INS and MAPK6

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		INS	MAPK6
Description		insulin	mitogen-activated protein kinase 6
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GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Transport Vesicle Endosome Lumen Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Secretory Granule Lumen	Nucleus Nucleoplasm Cytoplasm Cytosol Septin Cytoskeleton Protein-containing Complex
	Molecular Function	Protease Binding Insulin Receptor Binding Insulin-like Growth Factor Receptor Binding Hormone Activity Protein Binding Identical Protein Binding Receptor Ligand Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Protein Heterodimerization Activity Protein Serine Kinase Activity
	Biological Process	Positive Regulation Of Cytokine Production Negative Regulation Of Acute Inflammatory Response Glucose Metabolic Process Regulation Of DNA-templated Transcription Acute-phase Response G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Nitric Oxide Mediated Signal Transduction Positive Regulation Of Neuron Projection Development Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Regulation Of Protein Localization Nitric Oxide-cGMP-mediated Signaling TORC1 Signaling Wound Healing Negative Regulation Of Protein Catabolic Process Vasodilation Glucose Homeostasis Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of MAPK Cascade Positive Regulation Of Cell Differentiation Negative Regulation Of Gluconeogenesis Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Translation Negative Regulation Of Glycogen Catabolic Process Positive Regulation Of Glycolytic Process Positive Regulation Of Mitotic Nuclear Division Negative Regulation Of Fatty Acid Metabolic Process Positive Regulation Of D-glucose Import Positive Regulation Of Insulin Receptor Signaling Pathway Alpha-beta T Cell Activation Positive Regulation Of Lipid Biosynthetic Process Regulation Of Synaptic Plasticity Regulation Of Protein Secretion Negative Regulation Of Protein Secretion Positive Regulation Of Protein Secretion Cognition Negative Regulation Of Lipid Catabolic Process Positive Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Fatty Acid Homeostasis Negative Regulation Of Respiratory Burst Involved In Inflammatory Response Positive Regulation Of Respiratory Burst Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Brown Fat Cell Differentiation Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Long-term Synaptic Potentiation Cellular Response To Oxygen-containing Compound Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Dendritic Spine Maintenance Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Neuron Projection Maintenance Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Feeding Behavior	MAPK Cascade Protein Phosphorylation Signal Transduction Intracellular Signal Transduction Positive Regulation Of Dendritic Spine Development
Pathways		Regulation of gene expression in beta cells Insulin processing Insulin processing Synthesis, secretion, and deacylation of Ghrelin Regulation of insulin secretion COPI-mediated anterograde transport PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling IRS activation Signal attenuation Insulin receptor signalling cascade Signaling by Insulin receptor Insulin receptor recycling FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes NPAS4 regulates expression of target genes Amyloid fiber formation	MAPK6/MAPK4 signaling
Drugs		Glisoxepide Zinc M-Cresol Myristic acid Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Acetylsalicylic acid Minocycline Colforsin
Diseases		Permanent neonatal diabetes mellitus (PNDM) Type I diabetes mellitus Maturity onset diabetes of the young (MODY)
GWAS		Birth weight ( 27680694) Celiac disease ( 23936387) Fasting glucose ( 34059833) Glycated hemoglobin levels ( 34059833) Latent autoimmune diabetes vs. type 2 diabetes ( 30254083) Pediatric autoimmune diseases ( 26301688) Prostate cancer ( 19767753) Prostate cancer (SNP x SNP interaction) ( 22219177) Severe autoimmune type 2 diabetes ( 34737425) Type 1 diabetes ( 25751624 21829393 30659077 31152121 32005708 33830302 19430480 17632545 17554260) Type 1 diabetes autoantibodies in high risk HLA genotype individuals (time to event) ( 29310926) Type 1 diabetes in high risk HLA genotype individuals (time to event) ( 29310926) Type 2 diabetes ( 30297969 30718926 31049640 31324766 32499647)	Frailty index ( 34431594) Serum uric acid levels in response to allopurinol in gout ( 25676789)
Interacting Genes		32 interacting genes: ADAMTSL4 APP CCN3 CPE CRYAB CTSB CTSD CTSE CYSRT1 GCK HLA-DQA2 HLA-DQB1 HSPA1A HSPB1 IDE IGF1R IGFBP7 INSR KMT2A KRTAP1-1 KRTAP1-3 KRTAP10-8 LRP2 MAPK6 NBPF19 NOTCH2NLA PTEN RB1 RGS20 SYTL4 TCF4 TXNDC17	167 interacting genes: ACTG1 ACTR1B AMPH ANAPC5 ANK3 ANKRD2 APBA2 ARHGDIA ARPC3 ATG9A ATP5PF BAG6 BARX1 BBS10 BTRC CA1 CA12 CALR CASP6 CCND3 CCT3 CDH13 CERS1 CFAP298 CFL1 CNTN1 CNTRL COPS6 CSE1L CYRIB CYTH2 DBN1 DCTN2 DDOST DDR1 DGKZ DKC1 DNAJC28 DPPA4 DST DYNC2I2 EDF1 EEF1A2 EIF1 EIF3C EIF4A1 ELOF1 EMD FBXL16 FOXO3 FXYD3 GALNT7 GATA1 GLRX3 GORASP1 GPX1 HACL1 HAUS2 HDAC11 HIP1 HNRNPA0 HNRNPD HNRNPH3 HSP90AB1 HSP90B1 HSPD1 IDH3B INS ITGB3BP ITSN1 JUNB KDSR KLC1 KNSTRN LPXN MAP3K12 MAP3K7 MAPKAPK5 MASP1 MBIP MBOAT7 MCM3 MDK METTL17 METTL2A MGAT1 MIPEP MOK MON1A MTG2 MYBL2 MYOZ3 MZB1 NAT9 NAXE NDUFS6 NECTIN2 NELFB NOL4 NRXN2 NUDT5 OSTF1 PDCD6IP PDLIM1 PHACTR3 PHC2 PHGDH PIH1D1 PLEKHM1 PLSCR1 PPBP PPP1R7 PPP2R1A PRKAB1 PRKAR1A PRKCB PRPF38A PSAT1 PSIP1 PTPMT1 RAB2A RAB31 RACK1 RANBP9 RAP1GAP RARA RBL1 RGS19 RPL10 RRP7A SEPTIN3 SEPTIN5 SERPINA4 SHC1 SLC20A1 SLC41A3 SMAD6 SMS SNAPC4 SNW1 SOCS3 SPG7 SPRR2D SPTAN1 SRSF5 STX7 TDP2 THAP4 TPI1 TTK TUBA1A UBA52 UBE2L3 URB1 USP20 VPS26C WDR26 WFS1 WWC1 XPO1 ZNF133 ZNF205 ZNF331 ZNF579 ZNF600 ZNF671 ZNF775
Entrez ID		3630	5597
HPRD ID		01455	04213
Ensembl ID		ENSG00000254647	ENSG00000069956
Uniprot IDs		I3WAC9 P01308	Q16659
PDB IDs		1A7F 1AI0 1AIY 1B9E 1BEN 1EFE 1EV3 1EV6 1EVR 1FU2 1FUB 1G7A 1G7B 1GUJ 1HIQ 1HIS 1HIT 1HLS 1HTV 1HUI 1IOG 1IOH 1J73 1JCA 1JCO 1JK8 1K3M 1KMF 1LKQ 1LPH 1MHI 1MHJ 1MSO 1OS3 1OS4 1Q4V 1QIY 1QIZ 1QJ0 1RWE 1SF1 1SJT 1SJU 1T0C 1T1K 1T1P 1T1Q 1TRZ 1TYL 1TYM 1UZ9 1VKT 1W8P 1XDA 1XGL 1XW7 1ZEG 1ZEH 1ZNJ 2AIY 2C8Q 2C8R 2CEU 2G54 2G56 2H67 2HH4 2HHO 2HIU 2JMN 2JUM 2JUU 2JUV 2JV1 2JZQ 2K91 2K9R 2KJJ 2KJU 2KQP 2KQQ 2KXK 2L1Y 2L1Z 2LGB 2LWZ 2M1D 2M1E 2M2M 2M2N 2M2O 2M2P 2MLI 2MPG 2MPI 2MVC 2MVD 2N2V 2N2W 2N2X 2OLY 2OLZ 2OM0 2OM1 2OMG 2OMH 2OMI 2OMQ 2QIU 2R34 2R35 2R36 2RN5 2VJZ 2VK0 2W44 2WBY 2WC0 2WRU 2WRV 2WRW 2WRX 2WS0 2WS1 2WS4 2WS6 2WS7 3AIY 3BXQ 3E7Y 3E7Z 3EXX 3FQ9 3HYD 3I3Z 3I40 3ILG 3INC 3IR0 3JSD 3KQ6 3P2X 3P33 3Q6E 3ROV 3TT8 3U4N 3UTQ 3UTS 3UTT 3V19 3V1G 3W11 3W12 3W13 3W7Y 3W7Z 3W80 3ZI3 3ZQR 3ZS2 3ZU1 4AIY 4AJX 4AJZ 4AK0 4AKJ 4CXL 4CXN 4CY7 4EFX 4EWW 4EWX 4EWZ 4EX0 4EX1 4EXX 4EY1 4EY9 4EYD 4EYN 4EYP 4F0N 4F0O 4F1A 4F1B 4F1C 4F1D 4F1F 4F1G 4F4T 4F4V 4F51 4F8F 4FG3 4FKA 4GBC 4GBI 4GBK 4GBL 4GBN 4IUZ 4IYD 4IYF 4NIB 4OGA 4P65 4RXW 4UNE 4UNG 4UNH 4WDI 4XC4 4Y19 4Y1A 4Z76 4Z77 4Z78 5AIY 5BOQ 5BPO 5BQQ 5BTS 5C0D 5CJO 5CNY 5CO2 5CO6 5CO9 5E7W 5EMS 5EN9 5ENA 5HPR 5HPU 5HQI 5HRQ 5HYJ 5MAM 5MHD 5MT3 5MT9 5MWQ 5T7R 5UDP 5UOZ 5UQA 5URT 5URU 5USP 5USS 5USV 5UU2 5UU3 5UU4 5VIZ 5WBT 5WDM 5WOB 6B3Q 6B70 6BFC 6CE7 6CE9 6CEB 6CK2 6GNQ 6GV0 6H3M 6HN5 6JK8 6JR3 6K59 6NWV 6O17 6P4Z 6S34 6S4I 6S4J 6SOF 6TC2 6TYH 6U46 6VEP 6VER 6VES 6VET 6X4X 6Z7W 6Z7Y 7BW7 7BW8 7BWA 7JP3 7KD6 7MD4 7MD5 7MQO 7MQR 7MQS 7NHU 7NMG 7PG0 7PG2 7PG3 7PG4 7QAC 7QGF 7QID 7RKD 7RZE 7RZF 7RZI 7S4Y 7SL1 7SL2 7SL3 7SL4 7SL6 7SL7 7STH 7STI 7STJ 7STK 7U6E 7V3P 7YQ3 7YQ4 7YQ5 7Z5L 7Z5Q 8EYX 8EYY 8EZ0 8GSG 8GUY 8HGZ 8HSF 8HSK 8IPZ 8OKY 8ONI 8ONK 8ONP 8ONR 8PI4 8PI5 8PI6 8PJH 8RRP 8RVT 8SBD 8VCX 8VDD 8WU0 8Z4B 9LVC 9LVD 9LVE 9LVX 9LVY 9M4X 9M4Y 9M4Z 9M50 9M51	6YKY 6YLC 6YLL 7AQB
Enriched GO Terms of Interacting Partners?		Insulin Binding Antigen Processing And Presentation Of Peptide Antigen Amyloid-beta Clearance Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Exogenous Peptide Antigen Neuron Projection Organization Antigen Processing And Presentation Identical Protein Binding Insulin-like Growth Factor I Binding Antigen Processing And Presentation Of Exogenous Antigen Lysosome Transport Vesicle Membrane Insulin Metabolic Process PTB Domain Binding Endosome Lumen Insulin Receptor Activity Regulation Of Growth Insulin Receptor Signaling Pathway Protein Refolding Insulin Catabolic Process Insulin Receptor Complex Dendritic Spine Organization Cellular Response To Hormone Stimulus Regulation Of Apoptotic Process Negative Regulation Of Cell Population Proliferation Extracellular Exosome Regulation Of Programmed Cell Death Negative Regulation Of Growth Signal Transduction Symbiont Entry Into Host Cell Postsynapse Organization Regulation Of Generation Of Precursor Metabolites And Energy MHC Class II Receptor Activity Regulation Of Glycolytic Process Response To Hormone Intracellular Signaling Cassette Regulation Of Cell Population Proliferation Regulation Of Neuronal Synaptic Plasticity Cellular Response To Growth Factor Stimulus Insulin-like Growth Factor Binding Dendritic Spine Maintenance Regulation Of Cell Communication Regulation Of Signaling Biological Process Involved In Interaction With Host Regulation Of Carbohydrate Catabolic Process Neuron Projection Maintenance Neurexin Family Protein Binding Contractile Muscle Fiber	Cytosol Cytoplasm Nucleus Protein Binding Extracellular Exosome Ubiquitin Protein Ligase Binding
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