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ITGA4 and ITGB7
Number of citations of the paper that reports this interaction (PMID
14681217
)
29
Data Source:
HPRD
(in vivo)
ITGA4
ITGB7
Gene Name
integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
integrin, beta 7
Image
Gene Ontology Annotations
Cellular Component
Plasma Membrane
Cell-cell Junction
Focal Adhesion
External Side Of Plasma Membrane
Cell Surface
Membrane
Integrin Alpha4-beta7 Complex
Extracellular Vesicular Exosome
Plasma Membrane
Integrin Complex
Cell Surface
Membrane
Integrin Alpha4-beta7 Complex
Receptor Complex
Extracellular Vesicular Exosome
Molecular Function
Fibronectin Binding
Protein Binding
Metal Ion Binding
Cell Adhesion Molecule Binding
Virus Receptor Activity
Protein Binding
Metal Ion Binding
Cell Adhesion Molecule Binding
Biological Process
Blood Vessel Remodeling
Cell-matrix Adhesion Involved In Ameboidal Cell Migration
Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules
Leukocyte Cell-cell Adhesion
Cell-matrix Adhesion
Integrin-mediated Signaling Pathway
Heart Development
Blood Coagulation
B Cell Differentiation
Extracellular Matrix Organization
Heterotypic Cell-cell Adhesion
Substrate Adhesion-dependent Cell Spreading
Endodermal Cell Differentiation
Receptor Clustering
Regulation Of Immune Response
Leukocyte Migration
Leukocyte Tethering Or Rolling
Face Development
Chorio-allantoic Fusion
T Cell Migration
Negative Regulation Of Protein Homodimerization Activity
Cell-matrix Adhesion Involved In Ameboidal Cell Migration
Cell Adhesion
Cell-matrix Adhesion
Integrin-mediated Signaling Pathway
Multicellular Organismal Development
Response To Virus
Extracellular Matrix Organization
Heterotypic Cell-cell Adhesion
Substrate Adhesion-dependent Cell Spreading
Receptor Clustering
Regulation Of Immune Response
Leukocyte Tethering Or Rolling
T Cell Migration
Pathways
Integrin cell surface interactions
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Cell surface interactions at the vascular wall
Adaptive Immune System
Integrin cell surface interactions
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Adaptive Immune System
Drugs
Natalizumab
Tinzaparin
Diseases
GWAS
Celiac disease (
20190752
)
Monocyte count (
23314186
)
White blood cell count (
21738480
)
White blood cell types (
21738478
)
Obesity-related traits (
23251661
)
Protein-Protein Interactions
16 interactors:
ADAM28
CD81
CD82
EED
FN1
ICAM4
ITGB1
ITGB7
LGALS8
LPXN
MADCAM1
PRKACA
PRKAR1A
PXN
TGFB1I1
VCAN
15 interactors:
CDH1
DAB1
DOK1
EED
FLNA
FN1
GNB2L1
ITGA4
ITGAE
MADCAM1
PRKCB
PRKCD
TLN1
TNS2
VCAM1
Entrez ID
3676
3695
HPRD ID
01894
00948
Ensembl ID
ENSG00000115232
ENSG00000139626
Uniprot IDs
P13612
P26010
PDB IDs
3V4P
3V4V
4HKC
2BRQ
3V4P
3V4V
Enriched GO Terms of Interacting Partners
?
Cell Adhesion
Extracellular Matrix Organization
Extracellular Structure Organization
Cell-matrix Adhesion
Leukocyte Tethering Or Rolling
Cell-substrate Adhesion
Leukocyte Migration
Heterotypic Cell-cell Adhesion
Regulation Of Immune System Process
Integrin-mediated Signaling Pathway
Cellular Extravasation
Formation Of Primary Germ Layer
Calcium-independent Cell-matrix Adhesion
Positive Regulation Of Cellular Protein Metabolic Process
Viral Entry Into Host Cell
Substrate Adhesion-dependent Cell Spreading
Entry Into Host Cell
Positive Regulation Of Protein Metabolic Process
Gastrulation
Locomotion
Cell Junction Assembly
Cell Differentiation
Cell Migration
Cell Motility
Positive Regulation Of Protein Modification Process
Movement Of Cell Or Subcellular Component
Mesoderm Formation
Activation Of Protein Kinase Activity
Mesoderm Morphogenesis
Embryonic Morphogenesis
Tissue Morphogenesis
Interaction With Host
Tissue Development
Activation Of Protein Kinase A Activity
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Cellular Metabolic Process
Regulation Of Cellular Component Organization
Mesoderm Development
Regulation Of Cellular Protein Metabolic Process
Multicellular Organismal Development
Blood Coagulation
Hemostasis
Positive Regulation Of Phosphorylation
Positive Regulation Of MAPK Cascade
Cardiovascular System Development
Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of Immune Response
Anatomical Structure Development
ERBB Signaling Pathway
Renal Water Homeostasis
Cell Adhesion
Regulation Of Body Fluid Levels
Extracellular Matrix Organization
Extracellular Structure Organization
Leukocyte Tethering Or Rolling
Cell Activation
Platelet Activation
Blood Coagulation
Hemostasis
Single Organismal Cell-cell Adhesion
Cellular Extravasation
Wound Healing
Positive Regulation Of Cellular Protein Metabolic Process
B Cell Activation
Response To Wounding
Cell-matrix Adhesion
Positive Regulation Of Protein Metabolic Process
Receptor Clustering
Cell Junction Assembly
Cell-substrate Adhesion
Regulation Of Immune Response
Leukocyte Migration
Positive Regulation Of Protein Modification Process
Platelet Degranulation
Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules
Cell-cell Adhesion
Chorio-allantoic Fusion
Regulation Of Protein Metabolic Process
Signal Transduction
Regulation Of Cellular Process
Anatomical Structure Morphogenesis
Cellular Response To Stimulus
Response To Stimulus
Developmental Process
Cell Differentiation
Cell Morphogenesis Involved In Differentiation
Integrin-mediated Signaling Pathway
Protein Localization To Membrane
Signaling
Locomotion
Cell Communication
Regulation Of Immune System Process
Regulation Of Cellular Protein Metabolic Process
Labyrinthine Layer Morphogenesis
Heterotypic Cell-cell Adhesion
Lymphocyte Activation
Multicellular Organismal Development
Cell Migration
Membrane Organization
Embryonic Placenta Morphogenesis
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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