GIPC1 and SDC4

Number of citations of the paper that reports this interaction (PMID 10911369)
51

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid, in vivo, in vitro)

		GIPC1	SDC4
Gene Name		GIPC PDZ domain containing family, member 1	syndecan 4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Brush Border Cell Cortex Synaptic Vesicle Vesicle Membrane Membrane Cytoplasmic Membrane-bounded Vesicle Endocytic Vesicle Dendritic Spine Dendritic Shaft Extracellular Vesicular Exosome	Golgi Lumen Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Cell Surface Costamere Lysosomal Lumen Membrane Raft Extracellular Vesicular Exosome
	Molecular Function	Actin Binding Receptor Binding Protein Binding Myosin Binding PDZ Domain Binding Protein Homodimerization Activity	Fibronectin Binding Protein Kinase C Binding Protein Binding Thrombospondin Receptor Activity
	Biological Process	Protein Targeting G-protein Coupled Receptor Signaling Pathway Synaptic Transmission Glutamate Secretion Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Stability Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cytokinesis Endothelial Cell Migration Regulation Of Synaptic Plasticity	Retinoid Metabolic Process Ureteric Bud Development Carbohydrate Metabolic Process Glycosaminoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Phototransduction, Visible Light Biological_process Pathogenesis Extracellular Matrix Organization Glycosaminoglycan Metabolic Process Chondroitin Sulfate Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Protein Kinase Activity Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Exosomal Secretion Positive Regulation Of Extracellular Vesicular Exosome Assembly
Pathways			MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Defective B4GALT7 causes EDS, progeroid type Heparan sulfate/heparin (HS-GAG) metabolism MPS I - Hurler syndrome MPS IX - Natowicz syndrome Chondroitin sulfate/dermatan sulfate metabolism Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism Defective CHST14 causes EDS, musculocontractural type Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora Defective CHST6 causes MCDC1 Glycogen storage diseases MPS IIID - Sanfilippo syndrome D A tetrasaccharide linker sequence is required for GAG synthesis MPS IIIC - Sanfilippo syndrome C Retinoid metabolism and transport Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Non-integrin membrane-ECM interactions Diseases associated with visual transduction Defective EXT1 causes exostoses 1, TRPS2 and CHDS Syndecan interactions MPS IV - Morquio syndrome A Visual phototransduction MPS IV - Morquio syndrome B Defective CHSY1 causes TPBS MPS VII - Sly syndrome Metabolism of carbohydrates HS-GAG biosynthesis HS-GAG degradation MPS VI - Maroteaux-Lamy syndrome
Drugs
Diseases
GWAS			Psoriasis ( 20953189)
Protein-Protein Interactions		31 interactors: ACTN1 ADRB1 CD93 DDIT3 DRD2 DRD3 FZD3 GSK3B IGF1R ITGA5 ITGA6 KIF1B LHCGR LRP1 LRP2 LRP8 MYO6 NRP1 NTRK1 NTRK2 RGS1 RGS19 SDC4 SEMA4B SEMA4C SLC2A1 TGFBR3 TPBG TYRP1 ZFPM1 ZNF408	13 interactors: CASK CCL5 CXCR4 GIPC1 MDK PRKCA PRKCD PXN SDCBP SGTA TANK TGFB1I1 TGFB3
Entrez ID		10755	6385
HPRD ID		05462	08366
Ensembl ID		ENSG00000123159	ENSG00000124145
Uniprot IDs		A8K2I7 O14908	B4E1S6 P31431
PDB IDs			1EJP 1EJQ 1OBY 1YBO
Enriched GO Terms of Interacting Partners?		Response To External Stimulus Regulation Of Signaling Regulation Of Phosphorus Metabolic Process Regulation Of Adenylate Cyclase Activity Regulation Of Cyclase Activity Positive Regulation Of Phosphorylation Response To Abiotic Stimulus Cell Surface Receptor Signaling Pathway Cell Communication System Development Regulation Of CAMP Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Anatomical Structure Development Positive Regulation Of Metabolic Process Developmental Process Cognition Regulation Of CAMP Metabolic Process Signaling Regulation Of Signal Transduction Signal Transduction Multicellular Organismal Development Movement Of Cell Or Subcellular Component Cell Differentiation Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Learning Or Memory Cell Migration Negative Regulation Of Signal Transduction Activation Of Adenylate Cyclase Activity Anatomical Structure Morphogenesis Regulation Of Cell Development Response To Radiation Tissue Development Cellular Response To Stimulus Regulation Of Synaptic Transmission Cell Motility Regulation Of Apoptotic Process Negative Regulation Of Signaling Positive Regulation Of Adenylate Cyclase Activity Organ Development Response To Stimulus Response To Wounding Positive Regulation Of Cell Development Cell Morphogenesis Involved In Differentiation Response To Light Stimulus Positive Regulation Of Protein Phosphorylation Regulation Of Cell Death Locomotion Regulation Of Cell Differentiation Nervous System Development	Positive Regulation Of Signal Transduction Positive Regulation Of Cellular Metabolic Process Neutrophil Activation Regulation Of MAP Kinase Activity Cell Surface Receptor Signaling Pathway Regulation Of MAPK Cascade Positive Regulation Of Metabolic Process Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Regulation Of Signal Transduction Regulation Of Phosphorylation Positive Regulation Of Intracellular Signal Transduction Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Behavior Positive Regulation Of MAPK Cascade Cell Migration Positive Regulation Of Phosphorylation Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Cell Motility Positive Regulation Of Protein Modification Process Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component Regulation Of Signaling Signaling Positive Regulation Of Cellular Biosynthetic Process Cell Communication Positive Regulation Of Phospholipase Activity Cellular Response To Growth Factor Stimulus Regulation Of Protein Phosphorylation Negative Regulation Of Glial Cell Apoptotic Process Response To Growth Factor Response To Stress Regulation Of Phospholipase Activity Regulation Of Intracellular Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Lipase Activity Cell Adhesion Cell Activation Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Leukocyte Chemotaxis Locomotion Negative Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Protein Phosphorylation Dendritic Cell Chemotaxis Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Transport Regulation Of Platelet Aggregation
Tagcloud ?		adrb1 alpha5 appl1 assembles cargoes deafness dimerizing drd2 factorbeta gh1 gh2 gipc2 gipc3 gipcs gpcrs hbc lrp1 myo6 nonsyndromic nrp1 ntrk1 pdz rgs19 rtks sdc4 sema4c tgfbetar3 vangl2	alpha3beta1 alpha6beta4 beta4 block c2 competes coupling depends egf engagement engaging extreme her1 integrin laminin ln332 matrix migration penetrating platform qeexyx recognize sdc1 shares spreading syndecan syndecans utilized
Tagcloud (Difference) ?		adrb1 alpha5 appl1 assembles cargoes deafness dimerizing drd2 factorbeta gh1 gh2 gipc2 gipc3 gipcs gpcrs hbc lrp1 myo6 nonsyndromic nrp1 ntrk1 pdz rgs19 rtks sema4c tgfbetar3 vangl2	alpha3beta1 alpha6beta4 beta4 block c2 competes coupling depends egf engagement engaging extreme her1 integrin laminin ln332 matrix migration penetrating platform qeexyx recognize sdc1 shares spreading syndecan syndecans utilized
Tagcloud (Intersection) ?		sdc4