GIPC1 and SDC4

Number of citations of the paper that reports this interaction (PubMedID 10911369)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo, two hybrid)

		GIPC1	SDC4
Description		GIPC PDZ domain containing family member 1	syndecan 4
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cell Cortex Synaptic Vesicle Vesicle Membrane Membrane Cytoplasmic Vesicle Dendritic Spine Dendritic Shaft Extracellular Exosome Schaffer Collateral - CA1 Synapse Glutamatergic Synapse	Extracellular Region Golgi Lumen Plasma Membrane Focal Adhesion Cell Surface Membrane Costamere Lysosomal Lumen Extracellular Exosome
	Molecular Function	Actin Binding Signaling Receptor Binding Protein Binding Myosin Binding Identical Protein Binding Cadherin Binding	Fibronectin Binding Protein Kinase C Binding Protein Binding Identical Protein Binding Thrombospondin Receptor Activity
	Biological Process	Protein Targeting G Protein-coupled Receptor Signaling Pathway Chemical Synaptic Transmission Glutamate Secretion Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Stability Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cytokinesis Endothelial Cell Migration Positive Regulation Of Melanin Biosynthetic Process Regulation Of Synaptic Plasticity Cellular Response To Interleukin-7 Presynaptic Modulation Of Chemical Synaptic Transmission	Ureteric Bud Development Neural Tube Closure Regulation Of Fibroblast Migration Cell Migration Wound Healing Negative Regulation Of T Cell Proliferation Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Inner Ear Receptor Cell Stereocilium Organization Positive Regulation Of Exosomal Secretion Positive Regulation Of Extracellular Exosome Assembly
Pathways		FGFR1b ligand binding and activation FGFR1c ligand binding and activation TGFBR3 regulates TGF-beta signaling TGFBR3 regulates FGF2 signaling	Glycosaminoglycan-protein linkage region biosynthesis HS-GAG biosynthesis HS-GAG biosynthesis HS-GAG degradation Cell surface interactions at the vascular wall Syndecan interactions Syndecan interactions Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Defective B3GALT6 causes EDSP2 and SEMDJL1 Attachment and Entry Attachment and Entry Retinoid metabolism and transport Respiratory syncytial virus (RSV) attachment and entry RSV-host interactions
Drugs
Diseases
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847) Kidney stones ( 31729369)	Malaria ( 31844061) Psoriasis ( 20953189)
Interacting Genes		37 interacting genes: ACTN1 ADRB1 CARD10 CD93 DDIT3 DRD2 DRD3 FZD3 GSK3B IGF1R ITGA5 ITGA6 KCNJ6 KIF1B LHCGR LPAR1 LPAR2 LRP1 LRP2 LRP8 MYO6 NRP1 NTRK1 NTRK2 PLEKHA2 RGS1 RGS19 SDC4 SEMA4B SEMA4C SLC2A1 TGFBR3 TPBG TYRP1 VANGL2 ZFPM1 ZNF408	19 interacting genes: CASK CCL5 CXCR4 GIPC1 IL7R MAL MDK PMP22 PRKCA PRKCD PTEN PXN SDCBP SGTA SGTB TANK TGFB1I1 TGFB3 UBC
Entrez ID		10755	6385
HPRD ID		05462	08366
Ensembl ID		ENSG00000123159	ENSG00000124145
Uniprot IDs		A8K2I7 O14908	B4E1S6 P31431
PDB IDs			1EJP 1EJQ 1OBY 1YBO 8BLV
Enriched GO Terms of Interacting Partners?		Plasma Membrane Glutamatergic Synapse Membrane Cell Migration Regulation Of Locomotion Regulation Of Signal Transduction Regulation Of Cell Communication Positive Regulation Of Intracellular Signal Transduction Regulation Of Signaling Regulation Of Cell Migration Receptor Complex Positive Regulation Of Signal Transduction Axon Regulation Of Cell Motility Cell Motility PDZ Domain Binding Cell Projection Organization Positive Regulation Of MAPK Cascade Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cell Surface Anatomical Structure Formation Involved In Morphogenesis Signal Transduction Regulation Of MAPK Cascade Negative Regulation Of Signal Transduction Positive Regulation Of Nervous System Development Developmental Process Positive Regulation Of Multicellular Organismal Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Intracellular Signal Transduction Regulation Of Nervous System Development Positive Regulation Of Cellular Component Organization Endocytic Vesicle Positive Regulation Of Locomotion Dendrite Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Regulation Of Developmental Process Regulation Of Apoptotic Process Neural Tube Closure Anatomical Structure Morphogenesis Regulation Of Programmed Cell Death Tube Closure Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Migration Insulin-like Growth Factor I Binding Positive Regulation Of Developmental Process Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Motility	Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cell Adhesion Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Metabolic Process Positive Regulation Of Epithelial To Mesenchymal Transition TRC Complex Positive Regulation Of Cell Differentiation Positive Regulation Of Multicellular Organismal Process Regulation Of Cell Population Proliferation Positive Regulation Of Biosynthetic Process Protein Kinase C Signaling Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Cell-cell Adhesion Positive Regulation Of Receptor Signaling Pathway Via STAT Regulation Of Multicellular Organismal Process Regulation Of Cell Differentiation Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Transport Signal Transduction Regulation Of Smooth Muscle Cell Proliferation Intracellular Signaling Cassette Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Macromolecule Metabolic Process Apoptotic Process Response To Stress Locomotion Cell Migration Regulation Of Response To Wounding Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cell Population Proliferation Programmed Cell Death Cell Death Negative Regulation Of Glial Cell Apoptotic Process Positive Regulation Of Leukocyte Differentiation Regulation Of Cell Activation Positive Regulation Of Developmental Process Schmidt-Lanterman Incisure Regulation Of Proteolysis Protein Targeting To Membrane Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Regulation Of Plasma Membrane Bounded Cell Projection Organization Negative Regulation Of Wound Healing Regulation Of Cell Projection Organization
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