H1-1 and CDK4

Number of citations of the paper that reports this interaction (PubMedID 16431923)
35

Data Source:
BioGRID (enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study)

		H1-1	CDK4
Description		H1.1 linker histone, cluster member	cyclin dependent kinase 4
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GO Annotations	Cellular Component	Chromatin Nucleosome Euchromatin Nucleus Nucleoplasm Chromosome Cell Surface Vesicle	Cyclin-dependent Protein Kinase Holoenzyme Complex Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Nucleolus Cytoplasm Cytosol Bicellular Tight Junction Membrane Nuclear Membrane Cyclin D1-CDK4 Complex Cyclin D2-CDK4 Complex Cyclin D3-CDK4 Complex
	Molecular Function	DNA Binding Double-stranded DNA Binding Protein Binding Heparin Binding Structural Constituent Of Chromatin Chromatin DNA Binding Nucleosomal DNA Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Transferase Activity Cyclin Binding Protein Serine Kinase Activity
	Biological Process	Nucleosome Assembly Spermatogenesis Chromosome Condensation Negative Regulation Of DNA Recombination Positive Regulation Of Receptor-mediated Endocytosis	G1/S Transition Of Mitotic Cell Cycle Signal Transduction Positive Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Gene Expression Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Fibroblast Proliferation Cell Division Regulation Of Cell Cycle Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of Type B Pancreatic Cell Proliferation Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-4 Cellular Response To Phorbol 13-acetate 12-myristate Cellular Response To Ionomycin
Pathways		Apoptosis induced DNA fragmentation Formation of Senescence-Associated Heterochromatin Foci (SAHF)	SCF(Skp2)-mediated degradation of p27/p21 Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) Oncogene Induced Senescence RMTs methylate histone arginines Transcriptional regulation of white adipocyte differentiation Cyclin D associated events in G1 Ubiquitin-dependent degradation of Cyclin D Ubiquitin-dependent degradation of Cyclin D PTK6 Regulates Cell Cycle Transcriptional regulation by RUNX2 Meiotic recombination Transcriptional regulation of granulopoiesis Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) Drug-mediated inhibition of CDK4/CDK6 activity SPOP-mediated proteasomal degradation of PD-L1(CD274)
Drugs			Purvalanol Alvocidib Palbociclib Ribociclib Abemaciclib Fostamatinib Trilaciclib
Diseases			Malignant melanoma Glioma Cervical cancer
GWAS			Brain morphology (MOSTest) ( 32665545) Celiac disease or Rheumatoid arthritis ( 21383967) Rheumatoid arthritis ( 24390342 30423114)
Interacting Genes		54 interacting genes: AEBP2 APP CCNA1 CCNA2 CCNB1 CCND2 CCNE1 CDK1 CDK11B CDK2 CDK4 CDK5 CDK6 CDK7 CDKN1B CRP CTCFL EED EHMT2 EP300 EZH2 GADD45A GZMA IRAK4 KAT2B LIMK1 LIMK2 LOX NAP1L1 NAP1L4 NASP NSD3 PAK4 PARP1 PARP3 PELP1 PRDM1 PRKCA PRKCB PRKCD PRKCE PRKCZ PRKDC PTMA RBBP4 RPS6KA5 SET SMYD5 SNCA SUZ12 TAF1 TERF1 TERF2IP TLK1	136 interacting genes: AGAP2 AKT1 ANKRD12 ANXA7 APLP1 APP ARAF ARID4A ARNT ATP5F1B BAG6 BCL11A BECN1 BIRC5 BMPR1B BRCA1 CAMK1 CAPNS1 CCND1 CCND2 CCND3 CCNE1 CD44 CDC37 CDC45 CDC6 CDC7 CDKN1A CDKN1B CDKN1C CDKN2A CDKN2B CDKN2C CDKN2D CEBPA CIB1 CNOT7 CNTN2 DAZAP2 DDAH2 DUSP9 EIF4EBP2 EPHA2 ERBB2 FARP2 FBXO8 FGFR4 FOXM1 FZR1 GLIS2 GRM1 H1-0 H1-1 H1-3 HGF HIF1A HMGXB3 HOOK1 HSP90AB1 IFI27 IGF1R IKZF3 IL15RA INCA1 KDELR2 LATS2 LNX2 LUC7L2 MAP2K3 MAP2K5 MAP3K5 MAPK14 MAPRE2 MARCKS MCM2 MDM4 MET MYOD1 MZF1 NCOA2 NF2 NOL12 OGDHL ORC3 OTX2 PDGFRA PGD PIAS1 PKM POLD1 PPP2R1B PRKAR1A PSMD10 PTMA QARS1 RAF1 RASSF1 RB1 RBL1 RBL2 RFC1 RFC4 RPL34 SENP3 SERTAD1 SETDB1 SHOX2 SKP1 SLBP SMAD2 SMAD3 SNCA SPOP STK11 STUB1 TEAD2 TERT TGFBR1 TK1 TP53 TRMT2A TSC1 TSPYL2 UBE3A UBTF UHRF2 USP17L2 USP51 VTA1 WDR33 YBX3 ZBTB16 ZNF101 ZNF219 ZNF335 ZNF655
Entrez ID		3024	1019
HPRD ID		00820	00447
Ensembl ID		ENSG00000124610	ENSG00000135446
Uniprot IDs		Q02539	P11802
PDB IDs		9J8O	2W96 2W99 2W9F 2W9Z 3G33 5FWK 5FWL 5FWM 5FWP 6P8E 6P8F 6P8G 6P8H 7SJ3
Enriched GO Terms of Interacting Partners?		Chromatin Organization Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Chromatin Remodeling Nucleus Protein Kinase Activity Kinase Activity Cyclin-dependent Protein Kinase Holoenzyme Complex Regulation Of Nucleobase-containing Compound Metabolic Process Transferase Activity G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Regulation Of RNA Metabolic Process Nucleoplasm Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Protein Phosphorylation Regulation Of Gene Expression Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Phosphorylation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Mitotic Cell Cycle Phase Transition Regulation Of Metabolic Process Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Cell Cycle Cell Cycle Phase Transition Regulation Of Cell Cycle Process Negative Regulation Of Metabolic Process Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Cellular Response To Stress Cellular Response To Oxygen-containing Compound Negative Regulation Of Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Histone Binding Positive Regulation Of Macromolecule Metabolic Process Protein Modification Process Response To Stress Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Negative Regulation Of RNA Metabolic Process ESC/E(Z) Complex Regulation Of Cell Cycle Phase Transition Cell Division Diacylglycerol-dependent Serine/threonine Kinase Activity Protein Localization To Chromosome	Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Nucleus Regulation Of Cell Population Proliferation Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of Catalytic Activity Negative Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle G1/S Phase Transition Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Signal Transduction Negative Regulation Of Macromolecule Metabolic Process Regulation Of Protein Modification Process Regulation Of Phosphorus Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Negative Regulation Of Programmed Cell Death Regulation Of Kinase Activity Negative Regulation Of Apoptotic Process Intracellular Signal Transduction Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Regulation Of Phosphorylation Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Nucleoplasm Negative Regulation Of Cell Cycle Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Signaling Regulation Of Cell Communication Positive Regulation Of Macromolecule Metabolic Process Regulation Of Mitotic Cell Cycle Regulation Of Protein Kinase Activity Regulation Of Protein Phosphorylation Positive Regulation Of RNA Metabolic Process Negative Regulation Of Cell Population Proliferation Regulation Of Cell Cycle Process Cellular Response To Stress Protein Kinase Binding Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process
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