ITGA5 and FGFR2

Number of citations of the paper that reports this interaction (PMID 15728256)
18

Data Source:
HPRD (in vitro)

		ITGA5	FGFR2
Gene Name		integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	fibroblast growth factor receptor 2
Image
Gene Ontology Annotations	Cellular Component	Ruffle Cytoplasm Plasma Membrane Cell-cell Junction Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Ruffle Membrane Synapse Alphav-beta3 Integrin-vitronectin Complex	Extracellular Region Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Cell Cortex Cell Surface Membrane Integral Component Of Membrane Cytoplasmic Membrane-bounded Vesicle Extracellular Matrix Intracellular Membrane-bounded Organelle Excitatory Synapse
	Molecular Function	Epidermal Growth Factor Receptor Binding Platelet-derived Growth Factor Receptor Binding Integrin Binding Protein Binding Vascular Endothelial Growth Factor Receptor 2 Binding Metal Ion Binding	Protein Tyrosine Kinase Activity Fibroblast Growth Factor-activated Receptor Activity Protein Binding ATP Binding Heparin Binding Fibroblast Growth Factor Binding Protein Homodimerization Activity
	Biological Process	Angiogenesis Cell-substrate Junction Assembly Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Integrin-mediated Signaling Pathway Axon Guidance Blood Coagulation Memory Positive Regulation Of Cell-substrate Adhesion Viral Process Extracellular Matrix Organization Positive Regulation Of Cell Migration Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell-substrate Adhesion Cell-cell Adhesion Mediated By Integrin Heterotypic Cell-cell Adhesion Wound Healing, Spreading Of Epidermal Cells Endodermal Cell Differentiation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Leukocyte Migration Negative Regulation Of Anoikis	Negative Regulation Of Transcription From RNA Polymerase II Promoter Angiogenesis Ureteric Bud Development In Utero Embryonic Development Epithelial To Mesenchymal Transition Positive Regulation Of Mesenchymal Cell Proliferation Outflow Tract Septum Morphogenesis Membranous Septum Morphogenesis Apoptotic Process Epidermal Growth Factor Receptor Signaling Pathway Cell-cell Signaling Axonogenesis Neuromuscular Junction Development Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Smoothened Signaling Pathway Post-embryonic Development Embryonic Pattern Specification Organ Morphogenesis Regulation Of Cell Fate Commitment Positive Regulation Of Phospholipase Activity Morphogenesis Of Embryonic Epithelium Peptidyl-tyrosine Phosphorylation Orbitofrontal Cortex Development Ventricular Zone Neuroblast Division Pyramidal Neuron Development Gland Morphogenesis Positive Regulation Of Wnt Signaling Pathway Bone Mineralization Lung Development Epithelial Cell Differentiation Midbrain Development Otic Vesicle Formation Hair Follicle Morphogenesis Lacrimal Gland Development Regulation Of Osteoblast Proliferation Multicellular Organism Growth Organ Growth Fibroblast Growth Factor Receptor Signaling Pathway Involved In Negative Regulation Of Apoptotic Process In Bone Marrow Fibroblast Growth Factor Receptor Signaling Pathway Involved In Hemopoiesis Fibroblast Growth Factor Receptor Signaling Pathway Involved In Positive Regulation Of Cell Proliferation In Bone Marrow Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development Fc-epsilon Receptor Signaling Pathway Regulation Of Multicellular Organism Growth Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Inner Ear Morphogenesis Odontogenesis Positive Regulation Of MAPK Cascade Innate Immune Response Cell Fate Commitment Regulation Of Osteoblast Differentiation Positive Regulation Of Cell Cycle Negative Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Autophosphorylation Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Lung Alveolus Development Mesodermal Cell Differentiation Synaptic Vesicle Transport Embryonic Digestive Tract Morphogenesis Embryonic Organ Morphogenesis Digestive Tract Development Embryonic Organ Development Reproductive Structure Development Positive Regulation Of Smooth Muscle Cell Proliferation Embryonic Cranial Skeleton Morphogenesis Skeletal System Morphogenesis Epidermis Morphogenesis Branching Morphogenesis Of A Nerve Mesenchymal Cell Differentiation Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Regulation Of Smooth Muscle Cell Differentiation Positive Regulation Of Cell Division Ventricular Cardiac Muscle Tissue Morphogenesis Positive Regulation Of Cardiac Muscle Cell Proliferation Limb Bud Formation Bone Development Bone Morphogenesis Coronal Suture Morphogenesis Branching Involved In Prostate Gland Morphogenesis Branching Involved In Salivary Gland Morphogenesis Bud Elongation Involved In Lung Branching Lung Lobe Morphogenesis Lung-associated Mesenchyme Development Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Prostate Gland Morphogenesis Prostate Epithelial Cord Elongation Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis Squamous Basal Epithelial Stem Cell Differentiation Involved In Prostate Gland Acinus Development Fibroblast Growth Factor Receptor Signaling Pathway Involved In Mammary Gland Specification Lateral Sprouting From An Epithelium Mammary Gland Bud Formation Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis Branch Elongation Involved In Salivary Gland Morphogenesis Branching Involved In Labyrinthine Layer Morphogenesis Regulation Of Branching Involved In Prostate Gland Morphogenesis Regulation Of Morphogenesis Of A Branching Structure Mesenchymal Cell Differentiation Involved In Lung Development Mesenchymal Cell Proliferation Involved In Lung Development Endodermal Digestive Tract Morphogenesis Lens Fiber Cell Development Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		Signal transduction by L1 Axon guidance Elastic fibre formation Fibronectin matrix formation L1CAM interactions Integrin cell surface interactions Cell surface interactions at the vascular wall	Signaling by FGFR2 amplification mutants Signaling by FGFR2 mutants Signaling by FGFR in disease Signaling by FGFR mutants Activated point mutants of FGFR2
Drugs			Palifermin Thalidomide SU4984 4-[4-(1-Amino-1-Methylethyl)Phenyl]-5-Chloro-N-[4-(2-Morpholin-4-Ylethyl)Phenyl]Pyrimidin-2-Amine Regorafenib Ponatinib
Diseases
GWAS			Breast cancer ( 21263130 20872241 23354978 17529967 23535729 17529973 22951594 20453838 19330030 21060860) Prostate-specific antigen levels ( 21160077)
Protein-Protein Interactions		24 interactors: ANGPT1 ANGPTL3 ARHGAP5 AUP1 CD9 COL18A1 COL1A1 EGFR ERBB2 FGFR2 FLT4 FN1 GIPC1 GRK6 ITGB1 ITGB3 ITGB5 L1CAM NISCH PECAM1 RABIF SPP1 STAMBP TNC	21 interactors: APP CACNA1D EPHA4 FGF1 FGF10 FGF17 FGF18 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 ITGA5 NEDD4 PAK4 PLCG1 PPM1A PTK2B
Entrez ID		3678	2263
HPRD ID		00627	01492
Ensembl ID		ENSG00000161638	ENSG00000066468
Uniprot IDs		P08648	D2CGD1 P21802
PDB IDs		3VI3 3VI4	1DJS 1E0O 1EV2 1GJO 1II4 1IIL 1NUN 1OEC 1WVZ 2FDB 2PSQ 2PVF 2PVY 2PWL 2PY3 2PZ5 2PZP 2PZR 2Q0B 3B2T 3CAF 3CLY 3CU1 3DAR 3EUU 3OJ2 3OJM 3RI1 4J95 4J96 4J97 4J98 4J99
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Cell Adhesion Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Cell Migration Regulation Of Cell Motility Cardiovascular System Development Regulation Of Locomotion Regulation Of Cellular Component Movement Blood Vessel Development Vasculature Development Leukocyte Migration Response To Stimulus Positive Regulation Of Cell Proliferation Wound Healing Regulation Of Cell Proliferation Anatomical Structure Morphogenesis Response To Wounding Cell-substrate Adhesion Cell Migration Response To Growth Factor Movement Of Cell Or Subcellular Component Multicellular Organismal Development Blood Vessel Morphogenesis Blood Coagulation Cell Motility Hemostasis System Development Anatomical Structure Development Cellular Response To Stimulus Locomotion Cell Communication Positive Regulation Of Signal Transduction Regulation Of Signaling Cell-matrix Adhesion Angiogenesis Anatomical Structure Formation Involved In Morphogenesis Regulation Of Signal Transduction Developmental Process Response To Vitamin Response To Nutrient Regulation Of Body Fluid Levels Signaling Cell Activation Regulation Of Cellular Process Formation Of Primary Germ Layer Signal Transduction	Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Phosphatidylinositol-mediated Signaling Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Insulin Stimulus Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Fc Receptor Signaling Pathway Response To Insulin Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Enzyme Linked Receptor Protein Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Innate Immune Response Response To Peptide Hormone Immune Response-regulating Signaling Pathway Cellular Response To Organonitrogen Compound Response To Peptide Cell Surface Receptor Signaling Pathway Immune Response Cellular Response To Hormone Stimulus Response To Organonitrogen Compound Response To Hormone Defense Response Immune System Process Signal Transduction Cellular Response To Organic Substance Regulation Of Immune Response Cell-cell Signaling Signaling Positive Regulation Of Cell Division Cell Communication Regulation Of Immune System Process Positive Regulation Of Cell Proliferation Intracellular Signal Transduction Anatomical Structure Morphogenesis Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Stimulus Response To Organic Substance Positive Regulation Of Intracellular Signal Transduction Cell Differentiation Response To Stress System Development
Tagcloud ?			altogether basic bfgf bfgf1 bfgf55 bfgf75 bk1 bk2 chimera chimeras confer fgfr1 fgfr4 fibroblast gfg interacted kb1 kb2 keratinocyte kgf kgf111 kgf31 kgf91 kgfr neutralized neutralizing reciprocal structurally
Tagcloud (Difference) ?			altogether basic bfgf bfgf1 bfgf55 bfgf75 bk1 bk2 chimera chimeras confer fgfr1 fgfr4 fibroblast gfg interacted kb1 kb2 keratinocyte kgf kgf111 kgf31 kgf91 kgfr neutralized neutralizing reciprocal structurally
Tagcloud (Intersection) ?