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ITGA4 and PXN
Number of citations of the paper that reports this interaction (PMID
11533025
)
25
Data Source:
HPRD
(in vitro, in vivo)
ITGA4
PXN
Gene Name
integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
paxillin
Image
Gene Ontology Annotations
Cellular Component
Plasma Membrane
Cell-cell Junction
Focal Adhesion
External Side Of Plasma Membrane
Cell Surface
Membrane
Integrin Alpha4-beta7 Complex
Extracellular Vesicular Exosome
Stress Fiber
Nucleoplasm
Cytoplasm
Cytosol
Microtubule Associated Complex
Plasma Membrane
Focal Adhesion
Cell Cortex
Lamellipodium
Molecular Function
Fibronectin Binding
Protein Binding
Metal Ion Binding
Cell Adhesion Molecule Binding
Integrin Binding
Protein Binding
Beta-catenin Binding
Zinc Ion Binding
Vinculin Binding
Protein Kinase Binding
BH4 Domain Binding
Biological Process
Blood Vessel Remodeling
Cell-matrix Adhesion Involved In Ameboidal Cell Migration
Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules
Leukocyte Cell-cell Adhesion
Cell-matrix Adhesion
Integrin-mediated Signaling Pathway
Heart Development
Blood Coagulation
B Cell Differentiation
Extracellular Matrix Organization
Heterotypic Cell-cell Adhesion
Substrate Adhesion-dependent Cell Spreading
Endodermal Cell Differentiation
Receptor Clustering
Regulation Of Immune Response
Leukocyte Migration
Leukocyte Tethering Or Rolling
Face Development
Chorio-allantoic Fusion
T Cell Migration
Negative Regulation Of Protein Homodimerization Activity
Activation Of MAPK Activity
Movement Of Cell Or Subcellular Component
Muscle Contraction
Cytoskeleton Organization
Cell Adhesion
Signal Transduction
Signal Complex Assembly
Epidermal Growth Factor Receptor Signaling Pathway
Transforming Growth Factor Beta Receptor Signaling Pathway
Integrin-mediated Signaling Pathway
Regulation Of Cell Shape
Peptidyl-tyrosine Phosphorylation
Lamellipodium Assembly
Cell Junction Assembly
Substrate Adhesion-dependent Cell Spreading
Cellular Response To Reactive Oxygen Species
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Focal Adhesion Assembly
Branching Morphogenesis Of An Epithelial Tube
Growth Hormone Receptor Signaling Pathway
Pathways
Integrin cell surface interactions
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Cell surface interactions at the vascular wall
Adaptive Immune System
Cell junction organization
GAB1 signalosome
Smooth Muscle Contraction
Signaling by Ligand-Responsive EGFR Variants in Cancer
Signaling by EGFRvIII in Cancer
Signaling by Overexpressed Wild-Type EGFR in Cancer
VEGFA-VEGFR2 Pathway
Signaling by EGFR
Signaling by VEGF
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
Signaling by EGFR in Cancer
Localization of the PINCH-ILK-PARVIN complex to focal adhesions
Cell-extracellular matrix interactions
Drugs
Natalizumab
Tinzaparin
Diseases
GWAS
Celiac disease (
20190752
)
Monocyte count (
23314186
)
White blood cell count (
21738480
)
White blood cell types (
21738478
)
Protein-Protein Interactions
16 interactors:
ADAM28
CD81
CD82
EED
FN1
ICAM4
ITGB1
ITGB7
LGALS8
LPXN
MADCAM1
PRKACA
PRKAR1A
PXN
TGFB1I1
VCAN
73 interactors:
ABL1
AHCY
AR
ARHGEF7
ASAP1
ASAP2
BCAR1
BCL2
CASP3
CEACAM1
CLTC
CREB3L2
CRK
CRKL
CSK
DGUOK
EPHB1
FYN
GART
GIT1
GIT2
GRB2
GSK3A
GSK3B
GSN
HDAC6
ILK
ITGA4
ITGA6
ITGA9
ITGB1
ITGB3
LCK
LIMK1
MAPK1
MAPK3
MAPK8
MATK
NCK1
NEDD9
NF2
PABPC1
PAK1
PAK3
PARVA
PDPK1
PKD1
POLR1D
PPP2CA
PPP2R5C
PTEN
PTK2
PTK2B
PTPN11
PTPN12
PTPRH
RASA1
REPS2
RNF5
SDC4
SELE
SORBS1
SRC
SYK
TLN1
TRIP6
TUBA1B
TUBA3C
TUBA8
TUBG1
TUBG2
VCL
XPO1
Entrez ID
3676
5829
HPRD ID
01894
03937
Ensembl ID
ENSG00000115232
ENSG00000089159
Uniprot IDs
P13612
E7EMK8
F5GZ78
P49023
PDB IDs
3V4P
3V4V
4HKC
1KKY
1KL0
1OW6
1OW7
1OW8
2K2R
2O9V
2VZD
2VZG
2VZI
3GM1
3PY7
3RQE
3RQF
3RQG
3U3C
3U3F
4EDN
Enriched GO Terms of Interacting Partners
?
Cell Adhesion
Extracellular Matrix Organization
Extracellular Structure Organization
Cell-matrix Adhesion
Leukocyte Tethering Or Rolling
Cell-substrate Adhesion
Leukocyte Migration
Heterotypic Cell-cell Adhesion
Regulation Of Immune System Process
Integrin-mediated Signaling Pathway
Cellular Extravasation
Formation Of Primary Germ Layer
Calcium-independent Cell-matrix Adhesion
Positive Regulation Of Cellular Protein Metabolic Process
Viral Entry Into Host Cell
Substrate Adhesion-dependent Cell Spreading
Entry Into Host Cell
Positive Regulation Of Protein Metabolic Process
Gastrulation
Locomotion
Cell Junction Assembly
Cell Differentiation
Cell Migration
Cell Motility
Positive Regulation Of Protein Modification Process
Movement Of Cell Or Subcellular Component
Mesoderm Formation
Activation Of Protein Kinase Activity
Mesoderm Morphogenesis
Embryonic Morphogenesis
Tissue Morphogenesis
Interaction With Host
Tissue Development
Activation Of Protein Kinase A Activity
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Cellular Metabolic Process
Regulation Of Cellular Component Organization
Mesoderm Development
Regulation Of Cellular Protein Metabolic Process
Multicellular Organismal Development
Blood Coagulation
Hemostasis
Positive Regulation Of Phosphorylation
Positive Regulation Of MAPK Cascade
Cardiovascular System Development
Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of Immune Response
Anatomical Structure Development
ERBB Signaling Pathway
Renal Water Homeostasis
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme Linked Receptor Protein Signaling Pathway
Regulation Of Cellular Component Organization
Locomotion
Movement Of Cell Or Subcellular Component
Regulation Of Cell Adhesion
Cell Morphogenesis Involved In Differentiation
Response To Wounding
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Wound Healing
Blood Coagulation
Regulation Of Phosphorylation
Hemostasis
Cell Migration
Response To External Stimulus
Cell Projection Morphogenesis
Axonogenesis
Cell Part Morphogenesis
Cell Morphogenesis
Immune System Process
Immune Response-regulating Signaling Pathway
Neuron Projection Morphogenesis
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Cell Motility
Positive Regulation Of Catalytic Activity
Axon Development
Anatomical Structure Morphogenesis
Cell Morphogenesis Involved In Neuron Differentiation
Regulation Of Signal Transduction
Regulation Of Protein Kinase Activity
Cell Surface Receptor Signaling Pathway
Cell Projection Organization
Regulation Of Phosphorus Metabolic Process
Regulation Of Intracellular Signal Transduction
Fc Receptor Signaling Pathway
Integrin-mediated Signaling Pathway
Axon Guidance
Positive Regulation Of Phosphorylation
Regulation Of Protein Phosphorylation
Chemotaxis
Immune Response-activating Cell Surface Receptor Signaling Pathway
Regulation Of Catalytic Activity
Regulation Of Kinase Activity
Neuron Projection Development
Response To Stress
Positive Regulation Of Protein Phosphorylation
Signal Transduction
Cell-substrate Adhesion
Tagcloud
?
acclimatized
adra1d
altitude
araf
argef11
arhgap24
ascent
cardiogenic
circuitry
cldn23
cldn6
ece1
ednra
genic
hape
inciting
map2k2
map2k7
mapk10
mylk
oxphos
pak3
pathoetiology
plcb1
skew
sos1
unacclimatized
vasoconstriction
vcam1
Tagcloud (Difference)
?
acclimatized
adra1d
altitude
araf
argef11
arhgap24
ascent
cardiogenic
circuitry
cldn23
cldn6
ece1
ednra
genic
hape
inciting
map2k2
map2k7
mapk10
mylk
oxphos
pak3
pathoetiology
plcb1
skew
sos1
unacclimatized
vasoconstriction
vcam1
Tagcloud (Intersection)
?