ITGA5 and ITGB3

Number of citations of the paper that reports this interaction (PMID 1694173)
45

Data Source:
HPRD (in vitro)

		ITGA5	ITGB3
Gene Name		integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
Image
Gene Ontology Annotations	Cellular Component	Ruffle Cytoplasm Plasma Membrane Cell-cell Junction Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Ruffle Membrane Synapse Alphav-beta3 Integrin-vitronectin Complex	Nucleus Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Integrin Complex Cell Surface Platelet Alpha Granule Membrane Lamellipodium Membrane Filopodium Membrane Microvillus Membrane Ruffle Membrane Integrin Alphav-beta3 Complex Melanosome Receptor Complex Extracellular Vesicular Exosome Alphav-beta3 Integrin-vitronectin Complex
	Molecular Function	Epidermal Growth Factor Receptor Binding Platelet-derived Growth Factor Receptor Binding Integrin Binding Protein Binding Vascular Endothelial Growth Factor Receptor 2 Binding Metal Ion Binding	Fibronectin Binding Protease Binding Protein Disulfide Isomerase Activity Receptor Activity Platelet-derived Growth Factor Receptor Binding Protein Binding Identical Protein Binding Vascular Endothelial Growth Factor Receptor 2 Binding Cell Adhesion Molecule Binding Extracellular Matrix Binding
	Biological Process	Angiogenesis Cell-substrate Junction Assembly Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Integrin-mediated Signaling Pathway Axon Guidance Blood Coagulation Memory Positive Regulation Of Cell-substrate Adhesion Viral Process Extracellular Matrix Organization Positive Regulation Of Cell Migration Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell-substrate Adhesion Cell-cell Adhesion Mediated By Integrin Heterotypic Cell-cell Adhesion Wound Healing, Spreading Of Epidermal Cells Endodermal Cell Differentiation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Leukocyte Migration Negative Regulation Of Anoikis	Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation Platelet Degranulation Protein Folding Cell-substrate Junction Assembly Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Axon Guidance Blood Coagulation Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Lipid Storage Smooth Muscle Cell Migration Cell Growth Cell Migration Platelet Activation Extracellular Matrix Organization Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell-substrate Adhesion Activation Of Protein Kinase Activity Negative Regulation Of Lipid Transport Heterotypic Cell-cell Adhesion Substrate Adhesion-dependent Cell Spreading Tube Development Apolipoprotein A-I-mediated Signaling Pathway Wound Healing Regulation Of Bone Resorption Negative Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Viral Entry Into Host Cell Vascular Endothelial Growth Factor Receptor Signaling Pathway Mesodermal Cell Differentiation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Lipoprotein Metabolic Process Leukocyte Migration Negative Chemotaxis Angiogenesis Involved In Wound Healing Platelet Aggregation
Pathways		Signal transduction by L1 Axon guidance Elastic fibre formation Fibronectin matrix formation L1CAM interactions Integrin cell surface interactions Cell surface interactions at the vascular wall	Signal transduction by L1 Axon guidance Elastic fibre formation p130Cas linkage to MAPK signaling for integrins Integrin alphaIIb beta3 signaling L1CAM interactions Platelet degranulation Non-integrin membrane-ECM interactions GRB2:SOS provides linkage to MAPK signaling for Integrins Platelet Aggregation (Plug Formation) VEGFA-VEGFR2 Pathway Cell surface interactions at the vascular wall PECAM1 interactions Molecules associated with elastic fibres Syndecan interactions Signaling by VEGF Response to elevated platelet cytosolic Ca2+ ECM proteoglycans Integrin cell surface interactions Platelet activation, signaling and aggregation
Drugs			Abciximab Eptifibatide Antithymocyte globulin Tirofiban
Diseases
GWAS
Protein-Protein Interactions		24 interactors: ANGPT1 ANGPTL3 ARHGAP5 AUP1 CD9 COL18A1 COL1A1 EGFR ERBB2 FGFR2 FLT4 FN1 GIPC1 GRK6 ITGB1 ITGB3 ITGB5 L1CAM NISCH PECAM1 RABIF SPP1 STAMBP TNC	40 interactors: AKT1 ANGPTL3 CAPN1 CD36 CIB1 COL1A2 DAB1 DAB2 DOK1 EPS8 FBLN2 FGA FGG FLNA FLNB FN1 ILK ITGA2B ITGA5 ITGAV ITGB3BP KDR NID1 NUMB P2RY2 PDGFRA PDGFRB PDPK1 PECAM1 PTK2 PTK2B PXN SHC1 SRC TGM2 THBS1 THY1 TLN1 TNS2 VTN
Entrez ID		3678	3690
HPRD ID		00627	01428
Ensembl ID		ENSG00000161638	ENSG00000259207
Uniprot IDs		P08648	P05106
PDB IDs		3VI3 3VI4	1JV2 1KUP 1KUZ 1L5G 1M1X 1M8O 1MIZ 1MK7 1MK9 1RN0 1S4X 1TYE 1U8C 2INI 2K9J 2KNC 2KV9 2L1C 2L91 2LJD 2LJE 2LJF 2Q6W 2RMZ 2RN0 2VC2 2VDK 2VDL 2VDM 2VDN 2VDO 2VDP 2VDQ 2VDR 3FCS 3FCU 3IJE 3NID 3NIF 3NIG 3T3M 3T3P 3ZDX 3ZDY 3ZDZ 3ZE0 3ZE1 3ZE2 4G1E 4G1M
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Cell Adhesion Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Cell Migration Regulation Of Cell Motility Cardiovascular System Development Regulation Of Locomotion Regulation Of Cellular Component Movement Blood Vessel Development Vasculature Development Leukocyte Migration Response To Stimulus Positive Regulation Of Cell Proliferation Wound Healing Regulation Of Cell Proliferation Anatomical Structure Morphogenesis Response To Wounding Cell-substrate Adhesion Cell Migration Response To Growth Factor Movement Of Cell Or Subcellular Component Multicellular Organismal Development Blood Vessel Morphogenesis Blood Coagulation Cell Motility Hemostasis System Development Anatomical Structure Development Cellular Response To Stimulus Locomotion Cell Communication Positive Regulation Of Signal Transduction Regulation Of Signaling Cell-matrix Adhesion Angiogenesis Anatomical Structure Formation Involved In Morphogenesis Regulation Of Signal Transduction Developmental Process Response To Vitamin Response To Nutrient Regulation Of Body Fluid Levels Signaling Cell Activation Regulation Of Cellular Process Formation Of Primary Germ Layer Signal Transduction	Platelet Activation Positive Regulation Of Cell Adhesion Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Regulation Of Cell Adhesion Blood Coagulation Positive Regulation Of Cellular Component Movement Cell Adhesion Hemostasis Positive Regulation Of Locomotion Regulation Of Cell Migration Wound Healing Positive Regulation Of Phosphorylation Regulation Of Cell-substrate Adhesion Regulation Of Cell Motility Cell-substrate Adhesion Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Cell-substrate Adhesion Regulation Of Locomotion Regulation Of Cellular Component Movement Response To Wounding Regulation Of Body Fluid Levels Regulation Of Phosphorylation Cell-matrix Adhesion Positive Regulation Of Protein Phosphorylation Positive Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Cell Activation Blood Vessel Development Positive Regulation Of Protein Modification Process Signal Transduction Regulation Of Protein Phosphorylation Vasculature Development Regulation Of Cellular Component Organization Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Signaling Positive Regulation Of Protein Metabolic Process Cell Communication Positive Regulation Of Kinase Activity Locomotion Anatomical Structure Morphogenesis Regulation Of Protein Metabolic Process Movement Of Cell Or Subcellular Component Regulation Of Signaling Regulation Of Intracellular Signal Transduction Platelet Degranulation
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