ITGA4 and ICAM4

Number of citations: 0 (PubMedID 11435317)
Data Source: HPRD (in vitro)

		ITGA4	ICAM4
Name		integrin subunit alpha 4	intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
Structure			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Focal Adhesion Integrin Complex Cell Surface Membrane Growth Cone Integrin Alpha4-beta1 Complex Integrin Alpha4-beta7 Complex Neuronal Cell Body Extracellular Exosome	Extracellular Region Plasma Membrane Membrane
	Molecular Function	Fibronectin Binding Antigen Binding Integrin Binding Protein Binding Coreceptor Activity C-X3-C Chemokine Binding Signaling Receptor Activity Metal Ion Binding Cell Adhesion Molecule Binding Protein Antigen Binding	Integrin Binding Protein Binding
	Biological Process	Immune Response In Gut-associated Lymphoid Tissue Positive Regulation Of Leukocyte Migration Cell-matrix Adhesion Involved In Ameboidal Cell Migration Cell Adhesion Leukocyte Cell-cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Tissue Development B Cell Differentiation Cell-cell Adhesion Mediated By Integrin Heterotypic Cell-cell Adhesion Substrate Adhesion-dependent Cell Spreading Endodermal Cell Differentiation Receptor Clustering Negative Regulation Of Vasoconstriction Embryonic Morphogenesis Leukocyte Migration Leukocyte Tethering Or Rolling Diapedesis Axonogenesis Involved In Innervation Cellular Response To Cytokine Stimulus Negative Regulation Of Protein Homodimerization Activity Cell-cell Adhesion Import Into Cell Positive Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Leukocyte Tethering Or Rolling Cellular Response To Amyloid-beta Positive Regulation Of Vascular Endothelial Cell Proliferation Neuron Projection Extension Clathrin-dependent Extracellular Exosome Endocytosis Positive Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of T Cell Migration	Cell Adhesion Cell-cell Adhesion
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Cell surface interactions at the vascular wall Integrin cell surface interactions Integrin cell surface interactions RUNX3 Regulates Immune Response and Cell Migration Potential therapeutics for SARS	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Integrin cell surface interactions
Drugs		Natalizumab ATL1102 CDP323 R1295 R411 Tinzaparin Vedolizumab MK-0668	None
GWAS		Autoimmune traits (pleiotropy) ( 30572963 ) Celiac disease ( 20190752 22057235 ) Crohn's disease ( 28067908 ) Granulocyte percentage of myeloid white cells ( 27863252 ) High light scatter reticulocyte count ( 27863252 32888494 ) High light scatter reticulocyte percentage of red cells ( 27863252 32888494 ) Immature fraction of reticulocytes ( 27863252 32888494 ) Inflammatory bowel disease ( 28067908 ) Lymphocyte percentage of white cells ( 32888494 27863252 ) Mean reticulocyte volume ( 32888494 ) Monocyte count ( 23314186 32888494 29403010 28193307 27863252 25096241 ) Monocyte percentage of white cells ( 27863252 32888494 ) Monocyte-lymphocyte ratio ( 28193307 ) Multiple sclerosis ( 24076602 ) Neurofibrillary tangles ( 25188341 ) Neutrophil count ( 32888494 ) Neutrophil percentage of white cells ( 32888494 ) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245 ) Refractive error ( 32231278 ) Reticulocyte count ( 32888494 ) Reticulocyte fraction of red cells ( 32888494 ) Serum alkaline phosphatase levels ( 33547301 ) Sweet taste preference ( 32572145 ) Ulcerative colitis ( 28067908 ) White blood cell count ( 29403010 21738480 32888494 ) White blood cell count (basophil) ( 29403010 ) White blood cell count (monocyte) ( 28158719 ) White blood cell types ( 21738478 )	Blood protein levels ( 30072576 )
Novel Interactors		None recorded	1 novel interactors: AKAP8L
Interacting Genes		16 interacting genes: ADAM28 CD81 CD82 EED FN1 ICAM4 ITGB1 ITGB7 LGALS8 LPXN MADCAM1 PRKACA PRKAR1A PXN TGFB1I1 VCAN	14 interacting genes: CREB3 CYSRT1 ITGA4 ITGAM ITGAV ITGB1 ITGB2 KRT31 KRT34 KRTAP5-9 MTUS2 NBPF19 NOTCH2NLA RHAG
Entrez ID		3676	3386
HPRD ID		01894	00198
Ensembl ID		ENSG00000115232	ENSG00000105371
Uniprot IDs		P13612	Q14773 U5U6P8
PDB IDs		3V4P 3V4V 4HKC 5C7Z 5FPI	Not available
GO Terms Enriched among Interactors		Integrin Binding Cell-substrate Adhesion Endothelial Cell Migration Cell Adhesion Substrate Adhesion-dependent Cell Spreading Leukocyte Tethering Or Rolling Leukocyte Adhesion To Vascular Endothelial Cell Focal Adhesion Integrin-mediated Signaling Pathway Cell-matrix Adhesion Calcium-independent Cell-matrix Adhesion Heterotypic Cell-cell Adhesion Cell Migration Integrin Binding Involved In Cell-matrix Adhesion Leukocyte Cell-cell Adhesion Cell Motility CAMP-dependent Protein Kinase Complex Cellular Response To Glucagon Stimulus Nucleotide-activated Protein Kinase Complex Neuromuscular Junction Virus Receptor Activity Plasma Membrane Transforming Growth Factor Beta Receptor Signaling Pathway Response To Glucagon Symbiont Entry Into Host Cell Cell Surface Receptor Signaling Pathway Regulation Of B Cell Receptor Signaling Pathway Integrin Complex Myoblast Fusion Cell Adhesion Mediated By Integrin Response To Muscle Activity Cellular Response To Low-density Lipoprotein Particle Stimulus Biological Process Involved In Interaction With Host Anchoring Junction Plasma Membrane Raft Cell-cell Fusion Syncytium Formation By Plasma Membrane Fusion Cellular Response To Lipoprotein Particle Stimulus Syncytium Formation Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Positive Regulation Of Protein Localization Regulation Of Cell Adhesion Anatomical Structure Formation Involved In Morphogenesis Sarcomere Organization Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Ciliary Base T Cell Costimulation Immunological Synapse Mesoderm Formation Macrophage Fusion	Integrin Complex Heterotypic Cell-cell Adhesion C-X3-C Chemokine Binding Cell Adhesion Mediated By Integrin Integrin-mediated Signaling Pathway Cell-matrix Adhesion Integrin Binding Cell-substrate Adhesion Integrin AlphaM-beta2 Complex Integrin Alphav-beta1 Complex Fibronectin Binding Integrin Alpha4-beta1 Complex Positive Regulation Of Neutrophil Degranulation Endodermal Cell Differentiation Negative Regulation Of Dopamine Metabolic Process Epidermis Development Negative Regulation Of Catecholamine Metabolic Process Receptor-mediated Endocytosis Leukocyte Cell-cell Adhesion Cell-cell Adhesion Mediated By Integrin Regulation Of Neutrophil Degranulation Coreceptor Activity Tissue Development Endocytosis Complement Component C3b Binding Cell-cell Adhesion Specific Granule Membrane Negative Regulation Of Vasoconstriction Signaling Receptor Activity Cell Adhesion Molecule Binding Phagocytosis Wound Healing, Spreading Of Epidermal Cells Import Into Cell Leukocyte Tethering Or Rolling Regulation Of Dopamine Metabolic Process Positive Regulation Of Superoxide Anion Generation Regulation Of Superoxide Anion Generation Cell Surface Leukocyte Adhesion To Vascular Endothelial Cell Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell External Side Of Plasma Membrane Cellular Developmental Process Cargo Receptor Activity Positive Regulation Of Protein Targeting To Membrane Amyloid-beta Clearance Regulation Of Superoxide Metabolic Process Wound Healing, Spreading Of Cells Microglial Cell Activation Phagocytosis, Engulfment Cell Differentiation