GIPC1 and SLC2A1

Number of citations of the paper that reports this interaction (PMID 10198040)
50

Data Source:
HPRD (two hybrid, in vitro)

		GIPC1	SLC2A1
Gene Name		GIPC PDZ domain containing family, member 1	solute carrier family 2 (facilitated glucose transporter), member 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Brush Border Cell Cortex Synaptic Vesicle Vesicle Membrane Membrane Cytoplasmic Membrane-bounded Vesicle Endocytic Vesicle Dendritic Spine Dendritic Shaft Extracellular Vesicular Exosome	Female Pronucleus Cytosol Plasma Membrane Integral Component Of Plasma Membrane Caveola Cell-cell Junction Membrane Basolateral Plasma Membrane Midbody Cortical Actin Cytoskeleton Melanosome Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Actin Binding Receptor Binding Protein Binding Myosin Binding PDZ Domain Binding Protein Homodimerization Activity	Glucose Transmembrane Transporter Activity Protein Binding Kinase Binding Dehydroascorbic Acid Transporter Activity Identical Protein Binding Xenobiotic Transporter Activity Protein Self-association D-glucose Transmembrane Transporter Activity
	Biological Process	Protein Targeting G-protein Coupled Receptor Signaling Pathway Synaptic Transmission Glutamate Secretion Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Stability Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cytokinesis Endothelial Cell Migration Regulation Of Synaptic Plasticity	Carbohydrate Metabolic Process Energy Reserve Metabolic Process Protein Complex Assembly Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Response To Osmotic Stress Hexose Transport Pathogenesis Glucose Transport L-ascorbic Acid Metabolic Process Cellular Response To Glucose Starvation Xenobiotic Transport Small Molecule Metabolic Process Regulation Of Insulin Secretion Transmembrane Transport Dehydroascorbic Acid Transport
Pathways			Metabolism of vitamins and cofactors Defective CD320 causes methylmalonic aciduria Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Integration of energy metabolism Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MTR causes methylmalonic aciduria and homocystinuria type cblG SLC-mediated transmembrane transport Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective AMN causes hereditary megaloblastic anemia 1 Myoclonic epilepsy of Lafora Glycogen storage diseases Defects in cobalamin (B12) metabolism Defective GIF causes intrinsic factor deficiency Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Regulation of insulin secretion Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Vitamin C (ascorbate) metabolism Hexose transport Defective MMAA causes methylmalonic aciduria type cblA Defective CUBN causes hereditary megaloblastic anemia 1 Metabolism of water-soluble vitamins and cofactors Defective MUT causes methylmalonic aciduria mut type Defects in biotin (Btn) metabolism Metabolism of carbohydrates Glucose transport Defective TCN2 causes hereditary megaloblastic anemia Defects in vitamin and cofactor metabolism
Drugs
Diseases
GWAS			Cardiac hypertrophy ( 21348951)
Protein-Protein Interactions		31 interactors: ACTN1 ADRB1 CD93 DDIT3 DRD2 DRD3 FZD3 GSK3B IGF1R ITGA5 ITGA6 KIF1B LHCGR LRP1 LRP2 LRP8 MYO6 NRP1 NTRK1 NTRK2 RGS1 RGS19 SDC4 SEMA4B SEMA4C SLC2A1 TGFBR3 TPBG TYRP1 ZFPM1 ZNF408	11 interactors: CALR CANX COPS6 GAPDH GIPC1 PDIA3 PTK2B STOM SUMO1 UBE2I VHL
Entrez ID		10755	6513
HPRD ID		05462	00683
Ensembl ID		ENSG00000123159	ENSG00000117394
Uniprot IDs		A8K2I7 O14908	P11166 Q59GX2
PDB IDs			1SUK
Enriched GO Terms of Interacting Partners?		Response To External Stimulus Regulation Of Signaling Regulation Of Phosphorus Metabolic Process Regulation Of Adenylate Cyclase Activity Regulation Of Cyclase Activity Positive Regulation Of Phosphorylation Response To Abiotic Stimulus Cell Surface Receptor Signaling Pathway Cell Communication System Development Regulation Of CAMP Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Anatomical Structure Development Positive Regulation Of Metabolic Process Developmental Process Cognition Regulation Of CAMP Metabolic Process Signaling Regulation Of Signal Transduction Signal Transduction Multicellular Organismal Development Movement Of Cell Or Subcellular Component Cell Differentiation Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Learning Or Memory Cell Migration Negative Regulation Of Signal Transduction Activation Of Adenylate Cyclase Activity Anatomical Structure Morphogenesis Regulation Of Cell Development Response To Radiation Tissue Development Cellular Response To Stimulus Regulation Of Synaptic Transmission Cell Motility Regulation Of Apoptotic Process Negative Regulation Of Signaling Positive Regulation Of Adenylate Cyclase Activity Organ Development Response To Stimulus Response To Wounding Positive Regulation Of Cell Development Cell Morphogenesis Involved In Differentiation Response To Light Stimulus Positive Regulation Of Protein Phosphorylation Regulation Of Cell Death Locomotion Regulation Of Cell Differentiation Nervous System Development	Post-translational Protein Modification Peptidyl-amino Acid Modification Regulation Of Protein Stability Cellular Protein Modification Process Posttranscriptional Regulation Of Gene Expression Protein Stabilization Cellular Protein Metabolic Process Protein N-linked Glycosylation Via Asparagine Protein N-linked Glycosylation Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Protein Localization To Nucleus Protein Sumoylation Response To Lithium Ion Protein Metabolic Process Antigen Processing And Presentation Of Peptide Antigen Negative Regulation Of Cellular Metabolic Process Immune System Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Translation Protein Folding Antigen Processing And Presentation Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Chaperone-mediated Protein Folding Protein Glycosylation Macromolecule Glycosylation Positive Regulation Of Leukocyte Chemotaxis Glycosylation Peptide Antigen Assembly With MHC Class I Protein Complex Peptidyl-cysteine S-trans-nitrosylation Positive Regulation Of SUMO Transferase Activity Regulation Of Acid-sensing Ion Channel Activity Endothelial Cell Migration Regulation Of Protein Catabolic Process Glycoprotein Biosynthetic Process Regulation Of Signal Transduction Positive Regulation Of Leukocyte Migration Negative Regulation Of Translation Epithelial Cell Migration Epithelium Migration Carbohydrate Metabolic Process Regulation Of CGMP-mediated Signaling Marginal Zone B Cell Differentiation Positive Regulation Of B Cell Chemotaxis Glycoprotein Metabolic Process Protein Localization Positive Regulation Of Chemotaxis Negative Regulation Of Transcription, DNA-templated Regulation Of Cellular Protein Metabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Tagcloud ?		adrb1 alpha5 appl1 assembles cargoes deafness dimerizing drd2 factorbeta gh1 gh2 gipc2 gipc3 gipcs gpcrs hbc lrp1 myo6 nonsyndromic nrp1 ntrk1 pdz rgs19 rtks sdc4 sema4c tgfbetar3 vangl2	atp1a2 atp1b2 beef corpus cows diestrus follicle glandular gonadotropin lcl lf luteum manipulated nelore ovulation p4 periovulatory pof preovulatory proestrus receptivity slaughtered slc37a4 washings
Tagcloud (Difference) ?		adrb1 alpha5 appl1 assembles cargoes deafness dimerizing drd2 factorbeta gh1 gh2 gipc2 gipc3 gipcs gpcrs hbc lrp1 myo6 nonsyndromic nrp1 ntrk1 pdz rgs19 rtks sdc4 sema4c tgfbetar3 vangl2	atp1a2 atp1b2 beef corpus cows diestrus follicle glandular gonadotropin lcl lf luteum manipulated nelore ovulation p4 periovulatory pof preovulatory proestrus receptivity slaughtered slc37a4 washings
Tagcloud (Intersection) ?