HMGB1 and AGTRAP

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		HMGB1	AGTRAP
Description		high mobility group box 1	angiotensin II receptor associated protein
Image			No pdb structure
GO Annotations	Cellular Component	Condensed Chromosome Extracellular Region Extracellular Space Nucleus Nucleoplasm Chromosome Cytoplasm Endosome Early Endosome Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Plasma Membrane Cell Surface Membrane Transcription Repressor Complex Secretory Granule Lumen Alphav-beta3 Integrin-HMGB1 Complex Neuron Projection Ficolin-1-rich Granule Lumen	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Cell Cortex Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle
	Molecular Function	Four-way Junction DNA Binding Bubble DNA Binding Transcription Cis-regulatory Region Binding Lipopolysaccharide Binding Phosphatidylserine Binding DNA Binding Damaged DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Transcription Coactivator Activity Transcription Corepressor Activity RNA Binding Double-stranded RNA Binding Single-stranded RNA Binding Cytokine Activity Integrin Binding Protein Binding Lipid Binding DNA Binding, Bending Calcium-dependent Protein Kinase Regulator Activity Lyase Activity C-X-C Chemokine Binding Protein Kinase Activator Activity Chemoattractant Activity Receptor Ligand Activity RAGE Receptor Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA Polymerase Binding Supercoiled DNA Binding DNA-binding Transcription Factor Binding	Angiotensin Type II Receptor Activity Protein Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Eye Development Myeloid Dendritic Cell Activation Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Proliferation Activation Of Innate Immune Response Adaptive Immune Response Plasmacytoid Dendritic Cell Activation Macrophage Activation Involved In Immune Response Myeloid Progenitor Cell Differentiation Immune System Process Dendritic Cell Chemotaxis Inflammatory Response To Antigenic Stimulus Regulation Of Tolerance Induction Regulation Of T Cell Mediated Immune Response To Tumor Cell Glycogen Catabolic Process DNA Metabolic Process DNA Topological Change DNA Repair Base-excision Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination Chromatin Organization Chromatin Remodeling Transcription By RNA Polymerase II Autophagy Chemotaxis Inflammatory Response Immune Response DNA Damage Response Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Autophagy Negative Regulation Of Endothelial Cell Migration Negative Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Myeloid Cell Differentiation Lung Development Neuron Projection Development Heterochromatin Formation Regulation Of Restriction Endodeoxyribonuclease Activity DNA Geometric Change Positive Regulation Of Mismatch Repair Negative Regulation Of Type II Interferon Production Positive Regulation Of Chemokine Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production V(D)J Recombination Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Toll-like Receptor 9 Signaling Pathway T-helper 1 Cell Activation Endothelial Cell Chemotaxis Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of Apoptotic Process Apoptotic Cell Clearance Negative Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of DNA Binding Positive Regulation Of MAPK Cascade Positive Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Blood Vessel Endothelial Cell Migration T-helper 1 Cell Differentiation Innate Immune Response Positive Regulation Of Innate Immune Response Positive Regulation Of Cell Differentiation Positive Regulation Of Myeloid Cell Differentiation Positive Regulation Of Glycogen Catabolic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Positive Regulation Of Viral Entry Into Host Cell Cell Development Regulation Of Viral Process Positive Chemotaxis Regulation Of DNA Metabolic Process Response To Glucocorticoid Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipopolysaccharide Positive Regulation Of Monocyte Chemotactic Protein-1 Production Positive Regulation Of Monocyte Chemotaxis Positive Regulation Of Wound Healing Neutrophil Clearance Cellular Response To Interleukin-7 Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Sprouting Angiogenesis Regulation Of Hemopoiesis Positive Regulation Of Myeloid Progenitor Cell Differentiation Positive Regulation Of Vascular Endothelial Cell Proliferation Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Negative Regulation Of Apoptotic Cell Clearance Regulation Of Nucleotide-excision Repair Positive Regulation Of Dendritic Cell Differentiation	Response To Hypoxia Regulation Of Blood Pressure Angiotensin-activated Signaling Pathway
Pathways		ER-Phagosome pathway Apoptosis induced DNA fragmentation MyD88:MAL(TIRAP) cascade initiated on plasma membrane TAK1-dependent IKK and NF-kappa-B activation MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) Pyroptosis Regulation of TLR by endogenous ligand Neutrophil degranulation Advanced glycosylation endproduct receptor signaling Advanced glycosylation endproduct receptor signaling TRAF6 mediated NF-kB activation	Signaling by BRAF and RAF1 fusions
Drugs		Chloroquine Ethyl pyruvate
Diseases
GWAS		Adult body size ( 32376654) Apolipoprotein A1 levels ( 32203549) Blood osmolality (transformed sodium) ( 28360221) Carotid plaque burden ( 28282560) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Hippocampal volume ( 21116278) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Rapid response to perioperative phenylephrine (change in mean arterial pressure) ( 33168928) Red blood cell count ( 32888494) Triglyceride levels ( 32203549 32154731) Type 2 diabetes ( 30297969) Urate levels ( 31578528)	Arterial stiffness (brachial-femoral pulse wave velocity) ( 32790701) Basophil percentage of white cells ( 32888494) Systolic blood pressure ( 19430483)
Interacting Genes		132 interacting genes: ACBD3 AGER AGTRAP AKIP1 AR ATF7IP ATOH1 C1QA C1QBP C3 CASP3 CCAR1 CCNDBP1 CDK1 CEBPA CEBPB CREBBP CRMP1 CSNK1A1 CTCF CTNNBL1 CUX1 DAG1 DLAT DNAAF2 DNM2 DNMT1 DUX4 DYNC2I1 EIF1 ENAH EP300 ERF ERG28 FIP1L1 FOS FOXA3 FOXC1 GOLM1 GTF2A1 HDAC1 HDLBP HES1 HMGA1 HNRNPK HNRNPU HOXA10 HOXB1 HOXB3 HOXC6 HOXD10 HOXD11 HOXD3 HOXD8 HOXD9 HPF1 HR HSPA5 IRF2 KRT7 LRIF1 MALAT1 MAP1B MAPKAPK5 MECP2 MIEN1 MNAT1 MNT MT2A NCAN NEUROD6 NEXN NFKB1 NR3C1 PCOLCE PGR PLAT PLG POU5F1 PPP2R3A PRKCA PRKDC PSEN1 PSMA7 PTPN2 PTPRZ1 RAD23B RAG1 RASAL2 RASSF4 RB1 RBPJ RELA RFX1 RPL29 RPS12 RPS20 RSF1 SIX5 SOX18 SPIN1 SPINT1 SRSF3 STUB1 TAF1 TAF3 TBP TERF2 TERF2IP TFE3 TGIF1 TGM2 TGM3 TLE1 TLE2 TLE5 TLR2 TLR4 TP53 TP73 UBC UBE2E3 UBE2I UBXN1 UHRF2 UNC119 USP12 WNK4 YY1 ZFP36 ZNF24 ZNF428	138 interacting genes: ACSF2 AGTR1 AGTR2 ALDH18A1 ANKS6 AP3M1 APOA4 AQP6 ARAF ARFIP2 ARHGAP1 ATP5F1E BCL2L13 BPIFA2 CAPNS1 CCDC70 CD160 CD79A CELA3A CIAO2A COQ8A CPLX1 CPLX4 CRCT1 CYB5R3 CYBC1 DDA1 DDX55 DGCR6 DIABLO DNAJC1 ECPAS ERGIC3 ETFRF1 FAM114A1 FAM209A FARS2 FASTKD3 FATE1 FFAR2 FGA FHIP1B FNDC9 GABARAPL2 GAD1 GAD2 GDNF GPR152 GPX8 GTF2H1 GTF3C1 H4C7 HARS2 HIBADH HMGB1 HSBP1L1 HSCB HSD17B13 HSFX1 HSFX2 HSPA4 IL7R ISCU KCNK5 KIR2DL3 KIR3DL3 LMNA LMO2 LNX1 LRRC4C LRRC59 MCEE MGST3 MIEF1 MIEF2 MMD MRM1 MRPL11 MRRF MTERF3 MUTYH MYG1 NDRG4 NDUFAF3 NFU1 NFYB NKG7 PBX3 PCTP PCYT1A PDHX PIMREG PITPNC1 PNPO POLDIP2 PPIF PRPF18 PTPN9 RAB30 RACK1 RBFA RETREG3 RMDN2 S100B SCAND1 SENP2 SH3GLB1 SLC18A1 SLC7A14 SMG9 SNX1 SPG21 SSX3 SSX5 STAG3L1 STAR STARD4 STMN4 STX1A SUCLA2 SYT16 TBRG4 TCEA2 TCEANC2 TFAM THAP4 TMEM139 TMEM14B TMEM31 TMPPE TPD52L3 TTPA TUBA1B TXN2 UBE2I YARS2 ZFYVE21 ZNF391
Entrez ID		3146	57085
HPRD ID		01228	16379
Ensembl ID		ENSG00000189403	ENSG00000177674
Uniprot IDs		B7Z965 P09429 Q5T7C4	Q6RW13
PDB IDs		2LY4 2RTU 2YRQ 6CG0 6CIJ 6CIK 6CIL 6CIM 6OEM 6OEN 6OEO 8I9M
Enriched GO Terms of Interacting Partners?		Chromatin Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleoplasm Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Macromolecule Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process DNA Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Nucleus Positive Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Transcription Regulator Complex DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Sequence-specific DNA Binding Regionalization Anterior/posterior Pattern Specification Transcription Cis-regulatory Region Binding Macromolecule Metabolic Process Sequence-specific Double-stranded DNA Binding Pattern Specification Process Positive Regulation Of Developmental Process RNA Polymerase II Core Promoter Sequence-specific DNA Binding Chromatin Binding Macromolecule Biosynthetic Process Anatomical Structure Morphogenesis	Mitochondrial Matrix Mitochondrion Protein Binding Lipid Binding Succinate Metabolic Process Gamma-aminobutyrate Shunt Glutamate Decarboxylase Activity
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