ITGA4 and ICAM4

Number of citations of the paper that reports this interaction (PMID 11435317)
8

Data Source:
HPRD (in vitro)

		ITGA4	ICAM4
Gene Name		integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)	intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Cell-cell Junction Focal Adhesion External Side Of Plasma Membrane Cell Surface Membrane Integrin Alpha4-beta7 Complex Extracellular Vesicular Exosome	Extracellular Space Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	Fibronectin Binding Protein Binding Metal Ion Binding Cell Adhesion Molecule Binding	Integrin Binding
	Biological Process	Blood Vessel Remodeling Cell-matrix Adhesion Involved In Ameboidal Cell Migration Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Heart Development Blood Coagulation B Cell Differentiation Extracellular Matrix Organization Heterotypic Cell-cell Adhesion Substrate Adhesion-dependent Cell Spreading Endodermal Cell Differentiation Receptor Clustering Regulation Of Immune Response Leukocyte Migration Leukocyte Tethering Or Rolling Face Development Chorio-allantoic Fusion T Cell Migration Negative Regulation Of Protein Homodimerization Activity	Cell Adhesion Single Organismal Cell-cell Adhesion Extracellular Matrix Organization Regulation Of Immune Response
Pathways		Integrin cell surface interactions Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Cell surface interactions at the vascular wall Adaptive Immune System	Integrin cell surface interactions Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System
Drugs		Natalizumab Tinzaparin
Diseases
GWAS		Celiac disease ( 20190752) Monocyte count ( 23314186) White blood cell count ( 21738480) White blood cell types ( 21738478)
Protein-Protein Interactions		16 interactors: ADAM28 CD81 CD82 EED FN1 ICAM4 ITGB1 ITGB7 LGALS8 LPXN MADCAM1 PRKACA PRKAR1A PXN TGFB1I1 VCAN	8 interactors: ITGA4 ITGAM ITGAV ITGB1 ITGB2 KRT31 NOTCH2NL RHAG
Entrez ID		3676	3386
HPRD ID		01894	00198
Ensembl ID		ENSG00000115232	ENSG00000105371
Uniprot IDs		P13612	Q14773
PDB IDs		3V4P 3V4V 4HKC
Enriched GO Terms of Interacting Partners?		Cell Adhesion Extracellular Matrix Organization Extracellular Structure Organization Cell-matrix Adhesion Leukocyte Tethering Or Rolling Cell-substrate Adhesion Leukocyte Migration Heterotypic Cell-cell Adhesion Regulation Of Immune System Process Integrin-mediated Signaling Pathway Cellular Extravasation Formation Of Primary Germ Layer Calcium-independent Cell-matrix Adhesion Positive Regulation Of Cellular Protein Metabolic Process Viral Entry Into Host Cell Substrate Adhesion-dependent Cell Spreading Entry Into Host Cell Positive Regulation Of Protein Metabolic Process Gastrulation Locomotion Cell Junction Assembly Cell Differentiation Cell Migration Cell Motility Positive Regulation Of Protein Modification Process Movement Of Cell Or Subcellular Component Mesoderm Formation Activation Of Protein Kinase Activity Mesoderm Morphogenesis Embryonic Morphogenesis Tissue Morphogenesis Interaction With Host Tissue Development Activation Of Protein Kinase A Activity Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Metabolic Process Regulation Of Cellular Component Organization Mesoderm Development Regulation Of Cellular Protein Metabolic Process Multicellular Organismal Development Blood Coagulation Hemostasis Positive Regulation Of Phosphorylation Positive Regulation Of MAPK Cascade Cardiovascular System Development Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Immune Response Anatomical Structure Development ERBB Signaling Pathway Renal Water Homeostasis	Heterotypic Cell-cell Adhesion Cellular Extravasation Integrin-mediated Signaling Pathway Leukocyte Migration Extracellular Matrix Organization Extracellular Structure Organization Formation Of Primary Germ Layer Blood Coagulation Hemostasis Cell-matrix Adhesion Endodermal Cell Differentiation Single Organismal Cell-cell Adhesion Gastrulation Cell-substrate Adhesion Regulation Of Body Fluid Levels Wound Healing Endoderm Formation Response To Wounding Leukocyte Cell-cell Adhesion Endoderm Development Cell Migration Tissue Development Cell Motility Lymphocyte Activation Leukocyte Migration Involved In Inflammatory Response Leukocyte Tethering Or Rolling Developmental Process Cell Differentiation Leukocyte Activation Immune System Process Cell Adhesion Ameboidal-type Cell Migration Locomotion Activated T Cell Proliferation Chemotaxis Hemopoiesis Embryonic Morphogenesis Cell Activation Movement Of Cell Or Subcellular Component Immune System Development Viral Entry Into Host Cell Multicellular Organismal Development Entry Into Host Cell Substrate Adhesion-dependent Cell Spreading Neutrophil Chemotaxis Anatomical Structure Development Neutrophil Migration Regulation Of Immune Response Cell Surface Receptor Signaling Pathway Cell Development
Tagcloud ?			1beta activateds ccl20 ccl5 cl1 cldn1 csf2 cx cxcl1 cxcl10 cxcl11 cxcl3 cxcl5 cxcl6 granulocytes icam1 il23a il32 increaseds interleukins kappabeta laminin leucocyte metalloproteins mmp1 mmp3 msc survive trophic
Tagcloud (Difference) ?			1beta activateds ccl20 ccl5 cl1 cldn1 csf2 cx cxcl1 cxcl10 cxcl11 cxcl3 cxcl5 cxcl6 granulocytes icam1 il23a il32 increaseds interleukins kappabeta laminin leucocyte metalloproteins mmp1 mmp3 msc survive trophic
Tagcloud (Intersection) ?