GIPC1 and NRP1

Number of citations of the paper that reports this interaction (PMID 10414980)
59

Data Source:
HPRD (in vivo, in vitro)

		GIPC1	NRP1
Gene Name		GIPC PDZ domain containing family, member 1	neuropilin 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Brush Border Cell Cortex Synaptic Vesicle Vesicle Membrane Membrane Cytoplasmic Membrane-bounded Vesicle Endocytic Vesicle Dendritic Spine Dendritic Shaft Extracellular Vesicular Exosome	Semaphorin Receptor Complex Extracellular Space Early Endosome Cytosol Neurofilament Plasma Membrane Focal Adhesion Cell Surface Integral Component Of Membrane Axon Growth Cone Cytoplasmic Vesicle Neuronal Cell Body Receptor Complex Sorting Endosome
	Molecular Function	Actin Binding Receptor Binding Protein Binding Myosin Binding PDZ Domain Binding Protein Homodimerization Activity	Vascular Endothelial Growth Factor-activated Receptor Activity Protein Binding Heparin Binding Coreceptor Activity Semaphorin Receptor Activity Growth Factor Binding Cytokine Binding Vascular Endothelial Growth Factor Binding Metal Ion Binding
	Biological Process	Protein Targeting G-protein Coupled Receptor Signaling Pathway Synaptic Transmission Glutamate Secretion Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Stability Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cytokinesis Endothelial Cell Migration Regulation Of Synaptic Plasticity	Angiogenesis Patterning Of Blood Vessels Neuron Migration Positive Regulation Of Endothelial Cell Proliferation Sprouting Angiogenesis Cell Migration Involved In Sprouting Angiogenesis Signal Transduction Cell-cell Signaling Axon Guidance Axonal Fasciculation Response To Wounding Organ Morphogenesis Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Smooth Muscle Cell Migration Dendrite Development Facial Nerve Structural Organization Trigeminal Nerve Structural Organization Vestibulocochlear Nerve Structural Organization Nerve Development Branchiomotor Neuron Axon Guidance Gonadotrophin-releasing Hormone Neuronal Migration To The Hypothalamus Retinal Ganglion Cell Axon Guidance Cellular Response To Hepatocyte Growth Factor Stimulus Endothelial Cell Chemotaxis Cellular Response To Vascular Endothelial Growth Factor Stimulus Ventral Trunk Neural Crest Cell Migration VEGF-activated Neuropilin Signaling Pathway Otic Placode Formation Negative Regulation Of Neuron Apoptotic Process Platelet-derived Growth Factor Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Hepatocyte Growth Factor Receptor Signaling Pathway Positive Regulation Of Axon Extension Involved In Axon Guidance Negative Regulation Of Axon Extension Involved In Axon Guidance Artery Morphogenesis Axon Extension Involved In Axon Guidance Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Chemotaxis Positive Regulation Of Cytokine Activity Axonogenesis Involved In Innervation Regulation Of Vesicle-mediated Transport Dichotomous Subdivision Of Terminal Units Involved In Salivary Gland Branching Angiogenesis Involved In Coronary Vascular Morphogenesis Coronary Artery Morphogenesis Retina Vasculature Morphogenesis In Camera-type Eye Renal Artery Morphogenesis Sympathetic Ganglion Development Trigeminal Ganglion Development Ganglion Morphogenesis Positive Regulation Of ERK1 And ERK2 Cascade Semaphorin-plexin Signaling Pathway Commissural Neuron Axon Guidance Regulation Of Retinal Ganglion Cell Axon Guidance Endothelial Tip Cell Fate Specification Sensory Neuron Axon Guidance Sympathetic Neuron Projection Extension Sympathetic Neuron Projection Guidance Neural Crest Cell Migration Involved In Autonomic Nervous System Development Toxin Transport Semaphorin-plexin Signaling Pathway Involved In Neuron Projection Guidance Semaphorin-plexin Signaling Pathway Involved In Axon Guidance Positive Regulation Of Retinal Ganglion Cell Axon Guidance VEGF-activated Neuropilin Signaling Pathway Involved In Axon Guidance Protein Localization To Early Endosome Facioacoustic Ganglion Development Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways			Signal transduction by L1 CHL1 interactions Axon guidance Semaphorin interactions Signaling by VEGF Sema3A PAK dependent Axon repulsion Neurophilin interactions with VEGF and VEGFR L1CAM interactions SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion CRMPs in Sema3A signaling
Drugs
Diseases
GWAS			Schizophrenia ( 21682944) Tetralogy of Fallot ( 23297363)
Protein-Protein Interactions		31 interactors: ACTN1 ADRB1 CD93 DDIT3 DRD2 DRD3 FZD3 GSK3B IGF1R ITGA5 ITGA6 KIF1B LHCGR LRP1 LRP2 LRP8 MYO6 NRP1 NTRK1 NTRK2 RGS1 RGS19 SDC4 SEMA4B SEMA4C SLC2A1 TGFBR3 TPBG TYRP1 ZFPM1 ZNF408	22 interactors: FGF1 FGF2 FGF4 FGF7 FGFR1 FLT1 GIPC1 KDR L1CAM NRP2 PGF PLXNA1 RPL27 SEMA3A SEMA3B SEMA3C SEMA3F TGFBR1 TGFBR2 TGFBR3 VEGFA VEGFB
Entrez ID		10755	8829
HPRD ID		05462	03642
Ensembl ID		ENSG00000123159	ENSG00000099250
Uniprot IDs		A8K2I7 O14908	A8K9V7 O14786 Q59F20 Q68DN3 Q6AWA9
PDB IDs			1KEX 2QQI 2QQM 2QQN 3I97 4DEQ
Enriched GO Terms of Interacting Partners?		Response To External Stimulus Regulation Of Signaling Regulation Of Phosphorus Metabolic Process Regulation Of Adenylate Cyclase Activity Regulation Of Cyclase Activity Positive Regulation Of Phosphorylation Response To Abiotic Stimulus Cell Surface Receptor Signaling Pathway Cell Communication System Development Regulation Of CAMP Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Anatomical Structure Development Positive Regulation Of Metabolic Process Developmental Process Cognition Regulation Of CAMP Metabolic Process Signaling Regulation Of Signal Transduction Signal Transduction Multicellular Organismal Development Movement Of Cell Or Subcellular Component Cell Differentiation Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Learning Or Memory Cell Migration Negative Regulation Of Signal Transduction Activation Of Adenylate Cyclase Activity Anatomical Structure Morphogenesis Regulation Of Cell Development Response To Radiation Tissue Development Cellular Response To Stimulus Regulation Of Synaptic Transmission Cell Motility Regulation Of Apoptotic Process Negative Regulation Of Signaling Positive Regulation Of Adenylate Cyclase Activity Organ Development Response To Stimulus Response To Wounding Positive Regulation Of Cell Development Cell Morphogenesis Involved In Differentiation Response To Light Stimulus Positive Regulation Of Protein Phosphorylation Regulation Of Cell Death Locomotion Regulation Of Cell Differentiation Nervous System Development	Morphogenesis Of A Branching Epithelium Morphogenesis Of A Branching Structure Regulation Of Cellular Component Movement Anatomical Structure Morphogenesis Locomotion Regulation Of Epithelial Cell Migration Tissue Morphogenesis Regulation Of Locomotion Blood Vessel Development Vasculature Development Cellular Response To Growth Factor Stimulus Regulation Of Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Cell Migration Chemotaxis Positive Regulation Of Cell Proliferation Tissue Development Regulation Of Cell Motility Angiogenesis Cardiovascular System Development Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Cellular Component Movement Morphogenesis Of An Epithelium Positive Regulation Of Epithelial Cell Proliferation Cell Surface Receptor Signaling Pathway Ameboidal-type Cell Migration Blood Vessel Morphogenesis Regulation Of Epithelial Cell Proliferation Cell Migration Embryo Development Positive Regulation Of Endothelial Cell Proliferation Regulation Of Cell Proliferation Movement Of Cell Or Subcellular Component Cell Motility Positive Regulation Of Cell Division Positive Regulation Of Cell Migration System Development Positive Regulation Of Cell Motility Positive Regulation Of Angiogenesis Positive Regulation Of Locomotion Regulation Of Chemotaxis Organ Development Organ Morphogenesis Anatomical Structure Formation Involved In Morphogenesis Regulation Of Endothelial Cell Proliferation Cell Development Multicellular Organismal Development Cell Differentiation Anatomical Structure Development Regulation Of Behavior
Tagcloud ?		adrb1 alpha5 appl1 assembles cargoes deafness dimerizing drd2 factorbeta gh1 gh2 gipc2 gipc3 gipcs gpcrs hbc lrp1 myo6 nonsyndromic nrp1 ntrk1 pdz rgs19 rtks sdc4 sema4c tgfbetar3 vangl2	c57bl cd25 cd28 cd3 cd4 cd8 ctla cytometry distinguishing draining ebi3 foxp3 helios herein neuropilin nodes pdlns peripherally proportion ptreg reliable seems spleen stimulating thymic thymus treg ttreg younger
Tagcloud (Difference) ?		adrb1 alpha5 appl1 assembles cargoes deafness dimerizing drd2 factorbeta gh1 gh2 gipc2 gipc3 gipcs gpcrs hbc lrp1 myo6 nonsyndromic ntrk1 pdz rgs19 rtks sdc4 sema4c tgfbetar3 vangl2	c57bl cd25 cd28 cd3 cd4 cd8 ctla cytometry distinguishing draining ebi3 foxp3 helios herein neuropilin nodes pdlns peripherally proportion ptreg reliable seems spleen stimulating thymic thymus treg ttreg younger
Tagcloud (Intersection) ?		nrp1