INS and GCK

Number of citations of the paper that reports this interaction (PMID 12101177)
11

Data Source:
HPRD (in vitro)

		INS	GCK
Gene Name		insulin	glucokinase (hexokinase 4)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Endosome Lumen Secretory Granule Lumen	Nucleoplasm Mitochondrion Cytosol Actin Filament Secretory Granule Basal Cortex
	Molecular Function	Protease Binding Insulin Receptor Binding Insulin-like Growth Factor Receptor Binding Hormone Activity Protein Binding Identical Protein Binding	Magnesium Ion Binding Glucokinase Activity Protein Binding ATP Binding Glucose Binding Fructokinase Activity Mannokinase Activity Protein Phosphatase Binding ADP Binding
	Biological Process	MAPK Cascade Negative Regulation Of Acute Inflammatory Response Glucose Metabolic Process Energy Reserve Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Cellular Amino Acid Metabolic Process Acute-phase Response G-protein Coupled Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Glucose Transport Regulation Of Transmembrane Transporter Activity Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Endocrine Pancreas Development Positive Regulation Of Protein Autophosphorylation Activation Of Protein Kinase B Activity Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Oligomerization Regulation Of Protein Localization Negative Regulation Of NAD(P)H Oxidase Activity Wound Healing Negative Regulation Of Protein Catabolic Process Glucose Homeostasis Positive Regulation Of MAPK Cascade Cellular Protein Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Cell Differentiation Negative Regulation Of Gluconeogenesis Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of DNA Replication Negative Regulation Of Glycogen Catabolic Process Positive Regulation Of Glycolytic Process Positive Regulation Of Mitotic Nuclear Division Negative Regulation Of Proteolysis Negative Regulation Of Vasodilation Positive Regulation Of Vasodilation Negative Regulation Of Fatty Acid Metabolic Process Positive Regulation Of Glucose Import Positive Regulation Of Insulin Receptor Signaling Pathway Alpha-beta T Cell Activation Positive Regulation Of Lipid Biosynthetic Process Regulation Of Protein Secretion Negative Regulation Of Protein Secretion Positive Regulation Of Cytokine Secretion Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Insulin Secretion Negative Regulation Of Lipid Catabolic Process Positive Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Protein Kinase B Signaling Fatty Acid Homeostasis Negative Regulation Of Respiratory Burst Involved In Inflammatory Response Positive Regulation Of Respiratory Burst Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Brown Fat Cell Differentiation Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Feeding Behavior	Cellular Glucose Homeostasis Carbohydrate Metabolic Process Glycogen Biosynthetic Process Fructose 2,6-bisphosphate Metabolic Process Glucose Metabolic Process Glycolytic Process Regulation Of Glycolytic Process NADP Metabolic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Hexose Transport Pathogenesis Regulation Of Glucose Transport Glucose Transport Second-messenger-mediated Signaling Endocrine Pancreas Development Positive Regulation Of Insulin Secretion Negative Regulation Of Epinephrine Secretion Cellular Response To Insulin Stimulus Cellular Response To Glucose Starvation Positive Regulation Of Phosphorylation Glucose Homeostasis Regulation Of Potassium Ion Transport Small Molecule Metabolic Process Cellular Response To Leptin Stimulus Negative Regulation Of Gluconeogenesis Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Glycolytic Process Carbohydrate Phosphorylation Regulation Of Insulin Secretion Glucose 6-phosphate Metabolic Process Detection Of Glucose Transmembrane Transport Lipid Homeostasis Calcium Ion Import
Pathways		Synthesis, secretion, and deacylation of Ghrelin Insulin receptor signalling cascade Integration of energy metabolism Regulation of insulin secretion IRS-related events SHC-related events Insulin receptor recycling Peptide hormone metabolism IRS activation Regulation of beta-cell development Signal attenuation Regulation of gene expression in beta cells Insulin processing SHC activation Signaling by Insulin receptor	Regulation of Glucokinase by Glucokinase Regulatory Protein SLC-mediated transmembrane transport Hexose transport Regulation of beta-cell development Myoclonic epilepsy of Lafora Glycogen storage diseases Regulation of gene expression in beta cells Glucose transport Metabolism of carbohydrates
Drugs			Beta-D-Glucose 2-amino-N-(4-methyl-1,3-thiazol-2-yl)-5-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]benzamide 3-[(4-fluorophenyl)sulfanyl]-N-(4-methyl-1,3-thiazol-2-yl)-6-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]pyridine-2-carboxamide 2-(methylamino)-N-(4-methyl-1,3-thiazol-2-yl)-5-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]benzamide 2-AMINO-4-FLUORO-5-[(1-METHYL-1H-IMIDAZOL-2-YL)SULFANYL]-N-(1,3-THIAZOL-2-YL)BENZAMIDE
Diseases
GWAS		Prostate cancer ( 19767753) Type 1 diabetes ( 17632545 19430480 17554260) Type 1 diabetes autoantibodies ( 21829393)	Fasting glucose-related traits ( 20081858) Fasting glucose-related traits (interaction with BMI) ( 22581228) Fasting plasma glucose ( 19060907) Glycated hemoglobin levels ( 20858683 19096518) Glycemic traits ( 23575436) Metabolic syndrome ( 22399527) Metabolite levels ( 21909109)
Protein-Protein Interactions		23 interactors: APP CPE CRYAB CTSB CTSD CTSE GCK HLA-DQA2 HLA-DQB1 HSPB1 IDE IGF1R IGFBP7 INSR KMT2A LRP2 MAPK6 NOV RB1 RGS20 SYTL4 TCF4 TXNDC17	4 interactors: GCKR INS PCNA PFKFB2
Entrez ID		3630	2645
HPRD ID		01455	00680
Ensembl ID		ENSG00000254647	ENSG00000106633
Uniprot IDs		I3WAC9 P01308	P35557 Q53Y25
PDB IDs		1A7F 1AI0 1AIY 1B9E 1BEN 1EFE 1EV3 1EV6 1EVR 1FU2 1FUB 1G7A 1G7B 1GUJ 1HIQ 1HIS 1HIT 1HLS 1HTV 1HUI 1IOG 1IOH 1J73 1JCA 1JCO 1JK8 1K3M 1KMF 1LKQ 1LPH 1MHI 1MHJ 1MSO 1OS3 1OS4 1Q4V 1QIY 1QIZ 1QJ0 1RWE 1SF1 1SJT 1SJU 1T0C 1T1K 1T1P 1T1Q 1TRZ 1TYL 1TYM 1UZ9 1VKT 1W8P 1XDA 1XGL 1XW7 1ZEG 1ZEH 1ZNJ 2AIY 2C8Q 2C8R 2CEU 2G54 2G56 2H67 2HH4 2HHO 2HIU 2JMN 2JUM 2JUU 2JUV 2JV1 2JZQ 2K91 2K9R 2KJJ 2KJU 2KQP 2KQQ 2KXK 2L1Y 2L1Z 2LGB 2LWZ 2M1D 2M1E 2M2M 2M2N 2M2O 2M2P 2OLY 2OLZ 2OM0 2OM1 2OMG 2OMH 2OMI 2QIU 2R34 2R35 2R36 2RN5 2VJZ 2VK0 2W44 2WBY 2WC0 2WRU 2WRV 2WRW 2WRX 2WS0 2WS1 2WS4 2WS6 2WS7 3AIY 3BRR 3BXQ 3E7Y 3E7Z 3EXX 3FQ9 3HYD 3I3Z 3I40 3ILG 3INC 3IR0 3JSD 3KQ6 3P2X 3P33 3Q6E 3ROV 3TT8 3U4N 3UTQ 3UTS 3UTT 3V19 3V1G 3W11 3W12 3W13 3W7Y 3W7Z 3W80 3ZI3 3ZQR 3ZS2 3ZU1 4AIY 4AJX 4AJZ 4AK0 4AKJ 4EFX 4EWW 4EWX 4EWZ 4EX0 4EX1 4EXX 4EY1 4EY9 4EYD 4EYN 4EYP 4F0N 4F0O 4F1A 4F1B 4F1C 4F1D 4F1F 4F1G 4F4T 4F4V 4F51 4F8F 4FG3 4FKA 4GBC 4GBI 4GBK 4GBL 4GBN 4IUZ 5AIY	1GLK 1V4S 1V4T 3A0I 3F9M 3FGU 3FR0 3GOI 3H1V 3ID8 3IDH 3IMX 3QIC 3S41 3VEV 3VEY 3VF6 4DCH 4DHY 4ISE 4ISF 4ISG 4IWV 4IXC 4L3Q 4LC9 4MLE 4MLH
Enriched GO Terms of Interacting Partners?		Insulin Metabolic Process Signal Transduction Signaling Organ Development Cell Communication Cellular Response To Stimulus Response To Organic Substance Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Pancreas Development Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Cellular Response To Organic Substance Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Glucose Metabolic Process Positive Regulation Of Mitotic Nuclear Division Digestive System Development Immune System Process Cellular Response To Hormone Stimulus Regulation Of Protein Metabolic Process Multicellular Organismal Development Regulation Of Growth Response To Hormone Response To Stimulus Exocrine Pancreas Development System Development Exocrine System Development Regulation Of Cellular Process Regulation Of Cellular Component Organization Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Insulin Stimulus Regulation Of Protein Kinase Activity Positive Regulation Of Protein Kinase B Signaling Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Cycle Process Antigen Processing And Presentation Of Peptide Antigen Positive Regulation Of Glycolytic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Glycogen Biosynthetic Process Regulation Of Kinase Activity Negative Regulation Of Signaling Negative Regulation Of Cellular Protein Metabolic Process Male Sex Determination Developmental Process Positive Regulation Of Protein Metabolic Process Protein Metabolic Process Signal Transduction By Phosphorylation Positive Regulation Of Cell Cycle Protein Tetramerization Anatomical Structure Development	Regulation Of Glucose Metabolic Process Positive Regulation Of Glucokinase Activity Regulation Of Carbohydrate Metabolic Process Positive Regulation Of Catalytic Activity Positive Regulation Of Kinase Activity Positive Regulation Of Transferase Activity Glucose Transport Hexose Transport Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Regulation Of Glucose Transport Regulation Of Catalytic Activity Positive Regulation Of Hormone Secretion Response To Organic Substance Lipid Homeostasis Positive Regulation Of Cellular Metabolic Process Regulation Of Kinase Activity Carbohydrate Transport Positive Regulation Of Deoxyribonuclease Activity Regulation Of DNA Replication Positive Regulation Of Phosphorylation Glucose Metabolic Process Positive Regulation Of DNA Metabolic Process Negative Regulation Of Glycogen Catabolic Process Leading Strand Elongation Carbohydrate Metabolic Process Response To Carbohydrate Positive Regulation Of Protein Secretion Regulation Of Insulin Secretion Hexose Metabolic Process Positive Regulation Of Metabolic Process Glucose Homeostasis Pathogenesis Negative Regulation Of Respiratory Burst Involved In Inflammatory Response Negative Regulation Of NAD(P)H Oxidase Activity Regulation Of Peptide Hormone Secretion Monosaccharide Metabolic Process Regulation Of Phosphorylation Regulation Of Hormone Secretion Homeostatic Process Positive Regulation Of Brown Fat Cell Differentiation Glucose Catabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Brown Fat Cell Differentiation Negative Regulation Of Glucokinase Activity Regulation Of NAD(P)H Oxidase Activity Negative Regulation Of Feeding Behavior Positive Regulation Of Secretion Positive Regulation Of Protein Transport Positive Regulation Of Respiratory Burst
Tagcloud ?		catalytic cdna cloned embryonic enriched epidermal epithelial epithelium erbb2 exploits fraction fractions interactions ligands mesenchymal mesenchyme pancreas pancreata platelet prepared proper receptors screened similarities soluble surrounding thought tissues tyrosine	15del26 a1c acanthosis boy department dysmorphic exam fasting glucose height hemoglobin hyperglycemia increment l maturity mmol mody2 mother mu mutational nigricans ogtt proband referred segregated shifted stable stature unremarkable
Tagcloud (Difference) ?		catalytic cdna cloned embryonic enriched epidermal epithelial epithelium erbb2 exploits fraction fractions interactions ligands mesenchymal mesenchyme pancreas pancreata platelet prepared proper receptors screened similarities soluble surrounding thought tissues tyrosine	15del26 a1c acanthosis boy department dysmorphic exam fasting glucose height hemoglobin hyperglycemia increment l maturity mmol mody2 mother mu mutational nigricans ogtt proband referred segregated shifted stable stature unremarkable
Tagcloud (Intersection) ?