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HMGB1 and UNC119
Number of citations of the paper that reports this interaction (PMID
16169070
)
531
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
HMGB1
UNC119
Gene Name
high mobility group box 1
unc-119 homolog (C. elegans)
Image
Gene Ontology Annotations
Cellular Component
Condensed Chromosome
Extracellular Region
Extracellular Space
Nucleus
Nucleoplasm
Cell Surface
Transcriptional Repressor Complex
Spindle Pole
Centrosome
Cytosol
Intercellular Bridge
Spindle Midzone
Molecular Function
Chromatin Binding
Damaged DNA Binding
Double-stranded DNA Binding
Single-stranded DNA Binding
Sequence-specific DNA Binding Transcription Factor Activity
Cytokine Activity
Protein Binding
Transcription Factor Binding
DNA Binding, Bending
Chemoattractant Activity
Poly(A) RNA Binding
RAGE Receptor Binding
Repressing Transcription Factor Binding
Protein Binding
Lipid Binding
Biological Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Myeloid Dendritic Cell Activation
Dendritic Cell Chemotaxis
Inflammatory Response To Antigenic Stimulus
DNA Topological Change
Base-excision Repair, DNA Ligation
Apoptotic DNA Fragmentation
DNA Recombination
Chromatin Remodeling
Regulation Of Transcription From RNA Polymerase II Promoter
Apoptotic Process
Cellular Component Disassembly Involved In Execution Phase Of Apoptosis
Negative Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly
Neuron Projection Development
V(D)J Recombination
Positive Regulation Of Apoptotic Process
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Positive Regulation Of DNA Binding
Innate Immune Response
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Positive Chemotaxis
DNA Ligation Involved In DNA Repair
Negative Regulation Of Apoptotic Cell Clearance
Endocytosis
Cytokinesis, Completion Of Separation
Synaptic Transmission
Visual Perception
Phototransduction
Lipoprotein Transport
Positive Regulation Of Protein Tyrosine Kinase Activity
Negative Regulation Of Clathrin-mediated Endocytosis
Negative Regulation Of Caveolin-mediated Endocytosis
Pathways
Toll Like Receptor 7/8 (TLR7/8) Cascade
RIP-mediated NFkB activation via ZBP1
Toll Like Receptor TLR6:TLR2 Cascade
DEx/H-box helicases activate type I IFN and inflammatory cytokines production
Toll Like Receptor TLR1:TLR2 Cascade
Activated TLR4 signalling
MyD88 cascade initiated on plasma membrane
Activation of DNA fragmentation factor
Toll Like Receptor 5 (TLR5) Cascade
ZBP1(DAI) mediated induction of type I IFNs
Programmed Cell Death
MyD88 dependent cascade initiated on endosome
MyD88:Mal cascade initiated on plasma membrane
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
Toll Like Receptor 9 (TLR9) Cascade
Advanced glycosylation endproduct receptor signaling
Innate Immune System
TRIF-mediated TLR3/TLR4 signaling
Cytosolic sensors of pathogen-associated DNA
Apoptotic execution phase
MyD88-independent cascade
Toll Like Receptor 2 (TLR2) Cascade
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
Toll-Like Receptors Cascades
Toll Like Receptor 10 (TLR10) Cascade
Apoptosis induced DNA fragmentation
Toll Like Receptor 4 (TLR4) Cascade
Toll Like Receptor 3 (TLR3) Cascade
TRAF6 mediated NF-kB activation
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Drugs
Diseases
GWAS
MRI atrophy measures (
21116278
)
Protein-Protein Interactions
73 interactors:
AES
AGER
AGTRAP
AR
ATOH1
C14orf1
CASP3
CDK1
CEBPB
CREBBP
CRMP1
CSNK1A1
CTCF
CUX1
DNM2
DNMT1
ERF
FOXA3
FOXC1
GTF2A1
HES1
HMGA1
HNRNPK
HOXB1
HOXB3
HOXC6
HOXD10
HOXD11
HOXD3
HOXD8
HOXD9
HR
IRF2
LRIF1
MECP2
MNT
NCAN
NEUROD6
NFKB1
NR3C1
PGR
PLAT
PLG
POU5F1
PPP2R3A
PRKCA
PRKDC
PSEN1
PTPRZ1
RAD23B
RAG1
RASSF4
RB1
RBPJ
RELA
RFX1
SIX5
SOX18
TAF1
TBP
TERF2
TERF2IP
TFE3
TGIF1
TLE1
TLE2
TLR2
TLR4
TP53
TP73
UNC119
ZFP36
ZNF24
92 interactors:
AAGAB
ALDH2
AMOT
ANKRD24
ANXA1
ANXA3
ANXA7
ARL15
ARL2
ARL3
ARL4D
ASH2L
BCR
BRIX1
BTBD2
C16orf74
CBX8
CCL18
CD247
CD3E
CD4
CDC42
CDKN1A
CDKN2C
CETN3
CKMT2
CKS2
COX17
CYB561D2
EIF2S2
ERH
FKBPL
FXYD6
FYN
GIPC2
GSTM4
HCK
HLA-DQA1
HMGB1
HSPB3
HSPE1
ID2
IL5RA
ITSN1
KDM1A
LAMA4
LCK
LIG4
LUC7L2
LYN
MAPK10
MAPK8IP2
MPHOSPH6
MRPS12
ORAI2
PAFAH1B3
PAPSS1
PCDHA4
PFN1
PHF10
PIN1
PPA1
PPAP2C
PSMD11
PSMD2
PTPRS
QTRT1
RAP1B
RCC1
RFC5
RGL2
RPA2
RPS6KA5
RUFY3
S100A4
S100A8
SAT1
SEPHS1
SERPINB9
SMN1
SULT1E1
TK1
TP53BP2
TP53I3
TRDMT1
TSC22D1
UBE2B
UBE2I
UBQLN4
ZAK
ZFP64
ZNF24
Entrez ID
3146
9094
HPRD ID
01228
04927
Ensembl ID
ENSG00000189403
ENSG00000109103
Uniprot IDs
P09429
Q5T7C4
Q13432
PDB IDs
2LY4
2YRQ
3GQQ
3RBQ
4GOJ
4GOK
Enriched GO Terms of Interacting Partners
?
Transcription, DNA-templated
RNA Biosynthetic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Nitrogen Compound Metabolic Process
Cellular Macromolecule Biosynthetic Process
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Macromolecule Biosynthetic Process
Regulation Of RNA Biosynthetic Process
Positive Regulation Of Gene Expression
Regulation Of RNA Metabolic Process
Gene Expression
Nitrogen Compound Metabolic Process
Nucleobase-containing Compound Metabolic Process
Regulation Of Gene Expression
RNA Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Regulation Of Metabolic Process
Transcription From RNA Polymerase II Promoter
Positive Regulation Of Transcription, DNA-templated
Negative Regulation Of Biosynthetic Process
Positive Regulation Of Cellular Biosynthetic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Biosynthetic Process
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of Cellular Metabolic Process
Negative Regulation Of RNA Biosynthetic Process
Positive Regulation Of Cellular Metabolic Process
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Metabolic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of Gene Expression
Cellular Metabolic Process
Multicellular Organismal Development
Regulation Of Cellular Process
System Development
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Organ Development
Anatomical Structure Development
Developmental Process
Anatomical Structure Morphogenesis
Cell Differentiation
Chordate Embryonic Development
Embryo Development Ending In Birth Or Egg Hatching
Embryo Development
Anterior/posterior Pattern Specification
Regulation Of Cell Differentiation
Pattern Specification Process
T Cell Costimulation
Regulation Of Catalytic Activity
Response To Stress
Developmental Process
Immune System Process
Regulation Of Defense Response To Virus By Virus
System Development
Anatomical Structure Development
Positive Regulation Of Catalytic Activity
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Immune Response-regulating Signaling Pathway
Response To Stimulus
Immune Response
Regulation Of Apoptotic Process
Defense Response
Cell Cycle
Nervous System Development
Regulation Of Cellular Protein Metabolic Process
Multicellular Organismal Development
Positive Regulation Of Cellular Protein Metabolic Process
Regulation Of Cell Death
Intracellular Signal Transduction
Regulation Of Protein Metabolic Process
Cellular Response To Stimulus
Antigen Receptor-mediated Signaling Pathway
Positive Regulation Of Immune System Process
Positive Regulation Of Transferase Activity
Immune Response-activating Cell Surface Receptor Signaling Pathway
Positive Regulation Of T Cell Activation
Regulation Of Cell Activation
Regulation Of Cell Cycle
Innate Immune Response
Positive Regulation Of Homotypic Cell-cell Adhesion
Positive Regulation Of Cell Activation
Regulation Of Lymphocyte Activation
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Signal Transduction
G1/S Transition Of Mitotic Cell Cycle
Positive Regulation Of Cellular Metabolic Process
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Cell-cell Adhesion
Leukocyte Differentiation
T Cell Receptor Signaling Pathway
Regulation Of Cellular Component Organization
Positive Regulation Of Protein Modification Process
Viral Process
Positive Regulation Of Intracellular Signal Transduction
Cell Differentiation
Positive Regulation Of Metabolic Process
Cell Activation
Tagcloud
?
1racp
abilities
analysed
ankylosing
asdas
basdai
basfi
bath
besides
box
chromosomal
compare
correlations
crp
elisa
erythrocytesedimentationrate
esr
from71
healthy
index
mobility
pbmcs
rage
remarkably
spondylitis
surface
tlr2
tlr4
untreated
Tagcloud (Difference)
?
1racp
abilities
analysed
ankylosing
asdas
basdai
basfi
bath
besides
box
chromosomal
compare
correlations
crp
elisa
erythrocytesedimentationrate
esr
from71
healthy
index
mobility
pbmcs
rage
remarkably
spondylitis
surface
tlr2
tlr4
untreated
Tagcloud (Intersection)
?