VTN and SERPINE1

Number of citations of the paper that reports this interaction (PMID 8830783)
69

Data Source:
HPRD (in vivo, in vitro)

		VTN	SERPINE1
Gene Name		vitronectin	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Extracellular Matrix Extracellular Vesicular Exosome Alphav-beta3 Integrin-vitronectin Complex Blood Microparticle	Extracellular Region Extracellular Space Plasma Membrane Extracellular Matrix Platelet Alpha Granule Lumen Extracellular Vesicular Exosome
	Molecular Function	Scavenger Receptor Activity Integrin Binding Protein Binding Heparin Binding Polysaccharide Binding Extracellular Matrix Binding	Protease Binding Serine-type Endopeptidase Inhibitor Activity Receptor Binding Protein Binding
	Biological Process	Receptor-mediated Endocytosis Immune Response Cell Adhesion Cell-matrix Adhesion Positive Regulation Of Cell-substrate Adhesion Negative Regulation Of Endopeptidase Activity Positive Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Blood Coagulation Extracellular Matrix Organization Regulation Of Complement Activation Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Binding Cell Adhesion Mediated By Integrin Endodermal Cell Differentiation Innate Immune Response Positive Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Peptidyl-tyrosine Phosphorylation Smooth Muscle Cell-matrix Adhesion Positive Regulation Of Wound Healing	Chronological Cell Aging Angiogenesis Platelet Degranulation Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Transforming Growth Factor Beta Receptor Signaling Pathway Blood Coagulation Circadian Rhythm Gene Expression Regulation Of Receptor Activity Negative Regulation Of Plasminogen Activation Negative Regulation Of Endopeptidase Activity Negative Regulation Of Smooth Muscle Cell Migration Platelet Activation Positive Regulation Of Blood Coagulation Negative Regulation Of Blood Coagulation Extracellular Matrix Organization Negative Regulation Of Cell Migration Positive Regulation Of Interleukin-8 Production Negative Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of Leukotriene Production Involved In Inflammatory Response Regulation Of Cell Proliferation Fibrinolysis Positive Regulation Of Angiogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Inflammatory Response Defense Response To Gram-negative Bacterium Negative Regulation Of Fibrinolysis Negative Regulation Of Vascular Wound Healing Negative Regulation Of Wound Healing Cellular Response To Lipopolysaccharide Positive Regulation Of Monocyte Chemotaxis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Smooth Muscle Cell-matrix Adhesion Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways		Molecules associated with elastic fibres Syndecan interactions Regulation of Complement cascade Complement cascade Elastic fibre formation ECM proteoglycans Integrin cell surface interactions Non-integrin membrane-ECM interactions Innate Immune System	Loss of Function of TGFBR2 in Cancer SMAD2/3 MH2 Domain Mutants in Cancer Platelet degranulation Dissolution of Fibrin Clot TGFBR1 LBD Mutants in Cancer SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Generic Transcription Pathway Response to elevated platelet cytosolic Ca2+ ECM proteoglycans TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex Platelet activation, signaling and aggregation BMAL1:CLOCK,NPAS2 activates circadian gene expression SMAD4 MH2 Domain Mutants in Cancer
Drugs		Abciximab	Alteplase Urokinase Reteplase Anistreplase Tenecteplase Drotrecogin alfa Troglitazone
Diseases
GWAS			Plasminogen activator inhibitor type 1 levels (PAI-1) ( 22990020)
Protein-Protein Interactions		42 interactors: ADH5 ADTRP AMPH APP CBX1 CD247 CKS2 COPS5 CRADD CSNK2A1 EGF ETV7 FGF2 FGG GEM GLUD1 GOPC HGF IGF2 IGFBP5 ITGA8 ITGB3 ITGB6 ITGB8 KNG1 LACRT PLAUR POMC PRDX4 PRKACA PRKCA PRKCB PRKCG PVR RHOXF1 RPL13A SERPINE1 SIX1 TGFB1 TGFB2 TNFRSF11B VEGFA	19 interactors: ACTN4 ELANE F2 IGFBP5 KLK2 KRT18 LRP1 LRP1B LRP2 MMP3 ORM1 PLAT PLAU PLG SGTA SGTB UBQLN1 UBQLN4 VTN
Entrez ID		7448	5054
HPRD ID		01902	01418
Ensembl ID			ENSG00000106366
Uniprot IDs		D9ZGG2 P04004	P05121
PDB IDs		1OC0 1S4G 1SSU 2JQ8 3BT1 3BT2	1A7C 1B3K 1C5G 1DB2 1DVM 1DVN 1LJ5 1OC0 3CVM 3EOX 3PB1 3Q02 3Q03 3R4L 3UT3 4AQH 9PAI
Enriched GO Terms of Interacting Partners?		Platelet Activation Platelet Degranulation Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Response To Wounding Extracellular Matrix Organization Extracellular Structure Organization Cell Activation Exocytosis Signaling Cell Communication Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Response To External Stimulus Secretion Secretion By Cell Signal Transduction Regulation Of Peptidyl-tyrosine Phosphorylation Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Endothelial Cell Migration Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Epithelial Cell Proliferation Negative Regulation Of Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Phosphorylation Response To Stimulus Cellular Response To Stimulus Positive Regulation Of Angiogenesis Regulation Of Protein Kinase Activity Positive Regulation Of MAPK Cascade Cellular Localization Positive Regulation Of Metabolic Process Regulation Of Signaling Positive Regulation Of Cell Migration Response To Stress Positive Regulation Of Cell Motility Regulation Of MAPK Cascade Regulation Of Kinase Activity Histone H3-T6 Phosphorylation Regulation Of Epithelial Cell Migration Regulation Of Cellular Process Positive Regulation Of Cellular Component Movement Positive Regulation Of Intracellular Signal Transduction	Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Negative Regulation Of Wound Healing Fibrinolysis Regulation Of Blood Coagulation Regulation Of Smooth Muscle Cell Migration Regulation Of Wound Healing Extracellular Matrix Disassembly Vesicle-mediated Transport Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Wound Healing Regulation Of Locomotion Regulation Of Cellular Component Movement Response To Abiotic Stimulus Blood Coagulation Hemostasis Acute Inflammatory Response Negative Regulation Of Fibrinolysis Regulation Of Fibrinolysis Regulation Of Body Fluid Levels Response To Stress Response To Hypoxia Regulation Of Cell Migration Wound Healing Proteolysis Negative Regulation Of Smooth Muscle Cell Migration Regulation Of Cell Motility Endocytosis Receptor-mediated Endocytosis Response To Wounding Regulation Of Signaling Smooth Muscle Cell Migration Response To Stimulus Positive Regulation Of Blood Coagulation Cell Migration Regulation Of Cellular Protein Metabolic Process Platelet Activation Negative Regulation Of Protein Metabolic Process Regulation Of Cell-substrate Adhesion Muscle Cell Migration Acute-phase Response Cell Motility Positive Regulation Of Coagulation Regulation Of Signal Transduction Leukocyte Migration Negative Regulation Of Cellular Component Movement Regulation Of Cellular Response To Oxidative Stress Regulation Of Protein Metabolic Process Negative Regulation Of Locomotion
Tagcloud ?		accumulated aeamsq aeamsqv aeamsqvt aeamsqvtn aeamsqvtntatim desorption dimeric dimerization dissociated exclusion flight immunoblot maldi monomeric nonapeptide p17gag p24gag p2gag potently pr55gag protease proteolytic spectrometric sqnypivq succinyl suicide tof vtntatim	bag1 bcl2l2 bctis ccna2 comprehend ctsb deregulations fgf1 fosl1 gabrp gsn hnepi id2 il6r itgb4 klf5 klk5 map2k7 microdissected ngfb ngfr ontological pappa plau scgb1d2 scgb2a1 thbs1 thbs2
Tagcloud (Difference) ?		accumulated aeamsq aeamsqv aeamsqvt aeamsqvtn aeamsqvtntatim desorption dimeric dimerization dissociated exclusion flight immunoblot maldi monomeric nonapeptide p17gag p24gag p2gag potently pr55gag protease proteolytic spectrometric sqnypivq succinyl suicide tof vtntatim	bag1 bcl2l2 bctis ccna2 comprehend ctsb deregulations fgf1 fosl1 gabrp gsn hnepi id2 il6r itgb4 klf5 klk5 map2k7 microdissected ngfb ngfr ontological pappa plau scgb1d2 scgb2a1 thbs1 thbs2
Tagcloud (Intersection) ?