GIPC1 and MYO6

Number of citations of the paper that reports this interaction (PubMedID 10198040)
50

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		GIPC1	MYO6
Description		GIPC PDZ domain containing family member 1	myosin VI
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cell Cortex Synaptic Vesicle Vesicle Membrane Membrane Cytoplasmic Vesicle Dendritic Spine Dendritic Shaft Extracellular Exosome Schaffer Collateral - CA1 Synapse Glutamatergic Synapse	Ruffle Nucleus Nucleoplasm Cytoplasm Lysosomal Membrane Endosome Autophagosome Golgi Apparatus Cytosol Actin Filament Plasma Membrane Microvillus Clathrin-coated Pit Cell Cortex Actin Cytoskeleton Membrane Myosin Complex Unconventional Myosin Complex Clathrin-coated Vesicle Endocytic Vesicle Filopodium Clathrin-coated Vesicle Membrane Cytoplasmic Vesicle Filamentous Actin Nuclear Membrane Ruffle Membrane Protein-containing Complex Cell Projection Apical Part Of Cell Clathrin-coated Endocytic Vesicle Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Actin Binding Signaling Receptor Binding Protein Binding Myosin Binding Identical Protein Binding Cadherin Binding	Microfilament Motor Activity Nucleotide Binding Cytoskeletal Motor Activity Actin Binding Protein Binding Calmodulin Binding ATP Binding Identical Protein Binding ADP Binding Actin Filament Binding Minus-end Directed Microfilament Motor Activity
	Biological Process	Protein Targeting G Protein-coupled Receptor Signaling Pathway Chemical Synaptic Transmission Glutamate Secretion Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Stability Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cytokinesis Endothelial Cell Migration Positive Regulation Of Melanin Biosynthetic Process Regulation Of Synaptic Plasticity Cellular Response To Interleukin-7 Presynaptic Modulation Of Chemical Synaptic Transmission	Intracellular Protein Transport Endocytosis Actin Filament Organization Sensory Perception Of Sound Intracellular Protein Localization Response To Xenobiotic Stimulus Protein Transport Actin Filament-based Movement DNA Damage Response, Signal Transduction By P53 Class Mediator Inner Ear Morphogenesis Inner Ear Auditory Receptor Cell Differentiation Regulation Of Secretion
Pathways		FGFR1b ligand binding and activation FGFR1c ligand binding and activation TGFBR3 regulates TGF-beta signaling TGFBR3 regulates FGF2 signaling	Gap junction degradation Trafficking of AMPA receptors RHOBTB2 GTPase cycle RHOU GTPase cycle RHOBTB1 GTPase cycle
Drugs
Diseases			Deafness, autosomal recessive Deafness, autosomal dominant
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847) Kidney stones ( 31729369)	Hip circumference adjusted for BMI ( 34021172) Prostate cancer ( 25217961) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		37 interacting genes: ACTN1 ADRB1 CARD10 CD93 DDIT3 DRD2 DRD3 FZD3 GSK3B IGF1R ITGA5 ITGA6 KCNJ6 KIF1B LHCGR LPAR1 LPAR2 LRP1 LRP2 LRP8 MYO6 NRP1 NTRK1 NTRK2 PLEKHA2 RGS1 RGS19 SDC4 SEMA4B SEMA4C SLC2A1 TGFBR3 TPBG TYRP1 VANGL2 ZFPM1 ZNF408	24 interacting genes: ACTA1 APC CALCOCO2 CALM2 CDC42 CDH1 CLTB DAB1 DAB2 DLG1 GIPC1 LRCH3 OPTN PAK1 PAK3 PRMT2 RNF11 RNF26 SEPTIN9 SNCA TAX1BP1 TOM1L2 UBC WBP2
Entrez ID		10755	4646
HPRD ID		05462	02985
Ensembl ID		ENSG00000123159	ENSG00000196586
Uniprot IDs		A8K2I7 O14908	A0A0A0MRM8 A0A1Y0BRN3 A0A590UJ40 Q9UM54
PDB IDs			2N0Z 2N10 2N11 2N12 2N13 6E5N 6J56 8W41
Enriched GO Terms of Interacting Partners?		Plasma Membrane Glutamatergic Synapse Membrane Cell Migration Regulation Of Locomotion Regulation Of Signal Transduction Regulation Of Cell Communication Positive Regulation Of Intracellular Signal Transduction Regulation Of Signaling Regulation Of Cell Migration Receptor Complex Positive Regulation Of Signal Transduction Axon Regulation Of Cell Motility Cell Motility PDZ Domain Binding Cell Projection Organization Positive Regulation Of MAPK Cascade Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cell Surface Anatomical Structure Formation Involved In Morphogenesis Signal Transduction Regulation Of MAPK Cascade Negative Regulation Of Signal Transduction Positive Regulation Of Nervous System Development Developmental Process Positive Regulation Of Multicellular Organismal Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Intracellular Signal Transduction Regulation Of Nervous System Development Positive Regulation Of Cellular Component Organization Endocytic Vesicle Positive Regulation Of Locomotion Dendrite Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Regulation Of Developmental Process Regulation Of Apoptotic Process Neural Tube Closure Anatomical Structure Morphogenesis Regulation Of Programmed Cell Death Tube Closure Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Migration Insulin-like Growth Factor I Binding Positive Regulation Of Developmental Process Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Motility	Perinuclear Region Of Cytoplasm Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Cytoplasm Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Regulation Of Signal Transduction Intracellular Protein Localization Regulation Of Supramolecular Fiber Organization Cytosol Regulation Of Organelle Organization Septin Cytoskeleton Organization Protein Kinase Binding Cell Junction Organization Presynaptic Endocytosis Negative Regulation Of Cellular Component Organization Regulation Of Cellular Component Organization Regulation Of Cell Cycle Process Regulation Of Axonogenesis Positive Regulation Of Organelle Organization Positive Regulation Of Cellular Component Biogenesis Cadherin Binding Regulation Of Cytoskeleton Organization Leading Edge Membrane Cell-cell Junction Organization Positive Regulation Of Cellular Component Organization Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Glutamatergic Synapse Regulation Of Defense Response Lateral Plasma Membrane Negative Regulation Of Cell Cycle G1/S Phase Transition Gamma-catenin Binding Lamellipodium Positive Regulation Of Pseudopodium Assembly Regulation Of Protein Catabolic Process Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Cell Migration Golgi Localization Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Negative Regulation Of Mitotic Cell Cycle Autophagosome Regulation Of Cytokinesis Regulation Of Protein-containing Complex Assembly Vesicle-mediated Transport In Synapse Dendritic Spine Morphogenesis Regulation Of Neuron Projection Development Endocytosis Regulation Of Microtubule Polymerization Or Depolymerization
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