VTN and ITGB6

Number of citations of the paper that reports this interaction (PubMedID 8120056)
0

Data Source:
HPRD (in vitro)

		VTN	ITGB6
Description		vitronectin	integrin subunit beta 6
Image
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Extracellular Space Endoplasmic Reticulum Golgi Lumen Symbiont-containing Vacuole Extracellular Matrix Rough Endoplasmic Reticulum Lumen Extracellular Exosome Alphav-beta3 Integrin-vitronectin Complex Blood Microparticle Protein Complex Involved In Cell-matrix Adhesion Peptidase Inhibitor Complex	Plasma Membrane Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Membrane Integrin Alphav-beta6 Complex Receptor Complex Anchoring Junction
	Molecular Function	Scavenger Receptor Activity Integrin Binding Extracellular Matrix Structural Constituent Protein Binding Collagen Binding Heparin Binding Polysaccharide Binding Identical Protein Binding Extracellular Matrix Binding	Virus Receptor Activity Integrin Binding Protein Binding Metal Ion Binding
	Biological Process	Immune Response Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of Smooth Muscle Cell Migration Vesicle-mediated Transport Cell Migration Cell Differentiation Regulation Of Cell Adhesion Negative Regulation Of Blood Coagulation Extracellular Matrix Organization Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Adhesion Mediated By Integrin Endodermal Cell Differentiation Negative Regulation Of Proteolysis Positive Regulation Of Receptor-mediated Endocytosis Oligodendrocyte Differentiation Protein Polymerization Negative Regulation Of Fibrinolysis Smooth Muscle Cell-matrix Adhesion Positive Regulation Of Wound Healing Liver Regeneration Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Integrin-mediated Signaling Pathway	Cell Morphogenesis Inflammatory Response Immune Response Cell Adhesion Cell-matrix Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Response To Wounding Response To Virus Gene Expression Cell Migration Cell Adhesion Mediated By Integrin Wound Healing Surfactant Homeostasis Skin Development Symbiont Entry Into Host Cell Lung Alveolus Development Phospholipid Homeostasis Hard Palate Development Bone Development Bronchiole Development Langerhans Cell Differentiation Enamel Mineralization Cellular Response To Ionizing Radiation Transforming Growth Factor Beta Production Cell-cell Adhesion
Pathways		Molecules associated with elastic fibres Integrin cell surface interactions Syndecan interactions ECM proteoglycans ECM proteoglycans Regulation of Complement cascade Developmental Lineage of Pancreatic Ductal Cells	Elastic fibre formation Molecules associated with elastic fibres Integrin cell surface interactions TGF-beta receptor signaling activates SMADs ECM proteoglycans
Drugs		Abciximab Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form	PLN-74809
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Heel bone mineral density ( 30598549) LDL cholesterol ( 30275531) Low density lipoprotein cholesterol levels ( 32154731 33339817) Osteoprotegerin levels ( 25080503)	Appendicular lean mass ( 33097823) Asthma (childhood onset) ( 31036433) Eosinophil count ( 32888494) Haemorrhoidal disease ( 33888516) Hematocrit ( 32888494) Hemoglobin ( 32888494) Idiopathic membranous nephropathy ( 21323541) Proportion of activated microglia (inferior temporal cortex) ( 30679421) Tourette syndrome ( 30818990) Type 2 diabetes ( 20418489) Waist circumference adjusted for body mass index ( 25673412)
Interacting Genes		50 interacting genes: ADH5 ADTRP AMPH APP CBX1 CD247 CKS2 COPS5 CRADD CSNK2A1 DLG2 DLG3 EGF ETV7 FGF2 FGG GEM GLUD1 GOPC HGF IGF2 IGFBP5 ITGA2B ITGA5 ITGA8 ITGAV ITGB3 ITGB6 ITGB8 KNG1 LACRT LNX2 PLAUR POMC PRDX4 PRKACA PRKCA PRKCB PRKCG PVR RHOXF1 RPL13A SERPINE1 SIX1 SNTG1 TGFB1 TGFB2 TNFRSF11B UBQLN2 VEGFA	8 interacting genes: FHL2 FLNA FLNB FN1 ITGAV MAPK1 TGFB1 VTN
Entrez ID		7448	3694
HPRD ID		01902	00947
Ensembl ID		ENSG00000109072	ENSG00000115221
Uniprot IDs		D9ZGG2 P04004	A0A087WXP3 B4E2B8 E9PEE8 P18564
PDB IDs		1OC0 1S4G 1SSU 2JQ8 3BT1 3BT2 4K24 6O5E 7RJ9	4UM8 4UM9 5FFG 5FFO 5NEM 5NER 5NET 5NEU 8TCG 9CZ7 9CZA 9CZD 9CZF
Enriched GO Terms of Interacting Partners?		Platelet Alpha Granule Lumen Integrin Complex Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Programmed Cell Death Integrin Binding Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Cell-matrix Adhesion Regulation Of Apoptotic Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Locomotion Cell-cell Adhesion Positive Regulation Of Vasculature Development Cell Surface Regulation Of Vesicle-mediated Transport Regulation Of Cell Communication Regulation Of Signaling Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Epithelial Tube Formation Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Signaling Receptor Binding Negative Regulation Of Multicellular Organismal Process Cell Adhesion Growth Factor Activity Angiogenesis Cell-substrate Adhesion Integrin-mediated Signaling Pathway Cell Adhesion Mediated By Integrin Regulation Of Endocytosis Regulation Of Protein Metabolic Process Regulation Of Multicellular Organismal Process Negative Regulation Of Programmed Cell Death Alphav-beta3 Integrin-PKCalpha Complex Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Protein Localization Regulation Of Vasculature Development Regulation Of Transport Positive Regulation Of Angiogenesis Positive Regulation Of Protein Localization Regulation Of Morphogenesis Of An Epithelium Anatomical Structure Formation Involved In Morphogenesis Positive Regulation Of MAPK Cascade Regulation Of Cell Migration Positive Regulation Of Morphogenesis Of An Epithelium	Positive Regulation Of Locomotion Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Focal Adhesion Endodermal Cell Differentiation Cellular Developmental Process Regulation Of Cell Migration Regulation Of Cell Motility Positive Regulation Of Cell Adhesion Regulation Of Locomotion Cell Differentiation Anatomical Structure Formation Involved In Morphogenesis Regulation Of Cell Adhesion Regulation Of Protein Metabolic Process Integrin-mediated Signaling Pathway Cell-matrix Adhesion Positive Regulation Of Integrin-mediated Signaling Pathway Cell Development Cell Migration Blood Microparticle Positive Regulation Of Cell Population Proliferation Positive Regulation Of Cell-substrate Adhesion Z Disc Identical Protein Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Signal Transduction Protein Activation Cascade Integrin Binding Cell Motility Cell-substrate Adhesion Regulation Of Integrin-mediated Signaling Pathway Regulation Of Intracellular Signal Transduction Developmental Process Positive Regulation Of Cellular Component Organization Cell Surface Receptor Signaling Pathway Regulation Of Vesicle-mediated Transport Cell Morphogenesis Cell Adhesion Mediated By Integrin Wound Healing, Spreading Of Cells Liver Regeneration Extracellular Matrix Binding Regulation Of Cell Communication Regulation Of Signaling Regulation Of Cell-substrate Adhesion Positive Regulation Of Protein Import Into Nucleus Animal Organ Development Regulation Of Cellular Component Organization Regulation Of Intracellular Transport Substrate Adhesion-dependent Cell Spreading
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