INS and IGF1R

Number of citations of the paper that reports this interaction (PMID 1851182)
1

Data Source:
HPRD (in vivo)

		INS	IGF1R
Gene Name		insulin	insulin-like growth factor 1 receptor
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Endosome Lumen Secretory Granule Lumen	Plasma Membrane Integral Component Of Plasma Membrane Caveola Membrane Neuron Projection Intracellular Membrane-bounded Organelle Receptor Complex
	Molecular Function	Protease Binding Insulin Receptor Binding Insulin-like Growth Factor Receptor Binding Hormone Activity Protein Binding Identical Protein Binding	G-protein Alpha-subunit Binding Protein Tyrosine Kinase Activity Insulin-like Growth Factor-activated Receptor Activity Insulin Receptor Binding Protein Binding Insulin-like Growth Factor Binding ATP Binding Insulin-like Growth Factor I Binding Identical Protein Binding Phosphatidylinositol 3-kinase Binding Insulin Binding Insulin Receptor Substrate Binding
	Biological Process	MAPK Cascade Negative Regulation Of Acute Inflammatory Response Glucose Metabolic Process Energy Reserve Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Cellular Amino Acid Metabolic Process Acute-phase Response G-protein Coupled Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Glucose Transport Regulation Of Transmembrane Transporter Activity Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Endocrine Pancreas Development Positive Regulation Of Protein Autophosphorylation Activation Of Protein Kinase B Activity Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Oligomerization Regulation Of Protein Localization Negative Regulation Of NAD(P)H Oxidase Activity Wound Healing Negative Regulation Of Protein Catabolic Process Glucose Homeostasis Positive Regulation Of MAPK Cascade Cellular Protein Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Cell Differentiation Negative Regulation Of Gluconeogenesis Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of DNA Replication Negative Regulation Of Glycogen Catabolic Process Positive Regulation Of Glycolytic Process Positive Regulation Of Mitotic Nuclear Division Negative Regulation Of Proteolysis Negative Regulation Of Vasodilation Positive Regulation Of Vasodilation Negative Regulation Of Fatty Acid Metabolic Process Positive Regulation Of Glucose Import Positive Regulation Of Insulin Receptor Signaling Pathway Alpha-beta T Cell Activation Positive Regulation Of Lipid Biosynthetic Process Regulation Of Protein Secretion Negative Regulation Of Protein Secretion Positive Regulation Of Cytokine Secretion Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Insulin Secretion Negative Regulation Of Lipid Catabolic Process Positive Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Protein Kinase B Signaling Fatty Acid Homeostasis Negative Regulation Of Respiratory Burst Involved In Inflammatory Response Positive Regulation Of Respiratory Burst Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Brown Fat Cell Differentiation Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Feeding Behavior	Immune Response Signal Transduction Axonogenesis Brain Development Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Epidermis Development Negative Regulation Of Muscle Cell Apoptotic Process Phosphatidylinositol 3-kinase Signaling Establishment Of Cell Polarity Male Sex Determination Positive Regulation Of Cell Migration Mammary Gland Development Exocrine Pancreas Development Positive Regulation Of Cytokinesis Response To Vitamin E Peptidyl-tyrosine Autophosphorylation Negative Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of DNA Replication Positive Regulation Of Mitotic Nuclear Division Regulation Of JNK Cascade Protein Autophosphorylation Insulin-like Growth Factor Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Protein Tetramerization Protein Heterooligomerization Inactivation Of MAPKK Activity Positive Regulation Of Protein Kinase B Signaling Negative Regulation Of Protein Kinase B Signaling Prostate Gland Epithelium Morphogenesis Positive Regulation Of Steroid Hormone Biosynthetic Process
Pathways		Synthesis, secretion, and deacylation of Ghrelin Insulin receptor signalling cascade Integration of energy metabolism Regulation of insulin secretion IRS-related events SHC-related events Insulin receptor recycling Peptide hormone metabolism IRS activation Regulation of beta-cell development Signal attenuation Regulation of gene expression in beta cells Insulin processing SHC activation Signaling by Insulin receptor	IRS-related events triggered by IGF1R Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) SHC-related events triggered by IGF1R IGF1R signaling cascade
Drugs			Insulin Regular Insulin Lispro Insulin Glargine Insulin, porcine Mecasermin Alpha-D-Mannose Phosphoaminophosphonic Acid-Adenylate Ester (4Z)-6-bromo-4-({[4-(pyrrolidin-1-ylmethyl)phenyl]amino}methylidene)isoquinoline-1,3(2H,4H)-dione 3-[5-(1H-IMIDAZOL-1-YL)-7-METHYL-1H-BENZIMIDAZOL-2-YL]-4-[(PYRIDIN-2-YLMETHYL)AMINO]PYRIDIN-2(1H)-ONE
Diseases
GWAS		Prostate cancer ( 19767753) Type 1 diabetes ( 17632545 19430480 17554260) Type 1 diabetes autoantibodies ( 21829393)	Arthritis (juvenile idiopathic) ( 22354554) Height ( 20881960) Urate levels ( 23263486)
Protein-Protein Interactions		23 interactors: APP CPE CRYAB CTSB CTSD CTSE GCK HLA-DQA2 HLA-DQB1 HSPB1 IDE IGF1R IGFBP7 INSR KMT2A LRP2 MAPK6 NOV RB1 RGS20 SYTL4 TCF4 TXNDC17	59 interactors: AMY2A APP ARHGEF12 CAV1 CBL CRK CRKL CSK DOK4 DOK5 EEA1 EHD1 ESR1 FFAR2 GIPC1 GNAI1 GNAI2 GNB2L1 GRB10 GRB14 IGF1 IGF2 IGFBP3 INS INSR IRS1 IRS2 IRS4 ITGB1 JAK1 JAK2 KCNIP3 KL KRT27 MAP3K5 MDM2 NEDD4 PIK3R1 PIK3R2 PIK3R3 PRKCD PRKD1 PTPN1 PTPN11 RASA1 RPL11 SH2B1 SHC1 SOCS1 SOCS2 SOCS3 SRC STAT3 UBC VAV3 YWHAB YWHAE YWHAG YWHAZ
Entrez ID		3630	3480
HPRD ID		01455	00932
Ensembl ID		ENSG00000254647	ENSG00000140443
Uniprot IDs		I3WAC9 P01308	C9J5X1 P08069
PDB IDs		1A7F 1AI0 1AIY 1B9E 1BEN 1EFE 1EV3 1EV6 1EVR 1FU2 1FUB 1G7A 1G7B 1GUJ 1HIQ 1HIS 1HIT 1HLS 1HTV 1HUI 1IOG 1IOH 1J73 1JCA 1JCO 1JK8 1K3M 1KMF 1LKQ 1LPH 1MHI 1MHJ 1MSO 1OS3 1OS4 1Q4V 1QIY 1QIZ 1QJ0 1RWE 1SF1 1SJT 1SJU 1T0C 1T1K 1T1P 1T1Q 1TRZ 1TYL 1TYM 1UZ9 1VKT 1W8P 1XDA 1XGL 1XW7 1ZEG 1ZEH 1ZNJ 2AIY 2C8Q 2C8R 2CEU 2G54 2G56 2H67 2HH4 2HHO 2HIU 2JMN 2JUM 2JUU 2JUV 2JV1 2JZQ 2K91 2K9R 2KJJ 2KJU 2KQP 2KQQ 2KXK 2L1Y 2L1Z 2LGB 2LWZ 2M1D 2M1E 2M2M 2M2N 2M2O 2M2P 2OLY 2OLZ 2OM0 2OM1 2OMG 2OMH 2OMI 2QIU 2R34 2R35 2R36 2RN5 2VJZ 2VK0 2W44 2WBY 2WC0 2WRU 2WRV 2WRW 2WRX 2WS0 2WS1 2WS4 2WS6 2WS7 3AIY 3BRR 3BXQ 3E7Y 3E7Z 3EXX 3FQ9 3HYD 3I3Z 3I40 3ILG 3INC 3IR0 3JSD 3KQ6 3P2X 3P33 3Q6E 3ROV 3TT8 3U4N 3UTQ 3UTS 3UTT 3V19 3V1G 3W11 3W12 3W13 3W7Y 3W7Z 3W80 3ZI3 3ZQR 3ZS2 3ZU1 4AIY 4AJX 4AJZ 4AK0 4AKJ 4EFX 4EWW 4EWX 4EWZ 4EX0 4EX1 4EXX 4EY1 4EY9 4EYD 4EYN 4EYP 4F0N 4F0O 4F1A 4F1B 4F1C 4F1D 4F1F 4F1G 4F4T 4F4V 4F51 4F8F 4FG3 4FKA 4GBC 4GBI 4GBK 4GBL 4GBN 4IUZ 5AIY	1IGR 1JQH 1K3A 1M7N 1P4O 2OJ9 2ZM3 3D94 3F5P 3I81 3LVP 3LW0 3NW5 3NW6 3NW7 3O23 3QQU
Enriched GO Terms of Interacting Partners?		Insulin Metabolic Process Signal Transduction Signaling Organ Development Cell Communication Cellular Response To Stimulus Response To Organic Substance Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Pancreas Development Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Cellular Response To Organic Substance Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Glucose Metabolic Process Positive Regulation Of Mitotic Nuclear Division Digestive System Development Immune System Process Cellular Response To Hormone Stimulus Regulation Of Protein Metabolic Process Multicellular Organismal Development Regulation Of Growth Response To Hormone Response To Stimulus Exocrine Pancreas Development System Development Exocrine System Development Regulation Of Cellular Process Regulation Of Cellular Component Organization Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Insulin Stimulus Regulation Of Protein Kinase Activity Positive Regulation Of Protein Kinase B Signaling Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Cycle Process Antigen Processing And Presentation Of Peptide Antigen Positive Regulation Of Glycolytic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Glycogen Biosynthetic Process Regulation Of Kinase Activity Negative Regulation Of Signaling Negative Regulation Of Cellular Protein Metabolic Process Male Sex Determination Developmental Process Positive Regulation Of Protein Metabolic Process Protein Metabolic Process Signal Transduction By Phosphorylation Positive Regulation Of Cell Cycle Protein Tetramerization Anatomical Structure Development	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Signaling Cellular Response To Peptide Hormone Stimulus Regulation Of Signal Transduction Cellular Response To Peptide Cell Surface Receptor Signaling Pathway Response To Peptide Hormone Regulation Of Phosphorylation Cellular Response To Organic Substance Regulation Of Phosphorus Metabolic Process Response To Peptide Regulation Of Kinase Activity Cellular Response To Organonitrogen Compound Signal Transduction Signaling Response To Organic Substance Cellular Response To Hormone Stimulus Cell Communication Response To Hormone Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Blood Coagulation Hemostasis Cellular Response To Stimulus Cellular Response To Insulin Stimulus Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Response To Organonitrogen Compound Insulin Receptor Signaling Pathway Response To Growth Factor Wound Healing Regulation Of Catalytic Activity Regulation Of Protein Phosphorylation Cellular Response To Growth Factor Stimulus Regulation Of Body Fluid Levels Response To Insulin Response To Stress Response To Wounding Regulation Of Protein Kinase Activity Defense Response Positive Regulation Of Phosphorylation Positive Regulation Of Intracellular Signal Transduction Innate Immune Response Regulation Of MAPK Cascade Response To Stimulus Positive Regulation Of Transport Regulation Of Immune Response Regulation Of Cell Death
Tagcloud ?		catalytic cdna cloned embryonic enriched epidermal epithelial epithelium erbb2 exploits fraction fractions interactions ligands mesenchymal mesenchyme pancreas pancreata platelet prepared proper receptors screened similarities soluble surrounding thought tissues tyrosine	12q 12q21 14q31 15q25 16q23 18p 19q13 20p12 20pq 20q12 21q21 3p14 4pq 5p14 5q14 6p12 7p12 8q23 cardia cdkn2 fist gej mlvi2 mts1 nrasl3 parentheses ptpn1 rca1 xpq xq25
Tagcloud (Difference) ?		catalytic cdna cloned embryonic enriched epidermal epithelial epithelium erbb2 exploits fraction fractions interactions ligands mesenchymal mesenchyme pancreas pancreata platelet prepared proper receptors screened similarities soluble surrounding thought tissues tyrosine	12q 12q21 14q31 15q25 16q23 18p 19q13 20p12 20pq 20q12 21q21 3p14 4pq 5p14 5q14 6p12 7p12 8q23 cardia cdkn2 fist gej mlvi2 mts1 nrasl3 parentheses ptpn1 rca1 xpq xq25
Tagcloud (Intersection) ?