ITGA4 and ADAM28

Number of citations of the paper that reports this interaction (PubMedID 11724793)
0

Data Source:
HPRD (in vitro)

		ITGA4	ADAM28
Description		integrin subunit alpha 4	ADAM metallopeptidase domain 28
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Focal Adhesion Integrin Complex Cell Surface Membrane Growth Cone Integrin Alpha4-beta1 Complex Integrin Alpha4-beta7 Complex Neuronal Cell Body Extracellular Exosome	Extracellular Region Mitochondrion Plasma Membrane Cell Surface Membrane
	Molecular Function	Fibronectin Binding Antigen Binding Integrin Binding Protein Binding Coreceptor Activity C-X3-C Chemokine Binding Signaling Receptor Activity Metal Ion Binding Cell Adhesion Molecule Binding Protein Antigen Binding	Metalloendopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Hydrolase Activity Immunoglobulin Receptor Binding Metal Ion Binding
	Biological Process	Immune Response In Gut-associated Lymphoid Tissue Positive Regulation Of Leukocyte Migration Cell-matrix Adhesion Involved In Ameboidal Cell Migration Cell Adhesion Leukocyte Cell-cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Tissue Development B Cell Differentiation Cell-cell Adhesion Mediated By Integrin Heterotypic Cell-cell Adhesion Substrate Adhesion-dependent Cell Spreading Endodermal Cell Differentiation Receptor Clustering Negative Regulation Of Vasoconstriction Embryonic Morphogenesis Leukocyte Migration Leukocyte Tethering Or Rolling Diapedesis Axonogenesis Involved In Innervation Cellular Response To Cytokine Stimulus Negative Regulation Of Protein Homodimerization Activity Cell-cell Adhesion Import Into Cell Positive Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Leukocyte Tethering Or Rolling Cellular Response To Amyloid-beta Positive Regulation Of Vascular Endothelial Cell Proliferation Neuron Projection Extension Clathrin-dependent Extracellular Exosome Endocytosis Positive Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of T Cell Migration	Proteolysis Spermatogenesis
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Cell surface interactions at the vascular wall Integrin cell surface interactions Integrin cell surface interactions RUNX3 Regulates Immune Response and Cell Migration Potential therapeutics for SARS
Drugs		Natalizumab ATL1102 CDP323 R1295 R411 Tinzaparin Vedolizumab MK-0668	N-[(Furan-2-Yl)Carbonyl]-(S)-Leucyl-(R)-[1-Amino-2(1h-Indol-3-Yl)Ethyl]-Phosphonic Acid Furoyl-Leucine Ilomastat 2-(Thiomethylene)-4-Methylpentanoic Acid Pidolic acid Batimastat (2R,3R)-N^1^-[(1S)-2,2-DIMETHYL-1-(METHYLCARBAMOYL)PROPYL]-N^4^-HYDROXY-2-(2-METHYLPROPYL)-3-{[(1,3-THIAZOL-2-YLCARBONYL)AMINO]METHYL}BUTANEDIAMIDE
Diseases
GWAS		Autoimmune traits (pleiotropy) ( 30572963) Celiac disease ( 20190752 22057235) Crohn's disease ( 28067908) Granulocyte percentage of myeloid white cells ( 27863252) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 27863252 32888494) Inflammatory bowel disease ( 28067908) Lymphocyte percentage of white cells ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Monocyte count ( 23314186 32888494 29403010 28193307 27863252 25096241) Monocyte percentage of white cells ( 27863252 32888494) Monocyte-lymphocyte ratio ( 28193307) Multiple sclerosis ( 24076602) Neurofibrillary tangles ( 25188341) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Refractive error ( 32231278) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Serum alkaline phosphatase levels ( 33547301) Sweet taste preference ( 32572145) Ulcerative colitis ( 28067908) White blood cell count ( 29403010 21738480 32888494) White blood cell count (basophil) ( 29403010) White blood cell count (monocyte) ( 28158719) White blood cell types ( 21738478)	Ankylosing spondylitis ( 30946743) Blood urea nitrogen levels ( 29403010) Creatinine levels ( 29403010) Estimated glomerular filtration rate ( 31015462) Glomerular filtration rate ( 29403010) Hair greying ( 26926045) Height ( 20881960) Serum uric acid levels ( 30993211) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		16 interacting genes: ADAM28 CD81 CD82 EED FN1 ICAM4 ITGB1 ITGB7 LGALS8 LPXN MADCAM1 PRKACA PRKAR1A PXN TGFB1I1 VCAN	2 interacting genes: ITGA4 PLAU
Entrez ID		3676	10863
HPRD ID		01894	08391
Ensembl ID		ENSG00000115232	ENSG00000042980
Uniprot IDs		P13612	A0A384NKT9 Q9UKQ2
PDB IDs		3V4P 3V4V 4HKC 5C7Z 5FPI
Enriched GO Terms of Interacting Partners?		Integrin Binding Cell-substrate Adhesion Endothelial Cell Migration Cell Adhesion Substrate Adhesion-dependent Cell Spreading Leukocyte Tethering Or Rolling Leukocyte Adhesion To Vascular Endothelial Cell Focal Adhesion Integrin-mediated Signaling Pathway Cell-matrix Adhesion Calcium-independent Cell-matrix Adhesion Heterotypic Cell-cell Adhesion Cell Migration Integrin Binding Involved In Cell-matrix Adhesion Leukocyte Cell-cell Adhesion Cell Motility CAMP-dependent Protein Kinase Complex Cellular Response To Glucagon Stimulus Nucleotide-activated Protein Kinase Complex Neuromuscular Junction Virus Receptor Activity Plasma Membrane Transforming Growth Factor Beta Receptor Signaling Pathway Response To Glucagon Symbiont Entry Into Host Cell Cell Surface Receptor Signaling Pathway Regulation Of B Cell Receptor Signaling Pathway Integrin Complex Myoblast Fusion Cell Adhesion Mediated By Integrin Response To Muscle Activity Cellular Response To Low-density Lipoprotein Particle Stimulus Biological Process Involved In Interaction With Host Anchoring Junction Plasma Membrane Raft Cell-cell Fusion Syncytium Formation By Plasma Membrane Fusion Cellular Response To Lipoprotein Particle Stimulus Syncytium Formation Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Positive Regulation Of Protein Localization Regulation Of Cell Adhesion Anatomical Structure Formation Involved In Morphogenesis Sarcomere Organization Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Ciliary Base T Cell Costimulation Immunological Synapse Mesoderm Formation Macrophage Fusion	Clathrin-dependent Extracellular Exosome Endocytosis Cell-matrix Adhesion Involved In Ameboidal Cell Migration Negative Regulation Of Protein Homodimerization Activity Integrin Alpha4-beta7 Complex Urokinase Plasminogen Activator Signaling Pathway Integrin Alpha4-beta1 Complex C-X3-C Chemokine Binding Focal Adhesion Immune Response In Gut-associated Lymphoid Tissue Serine Protease Inhibitor Complex Regulation Of Smooth Muscle Cell-matrix Adhesion Positive Regulation Of Leukocyte Tethering Or Rolling Positive Regulation Of Locomotion Positive Regulation Of Cell Migration Diapedesis Axonogenesis Involved In Innervation Positive Regulation Of Cell Motility Protein Antigen Binding Cell-cell Adhesion Mediated By Integrin Serine-type Endopeptidase Complex Negative Regulation Of Plasminogen Activation Protein Complex Involved In Cell-matrix Adhesion Plasminogen Activation Negative Regulation Of Vasoconstriction Cell Surface Smooth Muscle Cell Migration Negative Regulation Of Fibrinolysis Regulation Of Leukocyte Tethering Or Rolling Regulation Of Fibrinolysis Regulation Of Plasminogen Activation Negative Regulation Of Protein Binding Regulation Of Cell Motility Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Positive Regulation Of T Cell Migration Fibronectin Binding Leukocyte Adhesion To Vascular Endothelial Cell Regulation Of Cell Migration Regulation Of Cell Adhesion Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Regulation Of Locomotion Leukocyte Tethering Or Rolling Regulation Of Cellular Extravasation Endodermal Cell Differentiation Cell Migration Clathrin-dependent Endocytosis Integrin Complex Cell Motility Antigen Binding Regulation Of Vascular Endothelial Cell Proliferation Heterotypic Cell-cell Adhesion
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