ITGA5 and ARHGAP5

Number of citations of the paper that reports this interaction (PMID 8537347)
31

Data Source:
HPRD (in vivo)

		ITGA5	ARHGAP5
Gene Name		integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	Rho GTPase activating protein 5
Image
Gene Ontology Annotations	Cellular Component	Ruffle Cytoplasm Plasma Membrane Cell-cell Junction Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Ruffle Membrane Synapse Alphav-beta3 Integrin-vitronectin Complex	Cytoplasm Cytosol Membrane
	Molecular Function	Epidermal Growth Factor Receptor Binding Platelet-derived Growth Factor Receptor Binding Integrin Binding Protein Binding Vascular Endothelial Growth Factor Receptor 2 Binding Metal Ion Binding	GTPase Activity Rho GTPase Activator Activity Protein Binding GTP Binding SH2 Domain Binding
	Biological Process	Angiogenesis Cell-substrate Junction Assembly Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Integrin-mediated Signaling Pathway Axon Guidance Blood Coagulation Memory Positive Regulation Of Cell-substrate Adhesion Viral Process Extracellular Matrix Organization Positive Regulation Of Cell Migration Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell-substrate Adhesion Cell-cell Adhesion Mediated By Integrin Heterotypic Cell-cell Adhesion Wound Healing, Spreading Of Epidermal Cells Endodermal Cell Differentiation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Leukocyte Migration Negative Regulation Of Anoikis	Positive Regulation Of Mesenchymal Cell Proliferation Cell Adhesion Small GTPase Mediated Signal Transduction Rho Protein Signal Transduction Metabolic Process Regulation Of Cell Size Positive Regulation Of Cell Migration Mammary Gland Development Positive Regulation Of Rho GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction
Pathways		Signal transduction by L1 Axon guidance Elastic fibre formation Fibronectin matrix formation L1CAM interactions Integrin cell surface interactions Cell surface interactions at the vascular wall	Rho GTPase cycle Signaling by Rho GTPases
Drugs
Diseases
GWAS
Protein-Protein Interactions		24 interactors: ANGPT1 ANGPTL3 ARHGAP5 AUP1 CD9 COL18A1 COL1A1 EGFR ERBB2 FGFR2 FLT4 FN1 GIPC1 GRK6 ITGB1 ITGB3 ITGB5 L1CAM NISCH PECAM1 RABIF SPP1 STAMBP TNC	11 interactors: ADRB2 ITGA5 ITGB1 PTK2B PTPN18 RASA1 RHOA RND1 RND2 RND3 SMURF2
Entrez ID		3678	394
HPRD ID		00627	04060
Ensembl ID		ENSG00000161638	ENSG00000100852
Uniprot IDs		P08648	Q13017
PDB IDs		3VI3 3VI4	2EE4 2EE5
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Cell Adhesion Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Cell Migration Regulation Of Cell Motility Cardiovascular System Development Regulation Of Locomotion Regulation Of Cellular Component Movement Blood Vessel Development Vasculature Development Leukocyte Migration Response To Stimulus Positive Regulation Of Cell Proliferation Wound Healing Regulation Of Cell Proliferation Anatomical Structure Morphogenesis Response To Wounding Cell-substrate Adhesion Cell Migration Response To Growth Factor Movement Of Cell Or Subcellular Component Multicellular Organismal Development Blood Vessel Morphogenesis Blood Coagulation Cell Motility Hemostasis System Development Anatomical Structure Development Cellular Response To Stimulus Locomotion Cell Communication Positive Regulation Of Signal Transduction Regulation Of Signaling Cell-matrix Adhesion Angiogenesis Anatomical Structure Formation Involved In Morphogenesis Regulation Of Signal Transduction Developmental Process Response To Vitamin Response To Nutrient Regulation Of Body Fluid Levels Signaling Cell Activation Regulation Of Cellular Process Formation Of Primary Germ Layer Signal Transduction	Axon Guidance Neuron Projection Development Regulation Of Cell-substrate Adhesion Cell Junction Assembly Generation Of Neurons Neuron Development Neurogenesis Axonogenesis Positive Regulation Of Neuron Projection Development Signal Transduction Axon Development Cell Morphogenesis Involved In Neuron Differentiation Response To External Stimulus Actin Cytoskeleton Organization Neuron Differentiation Chemotaxis Cell-cell Adhesion Mediated By Integrin Regulation Of Cell Adhesion Cell Projection Organization Signaling Positive Regulation Of Cell Projection Organization Neuron Projection Morphogenesis Actin Filament-based Process Cell Communication Locomotion Positive Regulation Of Signal Transduction Cell Morphogenesis Involved In Differentiation Positive Regulation Of Neuron Differentiation Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Adhesion Mediated By Integrin Positive Regulation Of Cell-substrate Adhesion Nervous System Development Integrin-mediated Signaling Pathway Regulation Of Neuron Projection Development Cell Differentiation Movement Of Cell Or Subcellular Component Negative Regulation Of Anoikis Cell Projection Morphogenesis Cellular Response To Stimulus Cell Part Morphogenesis Positive Regulation Of Neurogenesis Blood Vessel Morphogenesis Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Anoikis Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Cell Morphogenesis Blood Vessel Endothelial Cell Migration Heterotypic Cell-cell Adhesion Regulation Of Cell Projection Organization Positive Regulation Of Cell Development
Tagcloud ?			10a 200c 30a 30c cd36 cdh2 cdk5r1 chips cyp27b1 figure gemcitabine gna13 gp5 hist1h2bf hlf igsf3 ikbkb il32 intriguing mirs nrp2 oxidoreductase pak7 putatively rab23 rap2a slc11a1 sod3 tp53i3
Tagcloud (Difference) ?			10a 200c 30a 30c cd36 cdh2 cdk5r1 chips cyp27b1 figure gemcitabine gna13 gp5 hist1h2bf hlf igsf3 ikbkb il32 intriguing mirs nrp2 oxidoreductase pak7 putatively rab23 rap2a slc11a1 sod3 tp53i3
Tagcloud (Intersection) ?