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ITGA4 and VCAN
Number of citations of the paper that reports this interaction (PMID
11083865
)
32
Data Source:
HPRD
(in vitro)
ITGA4
VCAN
Gene Name
integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
versican
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Plasma Membrane
Cell-cell Junction
Focal Adhesion
External Side Of Plasma Membrane
Cell Surface
Membrane
Integrin Alpha4-beta7 Complex
Extracellular Vesicular Exosome
Extracellular Region
Proteinaceous Extracellular Matrix
Extracellular Space
Golgi Lumen
Membrane
Extracellular Matrix
Lysosomal Lumen
Intracellular Membrane-bounded Organelle
Molecular Function
Fibronectin Binding
Protein Binding
Metal Ion Binding
Cell Adhesion Molecule Binding
Extracellular Matrix Structural Constituent
Calcium Ion Binding
Protein Binding
Glycosaminoglycan Binding
Hyaluronic Acid Binding
Carbohydrate Binding
Biological Process
Blood Vessel Remodeling
Cell-matrix Adhesion Involved In Ameboidal Cell Migration
Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules
Leukocyte Cell-cell Adhesion
Cell-matrix Adhesion
Integrin-mediated Signaling Pathway
Heart Development
Blood Coagulation
B Cell Differentiation
Extracellular Matrix Organization
Heterotypic Cell-cell Adhesion
Substrate Adhesion-dependent Cell Spreading
Endodermal Cell Differentiation
Receptor Clustering
Regulation Of Immune Response
Leukocyte Migration
Leukocyte Tethering Or Rolling
Face Development
Chorio-allantoic Fusion
T Cell Migration
Negative Regulation Of Protein Homodimerization Activity
Skeletal System Development
Osteoblast Differentiation
Carbohydrate Metabolic Process
Cell Adhesion
Multicellular Organismal Development
Central Nervous System Development
Heart Development
Cell Recognition
Glial Cell Migration
Pathogenesis
Extracellular Matrix Organization
Glycosaminoglycan Metabolic Process
Chondroitin Sulfate Metabolic Process
Chondroitin Sulfate Biosynthetic Process
Chondroitin Sulfate Catabolic Process
Dermatan Sulfate Biosynthetic Process
Small Molecule Metabolic Process
Pathways
Integrin cell surface interactions
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Cell surface interactions at the vascular wall
Adaptive Immune System
MPS IIIB - Sanfilippo syndrome B
Diseases of glycosylation
Heparan sulfate/heparin (HS-GAG) metabolism
Defective B4GALT7 causes EDS, progeroid type
MPS I - Hurler syndrome
MPS IX - Natowicz syndrome
Chondroitin sulfate/dermatan sulfate metabolism
CS/DS degradation
Defective SLC26A2 causes chondrodysplasias
Glycosaminoglycan metabolism
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
Defective CHST14 causes EDS, musculocontractural type
Defective PAPSS2 causes SEMD-PA
MPS IIIA - Sanfilippo syndrome A
Myoclonic epilepsy of Lafora
ECM proteoglycans
Defective CHST6 causes MCDC1
Glycogen storage diseases
MPS IIID - Sanfilippo syndrome D
A tetrasaccharide linker sequence is required for GAG synthesis
Chondroitin sulfate biosynthesis
MPS IIIC - Sanfilippo syndrome C
Diseases associated with glycosaminoglycan metabolism
Mucopolysaccharidoses
Defective EXT2 causes exostoses 2
MPS II - Hunter syndrome
Defective B3GAT3 causes JDSSDHD
Defective CHST3 causes SEDCJD
Defective EXT1 causes exostoses 1, TRPS2 and CHDS
MPS IV - Morquio syndrome A
Dermatan sulfate biosynthesis
Defective CHSY1 causes TPBS
MPS IV - Morquio syndrome B
MPS VII - Sly syndrome
Metabolism of carbohydrates
MPS VI - Maroteaux-Lamy syndrome
Drugs
Natalizumab
Tinzaparin
Diseases
GWAS
Celiac disease (
20190752
)
Monocyte count (
23314186
)
White blood cell count (
21738480
)
White blood cell types (
21738478
)
Major depressive disorder (
20516156
)
Protein-Protein Interactions
16 interactors:
ADAM28
CD81
CD82
EED
FN1
ICAM4
ITGB1
ITGB7
LGALS8
LPXN
MADCAM1
PRKACA
PRKAR1A
PXN
TGFB1I1
VCAN
24 interactors:
ACAN
ADAMTS1
CCL2
CCL20
CCL21
CCL5
CCL8
CD44
CXCL10
CXCL12
CXCR3
FBLN1
FBLN2
FBN1
HAPLN1
ITGA4
ITGB1
PF4
PLA2G2A
SELL
SELP
SELPLG
TNR
XCL1
Entrez ID
3676
1462
HPRD ID
01894
00340
Ensembl ID
ENSG00000115232
ENSG00000038427
Uniprot IDs
P13612
P13611
Q59FG9
Q6MZK8
Q86W61
PDB IDs
3V4P
3V4V
4HKC
Enriched GO Terms of Interacting Partners
?
Cell Adhesion
Extracellular Matrix Organization
Extracellular Structure Organization
Cell-matrix Adhesion
Leukocyte Tethering Or Rolling
Cell-substrate Adhesion
Leukocyte Migration
Heterotypic Cell-cell Adhesion
Regulation Of Immune System Process
Integrin-mediated Signaling Pathway
Cellular Extravasation
Formation Of Primary Germ Layer
Calcium-independent Cell-matrix Adhesion
Positive Regulation Of Cellular Protein Metabolic Process
Viral Entry Into Host Cell
Substrate Adhesion-dependent Cell Spreading
Entry Into Host Cell
Positive Regulation Of Protein Metabolic Process
Gastrulation
Locomotion
Cell Junction Assembly
Cell Differentiation
Cell Migration
Cell Motility
Positive Regulation Of Protein Modification Process
Movement Of Cell Or Subcellular Component
Mesoderm Formation
Activation Of Protein Kinase Activity
Mesoderm Morphogenesis
Embryonic Morphogenesis
Tissue Morphogenesis
Interaction With Host
Tissue Development
Activation Of Protein Kinase A Activity
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Cellular Metabolic Process
Regulation Of Cellular Component Organization
Mesoderm Development
Regulation Of Cellular Protein Metabolic Process
Multicellular Organismal Development
Blood Coagulation
Hemostasis
Positive Regulation Of Phosphorylation
Positive Regulation Of MAPK Cascade
Cardiovascular System Development
Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of Immune Response
Anatomical Structure Development
ERBB Signaling Pathway
Renal Water Homeostasis
Leukocyte Migration
Cell Migration
Cell Motility
Regulation Of Leukocyte Migration
Locomotion
Positive Regulation Of Leukocyte Migration
Cell Chemotaxis
Movement Of Cell Or Subcellular Component
Regulation Of Lymphocyte Migration
Positive Regulation Of Locomotion
Positive Regulation Of T Cell Migration
Regulation Of T Cell Migration
Positive Regulation Of Chemotaxis
Chemotaxis
Positive Regulation Of Cell Migration
Positive Regulation Of Behavior
Positive Regulation Of Leukocyte Chemotaxis
Positive Regulation Of Cell Motility
Cell Adhesion
Positive Regulation Of Cellular Component Movement
Regulation Of Chemotaxis
Regulation Of Cell Migration
Inflammatory Response
Regulation Of Cell Motility
Immune System Process
Regulation Of Behavior
Leukocyte Chemotaxis
Regulation Of Locomotion
Regulation Of Cellular Component Movement
Chemokine-mediated Signaling Pathway
Response To Other Organism
Extracellular Matrix Organization
Extracellular Structure Organization
Response To Biotic Stimulus
Regulation Of Immune System Process
Cellular Extravasation
Lymphocyte Migration
Response To External Stimulus
Cellular Calcium Ion Homeostasis
Calcium Ion Homeostasis
Positive Regulation Of Calcium Ion Transport
Leukocyte Cell-cell Adhesion
Leukocyte Tethering Or Rolling
Single Organismal Cell-cell Adhesion
Response To Organic Substance
Defense Response
Positive Regulation Of Cell Adhesion
Lymphocyte Chemotaxis
T Cell Migration
Cellular Response To Cytokine Stimulus
Tagcloud
?
abundant
astrocytes
basic
bcan
cg
clustering
differentiated
diverse
embryos
enriched
fbln2
forebrain
foundation
functionally
glial
itih3
mesenchymal
ncam1
nervous
networks
neural
nsc
nscs
ontology
regulators
rich
tnr
transcriptomes
wnt
Tagcloud (Difference)
?
abundant
astrocytes
basic
bcan
cg
clustering
differentiated
diverse
embryos
enriched
fbln2
forebrain
foundation
functionally
glial
itih3
mesenchymal
ncam1
nervous
networks
neural
nsc
nscs
ontology
regulators
rich
tnr
transcriptomes
wnt
Tagcloud (Intersection)
?