ITGA4 and PRKAR1A

Number of citations of the paper that reports this interaction (PMID 17369818)
31

Data Source:
HPRD (in vivo)

		ITGA4	PRKAR1A
Gene Name		integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)	protein kinase, cAMP-dependent, regulatory, type I, alpha
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Cell-cell Junction Focal Adhesion External Side Of Plasma Membrane Cell Surface Membrane Integrin Alpha4-beta7 Complex Extracellular Vesicular Exosome	Cytosol Plasma Membrane CAMP-dependent Protein Kinase Complex Membrane AMP-activated Protein Kinase Complex Neuromuscular Junction Protein Complex Ciliary Base
	Molecular Function	Fibronectin Binding Protein Binding Metal Ion Binding Cell Adhesion Molecule Binding	CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding CAMP-dependent Protein Kinase Regulator Activity CAMP Binding Ubiquitin Protein Ligase Binding Protein Kinase A Catalytic Subunit Binding
	Biological Process	Blood Vessel Remodeling Cell-matrix Adhesion Involved In Ameboidal Cell Migration Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Heart Development Blood Coagulation B Cell Differentiation Extracellular Matrix Organization Heterotypic Cell-cell Adhesion Substrate Adhesion-dependent Cell Spreading Endodermal Cell Differentiation Receptor Clustering Regulation Of Immune Response Leukocyte Migration Leukocyte Tethering Or Rolling Face Development Chorio-allantoic Fusion T Cell Migration Negative Regulation Of Protein Homodimerization Activity	Mesoderm Formation Renal Water Homeostasis Energy Reserve Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Water Transport Female Meiotic Division Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Activation Of Phospholipase C Activity Blood Coagulation Fibroblast Growth Factor Receptor Signaling Pathway Activation Of Protein Kinase A Activity Intracellular Signal Transduction Small Molecule Metabolic Process Innate Immune Response Sarcomere Organization Negative Regulation Of Meiotic Nuclear Division Neurotrophin TRK Receptor Signaling Pathway Regulation Of Insulin Secretion Transmembrane Transport Cardiac Muscle Cell Proliferation Cellular Response To Glucagon Stimulus Negative Regulation Of CAMP-dependent Protein Kinase Activity
Pathways		Integrin cell surface interactions Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Cell surface interactions at the vascular wall Adaptive Immune System	Signaling by GPCR Ca-dependent events CaM pathway Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Hedgehog 'off' state Integration of energy metabolism Phospholipase C-mediated cascade Signaling by FGFR in disease Signaling by EGFRvIII in Cancer PLCG1 events in ERBB2 signaling DAG and IP3 signaling CaM pathway DAP12 signaling Downstream signaling of activated FGFR DARPP-32 events Glucagon signaling in metabolic regulation Innate Immune System Signaling by PDGF PKA activation in glucagon signalling Calmodulin induced events Signalling by NGF DAP12 interactions PKA-mediated phosphorylation of CREB PLC beta mediated events Vasopressin regulates renal water homeostasis via Aquaporins Opioid Signalling Regulation of insulin secretion Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane G-protein mediated events PKA activation Factors involved in megakaryocyte development and platelet production Signaling by Overexpressed Wild-Type EGFR in Cancer Aquaporin-mediated transport Signaling by FGFR EGFR interacts with phospholipase C-gamma Signaling by ERBB2 PKA-mediated phosphorylation of CREB Signaling by EGFR Downstream signal transduction Calmodulin induced events Signaling by Hedgehog PLC-gamma1 signalling Signaling by EGFR in Cancer PKA activation
Drugs		Natalizumab Tinzaparin
Diseases
GWAS		Celiac disease ( 20190752) Monocyte count ( 23314186) White blood cell count ( 21738480) White blood cell types ( 21738478)
Protein-Protein Interactions		16 interactors: ADAM28 CD81 CD82 EED FN1 ICAM4 ITGB1 ITGB7 LGALS8 LPXN MADCAM1 PRKACA PRKAR1A PXN TGFB1I1 VCAN	40 interactors: AKAP1 AKAP10 AKAP11 AKAP4 AKAP7 ARFGEF2 BAHD1 C2orf44 C2orf88 CAPN11 CBS CCNE1 CDK2 CDK4 EGFR GRB2 HIVEP1 HLA-A ITGA4 MAPK6 MAPT MYO7A NELL2 PATZ1 PJA2 PLEKHF2 PRKACA PRKAR1B PRKX PRPF40A PYCARD RAF1 RFC2 SET SETD7 SLC2A4 SMAD2 TAB1 WNK1 ZBED1
Entrez ID		3676	5573
HPRD ID		01894	01786
Ensembl ID		ENSG00000115232	ENSG00000108946
Uniprot IDs		P13612	B2R5T5 K7ER48 P10644 Q68DQ4
PDB IDs		3V4P 3V4V 4HKC
Enriched GO Terms of Interacting Partners?		Cell Adhesion Extracellular Matrix Organization Extracellular Structure Organization Cell-matrix Adhesion Leukocyte Tethering Or Rolling Cell-substrate Adhesion Leukocyte Migration Heterotypic Cell-cell Adhesion Regulation Of Immune System Process Integrin-mediated Signaling Pathway Cellular Extravasation Formation Of Primary Germ Layer Calcium-independent Cell-matrix Adhesion Positive Regulation Of Cellular Protein Metabolic Process Viral Entry Into Host Cell Substrate Adhesion-dependent Cell Spreading Entry Into Host Cell Positive Regulation Of Protein Metabolic Process Gastrulation Locomotion Cell Junction Assembly Cell Differentiation Cell Migration Cell Motility Positive Regulation Of Protein Modification Process Movement Of Cell Or Subcellular Component Mesoderm Formation Activation Of Protein Kinase Activity Mesoderm Morphogenesis Embryonic Morphogenesis Tissue Morphogenesis Interaction With Host Tissue Development Activation Of Protein Kinase A Activity Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Metabolic Process Regulation Of Cellular Component Organization Mesoderm Development Regulation Of Cellular Protein Metabolic Process Multicellular Organismal Development Blood Coagulation Hemostasis Positive Regulation Of Phosphorylation Positive Regulation Of MAPK Cascade Cardiovascular System Development Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Immune Response Anatomical Structure Development ERBB Signaling Pathway Renal Water Homeostasis	Blood Coagulation Hemostasis Regulation Of Protein Kinase Activity Regulation Of Protein Kinase A Signaling Regulation Of Body Fluid Levels Regulation Of Kinase Activity Intracellular Signal Transduction Wound Healing Protein Phosphorylation Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Organonitrogen Compound Response To Wounding Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Movement Of Cell Or Subcellular Component Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Regulation Of Phosphorylation Innate Immune Response Cellular Response To Growth Factor Stimulus Cellular Response To Stimulus Regulation Of Protein Phosphorylation Response To Stress Response To Growth Factor Signal Transduction Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Enzyme Linked Receptor Protein Signaling Pathway Activation Of Protein Kinase Activity Activation Of Phospholipase C Activity Cell Motility Regulation Of Phosphorus Metabolic Process Cell Activation Positive Regulation Of Phospholipase C Activity Cellular Response To Organic Substance G1/S Transition Of Mitotic Cell Cycle Signaling Locomotion Cellular Response To Peptide Hormone Stimulus Mitotic Cell Cycle Cell Communication Cellular Response To Peptide Regulation Of Cellular Protein Metabolic Process Cell Cycle Regulation Of Catalytic Activity Positive Regulation Of Phospholipase Activity Heterochromatin Organization
Tagcloud ?			agouti albinism asip atf1 delta25 dopachrome edn1 edn3 ednrb exoc2 exocyst kitlg ludwigshafen mc1r microphthalmia oca2 oculocutaneous pigmentation prkacb prkacg proopiomelanocortin slc24a4 slc45a2 tautomerase tpcn2 tubb3 tyrp1
Tagcloud (Difference) ?			agouti albinism asip atf1 delta25 dopachrome edn1 edn3 ednrb exoc2 exocyst kitlg ludwigshafen mc1r microphthalmia oca2 oculocutaneous pigmentation prkacb prkacg proopiomelanocortin slc24a4 slc45a2 tautomerase tpcn2 tubb3 tyrp1
Tagcloud (Intersection) ?