrane Receptor Protein Tyrosine Kinase Activity
Mesodermal Cell Differentiation
Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway
Wound Healing, Spreading Of Epidermal Cells
Extracellular Region
Regulation Of Cell-substrate Adhesion
Regulation Of Anatomical Structure Morphogenesis
Platelet Alpha Granule Membrane
Protein Tyrosine Kinase Activity
Positive Regulation Of Signal Transduction
Positive Regulation Of Cell Population Proliferation
Regulation Of Wound Healing
Regulation Of Cell Population Proliferation
Platelet Alpha Granule Lumen
Integrin Complex
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Positive Regulation Of Signal Transduction
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Cell Surface Receptor Signaling Pathway
Regulation Of Programmed Cell Death
Integrin Binding
Positive Regulation Of Cell Migration
Positive Regulation Of Cell Motility
Cell-matrix Adhesion
Regulation Of Apoptotic Process
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Locomotion
Cell-cell Adhesion
Positive Regulation Of Vasculature Development
Cell Surface
Regulation Of Vesicle-mediated Transport
Regulation Of Cell Communication
Regulation Of Signaling
Signal Transduction
Regulation Of Signal Transduction
Positive Regulation Of Epithelial Tube Formation
Positive Regulation Of Intracellular Signal Transduction
Negative Regulation Of Apoptotic Process
Signaling Receptor Binding
Negative Regulation Of Multicellular Organismal Process
Cell Adhesion
Growth Factor Activity
Angiogenesis
Cell-substrate Adhesion
Integrin-mediated Signaling Pathway
Cell Adhesion Mediated By Integrin
Regulation Of Endocytosis
Regulation Of Protein Metabolic Process
Regulation Of Multicellular Organismal Process
Negative Regulation Of Programmed Cell Death
Alphav-beta3 Integrin-PKCalpha Complex
Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity
Regulation Of Protein Localization
Regulation Of Vasculature Development
Regulation Of Transport
Positive Regulation Of Angiogenesis
Positive Regulation Of Protein Localization
Regulation Of Morphogenesis Of An Epithelium
Anatomical Structure Formation Involved In Morphogenesis
Positive Regulation Of MAPK Cascade
Regulation Of Cell Migration
Positive Regulation Of Morphogenesis Of An Epithelium
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Tagcloud (Difference)
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Tagcloud (Intersection)
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