INS and INSR

Number of citations of the paper that reports this interaction (PMID 2550426)
2

Data Source:
HPRD (in vivo)

		INS	INSR
Gene Name		insulin	insulin receptor
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Endosome Lumen Secretory Granule Lumen	Plasma Membrane Integral Component Of Plasma Membrane Insulin Receptor Complex Caveola Endosome Membrane Membrane Intracellular Membrane-bounded Organelle Receptor Complex Extracellular Vesicular Exosome
	Molecular Function	Protease Binding Insulin Receptor Binding Insulin-like Growth Factor Receptor Binding Hormone Activity Protein Binding Identical Protein Binding	Protein Tyrosine Kinase Activity Receptor Signaling Protein Tyrosine Kinase Activity Insulin-activated Receptor Activity Insulin-like Growth Factor Receptor Binding Protein Binding ATP Binding GTP Binding Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding Phosphatidylinositol 3-kinase Binding Insulin Binding Insulin Receptor Substrate Binding PTB Domain Binding
	Biological Process	MAPK Cascade Negative Regulation Of Acute Inflammatory Response Glucose Metabolic Process Energy Reserve Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Cellular Amino Acid Metabolic Process Acute-phase Response G-protein Coupled Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Glucose Transport Regulation Of Transmembrane Transporter Activity Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Endocrine Pancreas Development Positive Regulation Of Protein Autophosphorylation Activation Of Protein Kinase B Activity Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Oligomerization Regulation Of Protein Localization Negative Regulation Of NAD(P)H Oxidase Activity Wound Healing Negative Regulation Of Protein Catabolic Process Glucose Homeostasis Positive Regulation Of MAPK Cascade Cellular Protein Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Cell Differentiation Negative Regulation Of Gluconeogenesis Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of DNA Replication Negative Regulation Of Glycogen Catabolic Process Positive Regulation Of Glycolytic Process Positive Regulation Of Mitotic Nuclear Division Negative Regulation Of Proteolysis Negative Regulation Of Vasodilation Positive Regulation Of Vasodilation Negative Regulation Of Fatty Acid Metabolic Process Positive Regulation Of Glucose Import Positive Regulation Of Insulin Receptor Signaling Pathway Alpha-beta T Cell Activation Positive Regulation Of Lipid Biosynthetic Process Regulation Of Protein Secretion Negative Regulation Of Protein Secretion Positive Regulation Of Cytokine Secretion Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Insulin Secretion Negative Regulation Of Lipid Catabolic Process Positive Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Protein Kinase B Signaling Fatty Acid Homeostasis Negative Regulation Of Respiratory Burst Involved In Inflammatory Response Positive Regulation Of Respiratory Burst Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Brown Fat Cell Differentiation Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Feeding Behavior	Activation Of MAPK Activity Positive Regulation Of Protein Phosphorylation Heart Morphogenesis Carbohydrate Metabolic Process Regulation Of Transcription, DNA-templated G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Epidermis Development Peptidyl-tyrosine Phosphorylation Transformation Of Host Cell By Virus Signal Transduction By Phosphorylation Male Sex Determination Positive Regulation Of Cell Migration Exocrine Pancreas Development Activation Of Protein Kinase Activity Activation Of Protein Kinase B Activity Cellular Response To Insulin Stimulus Peptidyl-tyrosine Autophosphorylation Glucose Homeostasis Positive Regulation Of MAPK Cascade Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of DNA Replication Positive Regulation Of Glycolytic Process Positive Regulation Of Mitotic Nuclear Division Regulation Of Embryonic Development Positive Regulation Of Glucose Import Protein Autophosphorylation Positive Regulation Of Developmental Growth Protein Heterotetramerization Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Respiratory Burst Cellular Response To Growth Factor Stimulus
Pathways		Synthesis, secretion, and deacylation of Ghrelin Insulin receptor signalling cascade Integration of energy metabolism Regulation of insulin secretion IRS-related events SHC-related events Insulin receptor recycling Peptide hormone metabolism IRS activation Regulation of beta-cell development Signal attenuation Regulation of gene expression in beta cells Insulin processing SHC activation Signaling by Insulin receptor	Insulin receptor signalling cascade IRS activation Signal attenuation IRS-related events SHC-related events Insulin receptor recycling SHC activation Signaling by Insulin receptor
Drugs			Insulin Regular Insulin Lispro Insulin Glargine Insulin, porcine Mecasermin Insulin Aspart Insulin Detemir Insulin Glulisine Adenosine-5\'-[Beta, Gamma-Methylene]Triphosphate [4-({5-(AMINOCARBONYL)-4-[(3-METHYLPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENYL]ACETIC ACID Insulin, isophane
Diseases
GWAS		Prostate cancer ( 19767753) Type 1 diabetes ( 17632545 19430480 17554260) Type 1 diabetes autoantibodies ( 21829393)	Diabetic retinopathy ( 21441570) Height ( 20881960) Hypothyroidism ( 22493691) Polycystic ovary syndrome ( 22885925) Thyroid hormone levels ( 23408906) Urate levels ( 23263486)
Protein-Protein Interactions		23 interactors: APP CPE CRYAB CTSB CTSD CTSE GCK HLA-DQA2 HLA-DQB1 HSPB1 IDE IGF1R IGFBP7 INSR KMT2A LRP2 MAPK6 NOV RB1 RGS20 SYTL4 TCF4 TXNDC17	77 interactors: ACP1 ADRB2 AHSG ARF1 ARHGAP26 CALM1 CALM2 CALM3 CAV1 CAV3 CBL CEACAM1 CRK CRKL CSK DOK1 DOK4 DOK5 ENPP1 FABP4 FRS2 GAB1 GNB2L1 GRB10 GRB14 GRB7 HRAS IGF1R IGF2 INS INSRR IRF7 IRS1 IRS2 JAK1 JAK2 KHDRBS1 KRT27 KRT31 MAD2L1 MAPK3 PIK3R1 PIK3R3 PLCG1 PRKCA PRKCD PTK2 PTPN1 PTPN11 PTPN12 PTPN2 PTPN6 PTPRC PTPRF RAF1 RASA1 SH2B1 SH2B2 SHC1 SMAD2 SNX1 SNX2 SNX4 SNX6 SOCS1 SOCS2 SOCS3 SOCS6 SORBS1 SRC STAT5A STAT5B SYNCRIP TEAD1 VAV1 VAV3 YWHAB
Entrez ID		3630	3643
HPRD ID		01455	00975
Ensembl ID		ENSG00000254647	ENSG00000171105
Uniprot IDs		I3WAC9 P01308	P06213
PDB IDs		1A7F 1AI0 1AIY 1B9E 1BEN 1EFE 1EV3 1EV6 1EVR 1FU2 1FUB 1G7A 1G7B 1GUJ 1HIQ 1HIS 1HIT 1HLS 1HTV 1HUI 1IOG 1IOH 1J73 1JCA 1JCO 1JK8 1K3M 1KMF 1LKQ 1LPH 1MHI 1MHJ 1MSO 1OS3 1OS4 1Q4V 1QIY 1QIZ 1QJ0 1RWE 1SF1 1SJT 1SJU 1T0C 1T1K 1T1P 1T1Q 1TRZ 1TYL 1TYM 1UZ9 1VKT 1W8P 1XDA 1XGL 1XW7 1ZEG 1ZEH 1ZNJ 2AIY 2C8Q 2C8R 2CEU 2G54 2G56 2H67 2HH4 2HHO 2HIU 2JMN 2JUM 2JUU 2JUV 2JV1 2JZQ 2K91 2K9R 2KJJ 2KJU 2KQP 2KQQ 2KXK 2L1Y 2L1Z 2LGB 2LWZ 2M1D 2M1E 2M2M 2M2N 2M2O 2M2P 2OLY 2OLZ 2OM0 2OM1 2OMG 2OMH 2OMI 2QIU 2R34 2R35 2R36 2RN5 2VJZ 2VK0 2W44 2WBY 2WC0 2WRU 2WRV 2WRW 2WRX 2WS0 2WS1 2WS4 2WS6 2WS7 3AIY 3BRR 3BXQ 3E7Y 3E7Z 3EXX 3FQ9 3HYD 3I3Z 3I40 3ILG 3INC 3IR0 3JSD 3KQ6 3P2X 3P33 3Q6E 3ROV 3TT8 3U4N 3UTQ 3UTS 3UTT 3V19 3V1G 3W11 3W12 3W13 3W7Y 3W7Z 3W80 3ZI3 3ZQR 3ZS2 3ZU1 4AIY 4AJX 4AJZ 4AK0 4AKJ 4EFX 4EWW 4EWX 4EWZ 4EX0 4EX1 4EXX 4EY1 4EY9 4EYD 4EYN 4EYP 4F0N 4F0O 4F1A 4F1B 4F1C 4F1D 4F1F 4F1G 4F4T 4F4V 4F51 4F8F 4FG3 4FKA 4GBC 4GBI 4GBK 4GBL 4GBN 4IUZ 5AIY	1GAG 1I44 1IR3 1IRK 1P14 1RQQ 2AUH 2B4S 2DTG 2HR7 2Z8C 3BU3 3BU5 3BU6 3EKK 3EKN 3ETA 3LOH 3W11 3W12 3W13 3W14 4IBM
Enriched GO Terms of Interacting Partners?		Insulin Metabolic Process Signal Transduction Signaling Organ Development Cell Communication Cellular Response To Stimulus Response To Organic Substance Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Pancreas Development Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Cellular Response To Organic Substance Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Glucose Metabolic Process Positive Regulation Of Mitotic Nuclear Division Digestive System Development Immune System Process Cellular Response To Hormone Stimulus Regulation Of Protein Metabolic Process Multicellular Organismal Development Regulation Of Growth Response To Hormone Response To Stimulus Exocrine Pancreas Development System Development Exocrine System Development Regulation Of Cellular Process Regulation Of Cellular Component Organization Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Insulin Stimulus Regulation Of Protein Kinase Activity Positive Regulation Of Protein Kinase B Signaling Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Cycle Process Antigen Processing And Presentation Of Peptide Antigen Positive Regulation Of Glycolytic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Glycogen Biosynthetic Process Regulation Of Kinase Activity Negative Regulation Of Signaling Negative Regulation Of Cellular Protein Metabolic Process Male Sex Determination Developmental Process Positive Regulation Of Protein Metabolic Process Protein Metabolic Process Signal Transduction By Phosphorylation Positive Regulation Of Cell Cycle Protein Tetramerization Anatomical Structure Development	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Regulation Of Kinase Activity Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Peptide Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Cellular Response To Hormone Stimulus Regulation Of Signaling Cell Surface Receptor Signaling Pathway Regulation Of Protein Kinase Activity Cellular Response To Organic Substance Response To Organonitrogen Compound Regulation Of Signal Transduction Insulin Receptor Signaling Pathway Response To Hormone Cellular Response To Insulin Stimulus Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Immune System Process Regulation Of Immune Response Regulation Of Protein Phosphorylation Intracellular Signal Transduction Blood Coagulation Hemostasis Response To Insulin Response To Organic Substance Regulation Of Body Fluid Levels Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Wound Healing Signal Transduction Immune System Process Neurotrophin TRK Receptor Signaling Pathway Innate Immune Response Regulation Of Cellular Protein Metabolic Process Regulation Of Catalytic Activity Neurotrophin Signaling Pathway Growth Hormone Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Response To Wounding Defense Response Signaling Immune Response-regulating Signaling Pathway
Tagcloud ?		catalytic cdna cloned embryonic enriched epidermal epithelial epithelium erbb2 exploits fraction fractions interactions ligands mesenchymal mesenchyme pancreas pancreata platelet prepared proper receptors screened similarities soluble surrounding thought tissues tyrosine	birthweight cognate curly delays determinant dwarfing edema eliminated embryogenesis embryos epidermis generalized hypoplasia igf1r igf2 igr1r indistinguishable manifested mildly muscles nullizygotes nullizygous ossification phenotypically recognizes retardation solely thin xr
Tagcloud (Difference) ?		catalytic cdna cloned embryonic enriched epidermal epithelial epithelium erbb2 exploits fraction fractions interactions ligands mesenchymal mesenchyme pancreas pancreata platelet prepared proper receptors screened similarities soluble surrounding thought tissues tyrosine	birthweight cognate curly delays determinant dwarfing edema eliminated embryogenesis embryos epidermis generalized hypoplasia igf1r igf2 igr1r indistinguishable manifested mildly muscles nullizygotes nullizygous ossification phenotypically recognizes retardation solely thin xr
Tagcloud (Intersection) ?