VTN and SIX1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		VTN	SIX1
Description		vitronectin	SIX homeobox 1
Image
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Extracellular Space Endoplasmic Reticulum Golgi Lumen Symbiont-containing Vacuole Extracellular Matrix Rough Endoplasmic Reticulum Lumen Extracellular Exosome Alphav-beta3 Integrin-vitronectin Complex Blood Microparticle Protein Complex Involved In Cell-matrix Adhesion Peptidase Inhibitor Complex	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Nucleolus Cytoplasm
	Molecular Function	Scavenger Receptor Activity Integrin Binding Extracellular Matrix Structural Constituent Protein Binding Collagen Binding Heparin Binding Polysaccharide Binding Identical Protein Binding Extracellular Matrix Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coactivator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Immune Response Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of Smooth Muscle Cell Migration Vesicle-mediated Transport Cell Migration Cell Differentiation Regulation Of Cell Adhesion Negative Regulation Of Blood Coagulation Extracellular Matrix Organization Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Adhesion Mediated By Integrin Endodermal Cell Differentiation Negative Regulation Of Proteolysis Positive Regulation Of Receptor-mediated Endocytosis Oligodendrocyte Differentiation Protein Polymerization Negative Regulation Of Fibrinolysis Smooth Muscle Cell-matrix Adhesion Positive Regulation Of Wound Healing Liver Regeneration Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Integrin-mediated Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Ureteric Bud Development Branching Involved In Ureteric Bud Morphogenesis Organ Induction Kidney Development Outflow Tract Morphogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Apoptotic Process Notch Signaling Pathway Pattern Specification Process Skeletal Muscle Tissue Development Sensory Perception Of Sound Regulation Of Synaptic Assembly At Neuromuscular Junction Gene Expression Regulation Of Gene Expression Neural Crest Cell Differentiation Regulation Of Skeletal Muscle Satellite Cell Proliferation Regulation Of Skeletal Muscle Cell Proliferation Facial Nerve Morphogenesis Neurogenesis Epithelial Cell Differentiation Thyroid Gland Development Olfactory Placode Formation Regulation Of Protein Localization Protein Localization To Nucleus Aorta Morphogenesis Inner Ear Morphogenesis Middle Ear Morphogenesis Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Tongue Development Regulation Of Neuron Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Thymus Development Neuron Fate Specification Generation Of Neurons Embryonic Cranial Skeleton Morphogenesis Embryonic Skeletal System Morphogenesis Skeletal System Morphogenesis Skeletal Muscle Fiber Development Inner Ear Development Regulation Of Epithelial Cell Proliferation Myoblast Proliferation Myoblast Migration Pharyngeal System Development Myotome Development Fungiform Papilla Morphogenesis Trigeminal Ganglion Development Otic Vesicle Development Metanephric Mesenchyme Development Regulation Of Branch Elongation Involved In Ureteric Bud Branching Positive Regulation Of Ureteric Bud Formation Mesonephric Tubule Formation Ureter Smooth Muscle Cell Differentiation Mesenchymal Cell Proliferation Involved In Ureter Development Positive Regulation Of Secondary Heart Field Cardioblast Proliferation Endothelin Receptor Signaling Pathway Cochlea Morphogenesis Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Brown Fat Cell Differentiation Cellular Response To 3,3',5-triiodo-L-thyronine Positive Regulation Of Myoblast Proliferation Positive Regulation Of Mesenchymal Cell Proliferation Involved In Ureter Development Regulation Of Skeletal Muscle Cell Differentiation
Pathways		Molecules associated with elastic fibres Integrin cell surface interactions Syndecan interactions ECM proteoglycans ECM proteoglycans Regulation of Complement cascade Developmental Lineage of Pancreatic Ductal Cells	Formation of the ureteric bud
Drugs		Abciximab Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases			Contiguous gene deletion syndrome involving EYA1, including: Oto-facio-cervical syndrome (OFC); Branchiootic syndrome 1 (BOS1); Branchio-oto-renal syndrome (BOR)
GWAS		Advanced age-related macular degeneration ( 26691988) Heel bone mineral density ( 30598549) LDL cholesterol ( 30275531) Low density lipoprotein cholesterol levels ( 32154731 33339817) Osteoprotegerin levels ( 25080503)	Exhaled carbon monoxide levels in smokers with chronic obstructive pulmonary disease ( 29631575) Glaucoma ( 31959993) Glaucoma (multi-trait analysis) ( 31959993) Glaucoma (primary open-angle) ( 22419738 22570617 29891935) Gut microbiota (bacterial taxa) ( 27723756) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Optic disc size ( 31809533) Optic nerve measurement (rim area) ( 20395239) Prostate cancer ( 25217961) Refractive error ( 32231278) Vertical cup-disc ratio ( 20548946 25241763)
Interacting Genes		50 interacting genes: ADH5 ADTRP AMPH APP CBX1 CD247 CKS2 COPS5 CRADD CSNK2A1 DLG2 DLG3 EGF ETV7 FGF2 FGG GEM GLUD1 GOPC HGF IGF2 IGFBP5 ITGA2B ITGA5 ITGA8 ITGAV ITGB3 ITGB6 ITGB8 KNG1 LACRT LNX2 PLAUR POMC PRDX4 PRKACA PRKCA PRKCB PRKCG PVR RHOXF1 RPL13A SERPINE1 SIX1 SNTG1 TGFB1 TGFB2 TNFRSF11B UBQLN2 VEGFA	14 interacting genes: CCDC85B DACH1 EYA1 EYA2 EYA3 EYA4 MDFI PLEKHG4 POU6F2 REL TLE1 TLE3 TLE5 VTN
Entrez ID		7448	6495
HPRD ID		01902	03125
Ensembl ID		ENSG00000109072	ENSG00000126778
Uniprot IDs		D9ZGG2 P04004	Q15475
PDB IDs		1OC0 1S4G 1SSU 2JQ8 3BT1 3BT2 4K24 6O5E 7RJ9	4EGC
Enriched GO Terms of Interacting Partners?		Platelet Alpha Granule Lumen Integrin Complex Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Programmed Cell Death Integrin Binding Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Cell-matrix Adhesion Regulation Of Apoptotic Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Locomotion Cell-cell Adhesion Positive Regulation Of Vasculature Development Cell Surface Regulation Of Vesicle-mediated Transport Regulation Of Cell Communication Regulation Of Signaling Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Epithelial Tube Formation Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Signaling Receptor Binding Negative Regulation Of Multicellular Organismal Process Cell Adhesion Growth Factor Activity Angiogenesis Cell-substrate Adhesion Integrin-mediated Signaling Pathway Cell Adhesion Mediated By Integrin Regulation Of Endocytosis Regulation Of Protein Metabolic Process Regulation Of Multicellular Organismal Process Negative Regulation Of Programmed Cell Death Alphav-beta3 Integrin-PKCalpha Complex Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Protein Localization Regulation Of Vasculature Development Regulation Of Transport Positive Regulation Of Angiogenesis Positive Regulation Of Protein Localization Regulation Of Morphogenesis Of An Epithelium Anatomical Structure Formation Involved In Morphogenesis Positive Regulation Of MAPK Cascade Regulation Of Cell Migration Positive Regulation Of Morphogenesis Of An Epithelium	Histone H2AXY142 Phosphatase Activity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Signal Transduction Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Protein Tyrosine Phosphatase Activity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Cell Communication Negative Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Macromolecule Metabolic Process Phosphoprotein Phosphatase Activity Positive Regulation Of DNA Repair Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Regulation Of Metabolic Process Mesodermal Cell Fate Specification Developmental Process Regulation Of DNA Metabolic Process Regulation Of DNA Repair Negative Regulation Of Apoptotic Signaling Pathway Beta-catenin-TCF Complex Positive Regulation Of DNA Metabolic Process Regulation Of Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Anoikis Regulation Of Apoptotic Signaling Pathway Nucleus Negative Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Apoptotic Process Visual Perception Sensory Perception Of Light Stimulus Sensory Perception Negative Regulation Of RNA Metabolic Process Negative Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Negative Regulation Of Metabolic Process Transcription Corepressor Activity Anatomical Structure Morphogenesis DNA Repair Regulation Of Programmed Cell Death
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