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ITGA4 and ADAM28
Number of citations of the paper that reports this interaction (PMID
11724793
)
15
Data Source:
HPRD
(in vitro)
ITGA4
ADAM28
Gene Name
integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ADAM metallopeptidase domain 28
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Plasma Membrane
Cell-cell Junction
Focal Adhesion
External Side Of Plasma Membrane
Cell Surface
Membrane
Integrin Alpha4-beta7 Complex
Extracellular Vesicular Exosome
Extracellular Region
Plasma Membrane
Integral Component Of Membrane
Molecular Function
Fibronectin Binding
Protein Binding
Metal Ion Binding
Cell Adhesion Molecule Binding
Metalloendopeptidase Activity
Metallopeptidase Activity
Zinc Ion Binding
Biological Process
Blood Vessel Remodeling
Cell-matrix Adhesion Involved In Ameboidal Cell Migration
Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules
Leukocyte Cell-cell Adhesion
Cell-matrix Adhesion
Integrin-mediated Signaling Pathway
Heart Development
Blood Coagulation
B Cell Differentiation
Extracellular Matrix Organization
Heterotypic Cell-cell Adhesion
Substrate Adhesion-dependent Cell Spreading
Endodermal Cell Differentiation
Receptor Clustering
Regulation Of Immune Response
Leukocyte Migration
Leukocyte Tethering Or Rolling
Face Development
Chorio-allantoic Fusion
T Cell Migration
Negative Regulation Of Protein Homodimerization Activity
Proteolysis
Spermatogenesis
Pathways
Integrin cell surface interactions
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Cell surface interactions at the vascular wall
Adaptive Immune System
Drugs
Natalizumab
Tinzaparin
Diseases
GWAS
Celiac disease (
20190752
)
Monocyte count (
23314186
)
White blood cell count (
21738480
)
White blood cell types (
21738478
)
Height (
20881960
)
Protein-Protein Interactions
16 interactors:
ADAM28
CD81
CD82
EED
FN1
ICAM4
ITGB1
ITGB7
LGALS8
LPXN
MADCAM1
PRKACA
PRKAR1A
PXN
TGFB1I1
VCAN
1 interactors:
ITGA4
Entrez ID
3676
10863
HPRD ID
01894
08391
Ensembl ID
ENSG00000115232
ENSG00000042980
Uniprot IDs
P13612
Q9UKQ2
PDB IDs
3V4P
3V4V
4HKC
Enriched GO Terms of Interacting Partners
?
Cell Adhesion
Extracellular Matrix Organization
Extracellular Structure Organization
Cell-matrix Adhesion
Leukocyte Tethering Or Rolling
Cell-substrate Adhesion
Leukocyte Migration
Heterotypic Cell-cell Adhesion
Regulation Of Immune System Process
Integrin-mediated Signaling Pathway
Cellular Extravasation
Formation Of Primary Germ Layer
Calcium-independent Cell-matrix Adhesion
Positive Regulation Of Cellular Protein Metabolic Process
Viral Entry Into Host Cell
Substrate Adhesion-dependent Cell Spreading
Entry Into Host Cell
Positive Regulation Of Protein Metabolic Process
Gastrulation
Locomotion
Cell Junction Assembly
Cell Differentiation
Cell Migration
Cell Motility
Positive Regulation Of Protein Modification Process
Movement Of Cell Or Subcellular Component
Mesoderm Formation
Activation Of Protein Kinase Activity
Mesoderm Morphogenesis
Embryonic Morphogenesis
Tissue Morphogenesis
Interaction With Host
Tissue Development
Activation Of Protein Kinase A Activity
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Cellular Metabolic Process
Regulation Of Cellular Component Organization
Mesoderm Development
Regulation Of Cellular Protein Metabolic Process
Multicellular Organismal Development
Blood Coagulation
Hemostasis
Positive Regulation Of Phosphorylation
Positive Regulation Of MAPK Cascade
Cardiovascular System Development
Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of Immune Response
Anatomical Structure Development
ERBB Signaling Pathway
Renal Water Homeostasis
Cell-matrix Adhesion Involved In Ameboidal Cell Migration
Negative Regulation Of Protein Homodimerization Activity
Chorio-allantoic Fusion
Leukocyte Tethering Or Rolling
T Cell Migration
Regulation Of Protein Homodimerization Activity
Heterotypic Cell-cell Adhesion
Labyrinthine Layer Morphogenesis
Embryonic Placenta Morphogenesis
Cellular Extravasation
Lymphocyte Migration
Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules
Endodermal Cell Differentiation
Blood Vessel Remodeling
Substrate Adhesion-dependent Cell Spreading
Face Development
Receptor Clustering
Endoderm Formation
Negative Regulation Of Protein Binding
Labyrinthine Layer Development
Endoderm Development
Negative Regulation Of Binding
B Cell Differentiation
Tissue Remodeling
Embryonic Placenta Development
Integrin-mediated Signaling Pathway
Formation Of Primary Germ Layer
Regulation Of Protein Binding
B Cell Activation
Cell-matrix Adhesion
Ameboidal-type Cell Migration
Gastrulation
Placenta Development
Cell-substrate Adhesion
Leukocyte Migration
Lymphocyte Differentiation
Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules
Cell-cell Adhesion
Regulation Of Binding
Leukocyte Cell-cell Adhesion
Leukocyte Differentiation
Protein Localization To Membrane
Extracellular Matrix Organization
Extracellular Structure Organization
Lymphocyte Activation
Blood Coagulation
Hemostasis
Embryonic Organ Development
Leukocyte Activation
Reproductive Structure Development
Tagcloud
?
1e
3e
7e
accessed
adenocarcinomas
anxa3
cabig
cadm1
ccne1
cd24
cdk1
cdkn2a
com
datasets
demonstration
ercc1
geo
kmplot
logrank
online
opn
plot
plotted
rad51
repositories
silico
tcga
uni
www
Tagcloud (Difference)
?
1e
3e
7e
accessed
adenocarcinomas
anxa3
cabig
cadm1
ccne1
cd24
cdk1
cdkn2a
com
datasets
demonstration
ercc1
geo
kmplot
logrank
online
opn
plot
plotted
rad51
repositories
silico
tcga
uni
www
Tagcloud (Intersection)
?