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GIPC1 and NTRK2
Number of citations of the paper that reports this interaction (PubMedID
11251075
)
51
Data Source:
HPRD
(in vitro, in vivo, two hybrid)
GIPC1
NTRK2
Description
GIPC PDZ domain containing family member 1
neurotrophic receptor tyrosine kinase 2
Image
No pdb structure
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Cell Cortex
Synaptic Vesicle
Vesicle Membrane
Membrane
Cytoplasmic Vesicle
Dendritic Spine
Dendritic Shaft
Extracellular Exosome
Schaffer Collateral - CA1 Synapse
Glutamatergic Synapse
Cytoplasm
Endosome
Early Endosome
Cytosol
Plasma Membrane
Endosome Membrane
Postsynaptic Density
Membrane
Axon
Dendrite
Early Endosome Membrane
Cell Projection
Terminal Bouton
Dendritic Spine
Receptor Complex
Axon Terminus
Synapse
Perinuclear Region Of Cytoplasm
Molecular Function
Actin Binding
Signaling Receptor Binding
Protein Binding
Myosin Binding
Identical Protein Binding
Cadherin Binding
Nucleotide Binding
Protease Binding
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Neurotrophin Receptor Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Protein Homodimerization Activity
Neurotrophin Binding
Brain-derived Neurotrophic Factor Binding
Brain-derived Neurotrophic Factor Receptor Activity
Biological Process
Protein Targeting
G Protein-coupled Receptor Signaling Pathway
Chemical Synaptic Transmission
Glutamate Secretion
Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Regulation Of Protein Stability
Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Cytokinesis
Endothelial Cell Migration
Positive Regulation Of Melanin Biosynthetic Process
Regulation Of Synaptic Plasticity
Cellular Response To Interleukin-7
Presynaptic Modulation Of Chemical Synaptic Transmission
Vasculogenesis
Neuron Migration
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Nervous System Development
Learning
Circadian Rhythm
Feeding Behavior
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of Gene Expression
Positive Regulation Of Neuron Projection Development
Glutamate Secretion
Regulation Of Metabolic Process
Neuronal Action Potential Propagation
Central Nervous System Neuron Development
Cerebral Cortex Development
Myelination In Peripheral Nervous System
Cell Differentiation
Neuron Differentiation
Brain-derived Neurotrophic Factor Receptor Signaling Pathway
Neurotrophin Signaling Pathway
Mechanoreceptor Differentiation
Regulation Of GTPase Activity
Positive Regulation Of MAPK Cascade
Negative Regulation Of Neuron Apoptotic Process
Retinal Rod Cell Development
Protein Autophosphorylation
Oligodendrocyte Differentiation
Peripheral Nervous System Neuron Development
Positive Regulation Of Axonogenesis
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Synapse Assembly
Retina Development In Camera-type Eye
Long-term Synaptic Potentiation
Cellular Response To Amino Acid Stimulus
Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission
Negative Regulation Of Amyloid-beta Formation
Cellular Response To Brain-derived Neurotrophic Factor Stimulus
Negative Regulation Of Anoikis
Pathways
FGFR1b ligand binding and activation
FGFR1c ligand binding and activation
TGFBR3 regulates TGF-beta signaling
TGFBR3 regulates FGF2 signaling
PIP3 activates AKT signaling
NGF-independant TRKA activation
Constitutive Signaling by Aberrant PI3K in Cancer
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
BDNF activates NTRK2 (TRKB) signaling
NTF3 activates NTRK2 (TRKB) signaling
NTF4 activates NTRK2 (TRKB) signaling
Activated NTRK2 signals through RAS
Activated NTRK2 signals through PLCG1
Activated NTRK2 signals through PLCG1
Activated NTRK2 signals through PI3K
Activated NTRK2 signals through FRS2 and FRS3
Activated NTRK2 signals through FRS2 and FRS3
Activated NTRK2 signals through FYN
NTRK2 activates RAC1
NTRK2 activates RAC1
Activated NTRK2 signals through CDK5
Drugs
Amitriptyline
Esketamine
Entrectinib
Fostamatinib
Larotrectinib
Diseases
Neuroblastoma
GWAS
Femur bone mineral density x serum urate levels interaction (
34046847
)
Kidney stones (
31729369
)
Birth weight (
24950379
)
Body mass index (
25760438
28892062
)
Body size at age 10 (
32376654
)
Gout (normal type) (
32238385
)
Lifetime anxiety disorder (
31748690
)
Menarche (age at onset) (
25231870
)
Parkinson's disease progression (cognitive) (
33111402
)
Refractive error (
32231278
)
Serum metabolite concentrations in chronic kidney disease (
29545352
)
Type 2 diabetes (
31118516
)
Waist-to-hip circumference ratio (recreational physical activity interaction) (
23192594
)
Interacting Genes
37 interacting genes:
ACTN1
ADRB1
CARD10
CD93
DDIT3
DRD2
DRD3
FZD3
GSK3B
IGF1R
ITGA5
ITGA6
KCNJ6
KIF1B
LHCGR
LPAR1
LPAR2
LRP1
LRP2
LRP8
MYO6
NRP1
NTRK1
NTRK2
PLEKHA2
RGS1
RGS19
SDC4
SEMA4B
SEMA4C
SLC2A1
TGFBR3
TPBG
TYRP1
VANGL2
ZFPM1
ZNF408
35 interacting genes:
AP1B1
BDNF
DOK5
DYNLL1
EGFR
ERBB2
ERBB4
FRS2
FRS3
FYN
GIPC1
KIDINS220
NCK1
NCK2
NDFIP1
NGFR
NMNAT1
NTF3
NTF4
PIK3R1
PLCG1
POLR2G
PTPN1
PTPN11
RASGRF1
SH2B1
SH2B2
SHC1
SHC2
SHC3
SORT1
SQSTM1
TRAF6
UBB
USP8
Entrez ID
10755
4915
HPRD ID
05462
02712
Ensembl ID
ENSG00000123159
ENSG00000148053
Uniprot IDs
A8K2I7
O14908
A0A8I5KR47
A0A8I5KUZ1
A0A8I5KZB7
A0A8J8YUT9
Q16620
Q548C2
Q5VWE5
PDB IDs
1HCF
1WWB
2MFQ
4ASZ
4AT3
4AT4
4AT5
5MO9
8OYD
Enriched GO Terms of Interacting Partners
?
Plasma Membrane
Glutamatergic Synapse
Membrane
Cell Migration
Regulation Of Locomotion
Regulation Of Signal Transduction
Regulation Of Cell Communication
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Signaling
Regulation Of Cell Migration
Receptor Complex
Positive Regulation Of Signal Transduction
Axon
Regulation Of Cell Motility
Cell Motility
PDZ Domain Binding
Cell Projection Organization
Positive Regulation Of MAPK Cascade
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Cell Surface
Anatomical Structure Formation Involved In Morphogenesis
Signal Transduction
Regulation Of MAPK Cascade
Negative Regulation Of Signal Transduction
Positive Regulation Of Nervous System Development
Developmental Process
Positive Regulation Of Multicellular Organismal Process
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Regulation Of Intracellular Signal Transduction
Regulation Of Nervous System Development
Positive Regulation Of Cellular Component Organization
Endocytic Vesicle
Positive Regulation Of Locomotion
Dendrite
Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway
Regulation Of Developmental Process
Regulation Of Apoptotic Process
Neural Tube Closure
Anatomical Structure Morphogenesis
Regulation Of Programmed Cell Death
Tube Closure
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Cell Migration
Insulin-like Growth Factor I Binding
Positive Regulation Of Developmental Process
Regulation Of Multicellular Organismal Process
Positive Regulation Of Cell Motility
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Positive Regulation Of Cell Communication
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Signaling
Positive Regulation Of Signal Transduction
Receptor Tyrosine Kinase Binding
Positive Regulation Of Intracellular Signal Transduction
Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Positive Regulation Of MAPK Cascade
Regulation Of Cell Communication
Regulation Of Signaling
Regulation Of Apoptotic Process
Neurotrophin Signaling Pathway
Regulation Of Programmed Cell Death
Signal Transduction
Regulation Of Signal Transduction
Nerve Growth Factor Signaling Pathway
Neurotrophin TRKA Receptor Binding
Cellular Response To Growth Factor Stimulus
Regulation Of Intracellular Signal Transduction
Regulation Of MAPK Cascade
Response To Growth Factor
Regulation Of Protein Localization
Cell Projection Organization
Cellular Response To Epidermal Growth Factor Stimulus
Phosphotyrosine Residue Binding
Intracellular Signal Transduction
Cytosol
Nerve Growth Factor Receptor Binding
Response To Epidermal Growth Factor
Insulin Receptor Binding
Negative Regulation Of Programmed Cell Death
Regulation Of Protein Metabolic Process
Ephrin Receptor Binding
Negative Regulation Of Developmental Process
Signaling Adaptor Activity
Modulation Of Chemical Synaptic Transmission
Regulation Of Cell Population Proliferation
Regulation Of Endoplasmic Reticulum Unfolded Protein Response
Regulation Of Cellular Localization
Neuron Projection Morphogenesis
Negative Regulation Of Apoptotic Process
Positive Regulation Of Response To Endoplasmic Reticulum Stress
Negative Regulation Of PERK-mediated Unfolded Protein Response
Cell Projection Morphogenesis
Regulation Of ERK1 And ERK2 Cascade
Endosome Membrane
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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