VTN and TNFRSF11B

Number of citations: 0 (PubMedID 15799029)
Data Source: HPRD (in vivo)

		VTN	TNFRSF11B
Name		vitronectin	TNF receptor superfamily member 11b
Structure
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Extracellular Space Endoplasmic Reticulum Golgi Lumen Symbiont-containing Vacuole Extracellular Matrix Rough Endoplasmic Reticulum Lumen Extracellular Exosome Alphav-beta3 Integrin-vitronectin Complex Blood Microparticle Protein Complex Involved In Cell-matrix Adhesion Peptidase Inhibitor Complex	Extracellular Region Extracellular Space Plasma Membrane Extracellular Matrix Receptor Complex
	Molecular Function	Scavenger Receptor Activity Integrin Binding Extracellular Matrix Structural Constituent Protein Binding Collagen Binding Heparin Binding Polysaccharide Binding Identical Protein Binding Extracellular Matrix Binding	Cytokine Activity Protein Binding Signaling Receptor Activity Heparan Sulfate Binding
	Biological Process	Immune Response Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of Smooth Muscle Cell Migration Vesicle-mediated Transport Cell Migration Cell Differentiation Regulation Of Cell Adhesion Negative Regulation Of Blood Coagulation Extracellular Matrix Organization Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Adhesion Mediated By Integrin Endodermal Cell Differentiation Negative Regulation Of Proteolysis Positive Regulation Of Receptor-mediated Endocytosis Oligodendrocyte Differentiation Protein Polymerization Negative Regulation Of Fibrinolysis Smooth Muscle Cell-matrix Adhesion Positive Regulation Of Wound Healing Liver Regeneration Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Integrin-mediated Signaling Pathway	Skeletal System Development Apoptotic Process Signal Transduction Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Extracellular Matrix Organization Negative Regulation Of Odontogenesis Of Dentin-containing Tooth Negative Regulation Of Osteoclast Differentiation
Pathways		Molecules associated with elastic fibres Integrin cell surface interactions Syndecan interactions ECM proteoglycans ECM proteoglycans Regulation of Complement cascade Developmental Lineage of Pancreatic Ductal Cells	TNFs bind their physiological receptors
Drugs		Abciximab Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form	None
Diseases		None	Paget's disease of bone and related disorders, including: ; Paget's disease of bone (PDB); Familial expansile osteolysis (FEO); Early-onset Paget's disease of bone (PDB2); Expansile skeletal hyperphosphatasia (ESH); Juvenile Paget's disease (JPD)
GWAS		Advanced age-related macular degeneration ( 26691988 ) Heel bone mineral density ( 30598549 ) LDL cholesterol ( 30275531 ) Low density lipoprotein cholesterol levels ( 32154731 33339817 ) Osteoprotegerin levels ( 25080503 )	Asthma ( 29273806 ) Asthma (childhood onset) ( 30929738 ) Blood protein levels ( 30072576 ) Blood protein levels in cardiovascular risk ( 28369058 ) Bone mineral density ( 18455228 23437003 24249740 ) Bone mineral density (hip) ( 19801982 27311723 ) Bone mineral density (paediatric, skull) ( 24945404 ) Bone mineral density (spine) ( 19801982 ) Eosinophil count ( 32888494 27863252 ) Eosinophil percentage of white cells ( 32888494 ) Femoral neck bone mineral density ( 29499414 ) Heel bone mineral density ( 30598549 28869591 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Lumbar spine bone mineral density ( 29499414 22504420 ) Lumbar spine bone mineral density (integral) ( 27476799 ) Lumbar spine bone mineral density (trabecular) ( 27476799 ) Medication use (thyroid preparations) ( 31015401 ) Metabolite levels ( 23823483 ) Osteoporosis-related phenotypes ( 20548944 ) Osteoprotegerin levels ( 25080503 ) Physiological traits ( 31902109 ) Serum alkaline phosphatase levels ( 29403010 31666285 33547301 ) Serum sclerostin levels ( 31170332 ) Sum eosinophil basophil counts ( 27863252 ) Type 1 diabetes ( 21980299 )
Interacting Genes		50 interacting genes: ADH5 ADTRP AMPH APP CBX1 CD247 CKS2 COPS5 CRADD CSNK2A1 DLG2 DLG3 EGF ETV7 FGF2 FGG GEM GLUD1 GOPC HGF IGF2 IGFBP5 ITGA2B ITGA5 ITGA8 ITGAV ITGB3 ITGB6 ITGB8 KNG1 LACRT LNX2 PLAUR POMC PRDX4 PRKACA PRKCA PRKCB PRKCG PVR RHOXF1 RPL13A SERPINE1 SIX1 SNTG1 TGFB1 TGFB2 TNFRSF11B UBQLN2 VEGFA	7 interacting genes: FN1 THBS1 TNFSF10 TNFSF11 TNFSF13 VTN VWF
Entrez ID		7448	4982
HPRD ID		01902	04032
Ensembl ID		ENSG00000109072	ENSG00000164761
Uniprot IDs		D9ZGG2 P04004	O00300
PDB IDs		1OC0 1S4G 1SSU 2JQ8 3BT1 3BT2 4K24 6O5E 7RJ9	3URF
GO Terms Enriched among Interactors		Platelet Alpha Granule Lumen Integrin Complex Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Programmed Cell Death Integrin Binding Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Cell-matrix Adhesion Regulation Of Apoptotic Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Locomotion Cell-cell Adhesion Positive Regulation Of Vasculature Development Cell Surface Regulation Of Vesicle-mediated Transport Regulation Of Cell Communication Regulation Of Signaling Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Epithelial Tube Formation Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Signaling Receptor Binding Negative Regulation Of Multicellular Organismal Process Cell Adhesion Growth Factor Activity Angiogenesis Cell-substrate Adhesion Integrin-mediated Signaling Pathway Cell Adhesion Mediated By Integrin Regulation Of Endocytosis Regulation Of Protein Metabolic Process Regulation Of Multicellular Organismal Process Negative Regulation Of Programmed Cell Death Alphav-beta3 Integrin-PKCalpha Complex Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Protein Localization Regulation Of Vasculature Development Regulation Of Transport Positive Regulation Of Angiogenesis Positive Regulation Of Protein Localization Regulation Of Morphogenesis Of An Epithelium Anatomical Structure Formation Involved In Morphogenesis Positive Regulation Of MAPK Cascade Regulation Of Cell Migration Positive Regulation Of Morphogenesis Of An Epithelium	Extracellular Space Extracellular Matrix Structural Constituent Integrin Binding Tumor Necrosis Factor Receptor Binding Extracellular Region Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Collagen Binding Platelet Alpha Granule Lumen Tumor Necrosis Factor Receptor Superfamily Binding Positive Regulation Of Signal Transduction Fibrinogen Complex Blood Coagulation, Fibrin Clot Formation Positive Regulation Of Cell Communication Signaling Receptor Binding Protease Binding Positive Regulation Of Signaling Negative Regulation Of Fibrinolysis Extracellular Matrix Proteoglycan Binding Extracellular Exosome Regulation Of Fibrinolysis Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Protein Activation Cascade Heparin Binding Cell-substrate Adhesion Platelet Alpha Granule Regulation Of Extrinsic Apoptotic Signaling Pathway Immune Response Positive Regulation Of Blood Coagulation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell Activation Positive Regulation Of Coagulation Extracellular Matrix Binding Cytokine Activity Regulation Of Fatty Acid Transport Regulation Of Cell-substrate Adhesion Endodermal Cell Differentiation Regulation Of Cell Adhesion Regulation Of Body Fluid Levels Positive Regulation Of Multicellular Organismal Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Signal Transduction Cell Adhesion Identical Protein Binding Cell Migration Immune System Process Positive Regulation Of Wound Healing Regulation Of Blood Coagulation Regulation Of Cell Communication