ITGA5 and ANGPTL3

Number of citations of the paper that reports this interaction (PubMedID 11877390)
0

Data Source:
HPRD (in vitro)

		ITGA5	ANGPTL3
Description		integrin subunit alpha 5	angiopoietin like 3
Image
GO Annotations	Cellular Component	Ruffle Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Cell-cell Junction Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Membrane Cell Junction Cytoplasmic Vesicle Ruffle Membrane Integrin Alpha5-beta1 Complex Synapse Postsynaptic Membrane Anchoring Junction Alphav-beta3 Integrin-vitronectin Complex Glutamatergic Synapse	Extracellular Region Extracellular Space Early Endosome Golgi Apparatus Cell Surface Lamellipodium Extracellular Matrix Cell Projection
	Molecular Function	Virus Receptor Activity Signaling Receptor Binding Epidermal Growth Factor Receptor Binding Platelet-derived Growth Factor Receptor Binding Integrin Binding Calcium Ion Binding Protein Binding Signaling Receptor Activity Vascular Endothelial Growth Factor Receptor 2 Binding Metal Ion Binding Cell Adhesion Molecule Binding	Enzyme Inhibitor Activity Phospholipase Inhibitor Activity Integrin Binding Growth Factor Activity Heparin Binding Lipase Binding Lipase Inhibitor Activity
	Biological Process	Angiogenesis Formation Of Primary Germ Layer Cell-substrate Junction Assembly Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Female Pregnancy Memory Tissue Development Positive Regulation Of Cell-substrate Adhesion Response To Muscle Activity CD40 Signaling Pathway Positive Regulation Of Cell Migration Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell-substrate Adhesion Cell Adhesion Mediated By Integrin Cell-cell Adhesion Mediated By Integrin Heterotypic Cell-cell Adhesion Wound Healing, Spreading Of Epidermal Cells Endodermal Cell Differentiation Regulation Of Angiogenesis Symbiont Entry Into Host Cell Cell-cell Adhesion Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Sprouting Angiogenesis Negative Regulation Of Anoikis	Angiogenesis Glycerol Metabolic Process Lipid Metabolic Process Fatty Acid Metabolic Process Phospholipid Metabolic Process Cell Adhesion Cell-matrix Adhesion Signal Transduction Integrin-mediated Signaling Pathway Cholesterol Metabolic Process Phospholipid Catabolic Process Response To Hormone Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Lipid Storage Positive Regulation Of Cell Migration Cholesterol Homeostasis Positive Regulation Of Angiogenesis Artery Morphogenesis Positive Regulation Of Lipid Catabolic Process Lipid Homeostasis Acylglycerol Homeostasis Phospholipid Homeostasis Triglyceride Homeostasis Regulation Of Chylomicron Remodeling
Pathways		Elastic fibre formation Fibronectin matrix formation Cell surface interactions at the vascular wall Integrin cell surface interactions Integrin cell surface interactions Signal transduction by L1 RUNX2 regulates genes involved in cell migration GPER1 signaling Mechanical load activates signaling by PIEZO1 and integrins in osteocytes Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	Assembly of active LPL and LIPC lipase complexes NR1H2 & NR1H3 regulate gene expression linked to lipogenesis
Drugs		Resveratrol Tauroursodeoxycholic acid	Evinacumab
Diseases
GWAS		Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Blood protein levels ( 30072576) Cholesterol, total ( 26582766 20686565 25961943 24097068) Crohn's disease ( 28067908) LDL cholesterol ( 25961943 20686565 24097068) LDL cholesterol levels ( 28334899) Lipid metabolism phenotypes ( 22286219 19936222) Metabolite levels ( 22916037) Regular attendance at a gym or sports club ( 29970889) Total cholesterol levels ( 28334899) Total triglycerides levels ( 26690388) Triglyceride levels ( 28334899 29615537) Triglycerides ( 24097068 26582766 25961943 18193043 20864672 20686565 20139978 19060906 18193044)
Interacting Genes		32 interacting genes: ACKR5 ANGPT1 ANGPT2 ANGPTL3 ARHGAP5 AUP1 CD9 CLK1 COL18A1 COL1A1 EGFR ERBB2 FGFR2 FLT4 FN1 GIPC1 GRK6 ITGB1 ITGB3 ITGB5 L1CAM LGALS3BP NISCH PECAM1 RABIF SHARPIN SPP1 STAMBP TNC UBAP1 VCL VTN	4 interacting genes: ITGA5 ITGAV ITGB3 UBC
Entrez ID		3678	27329
HPRD ID		00627	10381
Ensembl ID		ENSG00000161638	ENSG00000132855
Uniprot IDs		B2R627 P08648	Q9Y5C1
PDB IDs		3VI3 3VI4 4WJK 4WK0 4WK2 4WK4 7NWL 7NXD 9B9J 9B9K 9CKV	6EUA
Enriched GO Terms of Interacting Partners?		Cell Adhesion Integrin Binding Cell-substrate Adhesion Cell-matrix Adhesion Regulation Of Cell Migration Regulation Of Cell Motility Regulation Of Locomotion Angiogenesis Anatomical Structure Formation Involved In Morphogenesis Positive Regulation Of Cell Migration Extracellular Matrix Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Cell Surface Receptor Signaling Pathway Integrin-mediated Signaling Pathway Cell Migration Receptor Complex Response To Growth Factor Signal Transduction Cell Adhesion Mediated By Integrin Enzyme-linked Receptor Protein Signaling Pathway Cell Motility Extracellular Exosome Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Cellular Response To Growth Factor Stimulus Regulation Of Response To Wounding Regulation Of ERK1 And ERK2 Cascade Focal Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cell Adhesion Extracellular Space Negative Regulation Of Blood Coagulation Cell Junction Organization Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Transmembrane Receptor Protein Tyrosine Kinase Activity Mesodermal Cell Differentiation Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Wound Healing, Spreading Of Epidermal Cells Extracellular Region Regulation Of Cell-substrate Adhesion Regulation Of Anatomical Structure Morphogenesis Platelet Alpha Granule Membrane Protein Tyrosine Kinase Activity Positive Regulation Of Signal Transduction Positive Regulation Of Cell Population Proliferation Regulation Of Wound Healing Regulation Of Cell Population Proliferation	Wound Healing, Spreading Of Epidermal Cells Wound Healing, Spreading Of Cells Integrin Complex Cell Adhesion Mediated By Integrin Heterotypic Cell-cell Adhesion Integrin Alphav-beta3 Complex Alphav-beta3 Integrin-vitronectin Complex Alphav-beta3 Integrin-PKCalpha Complex Alphav-beta3 Integrin-HMGB1 Complex Alphav-beta3 Integrin-IGF-1-IGF1R Complex Virus Receptor Activity Apolipoprotein A-I-mediated Signaling Pathway C-X3-C Chemokine Binding Negative Regulation Of Lipoprotein Metabolic Process Neuregulin Binding Ruffle Membrane Integrin-mediated Signaling Pathway Cell-matrix Adhesion Symbiont Entry Into Host Cell Vascular Endothelial Growth Factor Receptor 2 Binding Integrin Binding Biological Process Involved In Interaction With Host Cell-substrate Adhesion Negative Regulation Of Low-density Lipoprotein Particle Clearance Insulin-like Growth Factor I Binding Positive Regulation Of Osteoblast Proliferation Negative Regulation Of Macrophage Derived Foam Cell Differentiation Platelet-derived Growth Factor Receptor Binding Regulation Of Lipoprotein Metabolic Process Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Lipoprotein Particle Clearance Filopodium Membrane Regulation Of Low-density Lipoprotein Particle Clearance Negative Regulation Of Lipid Storage Fibroblast Growth Factor Binding Lamellipodium Membrane Apoptotic Cell Clearance Microvillus Membrane Fibronectin Binding Regulation Of Osteoblast Proliferation Extracellular Matrix Binding Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Angiogenesis Regulation Of Macrophage Derived Foam Cell Differentiation Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Endodermal Cell Differentiation Negative Regulation Of Lipid Transport Cell-substrate Junction Assembly Cell-substrate Junction Organization
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