VTN and ITGB8

Number of citations of the paper that reports this interaction (PMID 11156415)
25

Data Source:
HPRD (in vitro)

		VTN	ITGB8
Gene Name		vitronectin	integrin, beta 8
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Extracellular Matrix Extracellular Vesicular Exosome Alphav-beta3 Integrin-vitronectin Complex Blood Microparticle	Plasma Membrane Integrin Complex Cell Surface Integrin Alphav-beta8 Complex Extracellular Vesicular Exosome
	Molecular Function	Scavenger Receptor Activity Integrin Binding Protein Binding Heparin Binding Polysaccharide Binding Extracellular Matrix Binding	Receptor Activity Receptor Binding Extracellular Matrix Protein Binding
	Biological Process	Receptor-mediated Endocytosis Immune Response Cell Adhesion Cell-matrix Adhesion Positive Regulation Of Cell-substrate Adhesion Negative Regulation Of Endopeptidase Activity Positive Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Blood Coagulation Extracellular Matrix Organization Regulation Of Complement Activation Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Binding Cell Adhesion Mediated By Integrin Endodermal Cell Differentiation Innate Immune Response Positive Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Peptidyl-tyrosine Phosphorylation Smooth Muscle Cell-matrix Adhesion Positive Regulation Of Wound Healing	Ganglioside Metabolic Process Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Extracellular Matrix Organization Cartilage Development Placenta Blood Vessel Development
Pathways		Molecules associated with elastic fibres Syndecan interactions Regulation of Complement cascade Complement cascade Elastic fibre formation ECM proteoglycans Integrin cell surface interactions Non-integrin membrane-ECM interactions Innate Immune System	Molecules associated with elastic fibres Elastic fibre formation Integrin cell surface interactions
Drugs		Abciximab
Diseases
GWAS
Protein-Protein Interactions		42 interactors: ADH5 ADTRP AMPH APP CBX1 CD247 CKS2 COPS5 CRADD CSNK2A1 EGF ETV7 FGF2 FGG GEM GLUD1 GOPC HGF IGF2 IGFBP5 ITGA8 ITGB3 ITGB6 ITGB8 KNG1 LACRT PLAUR POMC PRDX4 PRKACA PRKCA PRKCB PRKCG PVR RHOXF1 RPL13A SERPINE1 SIX1 TGFB1 TGFB2 TNFRSF11B VEGFA	3 interactors: ITGAV TGFB1 VTN
Entrez ID		7448	3696
HPRD ID		01902	05001
Ensembl ID			ENSG00000105855
Uniprot IDs		D9ZGG2 P04004	B4DHD4 P26012 Q9BUG9
PDB IDs		1OC0 1S4G 1SSU 2JQ8 3BT1 3BT2
Enriched GO Terms of Interacting Partners?		Platelet Activation Platelet Degranulation Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Response To Wounding Extracellular Matrix Organization Extracellular Structure Organization Cell Activation Exocytosis Signaling Cell Communication Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Response To External Stimulus Secretion Secretion By Cell Signal Transduction Regulation Of Peptidyl-tyrosine Phosphorylation Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Endothelial Cell Migration Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Epithelial Cell Proliferation Negative Regulation Of Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Phosphorylation Response To Stimulus Cellular Response To Stimulus Positive Regulation Of Angiogenesis Regulation Of Protein Kinase Activity Positive Regulation Of MAPK Cascade Cellular Localization Positive Regulation Of Metabolic Process Regulation Of Signaling Positive Regulation Of Cell Migration Response To Stress Positive Regulation Of Cell Motility Regulation Of MAPK Cascade Regulation Of Kinase Activity Histone H3-T6 Phosphorylation Regulation Of Epithelial Cell Migration Regulation Of Cellular Process Positive Regulation Of Cellular Component Movement Positive Regulation Of Intracellular Signal Transduction	Endoderm Development Regulation Of Endocytosis Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Vesicle-mediated Transport Endodermal Cell Differentiation Endoderm Formation Regulation Of Cell Migration Regulation Of Cell Adhesion Regulation Of Cell Motility Regulation Of Phagocytosis Regulation Of Locomotion Regulation Of Cellular Component Movement Positive Regulation Of Transport Negative Regulation Of Protein Metabolic Process Interaction With Host Positive Regulation Of Endocytosis Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Binding Formation Of Primary Germ Layer Cell Growth Negative Regulation Of Entry Of Bacterium Into Host Cell Defense Response To Fungus, Incompatible Interaction Entry Of Symbiont Into Host Cell By Promotion Of Host Phagocytosis Positive Regulation Of NAD+ ADP-ribosyltransferase Activity Cell Adhesion Cell-matrix Adhesion Regulation Of Cellular Response To Growth Factor Stimulus Gastrulation Viral Life Cycle Vesicle-mediated Transport Regulation Of Entry Of Bacterium Into Host Cell Active Induction Of Host Immune Response By Virus Cell-substrate Adhesion MAPK Cascade Negative Regulation Of Locomotion Negative Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Negative Regulation Of Hyaluronan Biosynthetic Process Macrophage Derived Foam Cell Differentiation Evasion Or Tolerance Of Host Defenses By Virus Regulation Of Binding Tissue Development Signal Transduction By Phosphorylation Negative Regulation Of Macrophage Cytokine Production Ossification Involved In Bone Remodeling Tolerance Induction To Self Antigen
Tagcloud ?		accumulated aeamsq aeamsqv aeamsqvt aeamsqvtn aeamsqvtntatim desorption dimeric dimerization dissociated exclusion flight immunoblot maldi monomeric nonapeptide p17gag p24gag p2gag potently pr55gag protease proteolytic spectrometric sqnypivq succinyl suicide tof vtntatim	abcg2 agilent amplifying beta8 cepc cepcs connexin corneal cryosections dissociated epithelia genespring gx11 holoclone lentiviral limbal locked lpc mann micrornas oligo organotypic parabasal progenies rim scrambled transit v2 whitney
Tagcloud (Difference) ?		accumulated aeamsq aeamsqv aeamsqvt aeamsqvtn aeamsqvtntatim desorption dimeric dimerization exclusion flight immunoblot maldi monomeric nonapeptide p17gag p24gag p2gag potently pr55gag protease proteolytic spectrometric sqnypivq succinyl suicide tof vtntatim	abcg2 agilent amplifying beta8 cepc cepcs connexin corneal cryosections epithelia genespring gx11 holoclone lentiviral limbal locked lpc mann micrornas oligo organotypic parabasal progenies rim scrambled transit v2 whitney
Tagcloud (Intersection) ?		dissociated