VTN and TNFRSF11B

Number of citations of the paper that reports this interaction (PMID 15799029)
17

Data Source:
HPRD (in vivo)

		VTN	TNFRSF11B
Gene Name		vitronectin	tumor necrosis factor receptor superfamily, member 11b
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Extracellular Matrix Extracellular Vesicular Exosome Alphav-beta3 Integrin-vitronectin Complex Blood Microparticle	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space
	Molecular Function	Scavenger Receptor Activity Integrin Binding Protein Binding Heparin Binding Polysaccharide Binding Extracellular Matrix Binding	Receptor Activity Cytokine Activity
	Biological Process	Receptor-mediated Endocytosis Immune Response Cell Adhesion Cell-matrix Adhesion Positive Regulation Of Cell-substrate Adhesion Negative Regulation Of Endopeptidase Activity Positive Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Blood Coagulation Extracellular Matrix Organization Regulation Of Complement Activation Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Binding Cell Adhesion Mediated By Integrin Endodermal Cell Differentiation Innate Immune Response Positive Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Peptidyl-tyrosine Phosphorylation Smooth Muscle Cell-matrix Adhesion Positive Regulation Of Wound Healing	Skeletal System Development Apoptotic Process Signal Transduction Response To Nutrient Extracellular Matrix Organization Response To Magnesium Ion Negative Regulation Of Odontogenesis Of Dentin-containing Tooth Response To Drug Response To Estrogen Negative Regulation Of Bone Resorption Response To Arsenic-containing Substance
Pathways		Molecules associated with elastic fibres Syndecan interactions Regulation of Complement cascade Complement cascade Elastic fibre formation ECM proteoglycans Integrin cell surface interactions Non-integrin membrane-ECM interactions Innate Immune System
Drugs		Abciximab
Diseases
GWAS			Bone mineral density ( 18455228 23437003 22504420) Bone mineral density (hip) ( 19801982) Bone mineral density (spine) ( 19801982) Osteoporosis ( 20548944) Type 1 diabetes ( 21980299)
Protein-Protein Interactions		42 interactors: ADH5 ADTRP AMPH APP CBX1 CD247 CKS2 COPS5 CRADD CSNK2A1 EGF ETV7 FGF2 FGG GEM GLUD1 GOPC HGF IGF2 IGFBP5 ITGA8 ITGB3 ITGB6 ITGB8 KNG1 LACRT PLAUR POMC PRDX4 PRKACA PRKCA PRKCB PRKCG PVR RHOXF1 RPL13A SERPINE1 SIX1 TGFB1 TGFB2 TNFRSF11B VEGFA	7 interactors: FN1 THBS1 TNFSF10 TNFSF11 TNFSF13 VTN VWF
Entrez ID		7448	4982
HPRD ID		01902	04032
Ensembl ID			ENSG00000164761
Uniprot IDs		D9ZGG2 P04004	O00300
PDB IDs		1OC0 1S4G 1SSU 2JQ8 3BT1 3BT2	3URF
Enriched GO Terms of Interacting Partners?		Platelet Activation Platelet Degranulation Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Response To Wounding Extracellular Matrix Organization Extracellular Structure Organization Cell Activation Exocytosis Signaling Cell Communication Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Response To External Stimulus Secretion Secretion By Cell Signal Transduction Regulation Of Peptidyl-tyrosine Phosphorylation Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Endothelial Cell Migration Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Epithelial Cell Proliferation Negative Regulation Of Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Phosphorylation Response To Stimulus Cellular Response To Stimulus Positive Regulation Of Angiogenesis Regulation Of Protein Kinase Activity Positive Regulation Of MAPK Cascade Cellular Localization Positive Regulation Of Metabolic Process Regulation Of Signaling Positive Regulation Of Cell Migration Response To Stress Positive Regulation Of Cell Motility Regulation Of MAPK Cascade Regulation Of Kinase Activity Histone H3-T6 Phosphorylation Regulation Of Epithelial Cell Migration Regulation Of Cellular Process Positive Regulation Of Cellular Component Movement Positive Regulation Of Intracellular Signal Transduction	Platelet Degranulation Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Peptidase Activity Immune System Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Immune Response Positive Regulation Of Cellular Metabolic Process Platelet Activation Regulation Of Proteolysis Cell-substrate Adhesion Regulation Of Fatty Acid Transport Endodermal Cell Differentiation Positive Regulation Of Metabolic Process Positive Regulation Of Cell Activation Regulation Of Cellular Protein Metabolic Process Peptide Cross-linking Positive Regulation Of Wound Healing Exocytosis Endoderm Formation Regulation Of Protein Metabolic Process Positive Regulation Of Cell Adhesion Regulation Of Endopeptidase Activity Regulation Of Catalytic Activity Blood Coagulation Hemostasis Regulation Of Acute Inflammatory Response Cell Adhesion Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Signal Transduction Regulation Of Cell Activation Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Endoderm Development Regulation Of Immune System Process Negative Regulation Of CGMP-mediated Signaling Negative Regulation Of Dendritic Cell Antigen Processing And Presentation Positive Regulation Of Corticotropin-releasing Hormone Secretion Secretion By Cell Regulation Of Lipid Transport Regulation Of Blood Coagulation Multicellular Organismal Development Cellular Response To Tumor Necrosis Factor Vesicle-mediated Transport Anatomical Structure Development Regulation Of Body Fluid Levels Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of Catalytic Activity Wound Healing Regulation Of Cell Adhesion
Tagcloud ?		accumulated aeamsq aeamsqv aeamsqvt aeamsqvtn aeamsqvtntatim desorption dimeric dimerization dissociated exclusion flight immunoblot maldi monomeric nonapeptide p17gag p24gag p2gag potently pr55gag protease proteolytic spectrometric sqnypivq succinyl suicide tof vtntatim	arterial atherosclerosis atherosclerotic belongs causative cli concomitantly controversial cvd depending epidemiological females g1181c genotypes glycoprotein infarction males mediating occlusive opg osteoprotegerin paod polymorphisms restriction secretory synergistic synergistically t245g t950c
Tagcloud (Difference) ?		accumulated aeamsq aeamsqv aeamsqvt aeamsqvtn aeamsqvtntatim desorption dimeric dimerization dissociated exclusion flight immunoblot maldi monomeric nonapeptide p17gag p24gag p2gag potently pr55gag protease proteolytic spectrometric sqnypivq succinyl suicide tof vtntatim	arterial atherosclerosis atherosclerotic belongs causative cli concomitantly controversial cvd depending epidemiological females g1181c genotypes glycoprotein infarction males mediating occlusive opg osteoprotegerin paod polymorphisms restriction secretory synergistic synergistically t245g t950c
Tagcloud (Intersection) ?