Wiki-Pi
About
Search
People
Updates
Search
ITGA4 and LGALS8
Number of citations of the paper that reports this interaction (PubMedID
10852818
)
0
Data Source:
HPRD
(in vitro, in vivo)
ITGA4
LGALS8
Description
integrin subunit alpha 4
galectin 8
Image
GO Annotations
Cellular Component
Plasma Membrane
Focal Adhesion
Integrin Complex
Cell Surface
Membrane
Growth Cone
Integrin Alpha4-beta1 Complex
Integrin Alpha4-beta7 Complex
Neuronal Cell Body
Extracellular Exosome
Extracellular Space
Cytoplasm
Cytosol
Membrane
Cytoplasmic Vesicle
Molecular Function
Fibronectin Binding
Antigen Binding
Integrin Binding
Protein Binding
Coreceptor Activity
C-X3-C Chemokine Binding
Signaling Receptor Activity
Metal Ion Binding
Cell Adhesion Molecule Binding
Protein Antigen Binding
Integrin Binding
Protein Binding
Carbohydrate Binding
Biological Process
Immune Response In Gut-associated Lymphoid Tissue
Positive Regulation Of Leukocyte Migration
Cell-matrix Adhesion Involved In Ameboidal Cell Migration
Cell Adhesion
Leukocyte Cell-cell Adhesion
Cell-matrix Adhesion
Integrin-mediated Signaling Pathway
Tissue Development
B Cell Differentiation
Cell-cell Adhesion Mediated By Integrin
Heterotypic Cell-cell Adhesion
Substrate Adhesion-dependent Cell Spreading
Endodermal Cell Differentiation
Receptor Clustering
Negative Regulation Of Vasoconstriction
Embryonic Morphogenesis
Leukocyte Migration
Leukocyte Tethering Or Rolling
Diapedesis
Axonogenesis Involved In Innervation
Cellular Response To Cytokine Stimulus
Negative Regulation Of Protein Homodimerization Activity
Cell-cell Adhesion
Import Into Cell
Positive Regulation Of Leukocyte Cell-cell Adhesion
Positive Regulation Of Leukocyte Tethering Or Rolling
Cellular Response To Amyloid-beta
Positive Regulation Of Vascular Endothelial Cell Proliferation
Neuron Projection Extension
Clathrin-dependent Extracellular Exosome Endocytosis
Positive Regulation Of Endothelial Cell Apoptotic Process
Positive Regulation Of T Cell Migration
Plasma Cell Differentiation
Autophagy
T Cell Costimulation
Cellular Response To Virus
Xenophagy
Lymphatic Endothelial Cell Migration
Pathways
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Cell surface interactions at the vascular wall
Integrin cell surface interactions
Integrin cell surface interactions
RUNX3 Regulates Immune Response and Cell Migration
Potential therapeutics for SARS
Drugs
Natalizumab
ATL1102
CDP323
R1295
R411
Tinzaparin
Vedolizumab
MK-0668
Diseases
GWAS
Autoimmune traits (pleiotropy) (
30572963
)
Celiac disease (
20190752
22057235
)
Crohn's disease (
28067908
)
Granulocyte percentage of myeloid white cells (
27863252
)
High light scatter reticulocyte count (
27863252
32888494
)
High light scatter reticulocyte percentage of red cells (
27863252
32888494
)
Immature fraction of reticulocytes (
27863252
32888494
)
Inflammatory bowel disease (
28067908
)
Lymphocyte percentage of white cells (
32888494
27863252
)
Mean reticulocyte volume (
32888494
)
Monocyte count (
23314186
32888494
29403010
28193307
27863252
25096241
)
Monocyte percentage of white cells (
27863252
32888494
)
Monocyte-lymphocyte ratio (
28193307
)
Multiple sclerosis (
24076602
)
Neurofibrillary tangles (
25188341
)
Neutrophil count (
32888494
)
Neutrophil percentage of white cells (
32888494
)
Post bronchodilator FEV1/FVC ratio in COPD (
26634245
)
Refractive error (
32231278
)
Reticulocyte count (
32888494
)
Reticulocyte fraction of red cells (
32888494
)
Serum alkaline phosphatase levels (
33547301
)
Sweet taste preference (
32572145
)
Ulcerative colitis (
28067908
)
White blood cell count (
29403010
21738480
32888494
)
White blood cell count (basophil) (
29403010
)
White blood cell count (monocyte) (
28158719
)
White blood cell types (
21738478
)
Platelet count (
32888494
)
Platelet distribution width (
32888494
)
Plateletcrit (
32888494
)
Interacting Genes
16 interacting genes:
ADAM28
CD81
CD82
EED
FN1
ICAM4
ITGB1
ITGB7
LGALS8
LPXN
MADCAM1
PRKACA
PRKAR1A
PXN
TGFB1I1
VCAN
22 interacting genes:
ANXA1
APEH
BARD1
CALCOCO2
ERBB2
G3BP1
ITGA3
ITGA4
ITGB1
LRRK2
MEFV
MID2
NACC1
NR1D2
NUFIP2
TRIM17
TRIM22
TRIM23
TRIM49
TRIM5
TRIM6
WBP2
Entrez ID
3676
3964
HPRD ID
01894
09356
Ensembl ID
ENSG00000115232
ENSG00000116977
Uniprot IDs
P13612
O00214
PDB IDs
3V4P
3V4V
4HKC
5C7Z
5FPI
2YRO
2YV8
2YXS
3AP4
3AP5
3AP6
3AP7
3AP9
3APB
3OJB
3VKL
3VKM
3VKN
3VKO
4BMB
4BME
4FQZ
4GXL
4HAN
5GZC
5GZD
5GZE
5GZF
5GZG
5T7I
5T7S
5T7T
5T7U
5VWG
6W4Z
6Z6Y
7AEN
7ALS
7P1M
8CM8
8HL9
9FYJ
Enriched GO Terms of Interacting Partners
?
Integrin Binding
Cell-substrate Adhesion
Endothelial Cell Migration
Cell Adhesion
Substrate Adhesion-dependent Cell Spreading
Leukocyte Tethering Or Rolling
Leukocyte Adhesion To Vascular Endothelial Cell
Focal Adhesion
Integrin-mediated Signaling Pathway
Cell-matrix Adhesion
Calcium-independent Cell-matrix Adhesion
Heterotypic Cell-cell Adhesion
Cell Migration
Integrin Binding Involved In Cell-matrix Adhesion
Leukocyte Cell-cell Adhesion
Cell Motility
CAMP-dependent Protein Kinase Complex
Cellular Response To Glucagon Stimulus
Nucleotide-activated Protein Kinase Complex
Neuromuscular Junction
Virus Receptor Activity
Plasma Membrane
Transforming Growth Factor Beta Receptor Signaling Pathway
Response To Glucagon
Symbiont Entry Into Host Cell
Cell Surface Receptor Signaling Pathway
Regulation Of B Cell Receptor Signaling Pathway
Integrin Complex
Myoblast Fusion
Cell Adhesion Mediated By Integrin
Response To Muscle Activity
Cellular Response To Low-density Lipoprotein Particle Stimulus
Biological Process Involved In Interaction With Host
Anchoring Junction
Plasma Membrane Raft
Cell-cell Fusion
Syncytium Formation By Plasma Membrane Fusion
Cellular Response To Lipoprotein Particle Stimulus
Syncytium Formation
Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
Positive Regulation Of Protein Localization
Regulation Of Cell Adhesion
Anatomical Structure Formation Involved In Morphogenesis
Sarcomere Organization
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
Ciliary Base
T Cell Costimulation
Immunological Synapse
Mesoderm Formation
Macrophage Fusion
Ubiquitin Protein Ligase Activity
Innate Immune Response
Immune System Process
Defense Response To Symbiont
Defense Response To Other Organism
Positive Regulation Of Autophagy
Immune Response
Positive Regulation Of Metabolic Process
Defense Response
Regulation Of Metabolic Process
Response To Other Organism
Integrin Alpha3-beta1 Complex
Response To External Biotic Stimulus
Integrin Alpha4-beta1 Complex
Metal Ion Binding
Positive Regulation Of Catabolic Process
Integrin Complex
Positive Regulation Of Macromolecule Metabolic Process
Cytoplasm
Response To Stress
Regulation Of Autophagy
Fibronectin Binding
Protein Ubiquitination
Zinc Ion Binding
Regulation Of Protein Localization
C-X3-C Chemokine Binding
Protein Modification Process
Protein Modification By Small Protein Conjugation
Regulation Of Gene Expression
Positive Regulation Of Macromolecule Biosynthetic Process
Defense Response To Virus
Cell-cell Adhesion Mediated By Integrin
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Biosynthetic Process
Coreceptor Activity
Regulation Of Defense Response
Post-translational Protein Modification
Positive Regulation Of Gene Expression
Regulation Of Intracellular Signal Transduction
Negative Regulation Of Vasoconstriction
Response To Virus
Neuromuscular Junction
Mesodermal Cell Differentiation
Protein-macromolecule Adaptor Activity
Focal Adhesion
Transferase Activity
Regulation Of Rho Protein Signal Transduction
Suppression Of Viral Release By Host
Positive Regulation Of Immune System Process
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?