VTN and ADH5

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		VTN	ADH5
Gene Name		vitronectin	alcohol dehydrogenase 5 (class III), chi polypeptide
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Extracellular Matrix Extracellular Vesicular Exosome Alphav-beta3 Integrin-vitronectin Complex Blood Microparticle	Nucleus Mitochondrion Extracellular Vesicular Exosome
	Molecular Function	Scavenger Receptor Activity Integrin Binding Protein Binding Heparin Binding Polysaccharide Binding Extracellular Matrix Binding	Alcohol Dehydrogenase (NAD) Activity Fatty Acid Binding Zinc Ion Binding Electron Carrier Activity Formaldehyde Dehydrogenase Activity Protein Homodimerization Activity S-(hydroxymethyl)glutathione Dehydrogenase Activity
	Biological Process	Receptor-mediated Endocytosis Immune Response Cell Adhesion Cell-matrix Adhesion Positive Regulation Of Cell-substrate Adhesion Negative Regulation Of Endopeptidase Activity Positive Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Blood Coagulation Extracellular Matrix Organization Regulation Of Complement Activation Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Binding Cell Adhesion Mediated By Integrin Endodermal Cell Differentiation Innate Immune Response Positive Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Peptidyl-tyrosine Phosphorylation Smooth Muscle Cell-matrix Adhesion Positive Regulation Of Wound Healing	Retinoid Metabolic Process Respiratory System Process Ethanol Catabolic Process Ethanol Oxidation Aging Peptidyl-cysteine S-nitrosylation Response To Lipopolysaccharide Positive Regulation Of Blood Pressure Formaldehyde Catabolic Process Response To Nitrosative Stress Response To Redox State
Pathways		Molecules associated with elastic fibres Syndecan interactions Regulation of Complement cascade Complement cascade Elastic fibre formation ECM proteoglycans Integrin cell surface interactions Non-integrin membrane-ECM interactions Innate Immune System
Drugs		Abciximab	NADH Nicotinamide-Adenine-Dinucleotide 12-Hydroxydodecanoic Acid S-Hydroxymethyl Glutathione
Diseases
GWAS			Alcohol dependence ( 23456092) Obesity-related traits ( 23251661)
Protein-Protein Interactions		42 interactors: ADH5 ADTRP AMPH APP CBX1 CD247 CKS2 COPS5 CRADD CSNK2A1 EGF ETV7 FGF2 FGG GEM GLUD1 GOPC HGF IGF2 IGFBP5 ITGA8 ITGB3 ITGB6 ITGB8 KNG1 LACRT PLAUR POMC PRDX4 PRKACA PRKCA PRKCB PRKCG PVR RHOXF1 RPL13A SERPINE1 SIX1 TGFB1 TGFB2 TNFRSF11B VEGFA	9 interactors: APP ARNT CHD3 CSNK2B ESRRA PQLC1 PRDX1 SNTA1 VTN
Entrez ID		7448	128
HPRD ID		01902	00064
Ensembl ID			ENSG00000197894
Uniprot IDs		D9ZGG2 P04004	P11766 Q6IRT1
PDB IDs		1OC0 1S4G 1SSU 2JQ8 3BT1 3BT2	1M6H 1M6W 1MA0 1MC5 1MP0 1TEH 2FZE 2FZW 3QJ5
Enriched GO Terms of Interacting Partners?		Platelet Activation Platelet Degranulation Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Response To Wounding Extracellular Matrix Organization Extracellular Structure Organization Cell Activation Exocytosis Signaling Cell Communication Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Response To External Stimulus Secretion Secretion By Cell Signal Transduction Regulation Of Peptidyl-tyrosine Phosphorylation Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Endothelial Cell Migration Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Epithelial Cell Proliferation Negative Regulation Of Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Phosphorylation Response To Stimulus Cellular Response To Stimulus Positive Regulation Of Angiogenesis Regulation Of Protein Kinase Activity Positive Regulation Of MAPK Cascade Cellular Localization Positive Regulation Of Metabolic Process Regulation Of Signaling Positive Regulation Of Cell Migration Response To Stress Positive Regulation Of Cell Motility Regulation Of MAPK Cascade Regulation Of Kinase Activity Histone H3-T6 Phosphorylation Regulation Of Epithelial Cell Migration Regulation Of Cellular Process Positive Regulation Of Cellular Component Movement Positive Regulation Of Intracellular Signal Transduction	Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Intracellular Receptor Signaling Pathway Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Binding Regulation Of Metabolic Process Neuromuscular Junction Development Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Protein Metabolic Process Response To Oxidative Stress Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Vasoconstriction By Circulating Norepinephrine Positive Regulation Of Protein Metabolic Process Regulation Of Cellular Ketone Metabolic Process Regulation Of Phosphorylation Positive Regulation Of Cellular Metabolic Process Synaptic Growth At Neuromuscular Junction Regulation Of Phosphorus Metabolic Process Regulation Of Signal Transduction Hormone-mediated Signaling Pathway Collateral Sprouting In Absence Of Injury Regulation Of Protein Binding Multicellular Organismal Development Regulation Of Cellular Component Movement Synapse Organization Anatomical Structure Development Regulation Of Myeloid Cell Differentiation Regulation Of Signaling Regulation Of Nitrogen Compound Metabolic Process Collateral Sprouting Axon Midline Choice Point Recognition Negative Regulation Of Peptidyl-cysteine S-nitrosylation Regulation Of Cellular Response To Growth Factor Stimulus Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Transcription From RNA Polymerase II Promoter Innate Immune Response Cellular Response To Oxidative Stress Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Peptidyl-tyrosine Phosphorylation Axon Choice Point Recognition Positive Regulation Of Metabolic Process Positive Regulation Of Activin Receptor Signaling Pathway Negative Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Developmental Process Adiponectin-activated Signaling Pathway Neuron Remodeling Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity
Tagcloud ?		accumulated aeamsq aeamsqv aeamsqvt aeamsqvtn aeamsqvtntatim desorption dimeric dimerization dissociated exclusion flight immunoblot maldi monomeric nonapeptide p17gag p24gag p2gag potently pr55gag protease proteolytic spectrometric sqnypivq succinyl suicide tof vtntatim
Tagcloud (Difference) ?		accumulated aeamsq aeamsqv aeamsqvt aeamsqvtn aeamsqvtntatim desorption dimeric dimerization dissociated exclusion flight immunoblot maldi monomeric nonapeptide p17gag p24gag p2gag potently pr55gag protease proteolytic spectrometric sqnypivq succinyl suicide tof vtntatim
Tagcloud (Intersection) ?