VTN and ITGA8

Number of citations of the paper that reports this interaction (PMID 7559467)
31

Data Source:
HPRD (in vitro)

		VTN	ITGA8
Gene Name		vitronectin	integrin, alpha 8
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Extracellular Matrix Extracellular Vesicular Exosome Alphav-beta3 Integrin-vitronectin Complex Blood Microparticle	Endoplasmic Reticulum Plasma Membrane Focal Adhesion Integrin Complex Cell Surface Postsynaptic Density Dendritic Spine Membrane Integrin Alpha8-beta1 Complex Perikaryon Apical Part Of Cell
	Molecular Function	Scavenger Receptor Activity Integrin Binding Protein Binding Heparin Binding Polysaccharide Binding Extracellular Matrix Binding	Metal Ion Binding
	Biological Process	Receptor-mediated Endocytosis Immune Response Cell Adhesion Cell-matrix Adhesion Positive Regulation Of Cell-substrate Adhesion Negative Regulation Of Endopeptidase Activity Positive Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Blood Coagulation Extracellular Matrix Organization Regulation Of Complement Activation Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Binding Cell Adhesion Mediated By Integrin Endodermal Cell Differentiation Innate Immune Response Positive Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Peptidyl-tyrosine Phosphorylation Smooth Muscle Cell-matrix Adhesion Positive Regulation Of Wound Healing	Metanephros Development Kidney Development Cell-matrix Adhesion Integrin-mediated Signaling Pathway Brain Development Memory Single Organismal Cell-cell Adhesion Cell Projection Organization Extracellular Matrix Organization Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Substrate Adhesion-dependent Cell Spreading Inner Ear Morphogenesis Establishment Of Protein Localization Mesodermal Cell Differentiation Smooth Muscle Tissue Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Smooth Muscle Cell Differentiation
Pathways		Molecules associated with elastic fibres Syndecan interactions Regulation of Complement cascade Complement cascade Elastic fibre formation ECM proteoglycans Integrin cell surface interactions Non-integrin membrane-ECM interactions Innate Immune System	Molecules associated with elastic fibres Elastic fibre formation ECM proteoglycans Integrin cell surface interactions
Drugs		Abciximab
Diseases
GWAS			Parkinson's disease ( 19915575) Quantitative traits ( 19197348)
Protein-Protein Interactions		42 interactors: ADH5 ADTRP AMPH APP CBX1 CD247 CKS2 COPS5 CRADD CSNK2A1 EGF ETV7 FGF2 FGG GEM GLUD1 GOPC HGF IGF2 IGFBP5 ITGA8 ITGB3 ITGB6 ITGB8 KNG1 LACRT PLAUR POMC PRDX4 PRKACA PRKCA PRKCB PRKCG PVR RHOXF1 RPL13A SERPINE1 SIX1 TGFB1 TGFB2 TNFRSF11B VEGFA	4 interactors: FN1 ITGB1 NPNT VTN
Entrez ID		7448	8516
HPRD ID		01902	10361
Ensembl ID
Uniprot IDs		D9ZGG2 P04004	P53708
PDB IDs		1OC0 1S4G 1SSU 2JQ8 3BT1 3BT2
Enriched GO Terms of Interacting Partners?		Platelet Activation Platelet Degranulation Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Response To Wounding Extracellular Matrix Organization Extracellular Structure Organization Cell Activation Exocytosis Signaling Cell Communication Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Response To External Stimulus Secretion Secretion By Cell Signal Transduction Regulation Of Peptidyl-tyrosine Phosphorylation Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Endothelial Cell Migration Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Epithelial Cell Proliferation Negative Regulation Of Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Phosphorylation Response To Stimulus Cellular Response To Stimulus Positive Regulation Of Angiogenesis Regulation Of Protein Kinase Activity Positive Regulation Of MAPK Cascade Cellular Localization Positive Regulation Of Metabolic Process Regulation Of Signaling Positive Regulation Of Cell Migration Response To Stress Positive Regulation Of Cell Motility Regulation Of MAPK Cascade Regulation Of Kinase Activity Histone H3-T6 Phosphorylation Regulation Of Epithelial Cell Migration Regulation Of Cellular Process Positive Regulation Of Cellular Component Movement Positive Regulation Of Intracellular Signal Transduction	Cell Adhesion Mediated By Integrin Cell-matrix Adhesion Cell-substrate Adhesion Extracellular Matrix Organization Extracellular Structure Organization Calcium-independent Cell-matrix Adhesion Cell-cell Adhesion Mediated By Integrin Positive Regulation Of Cell-substrate Adhesion Formation Of Primary Germ Layer Regulation Of Cell-substrate Adhesion Gastrulation Cell Adhesion Positive Regulation Of Cell Adhesion Endodermal Cell Differentiation Tissue Development Endoderm Formation Regulation Of Cell Adhesion Endoderm Development Embryonic Morphogenesis Positive Regulation Of Endocytosis Anatomical Structure Morphogenesis Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cell Differentiation Positive Regulation Of Phosphorylation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Anatomical Structure Formation Involved In Morphogenesis Regulation Of Endocytosis Regulation Of Cellular Response To Growth Factor Stimulus Cell Junction Assembly Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Peptidyl-tyrosine Phosphorylation Embryo Development Cell Differentiation Positive Regulation Of Metabolic Process Pilomotor Reflex Regulation Of Collagen Catabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Smooth Muscle Cell Differentiation Positive Regulation Of Neuron Projection Development Leukocyte Migration Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Defense Response Formation Of Radial Glial Scaffolds Positive Regulation Of Cell Projection Organization Regulation Of Phosphorus Metabolic Process Muscle Cell Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Cell Migration Angiogenesis
Tagcloud ?		accumulated aeamsq aeamsqv aeamsqvt aeamsqvtn aeamsqvtntatim desorption dimeric dimerization dissociated exclusion flight immunoblot maldi monomeric nonapeptide p17gag p24gag p2gag potently pr55gag protease proteolytic spectrometric sqnypivq succinyl suicide tof vtntatim
Tagcloud (Difference) ?		accumulated aeamsq aeamsqv aeamsqvt aeamsqvtn aeamsqvtntatim desorption dimeric dimerization dissociated exclusion flight immunoblot maldi monomeric nonapeptide p17gag p24gag p2gag potently pr55gag protease proteolytic spectrometric sqnypivq succinyl suicide tof vtntatim
Tagcloud (Intersection) ?