HMGB1 and CEBPB

Number of citations of the paper that reports this interaction (PMID 11748221)
27

Data Source:
HPRD (in vitro)

		HMGB1	CEBPB
Gene Name		high mobility group box 1	CCAAT/enhancer binding protein (C/EBP), beta
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Gene Ontology Annotations	Cellular Component	Condensed Chromosome Extracellular Region Extracellular Space Nucleus Nucleoplasm Cell Surface Transcriptional Repressor Complex	Condensed Chromosome, Centromeric Region Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm Nuclear Matrix
	Molecular Function	Chromatin Binding Damaged DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Cytokine Activity Protein Binding Transcription Factor Binding DNA Binding, Bending Chemoattractant Activity Poly(A) RNA Binding RAGE Receptor Binding Repressing Transcription Factor Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Glucocorticoid Receptor Binding Protein Homodimerization Activity Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Myeloid Dendritic Cell Activation Dendritic Cell Chemotaxis Inflammatory Response To Antigenic Stimulus DNA Topological Change Base-excision Repair, DNA Ligation Apoptotic DNA Fragmentation DNA Recombination Chromatin Remodeling Regulation Of Transcription From RNA Polymerase II Promoter Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Negative Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Neuron Projection Development V(D)J Recombination Positive Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of DNA Binding Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Chemotaxis DNA Ligation Involved In DNA Repair Negative Regulation Of Apoptotic Cell Clearance	Embryonic Placenta Development Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Acute-phase Response Inflammatory Response Immune Response Neuron Differentiation Response To Lipopolysaccharide Mammary Gland Epithelial Cell Proliferation Response To Endoplasmic Reticulum Stress Negative Regulation Of Neuron Apoptotic Process Regulation Of Interleukin-6 Biosynthetic Process Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Brown Fat Cell Differentiation Mammary Gland Epithelial Cell Differentiation Regulation Of Transcription Involved In Cell Fate Commitment Cellular Response To Amino Acid Stimulus
Pathways		Toll Like Receptor 7/8 (TLR7/8) Cascade RIP-mediated NFkB activation via ZBP1 Toll Like Receptor TLR6:TLR2 Cascade DEx/H-box helicases activate type I IFN and inflammatory cytokines production Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane Activation of DNA fragmentation factor Toll Like Receptor 5 (TLR5) Cascade ZBP1(DAI) mediated induction of type I IFNs Programmed Cell Death MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade Advanced glycosylation endproduct receptor signaling Innate Immune System TRIF-mediated TLR3/TLR4 signaling Cytosolic sensors of pathogen-associated DNA Apoptotic execution phase MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Apoptosis induced DNA fragmentation Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade TRAF6 mediated NF-kB activation TAK1 activates NFkB by phosphorylation and activation of IKKs complex	Transcriptional regulation of white adipocyte differentiation Cellular Senescence Senescence-Associated Secretory Phenotype (SASP)
Drugs
Diseases
GWAS		MRI atrophy measures ( 21116278)	Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		73 interactors: AES AGER AGTRAP AR ATOH1 C14orf1 CASP3 CDK1 CEBPB CREBBP CRMP1 CSNK1A1 CTCF CUX1 DNM2 DNMT1 ERF FOXA3 FOXC1 GTF2A1 HES1 HMGA1 HNRNPK HOXB1 HOXB3 HOXC6 HOXD10 HOXD11 HOXD3 HOXD8 HOXD9 HR IRF2 LRIF1 MECP2 MNT NCAN NEUROD6 NFKB1 NR3C1 PGR PLAT PLG POU5F1 PPP2R3A PRKCA PRKDC PSEN1 PTPRZ1 RAD23B RAG1 RASSF4 RB1 RBPJ RELA RFX1 SIX5 SOX18 TAF1 TBP TERF2 TERF2IP TFE3 TGIF1 TLE1 TLE2 TLR2 TLR4 TP53 TP73 UNC119 ZFP36 ZNF24	54 interactors: AR ATF2 ATF4 CAMK2A CCL3 CEBPA CEBPD CEBPG CREB1 CREBBP DDIT3 EGFR EGR1 ELK1 EP300 ESR1 FOXO1 HMGA1 HMGB1 HNRNPK HOMER3 HSF1 KAT2A KAT2B MAPK1 MAPK3 MED23 MYB MYC NCOR2 NFKB1 NOLC1 NR3C1 PTGES2 RARB RB1 RELA RPS6KA1 RPS6KA5 RUNX1 RUNX2 SMAD3 SMAD4 SMARCA4 SMARCB1 SMARCC1 SP1 SPI1 SPIB SRF STAT5A STAT6 TAF9 TRIM28
Entrez ID		3146	1051
HPRD ID		01228	01801
Ensembl ID		ENSG00000189403	ENSG00000172216
Uniprot IDs		P09429 Q5T7C4	P17676
PDB IDs		2LY4 2YRQ	1GTW 1GU4 1GU5 1H88 1H89 1H8A 1HJB 1IO4 2E42 2E43
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of RNA Metabolic Process Gene Expression Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Metabolic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Cellular Metabolic Process Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Cellular Metabolic Process Multicellular Organismal Development Regulation Of Cellular Process System Development Negative Regulation Of Transcription From RNA Polymerase II Promoter Organ Development Anatomical Structure Development Developmental Process Anatomical Structure Morphogenesis Cell Differentiation Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Embryo Development Anterior/posterior Pattern Specification Regulation Of Cell Differentiation Pattern Specification Process	Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process RNA Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Cellular Response To Organic Substance Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Response To Organic Substance Negative Regulation Of RNA Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Gene Expression DNA-templated Transcription, Initiation Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Immune System Process Cellular Metabolic Process System Development Developmental Process Gland Development Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Multicellular Organismal Development Cellular Response To Stimulus Negative Regulation Of Cellular Metabolic Process Anatomical Structure Development Organ Development Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Growth Factor Stimulus
Tagcloud ?		1racp abilities analysed ankylosing asdas basdai basfi bath besides box chromosomal compare correlations crp elisa erythrocytesedimentationrate esr from71 healthy index mobility pbmcs rage remarkably spondylitis surface tlr2 tlr4 untreated	activates anticancer atf4 attenuated autophagy chip ddit4 depletion effectively elusive exo genomic greatly largely mitochondria mtorc1 nude pad pan perturbation potentials remain resolution responsive sesn2 triple unveiled xenograft yw3
Tagcloud (Difference) ?		1racp abilities analysed ankylosing asdas basdai basfi bath besides box chromosomal compare correlations crp elisa erythrocytesedimentationrate esr from71 healthy index mobility pbmcs rage remarkably spondylitis surface tlr2 tlr4 untreated	activates anticancer atf4 attenuated autophagy chip ddit4 depletion effectively elusive exo genomic greatly largely mitochondria mtorc1 nude pad pan perturbation potentials remain resolution responsive sesn2 triple unveiled xenograft yw3
Tagcloud (Intersection) ?