HNRNPH2 and PRMT6

Number of citations of the paper that reports this interaction (PubMedID 23455924)
0

Data Source:
BioGRID (two hybrid)

		HNRNPH2	PRMT6
Description		heterogeneous nuclear ribonucleoprotein H2	protein arginine methyltransferase 6
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Membrane Ribonucleoprotein Complex	Nucleus Nucleoplasm Nucleolus
	Molecular Function	Nucleic Acid Binding RNA Binding Protein Binding	Chromatin Binding Protein Binding Methyltransferase Activity Histone Arginine N-methyltransferase Activity Protein-arginine N-methyltransferase Activity Transferase Activity Protein-arginine Omega-N Monomethyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Histone Methyltransferase Activity Histone Binding Histone H4R3 Methyltransferase Activity Histone H3R2 Methyltransferase Activity Histone H2AR3 Methyltransferase Activity Histone H3 Methyltransferase Activity
	Biological Process	Regulation Of RNA Splicing	Negative Regulation Of Transcription By RNA Polymerase II DNA Repair Base-excision Repair Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription DNA Damage Response Regulation Of Mitochondrion Organization Methylation Cellular Response To Stress Regulation Of Megakaryocyte Differentiation Negative Regulation Of DNA-templated Transcription Cellular Senescence Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways		mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA	RMTs methylate histone arginines RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Drugs
Diseases
GWAS			Adult body size ( 32376654) Blood pressure measurement (low sodium intervention) ( 24165912) Intelligence ( 22449649) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Low density lipoprotein cholesterol levels ( 32154731) Non-obstructive azoospermia ( 22197933) Obesity (early onset extreme) ( 23563609) Refractive error ( 32231278) Response to SSRI in MDD or openness ( 29559929) Restless legs syndrome ( 29029846) Sex hormone-binding globulin levels ( 22829776) Waist circumference ( 28552196) Weight ( 28552196)
Interacting Genes		97 interacting genes: CCNK DDX5 FXR1 HNRNPA0 HNRNPUL1 HSF2BP ILF3 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I MSI1 MSI2 OGT PQBP1 PRMT6 PRPF31 PRPF8 QKI RACK1 RAD21 RBFOX2 RBM10 RBM4 SF1 SNRPC SUMO2 TEKT1 TLE5 WDR83 WEE2-AS1	90 interacting genes: AK8 AP1G2 ASB3 AUNIP BCAT1 BLZF1 BMP3 C8orf74 CDCA4 CETN2 DCAF16 DNAJA3 DNALI1 DXO FBL FIP1L1 FKBP7 FYCO1 FYN GBE1 GPS2 GRHL3 GSTCD GTPBP2 H2AC18 H2BC21 H3-5 H3C14 H3C15 H4C16 H4C6 HESX1 HMGA1 HMGA2 HNRNPH2 HOXA1 HOXA5 HOXC4 ID2 KIAA0408 KIF9 KLHL20 LDHAL6B LENG8 LINC02875 LOXL4 MALT1 MED28 METTL27 MLC1 MNDA MTF2 NEFL NOSTRIN NR1D2 OAS1 OPA3 PABPC1 PCGF5 PELO PEX7 PSMD11 PYCR3 PYGO1 RAC1 RAD17 RASSF2 SERGEF SLU7 SMAD9 SMARCD1 SNF8 SPATA22 SPIN1 SPSB1 SRGAP3 SSX2IP STARD10 SUV39H1 TDO2 TEX35 THEMIS TMED5 TRIB2 TSC1 UBXN10 WDFY3 ZNF436 ZNF557 ZSCAN9
Entrez ID		3188	55170
HPRD ID		03022	10505
Ensembl ID		ENSG00000126945	ENSG00000198890
Uniprot IDs		A0A384MDT2 P55795	Q96LA8
PDB IDs		1WEZ 1WG5 6DG1 8SGH	4HC4 4QPP 4QQK 4Y2H 4Y30 5E8R 5EGS 5HZM 5WCF 6P7I 6W6D 6WAD 7NR4
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing RISC Complex Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Translation MiRNA-mediated Gene Silencing By MRNA Destabilization Extracellular Vesicle Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Translation Negative Regulation Of Cytokine Production Positive Regulation Of MRNA Catabolic Process MRNA Destabilization Regulation Of Macromolecule Metabolic Process RNA Destabilization Regulation Of Metabolic Process Negative Regulation Of Cell Migration Positive Regulation Of MRNA Metabolic Process Regulation Of MRNA Stability Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Regulation Of RNA Stability Negative Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Protein Metabolic Process Regulation Of Angiogenesis Regulation Of MRNA Metabolic Process Regulation Of Vasculature Development Negative Regulation Of Multicellular Organismal Process Regulation Of Cytokine Production Negative Regulation Of Developmental Process Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Endothelial Cell Migration Regulation Of Cell Migration Regulation Of Endothelial Cell Migration Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Cell Motility	Nucleus Structural Constituent Of Chromatin Protein Binding Nucleosome Nucleoplasm Chromatin Organization Nucleosome Organization Chromatin Remodeling Chromosome Senescence-associated Heterochromatin Focus
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