ITGA5 and NISCH

Number of citations of the paper that reports this interaction (PMID 12868002)
3

Data Source:
HPRD (in vivo, in vitro)

		ITGA5	NISCH
Gene Name		integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	nischarin
Image
Gene Ontology Annotations	Cellular Component	Ruffle Cytoplasm Plasma Membrane Cell-cell Junction Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Ruffle Membrane Synapse Alphav-beta3 Integrin-vitronectin Complex	Early Endosome Cytosol Plasma Membrane Membrane Recycling Endosome
	Molecular Function	Epidermal Growth Factor Receptor Binding Platelet-derived Growth Factor Receptor Binding Integrin Binding Protein Binding Vascular Endothelial Growth Factor Receptor 2 Binding Metal Ion Binding	Integrin Binding Protein Binding G-protein Coupled Amine Receptor Activity Phosphatidylinositol Binding Identical Protein Binding
	Biological Process	Angiogenesis Cell-substrate Junction Assembly Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Integrin-mediated Signaling Pathway Axon Guidance Blood Coagulation Memory Positive Regulation Of Cell-substrate Adhesion Viral Process Extracellular Matrix Organization Positive Regulation Of Cell Migration Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell-substrate Adhesion Cell-cell Adhesion Mediated By Integrin Heterotypic Cell-cell Adhesion Wound Healing, Spreading Of Epidermal Cells Endodermal Cell Differentiation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Leukocyte Migration Negative Regulation Of Anoikis	Glucose Metabolic Process Apoptotic Process G-protein Coupled Receptor Signaling Pathway Regulation Of Blood Pressure Rac Protein Signal Transduction Actin Cytoskeleton Organization Negative Regulation Of Cell Migration Regulation Of Synaptic Transmission, GABAergic Norepinephrine Secretion
Pathways		Signal transduction by L1 Axon guidance Elastic fibre formation Fibronectin matrix formation L1CAM interactions Integrin cell surface interactions Cell surface interactions at the vascular wall
Drugs
Diseases
GWAS			Bipolar disorder ( 21926972) Waist-hip ratio ( 20935629)
Protein-Protein Interactions		24 interactors: ANGPT1 ANGPTL3 ARHGAP5 AUP1 CD9 COL18A1 COL1A1 EGFR ERBB2 FGFR2 FLT4 FN1 GIPC1 GRK6 ITGB1 ITGB3 ITGB5 L1CAM NISCH PECAM1 RABIF SPP1 STAMBP TNC	3 interactors: AR IRS4 ITGA5
Entrez ID		3678	11188
HPRD ID		00627	11391
Ensembl ID		ENSG00000161638	ENSG00000010322
Uniprot IDs		P08648	Q9Y2I1
PDB IDs		3VI3 3VI4	3P0C
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Cell Adhesion Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Cell Migration Regulation Of Cell Motility Cardiovascular System Development Regulation Of Locomotion Regulation Of Cellular Component Movement Blood Vessel Development Vasculature Development Leukocyte Migration Response To Stimulus Positive Regulation Of Cell Proliferation Wound Healing Regulation Of Cell Proliferation Anatomical Structure Morphogenesis Response To Wounding Cell-substrate Adhesion Cell Migration Response To Growth Factor Movement Of Cell Or Subcellular Component Multicellular Organismal Development Blood Vessel Morphogenesis Blood Coagulation Cell Motility Hemostasis System Development Anatomical Structure Development Cellular Response To Stimulus Locomotion Cell Communication Positive Regulation Of Signal Transduction Regulation Of Signaling Cell-matrix Adhesion Angiogenesis Anatomical Structure Formation Involved In Morphogenesis Regulation Of Signal Transduction Developmental Process Response To Vitamin Response To Nutrient Regulation Of Body Fluid Levels Signaling Cell Activation Regulation Of Cellular Process Formation Of Primary Germ Layer Signal Transduction	Negative Regulation Of Integrin Biosynthetic Process Positive Regulation Of Integrin Biosynthetic Process Regulation Of Integrin Biosynthetic Process Cell-cell Adhesion Mediated By Integrin Positive Regulation Of Transcription From RNA Polymerase III Promoter Wound Healing, Spreading Of Epidermal Cells Cell Adhesion Mediated By Integrin Regulation Of Signal Transduction Cellular Response To Hormone Stimulus Negative Regulation Of Anoikis Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Anoikis Regulation Of Signaling Heterotypic Cell-cell Adhesion Regulation Of Transcription From RNA Polymerase III Promoter Positive Regulation Of Phosphorylation Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Androgen Receptor Signaling Pathway Negative Regulation Of Programmed Cell Death Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Response To Hormone Endodermal Cell Differentiation Wound Healing, Spreading Of Cells Negative Regulation Of Cell Death Regulation Of Establishment Of Protein Localization To Plasma Membrane Cell-substrate Junction Assembly Regulation Of Protein Localization To Plasma Membrane Endoderm Formation Morphogenesis Of An Epithelial Sheet
Tagcloud ?			23b 27b antitumor augmented biologic cascade correlates delivered engineered erbb2 feedback intraperitoneally inversely mir mirnas neu noncoding notably nucleotides relevance repressed restored rnas substantially suppress suppressing underscoring xenograft
Tagcloud (Difference) ?			23b 27b antitumor augmented biologic cascade correlates delivered engineered erbb2 feedback intraperitoneally inversely mir mirnas neu noncoding notably nucleotides relevance repressed restored rnas substantially suppress suppressing underscoring xenograft
Tagcloud (Intersection) ?