H1-1 and CTCFL

Number of citations of the paper that reports this interaction (PubMedID 17048991)
46

Data Source:
BioGRID (far western blotting, pull down)

		H1-1	CTCFL
Description		H1.1 linker histone, cluster member	CCCTC-binding factor like
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleosome Euchromatin Nucleus Nucleoplasm Chromosome Cell Surface Vesicle	Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Nuclear Body
	Molecular Function	DNA Binding Double-stranded DNA Binding Protein Binding Heparin Binding Structural Constituent Of Chromatin Chromatin DNA Binding Nucleosomal DNA Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Histone Binding Chromatin Insulator Sequence Binding Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	Nucleosome Assembly Spermatogenesis Chromosome Condensation Negative Regulation Of DNA Recombination Positive Regulation Of Receptor-mediated Endocytosis	Chromatin Organization Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Protein Localization To Chromosome Epigenetic Regulation Of Gene Expression Transcription Initiation-coupled Chromatin Remodeling Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Establishment Of Protein Localization To Chromatin Genomic Imprinting
Pathways		Apoptosis induced DNA fragmentation Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Drugs
Diseases
GWAS			Liver enzyme levels (alkaline phosphatase) ( 33972514) Mean corpuscular hemoglobin ( 29403010) Mean corpuscular volume ( 29403010) Obesity-related traits ( 23251661) Prudent dietary pattern ( 28644415) Response to cytadine analogues (cytosine arabinoside) ( 24483146) Response to statin therapy ( 20339536) Triglyceride levels ( 32203549) Type 2 diabetes ( 23300278)
Interacting Genes		54 interacting genes: AEBP2 APP CCNA1 CCNA2 CCNB1 CCND2 CCNE1 CDK1 CDK11B CDK2 CDK4 CDK5 CDK6 CDK7 CDKN1B CRP CTCFL EED EHMT2 EP300 EZH2 GADD45A GZMA IRAK4 KAT2B LIMK1 LIMK2 LOX NAP1L1 NAP1L4 NASP NSD3 PAK4 PARP1 PARP3 PELP1 PRDM1 PRKCA PRKCB PRKCD PRKCE PRKCZ PRKDC PTMA RBBP4 RPS6KA5 SET SMYD5 SNCA SUZ12 TAF1 TERF1 TERF2IP TLK1	10 interacting genes: AURKA BAG6 BRCA1 H1-1 H2AC20 H3C1 PRMT7 SP1 TBP ZDHHC17
Entrez ID		3024	140690
HPRD ID		00820	09512
Ensembl ID		ENSG00000124610	ENSG00000124092
Uniprot IDs		Q02539	A6XGM0 A6XGM9 Q8NI51 V9GY73 V9GYX4
PDB IDs		9J8O
Enriched GO Terms of Interacting Partners?		Chromatin Organization Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Chromatin Remodeling Nucleus Protein Kinase Activity Kinase Activity Cyclin-dependent Protein Kinase Holoenzyme Complex Regulation Of Nucleobase-containing Compound Metabolic Process Transferase Activity G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Regulation Of RNA Metabolic Process Nucleoplasm Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Protein Phosphorylation Regulation Of Gene Expression Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Phosphorylation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Mitotic Cell Cycle Phase Transition Regulation Of Metabolic Process Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Cell Cycle Cell Cycle Phase Transition Regulation Of Cell Cycle Process Negative Regulation Of Metabolic Process Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Cellular Response To Stress Cellular Response To Oxygen-containing Compound Negative Regulation Of Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Histone Binding Positive Regulation Of Macromolecule Metabolic Process Protein Modification Process Response To Stress Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Negative Regulation Of RNA Metabolic Process ESC/E(Z) Complex Regulation Of Cell Cycle Phase Transition Cell Division Diacylglycerol-dependent Serine/threonine Kinase Activity Protein Localization To Chromosome	Chromatin Organization Chromatin Remodeling Euchromatin Pronucleus Epigenetic Regulation Of Gene Expression Structural Constituent Of Chromatin Nucleosome Nucleoplasm Regulation Of Macromolecule Metabolic Process Protein-DNA Complex Assembly Transcription Cis-regulatory Region Binding Centrosome Cycle Regulation Of Centrosome Cycle DNA Binding Chromosome Regulation Of Metabolic Process Male Germ Cell Nucleus Positive Regulation Of Hydrogen Sulfide Biosynthetic Process Cellular Response To Wortmannin Perforant Pathway To Dendrate Granule Cell Synapse Ubiquitin Protein Ligase Binding Histone H2AK127 Ubiquitin Ligase Activity Nucleus Microtubule Organizing Center Organization Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Programmed Cell Death Cellular Component Assembly Chromosome Organization Response To Wortmannin Protein Heterodimerization Activity Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Protein Modification Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Oocyte Maturation BAT3 Complex Protein-arginine Omega-N Symmetric Methyltransferase Activity Nucleosome Assembly BRCA1-B Complex Regulation Of Cell Cycle G2/M Phase Transition Male Gamete Generation Spermatogenesis Spindle Assembly Involved In Female Meiosis I Germinal Vesicle Positive Regulation Of Proteasomal Protein Catabolic Process Histone H3S10 Kinase Activity TFIIB-class Transcription Factor Binding
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