HMGB1 and ZFP36

Number of citations of the paper that reports this interaction (PMID 11748221)
27

Data Source:
HPRD (in vitro)

		HMGB1	ZFP36
Gene Name		high mobility group box 1	ZFP36 ring finger protein
Image
Gene Ontology Annotations	Cellular Component	Condensed Chromosome Extracellular Region Extracellular Space Nucleus Nucleoplasm Cell Surface Transcriptional Repressor Complex	Nucleus Cytoplasm Cytosol Cytoplasmic Stress Granule
	Molecular Function	Chromatin Binding Damaged DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Cytokine Activity Protein Binding Transcription Factor Binding DNA Binding, Bending Chemoattractant Activity Poly(A) RNA Binding RAGE Receptor Binding Repressing Transcription Factor Binding	DNA Binding Single-stranded RNA Binding MRNA Binding Protein Binding AU-rich Element Binding Enzyme Binding Protein Kinase Binding C-C Chemokine Binding MRNA 3'-UTR AU-rich Region Binding Poly(A) RNA Binding Metal Ion Binding 14-3-3 Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Myeloid Dendritic Cell Activation Dendritic Cell Chemotaxis Inflammatory Response To Antigenic Stimulus DNA Topological Change Base-excision Repair, DNA Ligation Apoptotic DNA Fragmentation DNA Recombination Chromatin Remodeling Regulation Of Transcription From RNA Polymerase II Promoter Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Negative Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Neuron Projection Development V(D)J Recombination Positive Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of DNA Binding Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Chemotaxis DNA Ligation Involved In DNA Repair Negative Regulation Of Apoptotic Cell Clearance	Negative Regulation Of Transcription From RNA Polymerase II Promoter Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening MRNA Catabolic Process Gene Expression Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Translation Involved In Gene Silencing By MiRNA Intracellular Signal Transduction Response To Starvation Negative Regulation Of Myeloid Cell Differentiation Negative Regulation Of Inflammatory Response RNA Destabilization Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening 3'-UTR-mediated MRNA Stabilization Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
Pathways		Toll Like Receptor 7/8 (TLR7/8) Cascade RIP-mediated NFkB activation via ZBP1 Toll Like Receptor TLR6:TLR2 Cascade DEx/H-box helicases activate type I IFN and inflammatory cytokines production Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane Activation of DNA fragmentation factor Toll Like Receptor 5 (TLR5) Cascade ZBP1(DAI) mediated induction of type I IFNs Programmed Cell Death MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade Advanced glycosylation endproduct receptor signaling Innate Immune System TRIF-mediated TLR3/TLR4 signaling Cytosolic sensors of pathogen-associated DNA Apoptotic execution phase MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Apoptosis induced DNA fragmentation Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade TRAF6 mediated NF-kB activation TAK1 activates NFkB by phosphorylation and activation of IKKs complex	Regulation of mRNA stability by proteins that bind AU-rich elements Tristetraprolin (TTP) destabilizes mRNA
Drugs
Diseases
GWAS		MRI atrophy measures ( 21116278)
Protein-Protein Interactions		73 interactors: AES AGER AGTRAP AR ATOH1 C14orf1 CASP3 CDK1 CEBPB CREBBP CRMP1 CSNK1A1 CTCF CUX1 DNM2 DNMT1 ERF FOXA3 FOXC1 GTF2A1 HES1 HMGA1 HNRNPK HOXB1 HOXB3 HOXC6 HOXD10 HOXD11 HOXD3 HOXD8 HOXD9 HR IRF2 LRIF1 MECP2 MNT NCAN NEUROD6 NFKB1 NR3C1 PGR PLAT PLG POU5F1 PPP2R3A PRKCA PRKDC PSEN1 PTPRZ1 RAD23B RAG1 RASSF4 RB1 RBPJ RELA RFX1 SIX5 SOX18 TAF1 TBP TERF2 TERF2IP TFE3 TGIF1 TLE1 TLE2 TLR2 TLR4 TP53 TP73 UNC119 ZFP36 ZNF24	22 interactors: APP CCDC85B CDK6 DCP1B DHX36 DNAJB1 EDC3 EXOSC6 EXOSC8 HMGB1 HOXC9 MAPK1 MAPKAPK2 NCL NUP214 SFN UPF2 XRN1 YWHAB YWHAG YWHAH ZDHHC17
Entrez ID		3146	7538
HPRD ID		01228	01835
Ensembl ID		ENSG00000189403	ENSG00000128016
Uniprot IDs		P09429 Q5T7C4	M0QY76 P26651
PDB IDs		2LY4 2YRQ	4J8S
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of RNA Metabolic Process Gene Expression Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Metabolic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Cellular Metabolic Process Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Cellular Metabolic Process Multicellular Organismal Development Regulation Of Cellular Process System Development Negative Regulation Of Transcription From RNA Polymerase II Promoter Organ Development Anatomical Structure Development Developmental Process Anatomical Structure Morphogenesis Cell Differentiation Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Embryo Development Anterior/posterior Pattern Specification Regulation Of Cell Differentiation Pattern Specification Process	Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway MRNA Catabolic Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway RNA Catabolic Process Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Aromatic Compound Catabolic Process Gene Expression Positive Regulation Of Mitochondrion Organization MRNA Metabolic Process RNA Metabolic Process Regulation Of Mitochondrion Organization Regulation Of Cellular Response To Heat Nucleobase-containing Compound Metabolic Process Cellular Macromolecule Catabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process System Development Apoptotic Process Cellular Nitrogen Compound Metabolic Process Programmed Cell Death Intrinsic Apoptotic Signaling Pathway Regulation Of Cellular Component Organization Positive Regulation Of Organelle Organization Cell Death Death Cellular Metabolic Process Cellular Response To Heat Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Intracellular Transport Regulation Of Protein Kinase Activity Developmental Process Nitrogen Compound Metabolic Process Multicellular Organismal Development Regulation Of Kinase Activity Positive Regulation Of Intracellular Transport Innate Immune Response Anatomical Structure Development Positive Regulation Of Signal Transduction Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Catabolic Process Regulation Of Organelle Organization Regulation Of Catalytic Activity Response To Heat Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death
Tagcloud ?		1racp abilities analysed ankylosing asdas basdai basfi bath besides box chromosomal compare correlations crp elisa erythrocytesedimentationrate esr from71 healthy index mobility pbmcs rage remarkably spondylitis surface tlr2 tlr4 untreated	annotation bub california cruz databases david deterioration downloaded exploring geo gse27567 h17 hub inheritance mendelian networks omim omnibus ranked santa topological visualization xpc xrcc4 xrcc5 ybx1 yy1 zfhx3 zmat3
Tagcloud (Difference) ?		1racp abilities analysed ankylosing asdas basdai basfi bath besides box chromosomal compare correlations crp elisa erythrocytesedimentationrate esr from71 healthy index mobility pbmcs rage remarkably spondylitis surface tlr2 tlr4 untreated	annotation bub california cruz databases david deterioration downloaded exploring geo gse27567 h17 hub inheritance mendelian networks omim omnibus ranked santa topological visualization xpc xrcc4 xrcc5 ybx1 yy1 zfhx3 zmat3
Tagcloud (Intersection) ?