ITGA4 and TGFB1I1

Number of citations: 0 (PubMedID 10604475)
Data Source: HPRD (in vitro)

		ITGA4	TGFB1I1
Name		integrin subunit alpha 4	transforming growth factor beta 1 induced transcript 1
Structure			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Focal Adhesion Integrin Complex Cell Surface Membrane Growth Cone Integrin Alpha4-beta1 Complex Integrin Alpha4-beta7 Complex Neuronal Cell Body Extracellular Exosome	Nucleus Cytoplasm Cytosol Cytoskeleton Focal Adhesion Nuclear Matrix Extracellular Matrix Anchoring Junction
	Molecular Function	Fibronectin Binding Antigen Binding Integrin Binding Protein Binding Coreceptor Activity C-X3-C Chemokine Binding Signaling Receptor Activity Metal Ion Binding Cell Adhesion Molecule Binding Protein Antigen Binding	Transcription Coactivator Activity Protein Binding Metal Ion Binding Roundabout Binding Nuclear Androgen Receptor Binding I-SMAD Binding
	Biological Process	Immune Response In Gut-associated Lymphoid Tissue Positive Regulation Of Leukocyte Migration Cell-matrix Adhesion Involved In Ameboidal Cell Migration Cell Adhesion Leukocyte Cell-cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Tissue Development B Cell Differentiation Cell-cell Adhesion Mediated By Integrin Heterotypic Cell-cell Adhesion Substrate Adhesion-dependent Cell Spreading Endodermal Cell Differentiation Receptor Clustering Negative Regulation Of Vasoconstriction Embryonic Morphogenesis Leukocyte Migration Leukocyte Tethering Or Rolling Diapedesis Axonogenesis Involved In Innervation Cellular Response To Cytokine Stimulus Negative Regulation Of Protein Homodimerization Activity Cell-cell Adhesion Import Into Cell Positive Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Leukocyte Tethering Or Rolling Cellular Response To Amyloid-beta Positive Regulation Of Vascular Endothelial Cell Proliferation Neuron Projection Extension Clathrin-dependent Extracellular Exosome Endocytosis Positive Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of T Cell Migration	Cell Adhesion Negative Regulation Of Cell Population Proliferation Positive Regulation Of Epithelial To Mesenchymal Transition Wnt Signaling Pathway Morphogenesis Of Embryonic Epithelium Cell Differentiation Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Epithelial Cell Differentiation Cell Fate Commitment Fat Cell Differentiation Negative Regulation Of Fat Cell Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Cell surface interactions at the vascular wall Integrin cell surface interactions Integrin cell surface interactions RUNX3 Regulates Immune Response and Cell Migration Potential therapeutics for SARS	None
Drugs		Natalizumab ATL1102 CDP323 R1295 R411 Tinzaparin Vedolizumab MK-0668	None
GWAS		Autoimmune traits (pleiotropy) ( 30572963 ) Celiac disease ( 20190752 22057235 ) Crohn's disease ( 28067908 ) Granulocyte percentage of myeloid white cells ( 27863252 ) High light scatter reticulocyte count ( 27863252 32888494 ) High light scatter reticulocyte percentage of red cells ( 27863252 32888494 ) Immature fraction of reticulocytes ( 27863252 32888494 ) Inflammatory bowel disease ( 28067908 ) Lymphocyte percentage of white cells ( 32888494 27863252 ) Mean reticulocyte volume ( 32888494 ) Monocyte count ( 23314186 32888494 29403010 28193307 27863252 25096241 ) Monocyte percentage of white cells ( 27863252 32888494 ) Monocyte-lymphocyte ratio ( 28193307 ) Multiple sclerosis ( 24076602 ) Neurofibrillary tangles ( 25188341 ) Neutrophil count ( 32888494 ) Neutrophil percentage of white cells ( 32888494 ) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245 ) Refractive error ( 32231278 ) Reticulocyte count ( 32888494 ) Reticulocyte fraction of red cells ( 32888494 ) Serum alkaline phosphatase levels ( 33547301 ) Sweet taste preference ( 32572145 ) Ulcerative colitis ( 28067908 ) White blood cell count ( 29403010 21738480 32888494 ) White blood cell count (basophil) ( 29403010 ) White blood cell count (monocyte) ( 28158719 ) White blood cell types ( 21738478 )	Metabolite levels ( 23823483 )
Novel Interactors		None recorded	2 novel interactors: DOC2A ST3GAL3
Interacting Genes		16 interacting genes: ADAM28 CD81 CD82 EED FN1 ICAM4 ITGB1 ITGB7 LGALS8 LPXN MADCAM1 PRKACA PRKAR1A PXN TGFB1I1 VCAN	33 interacting genes: AR CBLB CBLC CDKN2B CRKL CSK EP300 FKBP1A GIT1 GIT2 GP1BB HIPK3 HOXA1 HSPB1 ITCH ITGA4 MAPK15 NEDD4 NEDD4L NR3C1 PLA2G3 PTK2 PTK2B PTPN12 SDC4 SLC6A3 SMAD7 SVIL TGFBR2 TRAF4 UBQLN4 VCL YAP1
Entrez ID		3676	7041
HPRD ID		01894	03831
Ensembl ID		ENSG00000115232	ENSG00000140682
Uniprot IDs		P13612	O43294
PDB IDs		3V4P 3V4V 4HKC 5C7Z 5FPI	Not available
GO Terms Enriched among Interactors		Integrin Binding Cell-substrate Adhesion Endothelial Cell Migration Cell Adhesion Substrate Adhesion-dependent Cell Spreading Leukocyte Tethering Or Rolling Leukocyte Adhesion To Vascular Endothelial Cell Focal Adhesion Integrin-mediated Signaling Pathway Cell-matrix Adhesion Calcium-independent Cell-matrix Adhesion Heterotypic Cell-cell Adhesion Cell Migration Integrin Binding Involved In Cell-matrix Adhesion Leukocyte Cell-cell Adhesion Cell Motility CAMP-dependent Protein Kinase Complex Cellular Response To Glucagon Stimulus Nucleotide-activated Protein Kinase Complex Neuromuscular Junction Virus Receptor Activity Plasma Membrane Transforming Growth Factor Beta Receptor Signaling Pathway Response To Glucagon Symbiont Entry Into Host Cell Cell Surface Receptor Signaling Pathway Regulation Of B Cell Receptor Signaling Pathway Integrin Complex Myoblast Fusion Cell Adhesion Mediated By Integrin Response To Muscle Activity Cellular Response To Low-density Lipoprotein Particle Stimulus Biological Process Involved In Interaction With Host Anchoring Junction Plasma Membrane Raft Cell-cell Fusion Syncytium Formation By Plasma Membrane Fusion Cellular Response To Lipoprotein Particle Stimulus Syncytium Formation Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Positive Regulation Of Protein Localization Regulation Of Cell Adhesion Anatomical Structure Formation Involved In Morphogenesis Sarcomere Organization Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Ciliary Base T Cell Costimulation Immunological Synapse Mesoderm Formation Macrophage Fusion	Regulation Of Cellular Component Organization Cell Surface Receptor Signaling Pathway Developmental Process Focal Adhesion Regulation Of Signal Transduction Regulation Of Cell Adhesion Regulation Of Cell Communication Regulation Of Signaling Regulation Of Intracellular Signal Transduction Anchoring Junction Regulation Of Multicellular Organismal Process Response To Growth Factor Negative Regulation Of Signal Transduction Cell Activation Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Cell-cell Adhesion Regulation Of CD4-positive, Alpha-beta T Cell Activation Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of T Cell Tolerance Induction Type I Transforming Growth Factor Beta Receptor Binding Cellular Response To Growth Factor Stimulus Leukocyte Activation Positive Regulation Of Tolerance Induction Regulation Of Cell Population Proliferation Signal Transduction Positive Regulation Of Multicellular Organismal Process Regulation Of T Cell Tolerance Induction Anatomical Structure Morphogenesis Transferase Activity Costamere Negative Regulation Of Cell-cell Adhesion Regulation Of Protein Metabolic Process Enzyme-linked Receptor Protein Signaling Pathway Intracellular Signal Transduction Regulation Of Alpha-beta T Cell Activation Positive Regulation Of Cell Adhesion Plasma Membrane Proline-rich Region Binding Cytosol Regulation Of Immune System Process Regulation Of Tolerance Induction Negative Regulation Of T Cell Activation Developmental Growth Protein Modification Process Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Regulation Of T Cell Activation Positive Regulation Of Catabolic Process Regulation Of Apoptotic Process Tissue Morphogenesis