HIST1H1A and PRDM1

Number of citations of the paper that reports this interaction (PMID 14985713)
87

Data Source:
BioGRID (enzymatic study)

		HIST1H1A	PRDM1
Gene Name		histone cluster 1, H1a	PR domain containing 1, with ZNF domain
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleosome Nuclear Chromatin Nuclear Euchromatin	Nucleus Cytoplasm
	Molecular Function	Protein Binding Chromatin DNA Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Methyltransferase Activity Histone Deacetylase Binding Metal Ion Binding
	Biological Process	Nucleosome Assembly Spermatogenesis	Negative Regulation Of Transcription From RNA Polymerase II Promoter Maternal Placenta Development Transcription, DNA-templated Germ Cell Development Post-embryonic Development Positive Regulation Of Gene Expression Negative Regulation Of B Cell Proliferation Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Methylation Eye Photoreceptor Cell Development Cell Fate Commitment Positive Regulation Of B Cell Differentiation Intestinal Epithelial Cell Development Trophoblast Giant Cell Differentiation
Pathways		DNA Damage/Telomere Stress Induced Senescence Formation of Senescence-Associated Heterochromatin Foci (SAHF) Activation of DNA fragmentation factor Apoptosis induced DNA fragmentation Cellular Senescence Programmed Cell Death Apoptotic execution phase
Drugs
Diseases
GWAS			Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) ( 23648065) Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) ( 23648065) Crohn's disease ( 21102463) Systemic lupus erythematosus ( 23273568 19838193)
Protein-Protein Interactions		45 interactors: AEBP2 CCNA1 CCNA2 CCNB1 CCND2 CCNE1 CDK1 CDK2 CDK4 CDK6 CDK7 CDKN1B CRP CTCFL EED EHMT2 EP300 EZH2 GADD45A GZMA IRAK4 KAT2B LIMK1 LIMK2 LOX NAP1L4 NASP PARP1 PARP3 PELP1 PKN1 PRDM1 PRKCA PRKCB PRKCD PRKCE PRKCZ PRKDC PTMA RBBP4 SUZ12 TERF1 TERF2IP TLK1 WHSC1L1	9 interactors: AES ATXN1 HIST1H1A HIST2H3A IRF4 KDM1A PIAS1 TLE1 TLE2
Entrez ID		3024	639
HPRD ID		00820	04572
Ensembl ID		ENSG00000124610	ENSG00000057657
Uniprot IDs		Q02539	B4DW27 O75626
PDB IDs			3DAL
Enriched GO Terms of Interacting Partners?		Chromosome Organization Cell Cycle Chromatin Organization Chromatin Modification Regulation Of Cell Cycle Organelle Organization Cell Cycle Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cellular Protein Modification Process Regulation Of Cellular Protein Metabolic Process Histone Modification Regulation Of Metabolic Process Mitotic Cell Cycle Process Regulation Of Protein Metabolic Process Regulation Of Protein Kinase Activity Regulation Of Protein Phosphorylation Mitotic Cell Cycle Positive Regulation Of Cellular Metabolic Process Regulation Of Kinase Activity Regulation Of Phosphorylation Regulation Of Nitrogen Compound Metabolic Process Cellular Protein Metabolic Process G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Metabolic Process Regulation Of Phosphorus Metabolic Process Protein Phosphorylation Regulation Of Mitotic Cell Cycle Protein Metabolic Process G1/S Transition Of Mitotic Cell Cycle Cell Division Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Cell Cycle DNA Metabolic Process Cellular Response To Stress Response To Stress Histone Phosphorylation Regulation Of Catalytic Activity Peptidyl-amino Acid Modification Cellular Metabolic Process Regulation Of Cell Cycle Process Phosphorylation Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cell Cycle Regulation Of Cellular Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression, Epigenetic	Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Negative Regulation Of Cellular Metabolic Process Gene Expression Transcription, DNA-templated RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Signal Transduction Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Regulation Of Signaling Regulation Of Anoikis Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Wnt Signaling Pathway Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Regulation Of Binding Positive Regulation Of Gene Expression Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Negative Regulation Of Protein Binding Organ Development Biosynthetic Process Regulation Of Primitive Erythrocyte Differentiation Positive Regulation Of Interleukin-13 Biosynthetic Process Regulation Of DNA Binding Negative Regulation Of Binding Regulation Of Metabolic Process Positive Regulation Of Interleukin-10 Biosynthetic Process Positive Regulation Of Interleukin-4 Biosynthetic Process Myeloid Leukocyte Differentiation Positive Regulation Of Transcription, DNA-templated Interferon-gamma-mediated Signaling Pathway Notch Signaling Pathway Response To Stimulus
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Tagcloud (Difference) ?			122c 2012cb944901 9qh azoospermia blimp1 dazl ddx4 declare dppa3 envisioned fam122c funds grants hef ikbkg ipsc ipscs lin28 poi poi1 poi2 q26 rbmx stella sublines talents vasa xq znf
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