GIPC1 and FZD3

Number of citations of the paper that reports this interaction (PMID 12011974)
23

Data Source:
HPRD (in vivo)

		GIPC1	FZD3
Gene Name		GIPC PDZ domain containing family, member 1	frizzled class receptor 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Brush Border Cell Cortex Synaptic Vesicle Vesicle Membrane Membrane Cytoplasmic Membrane-bounded Vesicle Endocytic Vesicle Dendritic Spine Dendritic Shaft Extracellular Vesicular Exosome	Cytoplasm Plasma Membrane Cell Surface Integral Component Of Membrane Apical Plasma Membrane Lateral Plasma Membrane Axon Dendrite Neuronal Cell Body Presynaptic Active Zone
	Molecular Function	Actin Binding Receptor Binding Protein Binding Myosin Binding PDZ Domain Binding Protein Homodimerization Activity	G-protein Coupled Receptor Activity Protein Binding Wnt-protein Binding PDZ Domain Binding Wnt-activated Receptor Activity
	Biological Process	Protein Targeting G-protein Coupled Receptor Signaling Pathway Synaptic Transmission Glutamate Secretion Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Stability Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cytokinesis Endothelial Cell Migration Regulation Of Synaptic Plasticity	Establishment Of Planar Polarity Neuron Migration Neural Tube Closure Hair Follicle Development Positive Regulation Of Neuroblast Proliferation G-protein Coupled Receptor Signaling Pathway Neuron Differentiation Cell Proliferation In Midbrain Non-canonical Wnt Signaling Pathway Post-anal Tail Morphogenesis Inner Ear Morphogenesis Negative Regulation Of Mitotic Cell Cycle, Embryonic Canonical Wnt Signaling Pathway Sympathetic Ganglion Development Commissural Neuron Axon Guidance Negative Regulation Of Execution Phase Of Apoptosis
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Ca2+ pathway Asymmetric localization of PCP proteins Signaling by Wnt Metabolic disorders of biological oxidation enzymes GPCR ligand binding PCP/CE pathway Class B/2 (Secretin family receptors) beta-catenin independent WNT signaling
Drugs
Diseases
GWAS
Protein-Protein Interactions		31 interactors: ACTN1 ADRB1 CD93 DDIT3 DRD2 DRD3 FZD3 GSK3B IGF1R ITGA5 ITGA6 KIF1B LHCGR LRP1 LRP2 LRP8 MYO6 NRP1 NTRK1 NTRK2 RGS1 RGS19 SDC4 SEMA4B SEMA4C SLC2A1 TGFBR3 TPBG TYRP1 ZFPM1 ZNF408	3 interactors: GIPC1 GIPC2 GIPC3
Entrez ID		10755	7976
HPRD ID		05462	05849
Ensembl ID		ENSG00000123159	ENSG00000104290
Uniprot IDs		A8K2I7 O14908	A8K615 Q9NPG1
PDB IDs
Enriched GO Terms of Interacting Partners?		Response To External Stimulus Regulation Of Signaling Regulation Of Phosphorus Metabolic Process Regulation Of Adenylate Cyclase Activity Regulation Of Cyclase Activity Positive Regulation Of Phosphorylation Response To Abiotic Stimulus Cell Surface Receptor Signaling Pathway Cell Communication System Development Regulation Of CAMP Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Anatomical Structure Development Positive Regulation Of Metabolic Process Developmental Process Cognition Regulation Of CAMP Metabolic Process Signaling Regulation Of Signal Transduction Signal Transduction Multicellular Organismal Development Movement Of Cell Or Subcellular Component Cell Differentiation Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Learning Or Memory Cell Migration Negative Regulation Of Signal Transduction Activation Of Adenylate Cyclase Activity Anatomical Structure Morphogenesis Regulation Of Cell Development Response To Radiation Tissue Development Cellular Response To Stimulus Regulation Of Synaptic Transmission Cell Motility Regulation Of Apoptotic Process Negative Regulation Of Signaling Positive Regulation Of Adenylate Cyclase Activity Organ Development Response To Stimulus Response To Wounding Positive Regulation Of Cell Development Cell Morphogenesis Involved In Differentiation Response To Light Stimulus Positive Regulation Of Protein Phosphorylation Regulation Of Cell Death Locomotion Regulation Of Cell Differentiation Nervous System Development	Glutamate Secretion Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Cytokinesis Acid Secretion Regulation Of Cytokinesis Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Cellular Protein Catabolic Process Endothelial Cell Migration Dicarboxylic Acid Transport Epithelial Cell Migration Epithelium Migration Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Protein Catabolic Process Positive Regulation Of Cell Division Regulation Of Protein Stability Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Tagcloud ?		adrb1 alpha5 appl1 assembles cargoes deafness dimerizing drd2 factorbeta gh1 gh2 gipc2 gipc3 gipcs gpcrs hbc lrp1 myo6 nonsyndromic nrp1 ntrk1 pdz rgs19 rtks sdc4 sema4c tgfbetar3 vangl2	adds arealization axon axons barrel celsr2 celsr3 conditional contexts forebrain guidance guidepost inactivation mimics navigation pcp perturbs planar polarity projections redundantly thalamic thalamocortical thalamus unexpectedly vangl vangl1 vangl2 wiring
Tagcloud (Difference) ?		adrb1 alpha5 appl1 assembles cargoes deafness dimerizing drd2 factorbeta gh1 gh2 gipc2 gipc3 gipcs gpcrs hbc lrp1 myo6 nonsyndromic nrp1 ntrk1 pdz rgs19 rtks sdc4 sema4c tgfbetar3	adds arealization axon axons barrel celsr2 celsr3 conditional contexts forebrain guidance guidepost inactivation mimics navigation pcp perturbs planar polarity projections redundantly thalamic thalamocortical thalamus unexpectedly vangl vangl1 wiring
Tagcloud (Intersection) ?		vangl2