GIPC1 and DRD2

Number of citations of the paper that reports this interaction (PMID 14617818)
28

Data Source:
HPRD (two hybrid, in vitro)

		GIPC1	DRD2
Gene Name		GIPC PDZ domain containing family, member 1	dopamine receptor D2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Brush Border Cell Cortex Synaptic Vesicle Vesicle Membrane Membrane Cytoplasmic Membrane-bounded Vesicle Endocytic Vesicle Dendritic Spine Dendritic Shaft Extracellular Vesicular Exosome	Acrosomal Vesicle Plasma Membrane Integral Component Of Plasma Membrane Postsynaptic Density Lateral Plasma Membrane Endocytic Vesicle Axon Dendrite Synaptic Vesicle Membrane Sperm Flagellum Dendritic Spine Perikaryon Axon Terminus
	Molecular Function	Actin Binding Receptor Binding Protein Binding Myosin Binding PDZ Domain Binding Protein Homodimerization Activity	Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Protein Binding Drug Binding Potassium Channel Regulator Activity Dopamine Binding Ionotropic Glutamate Receptor Binding Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity
	Biological Process	Protein Targeting G-protein Coupled Receptor Signaling Pathway Synaptic Transmission Glutamate Secretion Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Stability Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cytokinesis Endothelial Cell Migration Regulation Of Synaptic Plasticity	Temperature Homeostasis Response To Hypoxia Synaptic Transmission, Dopaminergic Response To Amphetamine Neurological System Process Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Heart Rate Regulation Of Sodium Ion Transport G-protein Coupled Receptor Internalization Positive Regulation Of Neuroblast Proliferation Positive Regulation Of Receptor Internalization Cellular Calcium Ion Homeostasis Negative Regulation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Neuron-neuron Synaptic Transmission Axonogenesis Synapse Assembly Sensory Perception Of Smell Long-term Memory Grooming Behavior Locomotory Behavior Adult Walking Behavior Feeding Behavior Protein Localization Negative Regulation Of Cell Proliferation Associative Learning Visual Learning Response To Light Stimulus Response To Toxic Substance Response To Iron Ion Response To Inactivity Wnt Signaling Pathway Striatum Development Orbitofrontal Cortex Development Cerebral Cortex GABAergic Interneuron Migration Adenohypophysis Development Negative Regulation Of Cell Migration Peristalsis Regulation Of CAMP Metabolic Process Auditory Behavior Activation Of Protein Kinase Activity Regulation Of Synaptic Transmission, GABAergic Positive Regulation Of Cytokinesis Circadian Regulation Of Gene Expression Negative Regulation Of Dopamine Secretion Response To Histamine Response To Nicotine Intracellular Signal Transduction Positive Regulation Of Urine Volume Positive Regulation Of Renal Sodium Excretion Positive Regulation Of Multicellular Organism Growth Response To Cocaine Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Dopamine Metabolic Process Response To Drug Regulation Of Potassium Ion Transport Response To Morphine Pigmentation Regulation Of Phosphoprotein Phosphatase Activity Positive Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Negative Regulation Of Blood Pressure Positive Regulation Of Transcription From RNA Polymerase II Promoter Phosphatidylinositol Metabolic Process Negative Regulation Of Insulin Secretion Behavioral Response To Cocaine Behavioral Response To Ethanol Regulation Of Long-term Neuronal Synaptic Plasticity Response To Axon Injury Branching Morphogenesis Of A Nerve Arachidonic Acid Secretion Negative Regulation Of Protein Secretion Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Regulation Of Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Regulation Of Synapse Structural Plasticity Negative Regulation Of Protein Kinase B Signaling Negative Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of Growth Hormone Secretion Prepulse Inhibition Phospholipase C-activating Dopamine Receptor Signaling Pathway Negative Regulation Of Dopamine Receptor Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Locomotion Involved In Locomotory Behavior Positive Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Voltage-gated Calcium Channel Activity
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Class A/1 (Rhodopsin-like receptors) Amine ligand-binding receptors G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Dopamine receptors
Drugs			Ziprasidone Cabergoline Ropinirole Olanzapine Clozapine Thiethylperazine Sulpiride Loxapine Remoxipride Pramipexole Promazine Prochlorperazine Droperidol Chlorpromazine Buspirone Haloperidol Triflupromazine Amoxapine Cinnarizine Lisuride Fluphenazine Thioridazine Ergotamine Apomorphine Trimipramine Risperidone Propiomazine Minaprine Trifluoperazine Perphenazine Flupenthixol Amantadine Mesoridazine Dopamine Carphenazine Acetophenazine Promethazine Pimozide Doxepin Domperidone Pergolide Bromocriptine Ketamine Quetiapine Metoclopramide Levodopa Aripiprazole Chlorprothixene Paliperidone Yohimbine Methotrimeprazine Alizapride Rolicyclidine Acepromazine Molindone Pipotiazine Thioproperazine Thiothixene Zuclopenthixol Aniracetam Fluspirilene Tetrabenazine Iloperidone Rotigotine Sertindole Asenapine Amisulpride Lurasidone
Diseases
GWAS			Select biomarker traits ( 17903293) Working memory ( 21107309)
Protein-Protein Interactions		31 interactors: ACTN1 ADRB1 CD93 DDIT3 DRD2 DRD3 FZD3 GSK3B IGF1R ITGA5 ITGA6 KIF1B LHCGR LRP1 LRP2 LRP8 MYO6 NRP1 NTRK1 NTRK2 RGS1 RGS19 SDC4 SEMA4B SEMA4C SLC2A1 TGFBR3 TPBG TYRP1 ZFPM1 ZNF408	21 interactors: ADORA2A CADPS CADPS2 CALM1 CLIC6 EPB41 EPB41L1 FLNA GIPC1 GNAI2 GNAI3 GNAZ GRIA2 KCNJ6 KCNJ9 NCS1 NSF PAWR PPP1R9B SLC6A3 SSTR5
Entrez ID		10755	1813
HPRD ID		05462	00539
Ensembl ID		ENSG00000123159	ENSG00000149295
Uniprot IDs		A8K2I7 O14908	F8VUV1 P14416
PDB IDs			1I15
Enriched GO Terms of Interacting Partners?		Response To External Stimulus Regulation Of Signaling Regulation Of Phosphorus Metabolic Process Regulation Of Adenylate Cyclase Activity Regulation Of Cyclase Activity Positive Regulation Of Phosphorylation Response To Abiotic Stimulus Cell Surface Receptor Signaling Pathway Cell Communication System Development Regulation Of CAMP Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Anatomical Structure Development Positive Regulation Of Metabolic Process Developmental Process Cognition Regulation Of CAMP Metabolic Process Signaling Regulation Of Signal Transduction Signal Transduction Multicellular Organismal Development Movement Of Cell Or Subcellular Component Cell Differentiation Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Learning Or Memory Cell Migration Negative Regulation Of Signal Transduction Activation Of Adenylate Cyclase Activity Anatomical Structure Morphogenesis Regulation Of Cell Development Response To Radiation Tissue Development Cellular Response To Stimulus Regulation Of Synaptic Transmission Cell Motility Regulation Of Apoptotic Process Negative Regulation Of Signaling Positive Regulation Of Adenylate Cyclase Activity Organ Development Response To Stimulus Response To Wounding Positive Regulation Of Cell Development Cell Morphogenesis Involved In Differentiation Response To Light Stimulus Positive Regulation Of Protein Phosphorylation Regulation Of Cell Death Locomotion Regulation Of Cell Differentiation Nervous System Development	Synaptic Transmission Cell-cell Signaling Signaling Cell Communication G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Regulation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Regulation Of Cyclase Activity Secretion Regulation Of CAMP Biosynthetic Process Regulation Of CAMP Metabolic Process G-protein Coupled Receptor Signaling Pathway Secretion By Cell Transport Regulation Of Body Fluid Levels Exocytosis Regulation Of Ion Transport Regulation Of Cytokinesis Platelet Activation Regulation Of Ion Transmembrane Transport Blood Coagulation Synaptic Vesicle Priming Hemostasis Adenosine Receptor Signaling Pathway Regulation Of Cell Division Ion Transport Wound Healing Actin Cytoskeleton Organization Vesicle-mediated Transport Negative Regulation Of Adenylate Cyclase Activity Regulation Of Cellular Localization Actin Filament-based Process Negative Regulation Of Lyase Activity Cortical Actin Cytoskeleton Organization Potassium Ion Import Monoamine Transport Regulation Of Neurotransmitter Levels Cortical Cytoskeleton Organization Activation Of Adenylate Cyclase Activity Response To Wounding Negative Regulation Of CAMP Biosynthetic Process Regulation Of Exocytosis Negative Regulation Of CAMP Metabolic Process Neurotransmitter Transport Positive Regulation Of Adenylate Cyclase Activity Signal Transduction Positive Regulation Of Cytokinesis Negative Regulation Of Nucleotide Metabolic Process Metal Ion Transport
Tagcloud ?		adrb1 alpha5 appl1 assembles cargoes deafness dimerizing drd2 factorbeta gh1 gh2 gipc2 gipc3 gipcs gpcrs hbc lrp1 myo6 nonsyndromic nrp1 ntrk1 pdz rgs19 rtks sdc4 sema4c tgfbetar3 vangl2	a1 account alcoholic allele alleles amplitude benton boys coefficients cognitive correlations dopamine family fathers functioning lacking latency line minor negatively nonalcoholic orientation potentials preadolescent score taqi variance visuospatial
Tagcloud (Difference) ?		adrb1 alpha5 appl1 assembles cargoes deafness dimerizing factorbeta gh1 gh2 gipc2 gipc3 gipcs gpcrs hbc lrp1 myo6 nonsyndromic nrp1 ntrk1 pdz rgs19 rtks sdc4 sema4c tgfbetar3 vangl2	a1 account alcoholic allele alleles amplitude benton boys coefficients cognitive correlations dopamine family fathers functioning lacking latency line minor negatively nonalcoholic orientation potentials preadolescent score taqi variance visuospatial
Tagcloud (Intersection) ?		drd2