HMGB1 and MAP1B

Number of citations of the paper that reports this interaction (PubMedID 31694235)
108

Data Source:
BioGRID (two hybrid)

		HMGB1	MAP1B
Description		high mobility group box 1	microtubule associated protein 1B
Image			No pdb structure
GO Annotations	Cellular Component	Condensed Chromosome Extracellular Region Extracellular Space Nucleus Nucleoplasm Chromosome Cytoplasm Endosome Early Endosome Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Plasma Membrane Cell Surface Membrane Transcription Repressor Complex Secretory Granule Lumen Alphav-beta3 Integrin-HMGB1 Complex Neuron Projection Ficolin-1-rich Granule Lumen	Photoreceptor Outer Segment Cytoplasm Cytosol Cytoskeleton Microtubule Microtubule Associated Complex Plasma Membrane Postsynaptic Density Axon Dendrite Growth Cone Somatodendritic Compartment Cell Projection Neuronal Cell Body Varicosity Dendritic Spine Perikaryon Synapse Perinuclear Region Of Cytoplasm Apical Dendrite Basal Dendrite Hippocampal Mossy Fiber Postsynapse Glutamatergic Synapse
	Molecular Function	Four-way Junction DNA Binding Bubble DNA Binding Transcription Cis-regulatory Region Binding Lipopolysaccharide Binding Phosphatidylserine Binding DNA Binding Damaged DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Transcription Coactivator Activity Transcription Corepressor Activity RNA Binding Double-stranded RNA Binding Single-stranded RNA Binding Cytokine Activity Integrin Binding Protein Binding Lipid Binding DNA Binding, Bending Calcium-dependent Protein Kinase Regulator Activity Lyase Activity C-X-C Chemokine Binding Protein Kinase Activator Activity Chemoattractant Activity Receptor Ligand Activity RAGE Receptor Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA Polymerase Binding Supercoiled DNA Binding DNA-binding Transcription Factor Binding	Actin Binding Structural Molecule Activity Protein Binding Phospholipid Binding Microtubule Binding Protein-containing Complex Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Eye Development Myeloid Dendritic Cell Activation Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Proliferation Activation Of Innate Immune Response Adaptive Immune Response Plasmacytoid Dendritic Cell Activation Macrophage Activation Involved In Immune Response Myeloid Progenitor Cell Differentiation Immune System Process Dendritic Cell Chemotaxis Inflammatory Response To Antigenic Stimulus Regulation Of Tolerance Induction Regulation Of T Cell Mediated Immune Response To Tumor Cell Glycogen Catabolic Process DNA Metabolic Process DNA Topological Change DNA Repair Base-excision Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination Chromatin Organization Chromatin Remodeling Transcription By RNA Polymerase II Autophagy Chemotaxis Inflammatory Response Immune Response DNA Damage Response Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Autophagy Negative Regulation Of Endothelial Cell Migration Negative Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Myeloid Cell Differentiation Lung Development Neuron Projection Development Heterochromatin Formation Regulation Of Restriction Endodeoxyribonuclease Activity DNA Geometric Change Positive Regulation Of Mismatch Repair Negative Regulation Of Type II Interferon Production Positive Regulation Of Chemokine Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production V(D)J Recombination Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Toll-like Receptor 9 Signaling Pathway T-helper 1 Cell Activation Endothelial Cell Chemotaxis Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of Apoptotic Process Apoptotic Cell Clearance Negative Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of DNA Binding Positive Regulation Of MAPK Cascade Positive Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Blood Vessel Endothelial Cell Migration T-helper 1 Cell Differentiation Innate Immune Response Positive Regulation Of Innate Immune Response Positive Regulation Of Cell Differentiation Positive Regulation Of Myeloid Cell Differentiation Positive Regulation Of Glycogen Catabolic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Positive Regulation Of Viral Entry Into Host Cell Cell Development Regulation Of Viral Process Positive Chemotaxis Regulation Of DNA Metabolic Process Response To Glucocorticoid Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipopolysaccharide Positive Regulation Of Monocyte Chemotactic Protein-1 Production Positive Regulation Of Monocyte Chemotaxis Positive Regulation Of Wound Healing Neutrophil Clearance Cellular Response To Interleukin-7 Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Sprouting Angiogenesis Regulation Of Hemopoiesis Positive Regulation Of Myeloid Progenitor Cell Differentiation Positive Regulation Of Vascular Endothelial Cell Proliferation Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Negative Regulation Of Apoptotic Cell Clearance Regulation Of Nucleotide-excision Repair Positive Regulation Of Dendritic Cell Differentiation	Microtubule Cytoskeleton Organization Microtubule Bundle Formation Neuron Migration Negative Regulation Of Microtubule Depolymerization Nervous System Development Axonogenesis Synapse Assembly Response To Xenobiotic Stimulus Response To Mechanical Stimulus Response To Carbohydrate Peripheral Nervous System Axon Regeneration Dendrite Development Response To Insecticide Developmental Maturation Regulation Of Microtubule Depolymerization Positive Regulation Of Microtubule Polymerization Neuron Projection Development Response To Nutrient Levels Response To Estradiol Negative Regulation Of Intracellular Transport Response To Vitamin A Positive Regulation Of Neuron Differentiation Positive Regulation Of Axon Extension Intracellular Transport Mitochondrion Transport Along Microtubule Neuron Development Axon Extension Response To Axon Injury Induction Of Synaptic Plasticity By Chemical Substance Establishment Of Monopolar Cell Polarity Cellular Response To Growth Factor Stimulus Cellular Response To Peptide Hormone Stimulus Odontoblast Differentiation Regulation Of Postsynapse Assembly
Pathways		ER-Phagosome pathway Apoptosis induced DNA fragmentation MyD88:MAL(TIRAP) cascade initiated on plasma membrane TAK1-dependent IKK and NF-kappa-B activation MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) Pyroptosis Regulation of TLR by endogenous ligand Neutrophil degranulation Advanced glycosylation endproduct receptor signaling Advanced glycosylation endproduct receptor signaling TRAF6 mediated NF-kB activation	RSV-host interactions
Drugs		Chloroquine Ethyl pyruvate
Diseases
GWAS		Adult body size ( 32376654) Apolipoprotein A1 levels ( 32203549) Blood osmolality (transformed sodium) ( 28360221) Carotid plaque burden ( 28282560) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Hippocampal volume ( 21116278) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Rapid response to perioperative phenylephrine (change in mean arterial pressure) ( 33168928) Red blood cell count ( 32888494) Triglyceride levels ( 32203549 32154731) Type 2 diabetes ( 30297969) Urate levels ( 31578528)	Attention deficit hyperactivity disorder ( 18839057) Coronary artery disease in type 1 diabetes ( 29695241) Refractive error ( 32231278)
Interacting Genes		132 interacting genes: ACBD3 AGER AGTRAP AKIP1 AR ATF7IP ATOH1 C1QA C1QBP C3 CASP3 CCAR1 CCNDBP1 CDK1 CEBPA CEBPB CREBBP CRMP1 CSNK1A1 CTCF CTNNBL1 CUX1 DAG1 DLAT DNAAF2 DNM2 DNMT1 DUX4 DYNC2I1 EIF1 ENAH EP300 ERF ERG28 FIP1L1 FOS FOXA3 FOXC1 GOLM1 GTF2A1 HDAC1 HDLBP HES1 HMGA1 HNRNPK HNRNPU HOXA10 HOXB1 HOXB3 HOXC6 HOXD10 HOXD11 HOXD3 HOXD8 HOXD9 HPF1 HR HSPA5 IRF2 KRT7 LRIF1 MALAT1 MAP1B MAPKAPK5 MECP2 MIEN1 MNAT1 MNT MT2A NCAN NEUROD6 NEXN NFKB1 NR3C1 PCOLCE PGR PLAT PLG POU5F1 PPP2R3A PRKCA PRKDC PSEN1 PSMA7 PTPN2 PTPRZ1 RAD23B RAG1 RASAL2 RASSF4 RB1 RBPJ RELA RFX1 RPL29 RPS12 RPS20 RSF1 SIX5 SOX18 SPIN1 SPINT1 SRSF3 STUB1 TAF1 TAF3 TBP TERF2 TERF2IP TFE3 TGIF1 TGM2 TGM3 TLE1 TLE2 TLE5 TLR2 TLR4 TP53 TP73 UBC UBE2E3 UBE2I UBXN1 UHRF2 UNC119 USP12 WNK4 YY1 ZFP36 ZNF24 ZNF428	36 interacting genes: ACTB ANP32A ARHGEF11 CREBBP CSNK2A1 DYNLL1 EEF1D ERBB3 FOS GABRR1 GABRR2 GAN GSK3B HMGB1 HTR6 LRRK2 MAG MAGOH MAP1A MAPK8 MARCHF5 MINK1 NEIL3 NXF1 NXF2 PAFAH1B1 PRKAR1A RASSF1 RNF10 SNCA SPP1 STAU1 STRAP U2AF1 U2AF2 VHL
Entrez ID		3146	4131
HPRD ID		01228	01139
Ensembl ID		ENSG00000189403	ENSG00000131711
Uniprot IDs		B7Z965 P09429 Q5T7C4	A2BDK6 P46821 Q6PJD3 Q86X89
PDB IDs		2LY4 2RTU 2YRQ 6CG0 6CIJ 6CIK 6CIL 6CIM 6OEM 6OEN 6OEO 8I9M
Enriched GO Terms of Interacting Partners?		Chromatin Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleoplasm Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Macromolecule Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process DNA Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Nucleus Positive Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Transcription Regulator Complex DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Sequence-specific DNA Binding Regionalization Anterior/posterior Pattern Specification Transcription Cis-regulatory Region Binding Macromolecule Metabolic Process Sequence-specific Double-stranded DNA Binding Pattern Specification Process Positive Regulation Of Developmental Process RNA Polymerase II Core Promoter Sequence-specific DNA Binding Chromatin Binding Macromolecule Biosynthetic Process Anatomical Structure Morphogenesis	Tau Protein Binding Positive Regulation Of Cell Communication Cellular Response To Stress Positive Regulation Of Signaling Regulation Of Cell Communication Regulation Of Signaling Microtubule Associated Complex Axon Regulation Of Norepinephrine Uptake Regulation Of Biological Quality JNK Cascade Intracellular Signaling Cassette Intracellular Signal Transduction Transporter Regulator Activity Regulation Of Autophagy Regulation Of Cellular Response To Stress Regulation Of Protein Localization Negative Regulation Of Gene Expression Synapse Glutamatergic Synapse Positive Regulation Of Macromolecule Metabolic Process Regulation Of Programmed Cell Death Regulation Of Macromolecule Metabolic Process Regulation Of Synaptic Vesicle Recycling Positive Regulation Of Protein Localization Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Cell Development Chemical Synaptic Transmission Positive Regulation Of Biosynthetic Process Regulation Of Postsynaptic Membrane Potential Pre-mRNA 3'-splice Site Binding U2AF Complex Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Cellular Response To Oxidative Stress Trans-synaptic Signaling Synaptic Signaling Modulation Of Chemical Synaptic Transmission Nuclear RNA Export Factor Complex Negative Regulation Of Macromolecule Biosynthetic Process Response To Stress Substantia Nigra Development Regulation Of Apoptotic Process Nitric-oxide Synthase Regulator Activity Positive Regulation Of Macromolecule Biosynthetic Process
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